Detailed information for compound 898158

Basic information

Technical information
  • TDR Targets ID: 898158
  • Name: 5-methyl-5-(4-nitrophenyl)imidazolidine-2,4-d ione
  • MW: 235.196 | Formula: C10H9N3O4
  • H donors: 2 H acceptors: 4 LogP: 0.67 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(N1)(C)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C10H9N3O4/c1-10(8(14)11-9(15)12-10)6-2-4-7(5-3-6)13(16)17/h2-5H,1H3,(H2,11,12,14,15)
  • InChiKey: NWBOWKFCGBXAIE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-methyl-5-(4-nitrophenyl)hydantoin
  • BAS 00818749
  • Oprea1_083148
  • Oprea1_226837
  • STOCK1S-10993
  • 5-Methyl-5-(4-nitro-phenyl)-imidazolidine-2,4-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni multidrug resistance protein 0.0076 0.0995 0.0995
Echinococcus granulosus multidrug resistance protein 1 0.0076 0.0995 0.0995
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0033 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.0995 0.2177
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0207 0.0207
Echinococcus multilocularis multidrug resistance protein 1 0.0076 0.0995 0.0995
Loa Loa (eye worm) acetylcholinesterase 1 0.0552 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.1313 0.1313
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.0995 0.0995
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0033 0.0072
Trichomonas vaginalis abcb9, putative 0.0076 0.0995 0.2177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0419 0.0419
Echinococcus granulosus acetylcholinesterase 0.0552 1 1
Echinococcus granulosus para nitrobenzyl esterase 0.0093 0.1313 0.1313
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0076 0.0995 0.0995
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0076 0.0995 0.0995
Loa Loa (eye worm) inositol-1 0.0037 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0035 0.0207 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.4571 1
Echinococcus multilocularis multidrug resistance protein 1 0.0076 0.0995 0.0995
Echinococcus multilocularis snurportin 1 0.0372 0.6592 0.6592
Loa Loa (eye worm) carboxylesterase 0.0552 1 1
Brugia malayi MH2 domain containing protein 0.012 0.1824 0.1824
Mycobacterium ulcerans carboxylesterase, LipT 0.0093 0.1313 0.7992
Echinococcus granulosus BC026374 protein S09 family 0.0093 0.1313 0.1313
Entamoeba histolytica P-glycoprotein-2 0.0076 0.0995 0.2177
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0093 0.1313 0.1313
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0076 0.0995 0.0995
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0033 0.0033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0251 0.055
Echinococcus granulosus importin subunit beta 1 0.0035 0.0207 0.0207
Echinococcus multilocularis acetylcholinesterase 0.0552 1 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0076 0.0995 0.5
Plasmodium falciparum importin beta, putative 0.0035 0.0207 0.0453
Brugia malayi RNA, U transporter 1 0.0099 0.1424 0.1424
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.0995 0.2177
Brugia malayi Inositol-1 0.0037 0.0251 0.0251
Schistosoma mansoni arginase 0.0265 0.4571 0.4571
Loa Loa (eye worm) hypothetical protein 0.018 0.2966 0.2966
Trichomonas vaginalis spcc417.12 protein, putative 0.0093 0.1313 0.2873
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.0558 0.0558
Entamoeba histolytica hypothetical protein 0.0028 0.0082 0.018
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0033 0.0033
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0076 0.0995 0.7577
Schistosoma mansoni importin beta-1 0.0035 0.0207 0.0207
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0082 0.018
Plasmodium vivax importin-beta 2, putative 0.0035 0.0207 0.0453
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0151 0.092
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0076 0.0995 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0979 0.0979
Schistosoma mansoni ran 0.0026 0.0033 0.0033
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0178 1
Echinococcus granulosus multidrug resistance protein 1 0.0076 0.0995 0.0995
Trichomonas vaginalis Arginase, putative 0.0265 0.4571 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0033 0.0072
Entamoeba histolytica P-glycoprotein-2 0.0076 0.0995 0.2177
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.0995 0.2177
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0419 0.0419
Echinococcus granulosus carboxylesterase 5A 0.0552 1 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.1313 0.1313
