Detailed information for compound 897342

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.266 | Formula: C15H12N2O5
  • H donors: 1 H acceptors: 4 LogP: 2.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C=Nc1ccccc1C(=O)O)[N+](=O)[O-]
  • InChi: 1S/C15H12N2O5/c1-22-14-7-6-11(17(20)21)8-10(14)9-16-13-5-3-2-4-12(13)15(18)19/h2-9H,1H3,(H,18,19)/b16-9+
  • InChiKey: KHZQNGIAMGYZMG-CXUHLZMHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 0.0055 0.0419 0.0419
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.02 0.0222
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.02 0.3018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.6714 0.6714
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0116 0.0939 0.1041
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.02 0.3018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0116 0.0939 0.1041
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0008 0.002 0.002
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.252 0.5545
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0008 0.002 0.002
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0254 0.0254
Brugia malayi ecdysteroid receptor 0.0116 0.0939 0.1874
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.02 0.2803
Loa Loa (eye worm) nuclear receptor NHR-67 0.0055 0.0419 0.0921
Loa Loa (eye worm) hypothetical protein 0.0535 0.449 0.9878
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.095 0.2089
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0191 0.1573 0.8958
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0419 0.0419
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.02 0.3018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0131 0.1733
Echinococcus multilocularis nuclear receptor nhr 48 0.0055 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0037 0.0041
Brugia malayi glutathione reductase 0.0084 0.0664 0.1325
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0116 0.0939 0.1874
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0116 0.0939 0.2065
Trypanosoma brucei NADH dehydrogenase 0.0008 0.002 0.0298
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0008 0.002 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.095 0.2089
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0061 0.0474 0.1044
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0419 0.0419
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0055 0.0419 0.0419
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0061 0.0925
Echinococcus multilocularis FTZ F1 alpha 0.0116 0.0939 0.0939
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0131 0.1733
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0116 0.0939 0.0939
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0116 0.0939 0.1041
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0008 0.002 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0116 0.0939 0.0939
Schistosoma mansoni glutamate synthase 0.0008 0.002 0.002
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0061 0.2415
Loa Loa (eye worm) hypothetical protein 0.0061 0.0474 0.1044
Loa Loa (eye worm) hypothetical protein 0.0116 0.0939 0.2065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0116 0.0939 0.1874
Schistosoma mansoni importin beta-1 0.0028 0.0195 0.0195
Plasmodium vivax thioredoxin reductase, putative 0.0084 0.0664 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.02 0.3018
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0055 0.0419 0.0836
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0008 0.002 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0116 0.0939 0.1874
Brugia malayi conserved hypotetical protein 0.0055 0.0419 0.0836
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0419 0.0419
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1068 0.9016 0.9016
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0055 0.0419 0.0419
Echinococcus granulosus Smad4 0.0008 0.0022 0.0025
Onchocerca volvulus Bile acid receptor homolog 0.0116 0.0939 1
Brugia malayi hypothetical protein 0.0055 0.0419 0.0836
Loa Loa (eye worm) DR-78 0.0055 0.0419 0.0921
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0037 0.0559
Schistosoma mansoni nuclear receptor nhr-48 0.0055 0.0419 0.0419
Schistosoma mansoni hypothetical protein 0.0035 0.0254 0.0254
Brugia malayi nuclear hormone receptor 0.0055 0.0419 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0116 0.0939 0.1874
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0474 0.0474
Brugia malayi tailless protein 0.0055 0.0419 0.0836
Loa Loa (eye worm) hypothetical protein 0.0119 0.0962 0.2116
Trichomonas vaginalis apoptosis inducing factor, putative 0.0008 0.002 0.0988
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0131 0.0146
Entamoeba histolytica hypothetical protein 0.0035 0.0254 1
Echinococcus multilocularis smad 0.0008 0.0022 0.0022
Schistosoma mansoni ran 0.0021 0.0131 0.0131
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.02 0.3018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0116 0.0939 0.2065
Brugia malayi Smad1 0.0008 0.0022 0.0045
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0037 0.0559
Brugia malayi Steroid receptor seven-up type 2 0.0116 0.0939 0.1874
Brugia malayi glutamate synthase 0.0008 0.002 0.004
Onchocerca volvulus 0.0055 0.0419 0.4342
Trypanosoma brucei hypothetical protein, conserved 0.0008 0.002 0.0298
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0419 0.0836
Plasmodium falciparum glutathione reductase 0.0084 0.0664 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0131 0.1979
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0008 0.002 0.0022
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0037 0.0037
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.02 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0195 0.2935
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0008 0.002 0.0298
Mycobacterium tuberculosis Probable dehydrogenase 0.0191 0.1573 0.8958
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.02 0.3018
Trypanosoma cruzi trypanothione reductase, putative 0.0084 0.0664 1
Brugia malayi hypothetical protein 0.0061 0.0474 0.0947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0116 0.0939 0.2065
