Detailed information for compound 897980

Basic information

Technical information
  • TDR Targets ID: 897980
  • Name: N-[(4-chlorophenyl)-(8-hydroxyquinolin-7-yl)m ethyl]acetamide
  • MW: 326.777 | Formula: C18H15ClN2O2
  • H donors: 2 H acceptors: 3 LogP: 3.82 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NC(c1ccc2c(c1O)nccc2)c1ccc(cc1)Cl
  • InChi: 1S/C18H15ClN2O2/c1-11(22)21-16(13-4-7-14(19)8-5-13)15-9-6-12-3-2-10-20-17(12)18(15)23/h2-10,16,23H,1H3,(H,21,22)
  • InChiKey: IXRHAWQJTWGCCU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(4-chlorophenyl)-(8-hydroxy-7-quinolyl)methyl]acetamide
  • N-[(4-chlorophenyl)-(8-hydroxyquinolin-7-yl)methyl]ethanamide
  • Oprea1_083442
  • Oprea1_657458
  • BAS 01540902
  • N-[(4-Chloro-phenyl)-(8-hydroxy-quinolin-7-yl)-methyl]-acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens paired box 8 Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Human herpesvirus 4 (strain B95-8) Latent membrane protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cytochrome P450, putative 0.00208876 1 0.5
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0019 0.0116
Leishmania major cytochrome p450-like protein 0.0025 0.0527 0.3274
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0315 0.1959
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0757 0.4707
Brugia malayi Cytochrome P450 family protein 0.00208876 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0218 0.741 0.741
Trypanosoma brucei heat shock protein, putative 0.0055 0.1609 1
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Echinococcus granulosus heat shock protein 90 0.0047 0.1324 0.8229
Entamoeba histolytica hypothetical protein 0.0043 0.1185 0.7366
Loa Loa (eye worm) hypothetical protein 0.0019 0.0315 0.0315
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0462 0.2872
Schistosoma mansoni hypothetical protein 0.0019 0.0315 0.0919
Trypanosoma cruzi cytochrome P450, putative 0.00208876 1 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1783 0.1783
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0316 0.2126
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.1609 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.1609 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0721 0.4484
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0783 0.4866
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0037 0.0947 0.5884
Plasmodium falciparum heat shock protein 90, putative 0.0032 0.0783 0.1101
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1606 0.9979
Loa Loa (eye worm) heat shock protein 75 0.0037 0.0947 0.0947
Trypanosoma brucei heat shock protein, putative 0.0055 0.1609 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.1609 1
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Schistosoma mansoni dep domain containing protein 0.0011 0.0019 0.0054
Brugia malayi Hsp90 protein 0.0037 0.0947 0.0947
Schistosoma mansoni eyes absent homolog 0.0106 0.3431 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0316 0.0445
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1606 0.4681
Trypanosoma brucei heat shock protein, putative 0.0055 0.1609 1
Brugia malayi Cytochrome P450 family protein 0.0025 0.0527 0.0527
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.741 0.741
Plasmodium vivax heat shock protein 86, putative 0.0055 0.1609 0.2262
Loa Loa (eye worm) hypothetical protein 0.006 0.1783 0.1783
Echinococcus granulosus GPCR family 2 0.0019 0.0315 0.1959
Schistosoma mansoni dishevelled 0.0011 0.0019 0.0054
Entamoeba histolytica hypothetical protein 0.0043 0.1185 0.7366
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0019 0.0116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1606 0.9979
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0316 0.1966
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0721 0.4484
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0527 0.3274
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0316 0.1966
Loa Loa (eye worm) cytochrome P450 family protein 0.00208876 1 1
Schistosoma mansoni hypothetical protein 0.0041 0.1104 0.3217
Echinococcus granulosus endoplasmin 0.0052 0.1488 0.9247
Trichomonas vaginalis heat shock protein, putative 0.0047 0.1324 0.8229
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0757 0.4707
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0316 0.1966
Onchocerca volvulus 0.0011 0.0019 0.0019
Toxoplasma gondii Hsp90 domain-containing protein 0.021 0.7114 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.1488 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.1609 1
Schistosoma mansoni hypothetical protein 0.0019 0.0315 0.0919
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0019 0.0116
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Brugia malayi hypothetical protein 0.0106 0.3431 0.3431
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0721 0.1014
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0316 0.1966
Trypanosoma brucei heat shock protein, putative 0.0055 0.1609 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0316 0.1966
Brugia malayi Cytochrome P450 family protein 0.0025 0.0527 0.0527
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0019 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1185 0.7366
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4777 0.4777
Brugia malayi Endoplasmin precursor 0.0055 0.1609 0.1609
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0527 0.0527
Trypanosoma brucei heat shock protein, putative 0.0055 0.1609 1
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0019 0.0054
Trypanosoma brucei heat shock protein, putative 0.0055 0.1609 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0316 0.1966