Schistosoma mansoni inositol monophosphatase 0.0037 0.0251 0.0251
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 0.0079 0.1039 0.6323
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.0995 0.2177
Plasmodium falciparum arginase 0.0265 0.4571 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0093 0.1313 0.1313
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0076 0.0995 0.0995
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0093 0.1313 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.0995 0.0995
Echinococcus multilocularis para nitrobenzyl esterase 0.0093 0.1313 0.1313
Trichomonas vaginalis abcb9, putative 0.0076 0.0995 0.2177
Loa Loa (eye worm) hypothetical protein 0.0093 0.1313 0.1313
Echinococcus multilocularis neuroligin 0.0093 0.1313 0.1313
Echinococcus multilocularis 0.0265 0.4571 0.4571
Entamoeba histolytica P-glycoprotein-1 0.0076 0.0995 0.2177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0419 0.0419
Trichomonas vaginalis abcb9, putative 0.0076 0.0995 0.2177
Entamoeba histolytica P-glycoprotein 5, putative 0.0076 0.0995 0.2177
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0251 1
Brugia malayi Carboxylesterase family protein 0.0552 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0082 0.018
Treponema pallidum hypothetical protein 0.0027 0.0061 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0178 0.1353
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0251 0.153
Onchocerca volvulus 0.0093 0.1313 1
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.0265 0.4571 0.4571
Loa Loa (eye worm) hypothetical protein 0.018 0.2966 0.2966
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.0995 0.2177
Onchocerca volvulus 0.0093 0.1313 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.0995 0.0995
Brugia malayi Carboxylesterase family protein 0.0093 0.1313 0.1313
Trypanosoma brucei agmatinase, putative 0.0096 0.1375 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0251 0.055
Schistosoma mansoni multidrug resistance protein 0.0076 0.0995 0.0995
Trichomonas vaginalis ABC transporter, putative 0.0076 0.0995 0.2177
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0033 0.0238
Schistosoma mansoni hypothetical protein 0.0372 0.6592 0.6592
Schistosoma mansoni ran 0.0026 0.0033 0.0033
Schistosoma mansoni gliotactin 0.0093 0.1313 0.1313
Onchocerca volvulus 0.0093 0.1313 1
Trypanosoma cruzi agmatinase, putative 0.0096 0.1375 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.0995 0.2177
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0033 0.0328
Echinococcus multilocularis ATP binding cassette sub family B 0.0076 0.0979 0.0979
Loa Loa (eye worm) hypothetical protein 0.0552 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0419 0.0419
Loa Loa (eye worm) hypothetical protein 0.0076 0.0995 0.0995
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0053 0.0558 0.122
Entamoeba histolytica Ran family GTPase 0.0026 0.0033 0.0072
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0207 0.1505
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.0995 0.2177
Brugia malayi Muscleblind-like protein 0.018 0.2966 0.2966
Entamoeba histolytica P-glyco protein 6, putative 0.0076 0.0995 0.2177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0419 0.0419
Brugia malayi Importin beta-1 subunit 0.0035 0.0207 0.0207
Leishmania major GTP-binding protein, putative 0.0026 0.0033 0.0072
Trichomonas vaginalis taga, putative 0.0076 0.0995 0.2177
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0251 0.2527
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0167 0.2711 0.5932
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0093 0.1313 0.2873
Echinococcus granulosus multidrug resistance protein 1 0.0076 0.0995 0.0995
Mycobacterium tuberculosis Carboxylesterase LipT 0.0093 0.1313 1
Echinococcus granulosus multidrug resistance protein 1 0.0053 0.0558 0.0558
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.0995 0.2177
Loa Loa (eye worm) hypothetical protein 0.0093 0.1313 0.1313
Mycobacterium ulcerans hypothetical protein 0.0027 0.0061 0.0373
Echinococcus multilocularis carboxylesterase 5A 0.0552 1 1
Mycobacterium ulcerans carbon monoxyde dehydrogenase small chain CoxS 0.0032 0.0151 0.092
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0076 0.0995 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0033 0.0033
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0251 0.0251
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1824 0.1824
