Detailed information for compound 897969

Basic information

Technical information
  • TDR Targets ID: 897969
  • Name: 2-amino-4-(4-methylphenyl)-6-(2-methylpropyl) pyridine-3-carbonitrile
  • MW: 265.353 | Formula: C17H19N3
  • H donors: 1 H acceptors: 2 LogP: 4.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(N)nc(cc1c1ccc(cc1)C)CC(C)C
  • InChi: 1S/C17H19N3/c1-11(2)8-14-9-15(16(10-18)17(19)20-14)13-6-4-12(3)5-7-13/h4-7,9,11H,8H2,1-3H3,(H2,19,20)
  • InChiKey: IJUKXMWXHLTXAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-6-isobutyl-4-(4-methylphenyl)pyridine-3-carbonitrile
  • 2-amino-6-isobutyl-4-(4-methylphenyl)-3-pyridinecarbonitrile
  • 2-amino-6-isobutyl-4-(4-methylphenyl)nicotinonitrile
  • CBMicro_049318
  • Oprea1_654655
  • BIM-0049526.P001
  • STOCK2S-68770

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis potassium large conductance calcium activated 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Schistosoma mansoni transient receptor potential channel 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel protein 0.0005 0.0013 0.0013
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.065 0.065
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0005 0.0013 0.0013
Toxoplasma gondii peptidase S15, putative 0.0018 0.0267 0.2691
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0005 0.0013 0.0013
Schistosoma mansoni zinc finger protein 0.0005 0.0018 0.0018
Brugia malayi nuclear receptor RXR 0.0006 0.0029 0.0029
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0005 0.0013 0.0022
Loa Loa (eye worm) inositol-1 0.0038 0.065 0.065
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0308 0.5746 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0123 0.0123
Schistosoma mansoni transient receptor potential channel 4 0.0005 0.0013 0.0013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Mycobacterium tuberculosis Possible lysophospholipase 0.0308 0.5746 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Leishmania major hypothetical protein, conserved 0.0064 0.1139 0.1983
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0308 0.5746 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0005 0.0013 0.0013
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0123 0.0123
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0308 0.5746 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0123 0.0123
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0018 0.0018
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0005 0.0013 0.0013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0123 0.0123
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0064 0.1139 0.1592
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Chlamydia trachomatis hydrolase 0.0018 0.0267 0.2345
Brugia malayi steroid hormone receptor 0.0011 0.0123 0.0123
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0123 0.0123
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0029 0.0029
Brugia malayi Inositol-1 0.0038 0.065 0.065
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0123 0.0123
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0123 0.0123
Loa Loa (eye worm) ryanodine receptor 0.0005 0.0013 0.0013
Echinococcus multilocularis voltage gated potassium channel 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0005 0.0013 0.0013
Mycobacterium ulcerans amidase 0.0064 0.1139 0.1983
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0123 0.0123
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0123 0.0123
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0005 0.0013 0.0013
Echinococcus multilocularis transient receptor potential cation channel 0.0005 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0064 0.1139 1
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.796 0.796
Brugia malayi putative amidase 0.0064 0.1139 0.1139
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Echinococcus granulosus transient receptor potential cation channel 0.0005 0.0013 0.0013
Echinococcus granulosus calcium activated potassium channel 0.0005 0.0013 0.0013
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0064 0.0064
Mycobacterium ulcerans hypothetical protein 0.0308 0.5746 1
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0267 0.0465
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Mycobacterium ulcerans peptide amidase, GatA 0.0064 0.1139 0.1983
Loa Loa (eye worm) hypothetical protein 0.0155 0.2859 0.2859
Trichomonas vaginalis conserved hypothetical protein 0.0308 0.5746 1
Echinococcus multilocularis transfer RNA-Gly 0.0005 0.0013 0.0013
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0018 0.0267 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0488 0.0488
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0018 0.0018
Brugia malayi Transient-receptor-potential like protein 0.0005 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0425 0.796 0.796
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0018 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0993 1
Toxoplasma gondii phospholipase 0.0018 0.0267 0.2691
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.009
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0005 0.0013 0.0013
Plasmodium vivax PST-A protein 0.0308 0.5746 1
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0064 0.1139 0.1139
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0064 0.1139 0.1983
Echinococcus multilocularis short transient receptor potential channel 6 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0005 0.0013 0.0013