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1783 0.1783
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0019 0.0019
Toxoplasma gondii hypothetical protein 0.0011 0.0019 0.0026
Loa Loa (eye worm) endoplasmin 0.0055 0.1609 0.1609
Trypanosoma cruzi heat shock protein, putative 0.0037 0.0947 0.5884
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0037 0.0947 0.5884
Schistosoma mansoni hypothetical protein 0.0019 0.0315 0.0919
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 1 1
Schistosoma mansoni dishevelled 0.0011 0.0019 0.0054
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0757 0.4707
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1104 0.1104
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0315 0.1959
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.1609 1
Entamoeba histolytica hypothetical protein 0.0043 0.1185 0.7366
Leishmania major heat shock protein, putative 0.0037 0.0947 0.5884
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0757 0.4707
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0123 0.0764
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0019 0.0019
Schistosoma mansoni endoplasmin 0.0055 0.1609 0.4691
Echinococcus multilocularis GPCR, family 2 0.0019 0.0315 0.1959
Brugia malayi hypothetical protein 0.0043 0.1185 0.1185
Trypanosoma brucei heat shock protein 84, putative 0.0037 0.0947 0.5884
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0019 0.0054
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1606 0.1606
Brugia malayi isocitrate dehydrogenase 0.0019 0.0316 0.0316
Brugia malayi Flap endonuclease-1 0.0031 0.0757 0.0757
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0527 0.3274
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1609 1
Echinococcus granulosus heat shock protein 0.0055 0.1609 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0316 0.0922
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.1609 1
Echinococcus granulosus heat shock protein 90 0.0055 0.1609 1
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0757 0.4707
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0757 0.4707
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0757 0.4707
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0316 0.1966
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0721 0.1014
Trichomonas vaginalis endoplasmin, putative 0.004 0.1068 0.6638
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.00208876 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.1104 0.1104
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0019 0.0019
Leishmania major cytochrome p450-like protein 0.00208876 1 0.5
Echinococcus multilocularis heat shock protein 90 0.0055 0.1609 1
Plasmodium falciparum endoplasmin, putative 0.004 0.1068 0.1501
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0315 0.0315
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0019 0.0019
Echinococcus multilocularis heat shock protein 90 0.0047 0.1324 0.8229
Brugia malayi heat shock protein 90 0.0055 0.1609 0.1609
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0316 0.1966
Giardia lamblia Grp94/Hsp90 0.0052 0.1488 0.9247
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0019 0.0116
Trypanosoma brucei heat shock protein, putative 0.0055 0.1609 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0316 0.0316
Brugia malayi MH2 domain containing protein 0.0144 0.4777 0.4777
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1609 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1606 0.9979
Loa Loa (eye worm) heat shock protein 90 0.0055 0.1609 0.1609
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.0271
Plasmodium falciparum heat shock protein 90 0.0055 0.1609 0.2262
Echinococcus granulosus flap endonuclease 1 0.0031 0.0757 0.4707
Loa Loa (eye worm) hypothetical protein 0.0106 0.3431 0.3431
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0316 0.0445
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0527 0.3274
Mycobacterium ulcerans heat shock protein 90 0.0052 0.1488 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0037 0.0947 0.5884
Echinococcus multilocularis heat shock protein 0.0055 0.1609 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1185 0.3455
Schistosoma mansoni heat shock protein 0.0055 0.1609 0.4691
Plasmodium vivax heat shock protein 90, putative 0.0037 0.0947 0.1331
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0123 0.0764
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0316 0.0445
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0019 0.0116
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0019 0.0019
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Schistosoma mansoni flap endonuclease-1 0.0028 0.065 0.1894
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1606 0.4681
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.1609 1
Loa Loa (eye worm) cytochrome P450 family protein 0.00208876 1 1
Trichomonas vaginalis heat shock protein, putative 0.0052 0.1488 0.9247
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Brugia malayi hypothetical protein 0.0011 0.0019 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1783 0.1783
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0315 0.1959
Loa Loa (eye worm) CYP4Cod1 0.00208876 1 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0315 0.0315
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.1324 0.8229
Loa Loa (eye worm) hypothetical protein 0.0106 0.3431 0.3431
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0757 0.0757
Leishmania major hypothetical protein, conserved 0.003 0.0721 0.4484
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.1609 0.2262
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0757 0.1065
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0316 0.1966
