TDR Targets

Basic information

Technical information

TDR Targets ID: 896639
Name: 2-hydrazinyl-5,7-dimethylquinolin-8-ol
MW: 203.24 | Formula: C11H13N3O
H donors: 3 H acceptors: 2 LogP: 2.14 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: NNc1ccc2c(n1)c(O)c(cc2C)C
InChi: 1S/C11H13N3O/c1-6-5-7(2)11(15)10-8(6)3-4-9(13-10)14-12/h3-5,15H,12H2,1-2H3,(H,13,14)
InChiKey: YMOPKPJDBNRMRC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-hydrazino-5,7-dimethyl-quinolin-8-ol
2-hydrazino-5,7-dimethyl-8-quinolinol
2-hydrazinyl-5,7-dimethyl-quinolin-8-ol
IDI1_019489
ChemDiv3_000171
SMR000135172
CBDivE_006918
ZINC01233327
MLS000530195
Oprea1_668505

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Streptococcus pyogenes serotype M1	Streptokinase A	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4E	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma brucei	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Plasmodium berghei	transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Candida albicans	similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium knowlesi	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Candida albicans	similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp	Get druggable targets OG5_127333	All targets in OG5_127333
Theileria parva	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Brugia malayi	beta-NAC-like protein	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus granulosus	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Entamoeba histolytica	transcription factor BTF3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Cryptosporidium hominis	NAC domain protein	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania infantum	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma cruzi	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Cryptosporidium parvum	BTF domain, basal transcription factor	Get druggable targets OG5_127333	All targets in OG5_127333
Neospora caninum	hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma mansoni	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania donovani	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma brucei gambiense	nascent polypeptide associated complex alpha subunit, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania major	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium falciparum	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	transcription factor btf3	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania braziliensis	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Leishmania mexicana	basic transcription factor 3a, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium yoelii	basic transcription factor 3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Loa Loa (eye worm)	ICD-1 protein	Get druggable targets OG5_127333	All targets in OG5_127333
Toxoplasma gondii	NAC domain-containing protein	Get druggable targets OG5_127333	All targets in OG5_127333
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127333	All targets in OG5_127333
Schistosoma japonicum	ko:K01527 nascent polypeptide-associated complex subunit beta, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Plasmodium vivax	basic transcription factor 3b, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Babesia bovis	NAC domain containing protein	Get druggable targets OG5_127333	All targets in OG5_127333
Trypanosoma cruzi	transcription factor btf3, putative	Get druggable targets OG5_127333	All targets in OG5_127333
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0382	0.4077	0.4077
Plasmodium vivax	unspecified product	0.0121	0.0651	0.1225
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0084	0.0173	0.0236
Entamoeba histolytica	cysteine proteinase, putative	0.0382	0.4077	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0173	0.0236
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0382	0.4077	0.5574
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0651	0.089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.1756	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0629	0.7315	1
Onchocerca volvulus		0.0261	0.2494	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0629	0.7315	0.7315
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0382	0.4077	0.4077
Trypanosoma cruzi	cruzipain precursor, putative	0.0382	0.4077	0.5467
Leishmania major	cathepsin L-like protease	0.0382	0.4077	1
Onchocerca volvulus	Cathepsin L homolog	0.0382	0.4077	1
Loa Loa (eye worm)	cathepsin B	0.0253	0.2382	0.3256
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0253	0.2382	0.2697
Loa Loa (eye worm)	hypothetical protein	0.0382	0.4077	0.5574
Giardia lamblia	Cathepsin B precursor	0.0253	0.2382	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0382	0.4077	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0629	0.7315	0.7315
Brugia malayi	Cathepsin L-like precursor	0.0382	0.4077	0.5574
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0084	0.0173	0.0173
Giardia lamblia	Cathepsin B precursor	0.0253	0.2382	1
