Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0732 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.274 | 1 |
Brugia malayi | TAR-binding protein | 0.006 | 0.274 | 0.2545 |
Echinococcus multilocularis | tar DNA binding protein | 0.006 | 0.274 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.274 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0732 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.274 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.389 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.274 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0732 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.006 | 0.274 | 0.6358 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0732 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.006 | 0.274 | 0.6358 |
Brugia malayi | RNA binding protein | 0.006 | 0.274 | 0.2545 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0732 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.006 | 0.274 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0732 | 0.0483 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0732 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.006 | 0.274 | 0.2545 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0732 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.006 | 0.274 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0732 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.006 | 0.274 | 0.6358 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 3.7969 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | = 3.8 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | = 4.78 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 4.7819 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
IC50 (binding) | > 100 uM | Inhibition of Clostridium botulinum BoNT/A LC expressed in Escherichia coli assessed as cleavage of SNAPtide preincubated for 5 mins followed by SNAPtide addition measured for 105 mins by fluorescence assay | ChEMBL. | 24387280 |
Percent growth inhibition (functional) | = 99.5 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 105.3 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.