Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0204 | 0.2133 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0118 | 0 | 0.5 |
Onchocerca volvulus | 0.0118 | 0 | 0.5 | |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0204 | 0.2133 | 0.2133 |
Onchocerca volvulus | 0.0118 | 0 | 0.5 | |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0524 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0204 | 0.2133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0118 | 0 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0204 | 0.2133 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0524 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0118 | 0 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0204 | 0.2133 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0204 | 0.2133 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0118 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0204 | 0.2133 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0118 | 0 | 0.5 |
Onchocerca volvulus | 0.0118 | 0 | 0.5 | |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0204 | 0.2133 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0204 | 0.2133 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0524 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0524 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0524 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0524 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0204 | 0.2133 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0524 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0204 | 0.2133 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0118 | 0 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0524 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0524 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0524 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0524 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0524 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0524 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0118 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0204 | 0.2133 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0118 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0118 | 0 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0524 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.