Brugia malayi nuclear receptor RXR 0.0005 0.0018 0.0018
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0005 0.0013 0.0013
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0064 0.1139 0.1139
Plasmodium falciparum esterase, putative 0.0308 0.5746 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Schistosoma mansoni inositol monophosphatase 0.0038 0.065 0.065
Echinococcus granulosus potassium large conductance calcium activated 0.0005 0.0013 0.0013
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0018 0.0018
Brugia malayi cation channel family protein 0.0005 0.0013 0.0013
Schistosoma mansoni fatty-acid amide hydrolase 0.0533 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0267 0.0267
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0005 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0123 0.0123
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0267 0.0465
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0005 0.0013 0.0013
Echinococcus granulosus dnaJ subfamily B 0.0425 0.796 0.796
Brugia malayi Cyclic-nucleotide gated cation channel 0.0005 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.009
Echinococcus multilocularis ryanodine receptor 44f 0.0005 0.0013 0.0013
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0267 0.0267
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0005 0.0013 0.0013
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0018 0.0267 0.0465
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0123 0.0123
Toxoplasma gondii transporter, cation channel family protein 0.0005 0.0013 0.013
Mycobacterium ulcerans lysophospholipase 0.0308 0.5746 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0018 0.0018
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0018 0.0267 0.0267
Onchocerca volvulus 0.003 0.0488 1
Onchocerca volvulus 0.0005 0.0013 0.0264
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Loa Loa (eye worm) hypothetical protein 0.0006 0.0029 0.0029
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0005 0.0013 0.0013
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0005 0.0013 0.0013
Echinococcus multilocularis sodium channel protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) DR-78 0.0005 0.0018 0.0018
Echinococcus granulosus TRP transient receptor potential channel 0.0005 0.0013 0.0013
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0005 0.0013 0.0013
Brugia malayi Amidase family protein 0.0064 0.1139 0.1139
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.065 0.113
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0308 0.5746 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0005 0.0013 0.0013
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0308 0.5746 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0029 0.0029
Echinococcus granulosus sodium leak channel non selective protein 0.0005 0.0013 0.0013
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0267 0.0465
Plasmodium falciparum lysophospholipase, putative 0.0308 0.5746 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0018 0.0018
Brugia malayi hypothetical protein 0.0005 0.0018 0.0018
Echinococcus granulosus fatty acid amide hydrolase 1 0.0533 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0018 0.0018
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0005 0.0013 0.0022
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0018 0.0018
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0155 0.2859 0.2859
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0005 0.0013 0.0013
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0018 0.0018
Echinococcus multilocularis short transient receptor potential channel 6 0.0005 0.0017 0.0017
Trypanosoma cruzi serine peptidase, putative 0.0018 0.0267 0.0465
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.065 0.113
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Plasmodium falciparum lysophospholipase, putative 0.0308 0.5746 1
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0064 0.1139 0.1983
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0123 0.0123
Loa Loa (eye worm) amidase 0.0064 0.1139 0.1139
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0123 0.0123
Schistosoma mansoni cpg binding protein 0.0032 0.052 0.052
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0123 0.0123
Brugia malayi nuclear receptor NHR-67 0.0005 0.0018 0.0018
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0018 0.0018
Echinococcus granulosus transient receptor potential cation channel 0.0005 0.0013 0.0013
Schistosoma mansoni ryanodine receptor related 0.0005 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0123 0.0123
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0267 0.0465
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Echinococcus multilocularis transient receptor potential cation channel 0.0005 0.0017 0.0017
Echinococcus multilocularis two pore calcium channel protein 1 0.0005 0.0013 0.0013
Echinococcus multilocularis ankyrin repeat protein 0.0154 0.2837 0.2837
Schistosoma mansoni fatty-acid amide hydrolase 0.0064 0.1139 0.1139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Echinococcus multilocularis transient receptor potential cation channel 0.0159 0.293 0.293
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0308 0.5746 1
Echinococcus granulosus voltage gated potassium channel 0.0005 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Echinococcus granulosus transient receptor potential cation channel 0.0005 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0064 0.1139 0.1139
