Detailed information for compound 896988

Basic information

Technical information
  • TDR Targets ID: 896988
  • Name: butyl 2-amino-1'-(2-methoxy-2-oxoethyl)-7,7-d imethyl-2',5-dioxospiro[6,8-dihydrochromene-4 ,3'-indole]-3-carboxylate
  • MW: 482.526 | Formula: C26H30N2O7
  • H donors: 1 H acceptors: 4 LogP: 2.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOC(=O)C1=C(N)OC2=C(C31C(=O)N(c1c3cccc1)CC(=O)OC)C(=O)CC(C2)(C)C
  • InChi: 1S/C26H30N2O7/c1-5-6-11-34-23(31)21-22(27)35-18-13-25(2,3)12-17(29)20(18)26(21)15-9-7-8-10-16(15)28(24(26)32)14-19(30)33-4/h7-10H,5-6,11-14,27H2,1-4H3
  • InChiKey: GDCVSAGXUCEWSJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • butyl 2-amino-1'-(2-methoxy-2-oxo-ethyl)-7,7-dimethyl-2',5-dioxo-spiro[6,8-dihydrochromene-4,3'-indoline]-3-carboxylate
  • 2-amino-1'-(2-methoxy-2-oxoethyl)-7,7-dimethyl-2',5-dioxo-3-spiro[6,8-dihydrochromene-4,3'-indoline]carboxylic acid butyl ester
  • 2-amino-2',5-diketo-1'-(2-keto-2-methoxy-ethyl)-7,7-dimethyl-spiro[6,8-dihydrochromene-4,3'-indoline]-3-carboxylic acid butyl ester
  • butyl 2-amino-1'-(2-methoxy-2-oxo-ethyl)-7,7-dimethyl-2',5-dioxo-spiro[6,8-dihydrochromene-4,3'-indole]-3-carboxylate
  • UNM000000664401

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi bone morphogenetic protein type 1 receptor 0.0155 0.0114 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0023 0.0022
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0017 0.0731
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.003 0.0012 0.0544
Schistosoma mansoni hypothetical protein 0.0164 0.0121 0.0121
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0016 0.0697
Loa Loa (eye worm) TK/ALK protein kinase 0.0229 0.0174 0.0173
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.003 0.0012 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0012 0.0489
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0002 0.0001
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0169 0.0125 0.6487
Loa Loa (eye worm) hypothetical protein 0.0109 0.0077 0.0075
Mycobacterium ulcerans putative regulatory protein 0.0079 0.0052 0.4343
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0079 0.0052 0.4343
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0109 0.0077 0.391
Schistosoma mansoni sodium-bile acid cotransporter related 0.4968 0.4047 0.4047
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0019 0.3355
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0002 0.0002
Brugia malayi RNA binding protein 0.0061 0.0037 0.0035
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.003 0.0012 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0023 0.0022
Echinococcus granulosus activin receptor type 0.0072 0.0046 0.0045
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0023 0.1017
Echinococcus multilocularis musashi 0.0026 0.0009 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0023 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0023 0.0021
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0102 0.4442
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0012 0.001
Schistosoma mansoni ABC transporter 0.0025 0.0008 0.0008
Schistosoma mansoni bromodomain containing protein 0.0068 0.0042 0.0042
Echinococcus granulosus dual specificity protein kinase clk2 0.006 0.0036 0.0035
Brugia malayi Protein kinase domain containing protein 0.0092 0.0062 0.006
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.004 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Leishmania major hypothetical protein, conserved 0.003 0.0012 0.0527
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Brugia malayi Bromodomain containing protein 0.0079 0.0052 0.0049
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.003 0.0012 0.0012
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0062 0.2712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0206
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Brugia malayi Protein kinase domain containing protein 0.0229 0.0174 0.0172
Echinococcus granulosus sodium bile acid cotransporter 1.2252 1 1
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0071 0.0045 0.0044
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.0047 0.0025 0.0024
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0124 0.0088 0.3838
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Onchocerca volvulus 1.2252 1 1
Brugia malayi hypothetical protein 0.0027 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0026
Toxoplasma gondii hypothetical protein 0.0079 0.0052 0.3016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0023 0.0023
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0029 0.0028
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0003 0.0002
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0019 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0305
Echinococcus multilocularis zinc finger protein 0.0023 0.0006 0.0005
Echinococcus granulosus geminin 0.0164 0.0121 0.012
Echinococcus granulosus TGF-beta receptor type-1 0.0156 0.0114 0.0113
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0121 0.0112
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0075 0.4487
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.0036 0.1577
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0019 0.3355
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0015
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0004 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Entamoeba histolytica protein kinase, putative 0.0092 0.0062 1
Echinococcus multilocularis lamin 0.0026 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 0.009 0.0061 0.006
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0023 0.0022
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0017 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0023 0.1089
Echinococcus granulosus TGF beta receptor type 1 0.0156 0.0114 0.0113
