Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0038 | 0.1015 | 0.6307 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0862 | 0.0743 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0914 | 0.6498 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0194 | 0.0189 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.4658 | 0.4589 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0138 | 0.5079 | 0.5015 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0016 | 0.0129 | 0.0123 |
Schistosoma mansoni | thyroid hormone receptor | 0.0149 | 0.5528 | 0.547 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.468 | 0.7256 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0047 | 0.1407 | 0.9096 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0862 | 0.0743 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0018 | 0.0194 | 0.0466 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.1533 | 0.1366 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2462 | 0.2363 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0194 | 0.0466 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0038 | 0.1015 | 0.6307 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0259 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.1407 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0107 | 0.384 | 0.3836 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.017 | 0.6377 | 0.633 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.1533 | 0.1423 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0862 | 0.0743 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0035 | 0.0914 | 0.0734 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0259 | 1 | 1 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.002 | 0.0283 | 0.1095 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.1407 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0129 | 0.0916 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0047 | 0.1407 | 0.1294 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0862 | 0.0743 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0107 | 0.384 | 0.3836 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0129 | 0.0916 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.468 | 0.7256 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0521 | 0.3702 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.4159 | 0.6412 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.017 | 0.6377 | 0.633 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0047 | 0.1407 | 0.1294 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0047 | 0.1407 | 0.9096 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0047 | 0.1407 | 0.1402 |
Brugia malayi | glutathione reductase | 0.0051 | 0.1533 | 0.1529 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.1533 | 0.1366 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0522 | 0.3713 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0194 | 0.1382 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0521 | 0.3702 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0633 | 0.4499 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0022 | 0.0393 | 0.1883 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.4658 | 0.4655 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0862 | 0.0857 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0194 | 0.1382 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0774 | 0.5501 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Giardia lamblia | GTOR | 0.0047 | 0.1407 | 1 |
Leishmania major | trypanothione reductase | 0.0051 | 0.1533 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.1533 | 0.1366 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.1013 | 0.7204 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0047 | 0.1407 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.468 | 0.2283 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0914 | 0.6498 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0862 | 0.0857 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0115 | 0.4159 | 0.1526 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0621 | 0.4418 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.3107 | 0.2971 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0862 | 0.0743 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0862 | 0.0743 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0194 | 0.0466 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0522 | 0.3713 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0732 | 0.5205 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.4159 | 0.6412 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.017 | 0.6377 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.4159 | 0.6412 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0129 | 0.0916 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.468 | 0.7256 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0862 | 0.0743 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0633 | 0.4499 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.017 | 0.6377 | 0.4744 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0194 | 0.0466 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.1533 | 0.1529 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0194 | 0.0066 |
Toxoplasma gondii | hypothetical protein | 0.0089 | 0.3107 | 0.2971 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0194 | 0.0466 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0914 | 0.6498 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.017 | 0.6377 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0047 | 0.1407 | 0.1294 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0038 | 0.1015 | 0.6307 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.1533 | 0.1423 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0259 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0149 | 0.5528 | 0.547 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.1533 | 0.2166 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0259 | 1 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0194 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2462 | 0.2363 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.1013 | 0.7204 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0862 | 0.0743 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0047 | 0.1407 | 0.9096 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0633 | 0.4499 |
Schistosoma mansoni | thyroid hormone receptor | 0.0149 | 0.5528 | 0.547 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0129 | 0.0916 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0047 | 0.1407 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.1533 | 0.1366 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.4159 | 0.6412 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0047 | 0.1407 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0138 | 0.5079 | 0.5015 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.5079 | 0.5015 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.1533 | 0.1423 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0089 | 0.3107 | 0.2971 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0621 | 0.4418 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.4658 | 0.4589 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0129 | 0.0916 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0521 | 0.3702 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0259 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0914 | 0.6498 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0073 | 0.2462 | 0.2457 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0047 | 0.1407 | 0.9096 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0107 | 0.384 | 0.3759 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.1125 | 0.8002 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0047 | 0.1407 | 0.1294 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0914 | 0.6498 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.1533 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.384 | 0.3759 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0914 | 0.6498 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.1013 | 0.7204 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0259 | 1 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0089 | 0.3107 | 0.2971 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 1 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0047 | 0.1407 | 0.9096 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0194 | 0.0466 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.4159 | 0.6412 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0522 | 0.3713 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.4159 | 0.6412 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0914 | 0.6498 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.1013 | 0.7204 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0862 | 0.0743 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0194 | 0.0466 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.1533 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.1533 | 0.1366 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0862 | 0.0743 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0522 | 0.3713 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0862 | 0.0743 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0047 | 0.1407 | 0.9096 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0194 | 0.0466 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0194 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0862 | 0.0743 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.1013 | 0.7204 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.1533 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.