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0019 0.0116
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0316 0.1966
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0721 0.1014
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.1488 0.5
Schistosoma mansoni hypothetical protein 0.0019 0.0315 0.0919
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0527 0.0527
Onchocerca volvulus 0.0291 1 1
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0019 0.0116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0315 0.0315
Plasmodium falciparum heat shock protein 90, putative 0.021 0.7114 1
Schistosoma mansoni endoplasmin 0.0055 0.1609 0.4691
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1606 0.9979
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0316 0.0316
Brugia malayi Cytochrome P450 family protein 0.00208876 1 0.5
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0721 0.0721
Echinococcus multilocularis endoplasmin 0.0052 0.1488 0.9247
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1185 0.7366
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.1324 0.8229
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0019 0.0116
Toxoplasma gondii heat shock protein HSP90 0.0055 0.1609 0.2262
Toxoplasma gondii heat shock protein 75, putative 0.0037 0.0947 0.1331
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0757 0.1065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1606 0.4681
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.1609 1
Trypanosoma brucei cytochrome P450, putative 0.00208876 1 0.5
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.1488 0.9247
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0527 0.0527
Trichomonas vaginalis heat shock protein, putative 0.004 0.1068 0.6638
Brugia malayi hypothetical protein 0.003 0.0721 0.0721
Plasmodium falciparum flap endonuclease 1 0.0031 0.0757 0.1065
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0019 0.0116
Schistosoma mansoni hypothetical protein 0.0043 0.1185 0.3455
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Brugia malayi hypothetical protein 0.002 0.0337 0.0337
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0037 0.0947 0.0947
Entamoeba histolytica hypothetical protein 0.0043 0.1185 0.7366
Schistosoma mansoni hypothetical protein 0.0014 0.0123 0.0358
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0316 0.1966
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0721 0.1014
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0316 0.0445
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0315 0.1959
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Plasmodium vivax heat shock protein, putative 0.021 0.7114 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.1488 1
Trichomonas vaginalis heat shock protein, putative 0.0055 0.1609 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0527 0.3541
Schistosoma mansoni heat shock protein 0.0037 0.0947 0.276
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0721 0.4484
Brugia malayi N-terminal motif family protein 0.0218 0.741 0.741
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1606 0.1606
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4777 0.4777
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0019 0.0116
Trichomonas vaginalis heat shock protein, putative 0.0052 0.1488 0.9247
Brugia malayi DIX domain containing protein 0.0011 0.0019 0.0019
Chlamydia trachomatis metal transport ATPase 0.001 0 0.5
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0047 0.1324 0.8229
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.1609 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0019
Schistosoma mansoni heat shock protein 0.0055 0.1609 0.4691
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.1609 1
Treponema pallidum heat shock protein 90 0.0052 0.1488 1
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.1324 0.8229
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0011 0.0019 0.0019
Leishmania major heat shock protein 83-1 0.0055 0.1609 1
Plasmodium vivax endoplasmin, putative 0.0055 0.1609 0.2262

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 1.158 uM PUBCHEM_BIOASSAY: Viability counterscreen of potential LMP-1 inhibitors in HEK293 cell background Measured in Cell-Based System Using Plate Reader - 2122-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
AC50 (functional) = 1.212 uM PUBCHEM_BIOASSAY: Lymphoblastoid Cells (LCL) Cytotoxicity Secondary Assay Measured in Cell-Based System Using Plate Reader - 2122-03_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
AC50 (functional) = 2.09 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) = 2.578 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 2.678 uM PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (functional) = 4.08 uM PUBCHEM_BIOASSAY: Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586] ChEMBL. No reference
EC50 (functional) 1.9284 uM ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 1.93 uM Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
EC50 (functional) 2.1494 uM ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye ChEMBL. 20485428
EC50 (functional) = 2.15 uM Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye Saint Jude. 20485428
Percent growth inhibition (functional) = 97.4 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye Saint Jude. 20485428
Percent growth inhibition (functional) = 104.8 % Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye Saint Jude. 20485428
Potency (functional) 0.1995 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.1335 uM PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23 20485428

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.