Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.1518 | 0.6498 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0039 | 0.1686 | 0.6307 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0214 | 0.0916 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0049 | 0.2337 | 0.9096 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0049 | 0.2337 | 0.9096 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.003 | 0.1132 | 0.1762 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0279 | 0.0079 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0049 | 0.2337 | 0.9096 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.7739 | 1 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0049 | 0.2337 | 0.2366 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0865 | 0.3702 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.1518 | 0.6498 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0119 | 0.6909 | 0.8837 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0865 | 0.3702 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0018 | 0.0323 | 0.0466 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.7739 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0132 | 0.7775 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0142 | 0.8438 | 0.9168 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0142 | 0.8438 | 1 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0049 | 0.2337 | 0.5 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0088 | 0.4917 | 0.5697 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0088 | 0.4917 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.1683 | 0.7204 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0279 | 0.0086 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.1051 | 0.4499 |
Brugia malayi | Probable ClpP-like protease | 0.0088 | 0.4917 | 0.6349 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0868 | 0.3713 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.2337 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0279 | 0.0086 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0018 | 0.0323 | 0.0121 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0058 | 0.2928 | 0.3025 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0018 | 0.0323 | 0.0466 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0279 | 0.0079 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0119 | 0.6909 | 0.8837 |
Giardia lamblia | GTOR | 0.0049 | 0.2337 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0018 | 0.0323 | 0.0466 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.002 | 0.047 | 0.1095 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0119 | 0.6909 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0132 | 0.7775 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0039 | 0.1686 | 0.6307 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.9184 | 0.9166 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0279 | 0.0066 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0132 | 0.7775 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0052 | 0.2547 | 0.4843 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.1683 | 0.7204 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.8438 | 0.8403 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0058 | 0.2928 | 0.3495 |
Plasmodium falciparum | glutathione reductase | 0.0052 | 0.2547 | 0.4843 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0018 | 0.0323 | 0.0111 |
Leishmania major | trypanothione reductase | 0.0052 | 0.2547 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0058 | 0.2928 | 0.2703 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0052 | 0.2547 | 0.4843 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0214 | 0.0916 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.1518 | 0.6498 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2732 | 0.3347 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0214 | 0.0916 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0279 | 0.0066 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0018 | 0.0323 | 0.1382 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0049 | 0.2337 | 0.9096 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0132 | 0.7775 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0214 | 0.0916 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0052 | 0.2547 | 0.3101 |
Brugia malayi | glutathione reductase | 0.0052 | 0.2547 | 0.3284 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0865 | 0.3702 |
Mycobacterium tuberculosis | Probable reductase | 0.0119 | 0.6909 | 0.8837 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0042 | 0.187 | 0.8002 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0049 | 0.2337 | 0.2821 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.1683 | 0.7204 |
Toxoplasma gondii | thioredoxin reductase | 0.0052 | 0.2547 | 0.4843 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0049 | 0.2337 | 0.3011 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0016 | 0.0214 | 0.0264 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0049 | 0.2337 | 0.2581 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0088 | 0.4917 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0058 | 0.2928 | 0.33 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0018 | 0.0323 | 0.0466 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0868 | 0.3713 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.1518 | 0.6498 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.1051 | 0.4499 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0018 | 0.0323 | 0.1382 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.1285 | 0.5501 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1597 | 0.1413 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0279 | 0.0066 |
Brugia malayi | Thioredoxin reductase | 0.0052 | 0.2547 | 0.3284 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0052 | 0.2547 | 0.2601 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0279 | 0.0079 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0058 | 0.2928 | 0.3495 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.7739 | 1 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0023 | 0.0653 | 0.1883 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0323 | 0.0466 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0052 | 0.2547 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0279 | 0.0072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.1032 | 0.4418 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0279 | 0.0066 |
Toxoplasma gondii | hypothetical protein | 0.003 | 0.1132 | 0.1762 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.1216 | 0.5205 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.1518 | 0.6498 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1597 | 0.2053 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0868 | 0.3713 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0036 | 0.1518 | 0.2602 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0868 | 0.3713 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0119 | 0.6909 | 0.8837 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.2337 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0119 | 0.6909 | 0.8837 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0049 | 0.2337 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0154 | 0.9184 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0049 | 0.2337 | 0.9096 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.1683 | 0.7204 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0279 | 0.0072 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0052 | 0.2547 | 0.4843 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0039 | 0.1686 | 0.6307 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0049 | 0.2337 | 0.2169 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0088 | 0.4917 | 0.4806 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.003 | 0.1132 | 0.1762 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.2732 | 0.3523 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.003 | 0.1132 | 0.1762 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.2732 | 0.3523 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.1683 | 0.7204 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0049 | 0.2337 | 0.9096 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.1032 | 0.4418 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.1051 | 0.4499 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.2732 | 0.3347 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0049 | 0.2337 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0154 | 0.9184 | 0.9166 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.1518 | 0.6498 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0052 | 0.2547 | 0.2837 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0279 | 0.0348 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 0.5243 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.4917 | 0.625 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0279 | 0.0348 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 0.5718 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0279 | 0.0072 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0088 | 0.4917 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0052 | 0.2547 | 0.3101 |
Trypanosoma brucei | trypanothione reductase | 0.0052 | 0.2547 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0088 | 0.4917 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.1518 | 0.6498 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0018 | 0.0323 | 0.0466 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0119 | 0.6909 | 0.8696 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0052 | 0.2547 | 0.2985 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0018 | 0.0323 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1597 | 0.1837 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0018 | 0.0323 | 0.0466 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0018 | 0.0323 | 0.0405 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0016 | 0.0214 | 0.0916 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0018 | 0.0323 | 0.0466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.