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0017 0.0014
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0012 0.0011
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0109 0.0077 0.391
Plasmodium falciparum cGMP-specific phosphodiesterase 0.003 0.0012 0.1889
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0062 0.0062
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0316
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0018
Plasmodium falciparum GAF domain-related protein, putative 0.0079 0.0052 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0247 0.0189 0.8232
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0021 0.0931
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0102 0.4442
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0019 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0023 0.1017
Entamoeba histolytica protein kinase, putative 0.0092 0.0062 1
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0036 0.0036
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.003 0.0012 0.2761
Echinococcus granulosus tumor protein p63 0.0332 0.0259 0.0258
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0247 0.0189 0.8232
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0012 0.0489
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0033 0.0031
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0005 0.0239
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0005 0.023
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0003 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.003 0.0012 0.0527
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0005 0.0239
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0017 0.0725
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0092 0.0062 0.0061
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0247 0.0189 0.9908
Giardia lamblia ABC transporter 0.003 0.0011 0.2551
Toxoplasma gondii TIM10 family protein, putative 0.0046 0.0025 0.1364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0204
Entamoeba histolytica hypothetical protein 0.0092 0.0062 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0247 0.0189 0.9908
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.0165 0.8588
Entamoeba histolytica ABC transporter, putative 0.003 0.0012 0.1479
Schistosoma mansoni lamin 0.0026 0.0009 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.0084 0.0084
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.003 0.0012 0.0527
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0009 0.0007
Giardia lamblia Kinase, CMGC CLK 0.006 0.0036 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0003 0.5
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0017 0.2313
Schistosoma mansoni protein kinase 0.0156 0.0114 0.0114
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0002 0.0001
Toxoplasma gondii hypothetical protein 0.0048 0.0026 0.1456
Brugia malayi Protein kinase domain containing protein 0.0061 0.0037 0.0034
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0017 0.0017
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0021 0.0004 0.0004
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.006 0.0036 0.2064
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0046 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0012 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Echinococcus granulosus GPCR family 2 0.0031 0.0012 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0017 0.0725
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0003 0.0127
Plasmodium falciparum phosphodiesterase delta, putative 0.003 0.0012 0.1889
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0009 0.0006
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0023 0.3446
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0016 0.0697
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0014 0.0695
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0169 0.0125 0.6487
Echinococcus granulosus expressed protein 0.0046 0.0025 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0305
Echinococcus multilocularis activin receptor type 0.0072 0.0046 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0002 0.0099
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0036 0.1772
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0023 0.0023
Onchocerca volvulus 0.0056 0.0033 0.0024
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0012 0.0783
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0124 0.0088 0.0087
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0052 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0012 0.0783
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0021 0.0931
Loa Loa (eye worm) hypothetical protein 0.02 0.0151 0.015
Schistosoma mansoni sodium-bile acid cotransporter related 1.2252 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0012 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0247 0.0189 0.0188
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0023 0.1017
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Brugia malayi P38 map kinase family protein 2 0.0124 0.0088 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.003 0.0012 0.0783
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0012 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Echinococcus multilocularis tumor protein p63 0.0332 0.0259 0.0258
Entamoeba histolytica protein kinase domain containing protein 0.0092 0.0062 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0002 0.0002
Brugia malayi hypothetical protein 0.0059 0.0036 0.0033
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.003 0.0012 0.0011
Echinococcus multilocularis TGF beta receptor type 1 0.0156 0.0114 0.0113
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0017 0.0015
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0017 0.0015
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0124 0.0088 0.3838
