Detailed information for compound 897849

Basic information

Technical information
  • TDR Targets ID: 897849
  • Name: dimethyl 1-ethyl-2,6-dimethyl-4-(4-nitropheny l)-4H-pyridine-3,5-dicarboxylate
  • MW: 374.388 | Formula: C19H22N2O6
  • H donors: 0 H acceptors: 4 LogP: 2.89 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1C(=C(C(=O)OC)C(C(=C1C)C(=O)OC)c1ccc(cc1)[N+](=O)[O-])C
  • InChi: 1S/C19H22N2O6/c1-6-20-11(2)15(18(22)26-4)17(16(12(20)3)19(23)27-5)13-7-9-14(10-8-13)21(24)25/h7-10,17H,6H2,1-5H3
  • InChiKey: SXFPCJUPGQFXDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-ethyl-2,6-dimethyl-4-(4-nitrophenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
  • BIM-0047634.P001
  • STK006690
  • CBMicro_047478
  • MixCom6_002422
  • Oprea1_213615
  • ZINC02775253
  • EU-0040683

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0016 0.0016
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0013 0.0013
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0193 0.0193
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0097 0.0097
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0097 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.6385 0.6385
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0097 0.0084
Echinococcus multilocularis hexokinase 0.1049 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0035
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0304 0.0304
Mycobacterium ulcerans lipase LipD 0.0035 0.0194 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0044 0.0044
Echinococcus granulosus geminin 0.0164 0.1439 0.1439
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0324 0.0323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0016 0.0016
Brugia malayi hexokinase type II 0.0334 0.3082 0.3081
Trypanosoma brucei hexokinase 0.1049 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0004 0.0004
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0194 0.0906
Echinococcus granulosus GPCR family 2 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0046 0.0304 0.0303
Loa Loa (eye worm) acetyltransferase 0.0151 0.1312 0.1312
Echinococcus multilocularis chromobox protein 1 0.0067 0.0507 0.0507
Mycobacterium ulcerans hypothetical protein 0.0035 0.0194 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0057 0.0057
Leishmania major hexokinase, putative 0.1049 1 1
Plasmodium falciparum hexokinase 0.1049 1 1
Leishmania major hypothetical protein, conserved 0.0025 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0334 0.3082 0.3081
Plasmodium vivax hexokinase, putative 0.1049 1 1
Leishmania major hypothetical protein, conserved 0.0035 0.0194 0.0194
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0044 0.0044
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0013
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.125 0.1249
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0221
Echinococcus granulosus bloom syndrome protein 0.0019 0.0044 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0284 0.0284
Brugia malayi beta-lactamase family protein 0.0035 0.0194 0.0194
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0097 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0194 0.3372
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0035 0.0034
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0194 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.0519 0.0519
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0044 0.0044
Echinococcus multilocularis chromobox protein 1 0.0067 0.0507 0.0507
Onchocerca volvulus 0.0046 0.0304 0.0303
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.03 0.0288
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0035
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0249 0.0249
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2012 1
Schistosoma mansoni DNA helicase recq5 0.0019 0.0044 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0284 0.0283
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0243 0.0209
Brugia malayi Hexokinase family protein 0.0658 0.622 0.622
Loa Loa (eye worm) RecQ helicase 0.0019 0.0044 0.0044
Loa Loa (eye worm) beta-lactamase 0.0035 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0479 0.4482 0.4482
Schistosoma mansoni hypothetical protein 0.0033 0.0176 0.0176
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0044 0.0044
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0115 0.1699
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0068 0.0067
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0193 0.0193
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.2191 0.219
Brugia malayi Heterochromatin protein 1 0.0067 0.0507 0.0507
Onchocerca volvulus 0.1049 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0035
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0365 0.0365
Loa Loa (eye worm) hexokinase type II 0.1049 1 1
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.1312 0.1312
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0044 0.0459
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0304 0.0303
Loa Loa (eye worm) PHD-finger family protein 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0045 0.0291 0.0291
Echinococcus granulosus hexokinase 0.1049 1 1
Brugia malayi Bromodomain containing protein 0.0041 0.0251 0.025
Loa Loa (eye worm) hexokinase 0.1049 1 1
Echinococcus granulosus zinc finger protein 0.0023 0.0075 0.0075
Mycobacterium leprae Probable lipase LipE 0.0035 0.0194 0.5
Echinococcus granulosus chromobox protein 1 0.0067 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0479 0.4482 0.4482
Echinococcus granulosus hexokinase type 2 0.1049 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0044 0.0044
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0016 0.0016
Brugia malayi isocitrate dehydrogenase 0.0016 0.0013 0.0013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0044
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0194
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0304 0.0304
Schistosoma mansoni hexokinase 0.1049 1 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0194 0.0194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0004 0.0004
Brugia malayi hypothetical protein 0.0025 0.0097 0.0096
Loa Loa (eye worm) hexokinase 0.0325 0.2995 0.2995
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0044 0.0031
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0507 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.03 0.5623
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0365 0.0365
Schistosoma mansoni DNA helicase recq1 0.0019 0.0044 0.0044
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0035 0.0034
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0013 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0013
Treponema pallidum hexokinase (hxk) 0.1049 1 1
Schistosoma mansoni hypothetical protein 0.0285 0.2609 0.2609
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0365 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0221 0.3951
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.1312 0.1312
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.0164 0.1439 0.1439
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0044 0.0031
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0304 0.0303
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0243 0.023
Brugia malayi mbt repeat family protein 0.0046 0.0304 0.0303
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0044 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0194 0.3372
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0016 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0284 0.0283
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0304 0.0304
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0004 0.0004
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.03 0.5623
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.03 0.03
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0284 0.0283
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0004 0.0004
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0194 0.0906
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0194 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0013 0.0013
Onchocerca volvulus 0.1049 1 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0044 0.0044
Mycobacterium tuberculosis Conserved protein 0.0035 0.0194 0.0906