Brugia malayi	Papain family cysteine protease containing protein	0.0084	0.0173	0.0236
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0084	0.0173	0.0236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0205	0.1756	0.1756
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0261	0.2494	0.325
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Leishmania major	cathepsin L-like protease	0.0382	0.4077	1
Onchocerca volvulus		0.0382	0.4077	1
Entamoeba histolytica	cysteine proteinase, putative	0.0205	0.1756	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase	0.0084	0.0173	0.0236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0382	0.4077	0.5467
Loa Loa (eye worm)	ctsf protein	0.0382	0.4077	0.5574
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0084	0.0173	0.0173
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0205	0.1756	0.4054
Echinococcus granulosus	cathepsin L cysteine protease	0.0205	0.1756	0.1756
Entamoeba histolytica	cysteine proteinase 1, putative	0.0205	0.1756	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0205	0.1756	0.4054
Toxoplasma gondii	cathepsin B	0.0253	0.2382	0.5658
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Echinococcus granulosus	cathepsin L	0.0084	0.0173	0.0173
Echinococcus granulosus	cathepsin l1	0.0382	0.4077	0.4077
Entamoeba histolytica	cysteine proteinase, putative	0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0121	0.0651	0.067
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0382	0.4077	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0173	0.0236
Leishmania major	cathepsin L-like protease	0.0382	0.4077	1
Plasmodium vivax	vivapain-3	0.0205	0.1756	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0205	0.1756	0.1756
Onchocerca volvulus		0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0261	0.2494	0.5946
Brugia malayi	Papain family cysteine protease containing protein	0.0205	0.1756	0.24
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0084	0.0173	0.0236
Brugia malayi	Cathepsin L-like precursor	0.0382	0.4077	0.5574
Trypanosoma cruzi	cysteine peptidase, putative	0.0382	0.4077	0.5467
Leishmania major	cathepsin L-like protease	0.0382	0.4077	1
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0261	0.2494	0.341
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2494	0.341
Onchocerca volvulus	Cathepsin L homolog	0.0382	0.4077	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0084	0.0173	0.0236
Onchocerca volvulus		0.0382	0.4077	1
Loa Loa (eye worm)	cysteine protease	0.0382	0.4077	0.5574
Echinococcus multilocularis	cathepsin L cysteine protease	0.0382	0.4077	0.4077
Schistosoma mansoni	cathepsin F (C01 family)	0.0261	0.2494	0.2494
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0173	0.0236
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0173	0.0236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0121	0.0651	0.089
Entamoeba histolytica	cysteine protease, putative	0.0382	0.4077	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0084	0.0173	0.0236
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0205	0.1756	0.2216
Brugia malayi	Papain family cysteine protease containing protein	0.0084	0.0173	0.0236
Onchocerca volvulus		0.0382	0.4077	1
Leishmania major	cathepsin L-like protease	0.0382	0.4077	1
Brugia malayi	Cathepsin L-like precursor	0.0261	0.2494	0.341
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0629	0.7315	0.7315
Plasmodium vivax	vivapain-2	0.0382	0.4077	1
Leishmania major	cathepsin L-like protease	0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Brugia malayi	Cathepsin L-like precursor	0.0261	0.2494	0.341
Trypanosoma cruzi	cysteine protease, putative	0.0205	0.1756	0.2216
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0173	0.0173
Onchocerca volvulus	Cathepsin F homolog	0.0382	0.4077	1
Onchocerca volvulus		0.0382	0.4077	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0382	0.4077	0.4077
Plasmodium vivax	vivapain-2	0.0382	0.4077	1
Echinococcus granulosus	cathepsin L	0.0205	0.1756	0.1756
Schistosoma mansoni	microtubule-associated protein tau	0.0833	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0084	0.0173	0.0236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0173	0.0236
Brugia malayi	cathepsin F-like cysteine proteinase	0.0084	0.0173	0.0236
Echinococcus multilocularis	cathepsin L cysteine protease	0.0382	0.4077	0.4077
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0084	0.0173	0.0173
Brugia malayi	cathepsin L precursor	0.0084	0.0173	0.0236
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0084	0.0173	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0173	0.0236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Leishmania major	cysteine peptidase A (CPA)	0.0382	0.4077	1
Plasmodium vivax	unspecified product	0.0205	0.1756	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0651	0.089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Schistosoma mansoni	cathepsin s	0.0121	0.0651	0.0651
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0382	0.4077	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0173	0.0173