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.0419 0.4342
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0212 0.1754 1
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0008 0.002 0.0298
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0155 0.0309
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.02 0.04
Schistosoma mansoni thyroid hormone receptor 0.1184 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0149 0.5873
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0061 0.0474 0.0474
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0008 0.002 0.0298
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0155 0.7717
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0022 0.0049
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.0419 0.4342
Echinococcus granulosus bloom syndrome protein 0.0024 0.0155 0.0172
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0037 0.0559
Entamoeba histolytica hypothetical protein 0.0035 0.0254 1
Trypanosoma brucei trypanothione reductase 0.0084 0.0664 1
Leishmania major hypothetical protein, conserved 0.0008 0.002 0.0298
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0055 0.0419 0.0419
Schistosoma mansoni DNA helicase recq1 0.001 0.0037 0.0037
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0419 0.0465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0116 0.0939 0.2065
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0037 0.0074
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0008 0.002 0.0022
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.02 1
Brugia malayi Nuclear hormone receptor-like 1 0.0596 0.501 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0191 0.1573 0.8958
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0008 0.002 0.0988
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0131 0.0131
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0116 0.0939 0.0939
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.009 0.1353
Onchocerca volvulus Protein ultraspiracle homolog 0.0116 0.0939 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0055 0.0419 0.0836
Plasmodium falciparum thioredoxin reductase 0.0029 0.02 0.3018
Echinococcus multilocularis snurportin 1 0.0302 0.252 0.252
Entamoeba histolytica hypothetical protein 0.0035 0.0254 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0084 0.0668 0.0668
Loa Loa (eye worm) nuclear hormone receptor 0.0055 0.0419 0.0921
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0008 0.002 0.0988
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Echinococcus granulosus importin subunit beta 1 0.0028 0.0195 0.0216
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0008 0.002 0.0988
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0061 0.0474 0.0474
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0116 0.0939 0.0939
Schistosoma mansoni ran 0.0021 0.0131 0.0131
Schistosoma mansoni Smad4 0.0008 0.0022 0.0022
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.02 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.02 0.2803
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0116 0.0939 0.1041
Trichomonas vaginalis glutamate synthase, putative 0.0008 0.002 0.0988
Plasmodium vivax ferrodoxin reductase, putative 0.0008 0.002 0.0298
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0191 0.1573 0.8958
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0113 0.0113
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0008 0.002 0.0298
Brugia malayi nuclear receptor NHR-67 0.0055 0.0419 0.0836
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0254 0.0282
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0541 0.4545 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0116 0.0939 0.0939
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0008 0.002 0.0988
Schistosoma mansoni steroid hormone receptor ad4bp 0.0116 0.0939 0.0939
Plasmodium falciparum glutathione reductase 0.0029 0.02 0.3018
Onchocerca volvulus 0.0055 0.0419 0.4342
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0116 0.0939 0.0939
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0149 0.7457
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0008 0.002 0.0022
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1068 0.9016 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.02 0.2803
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0116 0.0939 0.2065
Entamoeba histolytica disulphide oxidoreductase, putative 0.0008 0.002 0.0778
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0195 0.2935
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0135 0.027
Loa Loa (eye worm) hypothetical protein 0.0116 0.0939 0.2065
Brugia malayi steroid hormone receptor 0.0116 0.0939 0.1874
Brugia malayi nuclear hormone receptor 0.0116 0.0939 0.1874
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0008 0.002 0.0988
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0116 0.0939 0.0939
Leishmania major GTP-binding protein, putative 0.0021 0.0131 0.1979
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0135 0.027
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0037 0.0037
Leishmania major NADH dehydrogenase, putative 0.0008 0.002 0.0298
Loa Loa (eye worm) hypothetical protein 0.0116 0.0939 0.2065
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0008 0.002 0.004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0022 0.0025
Brugia malayi MH2 domain containing protein 0.0117 0.095 0.1896
Brugia malayi nuclear receptor RXR 0.0061 0.0474 0.0947
Echinococcus granulosus ecdysone induced protein 78C 0.0116 0.0939 0.1041
Schistosoma mansoni sulfide quinone reductase 0.0008 0.002 0.002
Brugia malayi hypothetical protein 0.0055 0.0419 0.0836
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0419 0.0465
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0037 0.0041
Trichomonas vaginalis glutamate synthase, putative 0.0008 0.002 0.0988
Trichomonas vaginalis ran, putative 0.0021 0.0131 0.6559
Entamoeba histolytica thioredoxin reductase, putative 0.0008 0.002 0.0778
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0055 0.0419 0.0921
Loa Loa (eye worm) hypothetical protein 0.0116 0.0939 0.2065