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0109 0.0077 0.0075
Echinococcus granulosus mitogen activated protein kinase 11 0.0124 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.009 0.0061 0.006
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.0088 0.3838
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0012 0.001
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.004 0.0038
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0005 0.0239
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.0088 0.0087
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.003 0.0012 0.0011
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.003 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0059 0.0036 0.0034
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0017 0.0725
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0037 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0029 0.1256
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0109 0.0077 0.0077
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0489
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0109 0.0077 0.0075
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0023 0.0022
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0017 0.0016
Echinococcus multilocularis dual specificity 0.0092 0.0062 0.0061
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Echinococcus multilocularis microtubule associated protein 2 0.0679 0.0542 0.0541
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0204
Brugia malayi CXXC zinc finger family protein 0.0056 0.0033 0.003
Echinococcus multilocularis sodium bile acid cotransporter 1.2252 1 1
Schistosoma mansoni hypothetical protein 0.0039 0.0019 0.0019
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.003 0.0012 0.0527
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.0072 0.0046 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0036 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0042 0.0039
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0247 0.0189 0.8232
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0025 0.4523
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0061 0.0037 0.0037
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.003 0.0012 0.0527
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.0191 0.0188
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0012 0.001
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0489
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0527
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0025 0.1364
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0023 0.3446
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0052 0.5
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0012 0.001
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0017 0.0725
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.0058 0.0035 0.0034
Echinococcus granulosus tar DNA binding protein 0.0061 0.0037 0.0036
Echinococcus granulosus ATP binding cassette sub family G 0.003 0.0012 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Echinococcus multilocularis MAM 0.0027 0.001 0.0008
Brugia malayi Bromodomain containing protein 0.0039 0.0019 0.0016
Echinococcus multilocularis sodium bile acid cotransporter 1.2252 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0021 0.0931
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.003 0.0012 0.0012
Brugia malayi PHD-finger family protein 0.0029 0.0011 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0003 0.0127
Leishmania major cytochrome p450-like protein 0.0022 0.0005 0.0239
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0092 0.0062 0.2712
Brugia malayi hypothetical protein 0.0035 0.0016 0.0013
Plasmodium falciparum ABC transporter G family member 2 0.003 0.0012 0.1804
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0019 0.1012
Echinococcus granulosus mitogen activated protein kinase 14 0.0124 0.0088 0.0087
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0017 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.0007
Brugia malayi Cytochrome P450 family protein 0.0022 0.0005 0.0003
Schistosoma mansoni cpg binding protein 0.0056 0.0033 0.0033
Echinococcus granulosus zinc finger protein 0.0023 0.0006 0.0005
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0247 0.0189 0.8232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0206
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0012 0.0009
Leishmania major hypothetical protein, conserved 0.003 0.0012 0.0527
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.003 0.0012 0.0011
Echinococcus granulosus hypothetical protein 0.0058 0.0035 0.0034
Schistosoma mansoni cpg binding protein 0.0061 0.0037 0.0037
Echinococcus granulosus lamin 0.0026 0.0009 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0017 0.0731
Schistosoma mansoni hypothetical protein 0.0027 0.001 0.001
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0009 0.0007
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0037 0.0036
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0102 0.4442
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0016 0.0697
Loa Loa (eye worm) hypothetical protein 0.0066 0.0042 0.004
Leishmania major protein kinase, putative 0.006 0.0036 0.1577
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0037 0.0036
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0247 0.0189 0.0189
Brugia malayi Cytochrome P450 family protein 0.0051 0.0029 0.0026
Trypanosoma cruzi ABC transporter, putative 0.003 0.0012 0.0509
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.003 0.0012 0.0009
Echinococcus granulosus MAM 0.0027 0.001 0.0008
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0023 0.0023
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.003 0.0012 0.0527
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0247 0.0189 0.0188
Onchocerca volvulus 0.0027 0.001 0.0001