Entamoeba histolytica hexokinase 1 0.1049 1 1
Echinococcus granulosus hexokinase 0.1049 1 1
Onchocerca volvulus 0.0035 0.0194 0.0194
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0096
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0097 0.0097
Echinococcus granulosus hexokinase 0.1049 1 1
Echinococcus multilocularis geminin 0.0164 0.1439 0.1439
Schistosoma mansoni zinc finger protein 0.0023 0.0075 0.0075
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0044 0.0203
Echinococcus multilocularis hexokinase type 2 0.1049 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0451 0.0451
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0194 0.3372
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0115 0.1699
Onchocerca volvulus 0.0035 0.0194 0.0194
Toxoplasma gondii ABC1 family protein 0.0035 0.0194 0.0181
Onchocerca volvulus 0.0035 0.0194 0.0194
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0004 0.0004
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0304 0.0303
Echinococcus multilocularis hexokinase 0.1049 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0194 0.0194
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0194 0.0906
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0507 0.0507
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0194 0.0194
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0194 0.0906
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0044 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0284 0.0284
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.0022
Onchocerca volvulus 0.0658 0.622 0.622
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0221 0.0221
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.6385 0.6385
Echinococcus multilocularis GPCR, family 2 0.0015 0.0004 0.0004
Loa Loa (eye worm) MBCTL1 0.0053 0.0365 0.0365
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0013
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0365 0.0365
Echinococcus granulosus chromobox protein 1 0.0067 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0053 0.0365 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0221 0.3951
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0216 0.0216
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0243 1
Trypanosoma brucei hexokinase, putative 0.1049 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0016 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0284 0.0283
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0194 0.0906
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0194
Schistosoma mansoni bromodomain containing protein 0.0065 0.0485 0.0485
Schistosoma mansoni chromobox protein 0.0067 0.0507 0.0507
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0044 0.0203
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0016
Onchocerca volvulus 0.003 0.0143 0.0142
Echinococcus multilocularis hexokinase 0.1049 1 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0194 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0284 0.0284
Loa Loa (eye worm) hexokinase 0.0658 0.622 0.622
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0194 0.0906
Brugia malayi beta-lactamase family protein 0.0035 0.0194 0.0194
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0284 0.0283
Brugia malayi PHD-finger family protein 0.0028 0.0125 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0035 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0194 0.3372
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0035 0.0108
Loa Loa (eye worm) hypothetical protein 0.0043 0.0273 0.0273
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0068 0.0067
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0016
Trypanosoma cruzi hexokinase, putative 0.1049 1 1
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0035
Onchocerca volvulus 0.1049 1 1
Trichomonas vaginalis esterase, putative 0.0035 0.0194 0.3372
Echinococcus granulosus microtubule associated protein 2 0.0675 0.6385 0.6385
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0249 0.4537
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0284 0.0283
Entamoeba histolytica hexokinase 2 0.1049 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0097 0.0084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0035 0.0034
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.0022
Brugia malayi beta-lactamase 0.0035 0.0194 0.0194
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0194 0.3372
Trypanosoma cruzi hexokinase, putative 0.1049 1 1
Brugia malayi mbt repeat family protein 0.0046 0.0304 0.0303
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0176 0.0176
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0044 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0194 0.0194
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0304 0.0303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0004 0.0004
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.1312 0.1312
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0013 0.0013
Loa Loa (eye worm) hexokinase 0.1049 1 1
Leishmania major hexokinase, putative 0.1049 1 1
Schistosoma mansoni hypothetical protein 0.002 0.005 0.005
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.1654 0.1653
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0194 0.0194
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0035 0.0034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0324 0.0323
Mycobacterium ulcerans beta-lactamase 0.0035 0.0194 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0044 0.0044
Brugia malayi Bromodomain containing protein 0.0076 0.0594 0.0594
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0451 0.0451
Brugia malayi Hexokinase family protein 0.1049 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0143 0.0142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0194 0.0906
Toxoplasma gondii hexokinase 0.1049 1 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0013 0.0013
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0044 0.0203
Schistosoma mansoni hypothetical protein 0.0164 0.1439 0.1439
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0044 0.0044
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0013 0.0013
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0249 0.4537
Brugia malayi follicle stimulating hormone receptor 0.0241 0.2191 0.219
Brugia malayi chromobox protein homolog 3 0.0038 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0716 0.6775 0.6775
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.1654 0.1653
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0004
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0013 0.0013
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0324 0.0323
Brugia malayi Hexokinase family protein 0.0325 0.2995 0.2995
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0507 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.03 0.0288
Brugia malayi hypothetical protein 0.0016 0.0012 0.0011
Toxoplasma gondii exonuclease III APE 0.0018 0.0035 0.0022
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0304 0.0303
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0044 0.0031
Trypanosoma brucei hexokinase 0.1049 1 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.3082 0.3081
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0194 0.0194
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0035 0.5
Onchocerca volvulus Hexokinase homolog 0.0658 0.622 0.622
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0044 0.0031
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.03 0.0288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0324 0.0323
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0304 0.0303
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0194
Echinococcus multilocularis zinc finger protein 0.0023 0.0075 0.0075
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0016 0.0016
Mycobacterium tuberculosis Conserved protein 0.0035 0.0194 0.0906
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0016 0.0016
Mycobacterium tuberculosis Conserved protein 0.0035 0.0194 0.0906
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0004 0.0004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0194 0.0194
Schistosoma mansoni chromobox protein 0.0067 0.0507 0.0507

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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