Schistosoma mansoni calcium-activated potassium channel 0.0005 0.0013 0.0013
Onchocerca volvulus 0.0005 0.0018 0.0361
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0064 0.1139 0.1983
Echinococcus multilocularis potassium voltage gated channel protein 0.0005 0.0013 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Entamoeba histolytica ;Alias 0.0018 0.0267 0.0465
Echinococcus multilocularis conserved hypothetical protein 0.0005 0.0013 0.0013
Toxoplasma gondii hypothetical protein 0.0018 0.0267 0.2691
Echinococcus granulosus hypothetical protein 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0005 0.0013 0.0013
Echinococcus multilocularis sodium leak channel non selective protein 0.0005 0.0013 0.0013
Leishmania major monoglyceride lipase, putative 0.0308 0.5746 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0029 0.0029
Echinococcus multilocularis Phospholipase carboxylesterase 0.0018 0.0267 0.0267
Chlamydia trachomatis acyltransferase family protein 0.0018 0.0267 0.2345
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) voltage-gated potassium channel 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0064 0.1139 0.1983
Echinococcus multilocularis abhydrolase domain containing 3 0.0018 0.0267 0.0267
Brugia malayi ecdysteroid receptor 0.0011 0.0123 0.0123
Schistosoma mansoni transient receptor potential channel 0.0005 0.0013 0.0013
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0018 0.0267 0.0465
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0123 0.0123
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0005 0.0013 0.0013
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0005 0.0013 0.0013
Leishmania major hypothetical protein, conserved 0.0018 0.0267 0.0465
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0267 0.0465
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0123 0.0123
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0123 0.0123
Trypanosoma cruzi amidase, putative 0.0064 0.1139 0.1983
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0123 0.0123
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Echinococcus multilocularis voltage dependent calcium channel 0.0005 0.0013 0.0013
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0018 0.0361
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0267 0.0465
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Echinococcus granulosus short transient receptor potential channel 6 0.0005 0.0017 0.0017
Mycobacterium ulcerans hypothetical protein 0.0018 0.0267 0.0465
Brugia malayi hypothetical protein 0.0006 0.0029 0.0029
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0052 0.009
Echinococcus granulosus two pore calcium channel protein 1 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0005 0.0013 0.0013
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0005 0.0013 0.0022
Toxoplasma gondii hypothetical protein 0.0005 0.0013 0.013
Brugia malayi nuclear receptor NHR-88 0.0011 0.0123 0.0123
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0064 0.1139 0.5
Loa Loa (eye worm) hypothetical protein 0.0006 0.0029 0.0029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0005 0.0013 0.013
Echinococcus multilocularis shaker cognate 0.0005 0.0013 0.0013
Trypanosoma cruzi serine peptidase, putative 0.0018 0.0267 0.0465
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0123 0.0123
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0005 0.0013 0.0013
Schistosoma mansoni amidase 0.0533 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Schistosoma mansoni vesicular amine transporter 0.0005 0.0013 0.0013
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0005 0.0013 0.0013
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0123 0.0123
Brugia malayi nuclear receptor NHR-88 0.0005 0.0018 0.0018
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Brugia malayi conserved hypotetical protein 0.0005 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Echinococcus multilocularis voltage gated potassium channel 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0018 0.0018
Schistosoma mansoni 60S ribosomal protein L21 0.0005 0.0013 0.0013
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0005 0.0013 0.0013
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0064 0.1139 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0123 0.0123
Echinococcus granulosus abhydrolase domain containing 3 0.0018 0.0267 0.0267
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0018 0.0018
Echinococcus multilocularis cpg binding protein 0.0032 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0123 0.0123
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0005 0.0013 0.0013
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0123 0.0123
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Echinococcus multilocularis muscleblind protein 1 0.0155 0.2859 0.2859
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0123 0.0123
Brugia malayi olfactory channel protein osm-9 0.0005 0.0017 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0123 0.0123
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0005 0.0013 0.0013
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0005 0.0013 0.0022
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0029 0.0029
Echinococcus granulosus potassium voltage gated channel protein 0.0005 0.0013 0.0013