Giardia lamblia Hypothetical protein 0.003 0.0012 0.2761
Schistosoma mansoni microtubule-associated protein tau 0.0679 0.0542 0.0542
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Giardia lamblia GTOR 0.0044 0.0023 0.6143
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0012 0.0011
Echinococcus multilocularis expressed protein 0.0046 0.0025 0.0024
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0128 0.6658
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.003 0.0012 0.0527
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0017 0.0015
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0012 0.001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0067 0.0064
Schistosoma mansoni zinc finger protein 0.0023 0.0006 0.0006
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0021 0.0931
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0012 0.0011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0092 0.0062 0.2712
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0017 0.0731
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0023 0.0022
Giardia lamblia hypothetical protein 0.003 0.0012 0.2761
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0046 0.0025 0.0024
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis conserved hypothetical protein 0.0247 0.0189 0.9908
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0005 0.0004
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0079 0.0052 0.4343
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.003 0.0012 0.0011
Leishmania major protein kinase, putative 0.006 0.0036 0.1577
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0155 0.0114 0.0113
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0061 0.0037 0.0036
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0061 0.0037 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0128 0.6658
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0023 0.0022
Echinococcus granulosus cpg binding protein 0.0061 0.0037 0.0036
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0003 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Plasmodium falciparum phosphodiesterase gamma, putative 0.003 0.0012 0.1889
Echinococcus multilocularis 0.0058 0.0035 0.0034
Brugia malayi TAR-binding protein 0.0061 0.0037 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0052 0.259
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.003 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.0012 0.0489
Trypanosoma cruzi ATP-binding cassette protein, putative 0.003 0.0012 0.0509
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0067 0.0064
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0109 0.0077 0.0074
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0017 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.003 0.0012 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0023 0.1089
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Mycobacterium ulcerans putative regulatory protein 0.0079 0.0052 0.4343
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0011
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) PDE1B protein 0.003 0.0012 0.0011
Echinococcus multilocularis dual specificity protein kinase clk2 0.006 0.0036 0.0035
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.003 0.0012 0.0009
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0016 0.0696
Loa Loa (eye worm) hypothetical protein 0.0097 0.0067 0.0065
Toxoplasma gondii hypothetical protein 0.0079 0.0052 0.3016
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0023 0.1017
Brugia malayi Protein kinase domain containing protein 0.006 0.0036 0.0034
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.006 0.0036 0.1577
Echinococcus granulosus sodium bile acid cotransporter 1.2252 1 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.003 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0079 0.0052 0.005
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.006 0.0036 0.1577
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0109 0.0077 0.391
Loa Loa (eye worm) CMGC/CLK protein kinase 0.006 0.0036 0.0035
Trypanosoma brucei ATP-binding cassette protein, putative 0.003 0.0012 0.0509
Schistosoma mansoni ap endonuclease 0.0019 0.0003 0.0003
Echinococcus granulosus lamin dm0 0.0026 0.0009 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0121 0.6276
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.003 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0023 0.1089
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.0191 0.019
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0204
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0079 0.0052 0.4343
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0169 0.0125 0.5433
Trypanosoma brucei ABC transporter, putative 0.003 0.0012 0.0509
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0012 0.0527
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.0012 0.0009
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0316
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0316
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.0088 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0037 0.0037
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.023 1
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.003 0.0012 0.0509
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0002 0.0001
Echinococcus multilocularis sodium bile acid cotransporter 1.2252 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0007
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Onchocerca volvulus 0.0027 0.001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0003 0.0127
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0005 0.0004
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Plasmodium falciparum cGMP-specific phosphodiesterase 0.003 0.0012 0.1889
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0025 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0793 0.0635 0.0634
