Detailed information for compound 896980

Basic information

Technical information
  • TDR Targets ID: 896980
  • Name: methyl 2-amino-1-butylpyrrolo[5,4-b]quinoxali ne-3-carboxylate
  • MW: 298.34 | Formula: C16H18N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c2nc3ccccc3nc2c(c1N)C(=O)OC
  • InChi: 1S/C16H18N4O2/c1-3-4-9-20-14(17)12(16(21)22-2)13-15(20)19-11-8-6-5-7-10(11)18-13/h5-8H,3-4,9,17H2,1-2H3
  • InChiKey: ILWDEDFFKIKSHF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-amino-1-butyl-pyrrolo[5,4-b]quinoxaline-3-carboxylate
  • 2-amino-1-butyl-3-pyrrolo[5,4-b]quinoxalinecarboxylic acid methyl ester
  • 2-amino-1-butyl-pyrrolo[5,4-b]quinoxaline-3-carboxylic acid methyl ester
  • ZINC02342036
  • STOCK5S-52718
  • Oprea1_158312
  • Oprea1_493322

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cysteine protease 0.0016 0.003 0.003
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0172 0.0172
Echinococcus multilocularis orexin receptor type 2 0.002 0.0172 0.0172
Brugia malayi G protein-coupled receptor 0.002 0.0172 0.0359
Schistosoma mansoni opsin-like receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Schistosoma mansoni amine GPCR 0.002 0.0172 0.0172
Echinococcus multilocularis neuropeptide receptor 0.002 0.0172 0.0172
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0155 0.4783 1
Echinococcus granulosus neuropeptide receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus granulosus fmrfamide receptor 0.002 0.0172 0.0172
Schistosoma mansoni amine GPCR 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0172 0.0359
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0172 0.0172
Leishmania major cathepsin L-like protease 0.0062 0.1604 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0172 0.0359
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0172 0.0172
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0172 0.0172
Echinococcus granulosus hypothetical protein 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.003 0.003
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0172 0.0172
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.003 0.0063
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0172 0.0172
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Plasmodium vivax vivapain-2 0.0016 0.003 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Brugia malayi G-protein coupled receptor 0.002 0.0172 0.0359
Echinococcus multilocularis fmrfamide receptor 0.002 0.0172 0.0172
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Loa Loa (eye worm) ctsf protein 0.0016 0.003 0.003
Onchocerca volvulus 0.002 0.0172 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.003 1
Onchocerca volvulus 0.002 0.0172 1
Brugia malayi G-protein coupled receptor 0.002 0.0172 0.0359
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0172 0.0172
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.003 0.5
Echinococcus multilocularis cysteine protease 0.0016 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0307 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0172 0.0172
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0172 0.0359
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1604 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0172 0.0172
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0172 1
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0172 0.0172
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0172 0.0172
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0155 0.4783 0.4783
Toxoplasma gondii cathepsin CPL 0.0016 0.003 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0172 0.0172
Brugia malayi Dopamine receptor protein 1 0.002 0.0172 0.0359
Loa Loa (eye worm) fibroinase 0.0016 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0172 0.0172
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0172 0.0172
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0139 0.4253 0.4253
Echinococcus granulosus beta-adrenergic receptor kinase 0.0016 0.0013 0.0013
Onchocerca volvulus 0.002 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Echinococcus multilocularis sex peptide receptor 0.002 0.0172 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Brugia malayi neuropeptide F receptor 0.002 0.0172 0.0359
Onchocerca volvulus 0.002 0.0172 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0172 0.0172
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.003 0.003
Echinococcus granulosus g protein coupled receptor 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1604 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Brugia malayi Serotonin receptor 0.002 0.0172 0.0359
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0172 0.0172
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0172 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Plasmodium vivax vivapain-2 0.0016 0.003 0.5
Entamoeba histolytica cysteine protease, putative 0.0016 0.003 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Brugia malayi follicle stimulating hormone receptor 0.002 0.0172 0.0359
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0172 0.0172
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0172 0.0172
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0172 0.0172
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0139 0.4253 0.4253
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0172 0.0172
Echinococcus multilocularis cysteine protease 0.0016 0.003 0.003
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0172 0.0172
Brugia malayi Dopamine receptor protein 2 0.002 0.0172 0.0359
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.003 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni histamine h1 receptor 0.002 0.0172 0.0172
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.003 1
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus granulosus allatostatin A receptor 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Schistosoma mansoni amine GPCR 0.002 0.0172 0.0172
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0172 0.0172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.003 0.003
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0172 0.0172
Echinococcus granulosus cathepsin l1 0.0016 0.003 0.003
Onchocerca volvulus 0.002 0.0172 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0172 0.0172
Brugia malayi Serotonin receptor 0.002 0.0172 0.0359
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0172 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.002 0.0172 0.0172
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.1147 0.7098
Schistosoma mansoni neuropeptide receptor 0.002 0.0172 0.0172
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0172 0.0172
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0172 0.0172
Brugia malayi Dopamine receptor 0.002 0.0172 0.0359
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0172 0.0172
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0172 0.0172
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0063
Echinococcus multilocularis g protein coupled receptor 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Echinococcus granulosus neuropeptide receptor 0.002 0.0172 0.0172
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1604 1
Brugia malayi ORL1-like opioid receptor 0.002 0.0172 0.0359
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0172 0.0172