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0005 0.0013 0.0013
Brugia malayi Muscleblind-like protein 0.0155 0.2859 0.2859
Echinococcus granulosus voltage gated hydrogen channel 1 0.0005 0.0013 0.0013
Echinococcus multilocularis hyperpolarization activated cyclic 0.0005 0.0013 0.0013
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0029 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0123 0.0123
Echinococcus multilocularis transient receptor potential cation channel 0.0005 0.0013 0.0013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0123 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0123 0.0123
Brugia malayi hypothetical protein 0.0005 0.0013 0.0013
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0018 0.0267 0.0267
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0018 0.0267 0.0465
Toxoplasma gondii transporter, cation channel family protein 0.0005 0.0013 0.013
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0018 0.0267 0.0267
Mycobacterium ulcerans hydrolase 0.0018 0.0267 0.0465
Schistosoma mansoni voltage-gated ion channel 0.0005 0.0013 0.0013
Toxoplasma gondii hypothetical protein 0.0018 0.0267 0.2691
Loa Loa (eye worm) voltage-gated potassium channel 0.0005 0.0013 0.0013
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0018 0.0267 0.2691
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0123 0.0123
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0018 0.0018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0005 0.0013 0.013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.065 0.113
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0005 0.0013 0.0013
Toxoplasma gondii protein c14orf29, putative 0.0018 0.0267 0.2691
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0005 0.0013 0.0264
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0005 0.0013 0.0013
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated cation channel 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel protein 0.0005 0.0013 0.0013
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0123 0.0123
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0005 0.0013 0.0013
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0005 0.0013 0.0013
Brugia malayi MGC83647 protein 0.0018 0.0267 0.0267
Echinococcus multilocularis transient receptor potential cation channel 0.0005 0.0013 0.0013
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0308 0.5746 1
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0308 0.5746 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0123 0.0123
Loa Loa (eye worm) ion channel NompC 0.0005 0.0013 0.0013
Toxoplasma gondii hypothetical protein 0.0005 0.0013 0.013
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0123 0.0123
Entamoeba histolytica hypothetical protein 0.0018 0.0267 0.0465
Echinococcus multilocularis muscleblind protein 0.0155 0.2859 0.2859
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Brugia malayi nuclear hormone receptor 0.0011 0.0123 0.0123
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0005 0.0013 0.0013
Trypanosoma cruzi amidase, putative 0.0064 0.1139 0.1983
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0123 0.0123
Echinococcus granulosus abhydrolase domain containing protein 13 0.0018 0.0267 0.0267
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0267 0.0465
Loa Loa (eye worm) hypothetical protein 0.0006 0.0029 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.065 0.113
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0005 0.0013 0.0013
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0123 0.251
Echinococcus granulosus voltage dependent calcium channel 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0029 0.0029
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0123 0.0123
Echinococcus granulosus fatty acid amide hydrolase 1 0.0533 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0005 0.0013 0.0013
Echinococcus granulosus transient receptor potential cation channel 0.0005 0.0013 0.0013
Trypanosoma cruzi monoglyceride lipase, putative 0.0308 0.5746 1
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0018 0.0267 0.2691
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0005 0.0013 0.0013
Mycobacterium ulcerans hypothetical protein 0.0018 0.0267 0.0465
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0005 0.0013 0.0013
Brugia malayi ecdysone receptor 0.0005 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0123 0.0123
Leishmania major hypothetical protein, conserved 0.0005 0.0013 0.0022
Trypanosoma brucei monoglyceride lipase, putative 0.0308 0.5746 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0123 0.0123
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0123 0.0123
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0123 0.0123
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0574 0.0998
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0005 0.0013 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Echinococcus granulosus potassium voltage gated channel protein 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Trypanosoma brucei monoglyceride lipase, putative 0.0308 0.5746 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0005 0.0013 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0064 0.0064
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.009
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0018 0.0018
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0018 0.0267 0.0267