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.023 1
Echinococcus multilocularis geminin 0.0164 0.0121 0.012
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0009 0.0007
Echinococcus granulosus sodium bile acid cotransporter 1.2252 1 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0012 0.0011
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Toxoplasma gondii GAF domain-containing protein 0.0079 0.0052 0.3016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0018 0.0808
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0017 0.4124
Schistosoma mansoni hypothetical protein 0.0066 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Brugia malayi Cytochrome P450 family protein 0.0022 0.0005 0.0003
Toxoplasma gondii hypothetical protein 0.0217 0.0165 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0004 0.019
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.003 0.0012 0.0011
Plasmodium vivax phosphodiesterase gamma, putative 0.003 0.0012 0.1889
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0527
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0003 0.0002
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.003 0.0012 0.0011
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0092 0.0062 0.2712
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.003 0.0012 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0489
Echinococcus multilocularis lamin dm0 0.0026 0.0009 0.0007
Loa Loa (eye worm) hypothetical protein 1.2252 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0023 0.1017
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.0088 0.3838
Schistosoma mansoni protein kinase 0.007 0.0045 0.0045
Echinococcus granulosus intermediate filament protein 0.0026 0.0009 0.0007
Echinococcus multilocularis dnaJ subfamily B 0.0793 0.0635 0.0634
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0037 0.0036
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.1889
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0067 0.0065
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0009 0.0007
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.0036 0.1577
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0023 0.1017
Echinococcus granulosus dual specificity 0.0092 0.0062 0.0061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0023 0.0022
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0012 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.023 1
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.0165 0.8588
Echinococcus multilocularis GPCR, family 2 0.0031 0.0012 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0191 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0019 0.0017
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.003 0.0012 0.0489
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.0036 0.1577
Echinococcus granulosus microtubule associated protein 2 0.0679 0.0542 0.0541
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.0036 0.1577
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0025 0.0008 0.0427
Brugia malayi intermediate filament protein 0.0026 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0027 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0157 0.0115 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0011 0.0415
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0017 0.0017
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.003 0.0012 0.0509
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.003 0.0012 0.0527
Brugia malayi protein C17H12.11 0.0059 0.0036 0.0033
Plasmodium vivax serine/threonine kinase-1, putative 0.006 0.0036 0.6842
Schistosoma mansoni hypothetical protein 0.0793 0.0635 0.0635
Brugia malayi hypothetical protein 0.0035 0.0016 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0007 0.0206
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0115 1
Echinococcus multilocularis ATP binding cassette sub family G 0.003 0.0012 0.001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0012 0.0011
Plasmodium vivax ABC transporter G family member 2, putative 0.003 0.0012 0.1804
Schistosoma mansoni lamin 0.0026 0.0009 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0003 0.0127
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.0088 0.0087
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0109 0.0077 0.0074
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0247 0.0189 0.8232
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0011
Echinococcus multilocularis cpg binding protein 0.0061 0.0037 0.0036
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.023 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0018
Schistosoma mansoni sodium-bile acid cotransporter 0.7284 0.594 0.594
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.0165 0.8588
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0247 0.0189 0.9908
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.001 0.0008
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0046 0.0025 0.0022
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0247 0.0189 0.9908
Loa Loa (eye worm) RNA binding protein 0.0061 0.0037 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0014 0.0597
Loa Loa (eye worm) ABC transporter 0.0025 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0164 0.0121 0.0121
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0017 0.0016
Schistosoma mansoni intermediate filament proteins 0.0026 0.0009 0.0009
Plasmodium falciparum protein serine/threonine kinase-1 0.006 0.0036 0.6842
Brugia malayi ABC transporter family protein 0.0025 0.0008 0.0005
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0025 0.4523
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.003 0.0012 0.0011
Onchocerca volvulus 0.0049 0.0027 0.0018

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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