Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0138 | 0.5 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0016 | 0.0578 | 0.2108 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0138 | 0.0177 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0138 | 0.0504 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0138 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0138 | 0.0138 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0138 | 0.0504 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0119 | 0.7834 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.7798 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0138 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0138 | 0.0177 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0138 | 0.0138 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0578 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0138 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0119 | 0.7834 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0047 | 0.2744 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0138 | 0.0177 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0138 | 0.0504 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0107 | 0.699 | 0.8837 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.0578 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0138 | 0.0504 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0138 | 0.0504 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0274 | 0.0351 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0274 | 0.0351 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0138 | 0.0177 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.2744 | 0.3519 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0138 | 0.0177 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0138 | 0.0504 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.2744 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.2744 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0138 | 0.0177 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0107 | 0.699 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0138 | 0.0177 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.2744 | 0.3519 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.2744 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0016 | 0.0578 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0138 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0138 | 0.0177 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0138 | 0.0138 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0138 | 0.0177 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.0578 | 0.5 |
Brugia malayi | glutathione reductase | 0.0047 | 0.2744 | 0.3519 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0138 | 0.0177 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0138 | 0.0177 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0016 | 0.0578 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0138 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0138 | 0.0177 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0138 | 0.0504 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.2744 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0138 | 0.0504 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0138 | 0.0504 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0138 | 0.0504 |
Trypanosoma brucei | trypanothione reductase | 0.0047 | 0.2744 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0138 | 0.0177 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.0578 | 0.0742 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0138 | 0.0177 |
Onchocerca volvulus | 0.001 | 0.0138 | 0.5 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0138 | 0.0177 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0016 | 0.0578 | 0.0578 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0107 | 0.699 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0016 | 0.0578 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0107 | 0.699 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0119 | 0.7834 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0107 | 0.699 | 0.8837 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.7798 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.7798 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0138 | 0.0177 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0138 | 0.0177 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0138 | 0.0138 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.0578 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.2744 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0138 | 0.0138 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0138 | 0.0177 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0138 | 0.0504 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0138 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0138 | 0.0177 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0138 | 0.0504 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0138 | 0.0177 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0138 | 0.0504 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0138 | 0.0177 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0107 | 0.699 | 0.8837 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0016 | 0.0578 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0138 | 0.0177 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0138 | 0.0177 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0138 | 0.0138 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0138 | 0.0138 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0138 | 0.0177 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0119 | 0.7834 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0138 | 0.0177 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0138 | 0.0177 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0016 | 0.0578 | 0.2108 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.2744 | 0.3519 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0138 | 0.0177 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0016 | 0.0578 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.2744 | 1 |
Leishmania major | trypanothione reductase | 0.0047 | 0.2744 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0138 | 0.0177 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0138 | 0.0504 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0138 | 0.0138 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.2744 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0138 | 0.0504 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0138 | 0.0504 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0138 | 0.0177 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0138 | 0.0504 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0138 | 0.0138 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0138 | 0.0177 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0138 | 0.0177 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0138 | 0.0138 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0138 | 0.0138 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0138 | 0.0177 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0138 | 0.0504 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0047 | 0.2744 | 0.2985 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0016 | 0.0578 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.