Brugia malayi tailless protein 0.0005 0.0018 0.0018
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0005 0.0013 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0029 0.0029
Schistosoma mansoni coup transcription factor 0.0011 0.0123 0.0123
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0005 0.0013 0.0013
Echinococcus granulosus transient receptor potential cation channel 0.0005 0.0013 0.0013
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0267 0.0465
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0018 0.0018
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0123 0.251
Echinococcus multilocularis transient receptor potential cation channel 0.0005 0.0013 0.0013
Brugia malayi Amidase family protein 0.0064 0.1139 0.1139
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0064 0.1139 0.1983
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Loa Loa (eye worm) amidase 0.0064 0.1139 0.1139
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0064 0.1139 0.1983
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0005 0.0013 0.0013
Mycobacterium ulcerans amidase 0.0064 0.1139 0.1983
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0018 0.0018
Toxoplasma gondii hypothetical protein 0.0018 0.0267 0.2691
Schistosoma mansoni inositol monophosphatase 0.0038 0.065 0.065
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0096 0.0096
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0005 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.009
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0005 0.0013 0.0013
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0018 0.0267 0.0465
Toxoplasma gondii hypothetical protein 0.0018 0.0267 0.2691
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.065 0.065
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.065 0.113
Loa Loa (eye worm) hypothetical protein 0.0533 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0064 0.1139 0.1983
Brugia malayi MGC79044 protein 0.0018 0.0267 0.0267
Schistosoma mansoni nuclear receptor 0.0005 0.0018 0.0018
Brugia malayi nuclear hormone receptor 0.0005 0.0018 0.0018
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0123 0.251
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0064 0.1139 0.1983
Plasmodium falciparum lysophospholipase, putative 0.0308 0.5746 1
Loa Loa (eye worm) voltage-dependent calcium channel 0.0005 0.0013 0.0013
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0064 0.1139 0.1983
Echinococcus multilocularis potassium voltage gated channel protein 0.0005 0.0013 0.0013
Onchocerca volvulus 0.0011 0.0123 0.251
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0099 0.0099
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0123 0.0123
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0005 0.0013 0.0013
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0005 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0005 0.0013 0.0013
Loa Loa (eye worm) calcium channel 0.0005 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0123 0.0123
Echinococcus granulosus sodium channel protein 0.0005 0.0013 0.0013
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Echinococcus multilocularis hyperpolarization activated cyclic 0.0005 0.0013 0.0013
Echinococcus multilocularis potassium voltage gated channel protein 0.0005 0.0013 0.0013
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0267 0.0465
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0267 0.0267
Schistosoma mansoni two-pore calcium channel 0.0005 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.009
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0005 0.0013 0.0264
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.065 0.6542
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0123 0.0123
Onchocerca volvulus 0.0005 0.0018 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0123 0.0123
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0005 0.0013 0.0013
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0018 0.0267 0.0465
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0018 0.0267 0.0465
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0018 0.0267 0.2691
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.065 0.113
Schistosoma mansoni hypothetical protein 0.0005 0.0013 0.0013
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0574 0.0998
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.065 0.113
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.065 0.113
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Schistosoma mansoni voltage-dependent calcium channel 0.0005 0.0013 0.0013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0064 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0018 0.0018
Echinococcus granulosus transient receptor potential gamma protein 0.0005 0.0013 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0029 0.0029
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Schistosoma mansoni nuclear receptor 0.0005 0.0018 0.0018
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0005 0.0013 0.0013
Schistosoma mansoni transient receptor potential channel 0.0005 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Echinococcus granulosus voltage dependent calcium channel 0.0005 0.0013 0.0013
Echinococcus granulosus hyperpolarization activated cyclic 0.0005 0.0013 0.0013
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0005 0.0013 0.0013
Echinococcus granulosus fatty acid amide hydrolase 1 0.0064 0.1139 0.1139