Brugia malayi ecdysone receptor 0.0055 0.0419 0.0836
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0149 0.2012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.02 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0055 0.0419 0.0465
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0116 0.0939 0.0939
Brugia malayi Thioredoxin reductase 0.0084 0.0664 0.1325
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0022 0.0025
Onchocerca volvulus 0.0116 0.0939 1
Loa Loa (eye worm) programmed cell death 8 0.0008 0.002 0.0044
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.02 0.3018
Loa Loa (eye worm) hypothetical protein 0.0116 0.0939 0.2065
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0149 0.7457
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0116 0.0939 0.1874
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0055 0.0419 0.0419
Loa Loa (eye worm) Smad1 0.0008 0.0022 0.0049
Schistosoma mansoni disulfide oxidoreductase 0.0008 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0116 0.0939 0.2065
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0149 0.7457
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0116 0.0939 0.0939
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.02 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0008 0.002 0.002
Echinococcus granulosus thyroid hormone receptor alpha 0.0055 0.0419 0.0465
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0008 0.002 0.002
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0008 0.002 0.0298
Plasmodium falciparum thioredoxin reductase 0.0084 0.0664 1
Plasmodium falciparum importin beta, putative 0.0028 0.0195 0.2935
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0022 0.0022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0191 0.1573 0.8958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.02 0.2803
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0116 0.0939 0.1874
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0008 0.002 0.0022
Treponema pallidum NADH oxidase 0.0029 0.02 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.02 0.02
Brugia malayi nuclear receptor NHR-88 0.0055 0.0419 0.0836
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0131 0.1979
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0131 0.6182
Schistosoma mansoni glutamate synthase 0.0008 0.002 0.002
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0131 0.0262
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0419 0.0419
Schistosoma mansoni zinc finger protein 0.0055 0.0419 0.0419
Schistosoma mansoni RAR-like nuclear receptor 0.0116 0.0939 0.0939
Entamoeba histolytica Ran family GTPase 0.0021 0.0131 0.5166
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0008 0.002 0.0298
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0022 0.0022
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.02 0.3018
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0008 0.002 0.0988
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Schistosoma mansoni hypothetical protein 0.0302 0.252 0.252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0116 0.0939 0.1874
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.02 0.2803
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0212 0.1754 1
Schistosoma mansoni hypothetical protein 0.1068 0.9016 0.9016
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.02 0.3018
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0155 0.7717
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0044
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0116 0.0939 0.1874
Brugia malayi MH1 domain containing protein 0.0008 0.0022 0.0045
Schistosoma mansoni retinoic acid receptor RXR 0.0116 0.0939 0.0939
Loa Loa (eye worm) thioredoxin reductase 0.0084 0.0664 0.1461
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0061 0.0925
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0061 0.0646
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0419 0.0836
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0212 0.1754 1
Loa Loa (eye worm) steroid hormone receptor 0.0116 0.0939 0.2065
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0008 0.002 0.002
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0008 0.002 0.0298
Brugia malayi MH2 domain containing protein 0.0008 0.0022 0.0045
Brugia malayi Importin beta-1 subunit 0.0028 0.0195 0.0389
Toxoplasma gondii thioredoxin reductase 0.0084 0.0664 1
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0037 0.096
Echinococcus granulosus glutamate synthase 0.0008 0.002 0.0022
Loa Loa (eye worm) hypothetical protein 0.0116 0.0939 0.2065
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0008 0.002 0.0298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0116 0.0939 0.1041
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.02 0.3018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0116 0.0939 0.1041
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0008 0.002 0.0778
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.02 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0061 0.0474 0.0526
Leishmania major hypothetical protein, conserved 0.0008 0.002 0.0298
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0008 0.002 0.0778
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0195 0.0195
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0008 0.002 0.0778
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0131 0.1979
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0008 0.002 0.002
Echinococcus multilocularis Smad4 0.0008 0.0022 0.0022
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.02 0.3018
Brugia malayi photoreceptor-specific nuclear receptor 0.0116 0.0939 0.1874
Brugia malayi nuclear hormone receptor family member nhr-6 0.0055 0.0419 0.0836
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0022
Brugia malayi MH2 domain containing protein 0.0008 0.0022 0.0045
Loa Loa (eye worm) hypothetical protein 0.0028 0.0195 0.0429
Brugia malayi nuclear receptor NHR-88 0.0116 0.0939 0.1874
Loa Loa (eye worm) hypothetical protein 0.0061 0.0474 0.1044
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0008 0.002 0.0298