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.003 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Brugia malayi sulfakinin receptor protein 0.002 0.0172 0.0359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.003 0.003
Brugia malayi RE15519p 0.002 0.0172 0.0359
Schistosoma mansoni opsin-like receptor 0.002 0.0172 0.0172
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0172 0.0172
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0172 0.0172
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.003 0.003
Schistosoma mansoni neuropeptide receptor 0.002 0.0172 0.0172
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1419 0.8824
Brugia malayi Melatonin receptor type 1A 0.002 0.0172 0.0359
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0172 0.0172
Echinococcus multilocularis serotonin receptor 0.0307 1 1
Onchocerca volvulus 0.002 0.0172 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0172 0.0172
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0172 0.0172
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0172 0.0359
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Echinococcus granulosus serotonin receptor 0.002 0.0172 0.0172
Schistosoma mansoni myosin xvIII 0.002 0.0172 0.0172
Schistosoma mansoni neuropeptide receptor 0.002 0.0172 0.0172
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0172 0.0359
Schistosoma mansoni neuropeptide receptor 0.002 0.0172 0.0172
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0172 0.0172
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0172 0.0172
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0172 0.0172
Echinococcus granulosus g protein coupled receptor 0.002 0.0172 0.0172
Schistosoma mansoni biogenic amine receptor 0.002 0.0172 0.0172
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.003 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0172 0.0172
Schistosoma mansoni opsin-like receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0172 0.0172
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0063
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0172 0.0359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Onchocerca volvulus 0.002 0.0172 1
Brugia malayi GnHR receptor homolog 0.002 0.0172 0.0359
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.003 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0307 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Leishmania major cathepsin L-like protease 0.0062 0.1604 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0172 0.0172
Schistosoma mansoni adenoreceptor 0.002 0.0172 0.0172
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0139 0.4253 0.4253
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0172 0.0172
Echinococcus granulosus neuropeptide s receptor 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0172 0.0172
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0172 0.0172
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0172 0.0172
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0172 0.0359
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis g protein coupled receptor 0.002 0.0172 0.0172
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Brugia malayi larval opioid receptor 0.002 0.0172 0.0359
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0063
Echinococcus granulosus sex peptide receptor 0.002 0.0172 0.0172
Schistosoma mansoni amine GPCR 0.002 0.0172 0.0172
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0139 0.4253 0.4253
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0172 0.0172
Schistosoma mansoni biogenic amine receptor 0.002 0.0172 0.0172
Echinococcus multilocularis g protein coupled receptor 0.002 0.0172 0.0172
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0172 0.0172
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0172 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.4783 0.4783
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0172 0.0172
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0172 0.0172
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0172 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1604 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0172 0.0172
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0172 0.0172
Brugia malayi hypothetical protein 0.002 0.0172 0.0359
Onchocerca volvulus 0.002 0.0172 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0172 0.0172
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.003 0.003
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0307 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0172 0.0172
Echinococcus multilocularis serotonin receptor 0.0307 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis neuropeptide receptor 0.002 0.0172 0.0172
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.003 0.003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0172 0.0172
Schistosoma mansoni amine GPCR 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Schistosoma mansoni biogenic amine receptor 0.002 0.0172 0.0172
Echinococcus granulosus g-protein coupled receptor 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0172 0.0172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0172 0.0172
Brugia malayi AKH receptor 0.002 0.0172 0.0359
Schistosoma mansoni hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis allatostatin A receptor 0.002 0.0172 0.0172
Brugia malayi putative neuropeptide receptor 0.002 0.0172 0.0359
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0172 0.0172
Brugia malayi neuropeptide F receptor 0.002 0.0172 0.0359
Leishmania major cathepsin L-like protease 0.0062 0.1604 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.003 0.0063
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0016 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0172 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.003 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus granulosus orexin receptor type 2 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0172 0.0172
Onchocerca volvulus 0.002 0.0172 1
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0013 0.0013
Echinococcus granulosus somatostatin receptor 0.002 0.0172 0.0172
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.003 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0172 0.0172
Echinococcus multilocularis somatostatin receptor 0.002 0.0172 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.003 1
Echinococcus granulosus g protein coupled receptor 0.002 0.0172 0.0172
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0172 0.0359
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0172 0.0172
Echinococcus multilocularis beta adrenergic receptor kinase 0.0016 0.0013 0.0013
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0172 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0172 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0172 0.0172
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0139 0.4253 0.8892
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5
Echinococcus multilocularis fmrfamide receptor 0.002 0.0172 0.0172
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0172 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0172 0.0172
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0172 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1604 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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