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Echinococcus granulosus shaker cognate 0.0005 0.0013 0.0013
Brugia malayi hypothetical protein 0.0006 0.0029 0.0029
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0308 0.5746 1
Mycobacterium ulcerans amidase 0.0064 0.1139 0.1983
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0011 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0005 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0123 0.0123
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0064 0.1139 0.1139
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0005 0.0013 0.0022
Brugia malayi CXXC zinc finger family protein 0.003 0.0488 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0267 0.0465
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0018 0.0267 0.0465
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Brugia malayi hypothetical protein 0.0005 0.0018 0.0018
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0018 0.0018
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0052 0.009
Echinococcus granulosus muscleblind protein 0.0155 0.2859 0.2859
Brugia malayi voltage-dependent calcium channel 0.0005 0.0013 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0123 0.0123
Echinococcus multilocularis calcium activated potassium channel 0.0005 0.0013 0.0013
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0005 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0018 0.0267 0.0465
Schistosoma mansoni peptidase 0.0018 0.0267 0.0267
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0018 0.0267 0.0465
Loa Loa (eye worm) hypothetical protein 0.0018 0.0267 0.0267
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0018 0.0267 0.0465
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0123 0.0123
Echinococcus granulosus short transient receptor potential channel 6 0.0005 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0052 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0308 0.5746 1
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Echinococcus multilocularis voltage dependent calcium channel 0.0005 0.0013 0.0013
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0005 0.0018 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1121 0.1121
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0005 0.0013 0.0013
Toxoplasma gondii transporter, cation channel family protein 0.0005 0.0013 0.013
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0005 0.0013 0.0013
Echinococcus granulosus cpg binding protein 0.0032 0.052 0.052
Mycobacterium ulcerans amidase 0.0064 0.1139 0.1983
Echinococcus multilocularis transient receptor potential gamma protein 0.0005 0.0013 0.0013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.065 0.113
Leishmania major hypothetical protein, unknown function 0.0005 0.0013 0.0022
Echinococcus multilocularis two pore calcium channel protein 2 0.0005 0.0013 0.0013
Echinococcus granulosus transient receptor potential cation channel 0.0159 0.2925 0.2925
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0099 0.0099
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0533 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0018 0.0361
Schistosoma mansoni cpg binding protein 0.003 0.0488 0.0488
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0123 0.0123
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0064 0.1139 0.1592
Toxoplasma gondii phospholipase/carboxylesterase 0.0018 0.0267 0.2691
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0533 1 1
Leishmania major hypothetical protein, conserved 0.0018 0.0267 0.0465
Brugia malayi ion channel NompC 0.0005 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0123 0.0123
Schistosoma mansoni voltage-gated potassium channel 0.0005 0.0013 0.0013
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0267 0.0465
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0005 0.0013 0.0013
Echinococcus granulosus ryanodine receptor 44f 0.0005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0013
Mycobacterium ulcerans amidase 0.0064 0.1139 0.1983
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0005 0.0013 0.0013
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0005 0.0013 0.0013
Echinococcus granulosus ankyrin repeat protein 0.0154 0.2837 0.2837
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0005 0.0005
Echinococcus granulosus two pore calcium channel protein 2 0.0005 0.0013 0.0013
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0018 0.0267 0.0465
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0123 0.0123
Loa Loa (eye worm) voltage-gated calcium channel 0.0005 0.0013 0.0013
Echinococcus granulosus Phospholipase carboxylesterase 0.0018 0.0267 0.0267
Brugia malayi Protein C20orf22 0.0018 0.0267 0.0267
Schistosoma mansoni cpg binding protein 0.0032 0.052 0.052
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0154 0.2837 0.2837
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Trichomonas vaginalis helicase, putative 0.0007 0.0052 0.009
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0005 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0052 0.009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0267 0.0267
Echinococcus granulosus voltage gated potassium channel 0.0005 0.0013 0.0013
Echinococcus granulosus hyperpolarization activated cyclic 0.0005 0.0013 0.0013
Brugia malayi cation channel family protein 0.0005 0.0013 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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