Toxoplasma gondii selenide, water dikinase 0.0008 0.002 0.0298
Loa Loa (eye worm) glutathione reductase 0.0084 0.0664 0.1461
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0008 0.002 0.0988
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.02 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0116 0.0939 0.1874
Loa Loa (eye worm) hypothetical protein 0.0061 0.0474 0.1044
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.02 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0116 0.0939 0.1874
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0116 0.0939 0.0939
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.02 0.02
Schistosoma mansoni thyroid hormone receptor 0.1184 1 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0008 0.002 0.0044
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0008 0.002 0.004
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0008 0.002 0.0298
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0116 0.0939 0.0939
Schistosoma mansoni smad 0.0008 0.0022 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0195 0.2935
Brugia malayi MH1 domain containing protein 0.0008 0.0022 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0212 0.1754 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0116 0.0939 0.1041
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0008 0.002 0.0778
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0116 0.0939 0.2065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.02 0.3018
Brugia malayi nuclear receptor RXR 0.0055 0.0419 0.0836
Brugia malayi hypothetical protein 0.0035 0.0254 0.0508
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.02 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0008 0.002 0.0298
Echinococcus granulosus smad 0.0008 0.0022 0.0025
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.02 0.2803
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.013 0.1963
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0131 0.1979
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Plasmodium vivax importin-beta 2, putative 0.0028 0.0195 0.2935
Schistosoma mansoni glutamate synthase 0.0008 0.002 0.002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0191 0.1573 0.8958
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0008 0.002 0.0988
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0008 0.002 0.0298
Leishmania major hypothetical protein, conserved 0.0008 0.002 0.0298
Echinococcus multilocularis glutamate synthase 0.0008 0.002 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0116 0.0939 0.1874
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0008 0.002 0.0298
Echinococcus granulosus FTZ F1 alpha 0.0116 0.0939 0.1041
Schistosoma mansoni nuclear receptor 0.0055 0.0419 0.0419
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.02 1
Echinococcus granulosus snurportin 1 0.0302 0.252 0.2796
Loa Loa (eye worm) hypothetical protein 0.0061 0.0474 0.1044
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0037 0.0074
Mycobacterium tuberculosis Probable reductase 0.0191 0.1573 0.8958
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0084 0.0664 0.3716
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0116 0.0939 0.1874
Brugia malayi Nuclear hormone receptor-like 1 0.0541 0.4545 0.9073
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0131 0.0289
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0088 0.1329
Loa Loa (eye worm) RecQ helicase 0.0024 0.0155 0.034
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0008 0.002 0.0988
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.02 0.3018
Loa Loa (eye worm) hypothetical protein 0.0116 0.0939 0.2065
Plasmodium vivax glutathione reductase, putative 0.0084 0.0664 1
Plasmodium falciparum ferrodoxin reductase-like protein 0.0008 0.002 0.0298
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0008 0.002 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0116 0.0939 0.2065
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0116 0.0939 0.1874
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.02 0.2803
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0037 0.0082
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0254 0.0254
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0419 0.0465
Entamoeba histolytica hypothetical protein 0.0035 0.0254 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0008 0.002 0.0298
Loa Loa (eye worm) hypothetical protein 0.001 0.0037 0.0082
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.02 0.3018
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0008 0.002 0.0298
Brugia malayi Nuclear hormone receptor-like 1 0.0541 0.4545 0.9073
Schistosoma mansoni hypothetical protein 0.0008 0.002 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0116 0.0939 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0008 0.002 0.0022
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0419 0.0419
Echinococcus granulosus nuclear receptor nhr 48 0.0055 0.0419 0.0465
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0061 0.3066
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0116 0.0939 0.0939
Brugia malayi RNA, U transporter 1 0.0081 0.0638 0.1274
Leishmania major importin beta-1 subunit, putative 0.0023 0.0149 0.2251
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.02 0.1042
Leishmania major trypanothione reductase 0.0084 0.0664 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0022 0.0049
Brugia malayi hypothetical protein 0.0061 0.0474 0.0947
Echinococcus granulosus thioredoxin glutathione reductase 0.0084 0.0668 0.0741
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0008 0.002 0.0778
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.02 1
Schistosoma mansoni coup transcription factor 0.0116 0.0939 0.0939
Brugia malayi orphan nuclear receptor NR2E1 0.0055 0.0419 0.0836
Schistosoma mansoni nuclear hormone receptor 0.0116 0.0939 0.0939
Loa Loa (eye worm) hypothetical protein 0.0055 0.0419 0.0921
Schistosoma mansoni DNA helicase recq5 0.001 0.0037 0.0037
Echinococcus multilocularis ecdysone induced protein 78C 0.0116 0.0939 0.0939

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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