Plasmodium vivax	vivapain-1	0.0205	0.1756	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0205	0.1756	0.24
Echinococcus multilocularis	cathepsin b	0.0629	0.7315	0.7315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0253	0.2382	0.2382
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0173	0.0173
Brugia malayi	Cathepsin L-like precursor	0.0382	0.4077	0.5574
Schistosoma mansoni	cathepsin F (C01 family)	0.0382	0.4077	0.4077
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0382	0.4077	0.5467
Brugia malayi	Cathepsin L-like precursor	0.0121	0.0651	0.089
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2494	0.341
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Schistosoma mansoni	cathepsin C	0.0084	0.0173	0.0173
Leishmania major	cathepsin L-like protease	0.0382	0.4077	1
Entamoeba histolytica	cysteine proteinase 2	0.0205	0.1756	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0382	0.4077	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0121	0.0651	0.089
Trypanosoma cruzi	cysteine peptidase, putative	0.0121	0.0651	0.067
Trypanosoma cruzi	cysteine peptidase, putative	0.0205	0.1756	0.2216
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0205	0.1756	0.2216
Toxoplasma gondii	cathepsin CPL	0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Entamoeba histolytica	cysteine proteinase, putative	0.0205	0.1756	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Loa Loa (eye worm)	hypothetical protein	0.0629	0.7315	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0205	0.1756	0.4054
Echinococcus multilocularis	microtubule associated protein 2	0.0833	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0205	0.1756	0.2216
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0173	0.0173
Schistosoma mansoni	cathepsin F (C01 family)	0.0382	0.4077	0.4077
Brugia malayi	cathepsin B-like cysteine proteinase	0.0629	0.7315	1
Echinococcus granulosus	cathepsin l1	0.0261	0.2494	0.2494
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0121	0.0651	0.089
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0253	0.2382	0.5658
Giardia lamblia	Cathepsin B precursor	0.0253	0.2382	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0084	0.0173	0.0173
Brugia malayi	Cathepsin L-like precursor	0.0382	0.4077	0.5574
Onchocerca volvulus		0.0382	0.4077	1
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0629	0.7315	0.7315
Echinococcus granulosus	cathepsin b	0.0629	0.7315	0.7315
Brugia malayi	fibroinase precursor	0.0084	0.0173	0.0236
Echinococcus multilocularis	cysteine protease	0.0382	0.4077	0.4077
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Onchocerca volvulus		0.0382	0.4077	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0651	0.089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0084	0.0173	0.0173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Brugia malayi	cathepsin L-like precursor	0.0261	0.2494	0.341
Echinococcus multilocularis	cathepsin L	0.0205	0.1756	0.1756
Trypanosoma cruzi	cysteine peptidase, putative	0.0382	0.4077	0.5467
Leishmania major	cathepsin L-like protease	0.0382	0.4077	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Loa Loa (eye worm)	fibroinase	0.0382	0.4077	0.5574
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0382	0.4077	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0084	0.0173	0.0173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0261	0.2494	0.5946
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0382	0.4077	0.5574
Entamoeba histolytica	cysteine proteinase, putative	0.0205	0.1756	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Echinococcus multilocularis	cathepsin L	0.0084	0.0173	0.0173
Entamoeba histolytica	cysteine protease, putative	0.0205	0.1756	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0253	0.2382	0.3093
Echinococcus granulosus	cysteine protease	0.0205	0.1756	0.1756
Echinococcus multilocularis	cathepsin b	0.0629	0.7315	0.7315
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0382	0.4077	0.4077
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0382	0.4077	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0382	0.4077	1
Entamoeba histolytica	cysteine proteinase, putative	0.0261	0.2494	0.5946
Brugia malayi	Papain family cysteine protease containing protein	0.0382	0.4077	0.5574
Brugia malayi	Cathepsin L-like precursor	0.0382	0.4077	0.5574
Echinococcus multilocularis	cysteine protease	0.0382	0.4077	0.4077
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2494	0.341
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0084	0.0173	0.0173
Brugia malayi	Cathepsin L-like precursor	0.0382	0.4077	0.5574
Echinococcus granulosus	cathepsin b	0.0629	0.7315	0.7315
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0205	0.1756	0.1756

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 6.083 um	PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)]	ChEMBL.	No reference
Potency (functional)	0.3294 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1497792
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 896639