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.0995 0.2177
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (medium chain) 0.0056 0.0615 0.4686
Trypanosoma cruzi arginase, putative 0.0096 0.1375 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0207 0.208
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.0995 0.2177
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0082 0.018
Leishmania major importin beta-1 subunit, putative 0.0028 0.0082 0.018
Trichomonas vaginalis ABC transporter, putative 0.0076 0.0995 0.2177
Schistosoma mansoni smdr2 0.0076 0.0995 0.0995
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0076 0.0995 0.0995
Trypanosoma cruzi arginase, putative 0.0096 0.1375 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.0995 0.0995
Loa Loa (eye worm) multidrug resistance protein 3 0.0076 0.0995 0.0995
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0251 0.1829
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.0995 0.2177
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.6592 0.6592
Echinococcus multilocularis muscleblind protein 1 0.018 0.2966 0.2966
Mycobacterium ulcerans carbon monoxyde dehydrogenase medium chain CoxM 0.0056 0.0615 0.3745
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0076 0.0995 0.2177
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.0995 0.2177
Leishmania major arginase 0.0265 0.4571 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0033 0.0033
Schistosoma mansoni neuroligin 3 (S09 family) 0.0093 0.1313 0.1313
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0049 0.0485 0.2952
Schistosoma mansoni multidrug resistance protein 0.0076 0.0995 0.0995
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0419 0.0419
Loa Loa (eye worm) carboxylesterase 0.0093 0.1313 0.1313
Brugia malayi hypothetical protein 0.0093 0.1313 0.1313
Echinococcus granulosus arginase 2 mitochondrial 0.0265 0.4571 0.4571
Schistosoma mansoni BC026374 protein (S09 family) 0.0093 0.1313 0.1313
Trichomonas vaginalis ABC transporter, putative 0.0076 0.0995 0.2177
Echinococcus multilocularis muscleblind protein 0.018 0.2966 0.2966
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (small chain) 0.0032 0.0151 0.1151
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.0995 0.2177
Echinococcus multilocularis BC026374 protein (S09 family) 0.0093 0.1313 0.1313
Echinococcus multilocularis multidrug resistance protein 1 0.0053 0.0558 0.0558
Plasmodium vivax arginase, putative 0.0265 0.4571 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.1313 0.1313
Brugia malayi ABC transporter family protein 0.0076 0.0995 0.0995
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0552 1 1
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) 0.0079 0.1039 0.7911
Trichomonas vaginalis aldehyde oxidase, putative 0.0167 0.2711 0.5932
Onchocerca volvulus 0.0093 0.1313 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0251 0.1829
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0093 0.1313 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0419 0.0419
Echinococcus granulosus muscleblind protein 0.018 0.2966 0.2966
Trichomonas vaginalis conserved hypothetical protein 0.0265 0.4571 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0995 0.0995
Echinococcus multilocularis acetylcholinesterase 0.0552 1 1
Onchocerca volvulus 0.0093 0.1313 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0093 0.1313 0.1313
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.0995 0.2177
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0251 0.055
Echinococcus granulosus acetylcholinesterase 0.0552 1 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0251 0.055
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.0995 0.2177
Plasmodium falciparum multidrug resistance protein 1 0.0076 0.0995 0.2177
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0251 0.055
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0033 0.0238
Loa Loa (eye worm) hypothetical protein 0.0093 0.1313 0.1313
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0207 0.1505
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.0995 0.2177
Brugia malayi Carboxylesterase family protein 0.0093 0.1313 0.1313
Trypanosoma cruzi agmatinase, putative 0.0096 0.1375 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0076 0.0995 0.2177
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0076 0.0995 0.2177
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 0.0056 0.0615 0.3745
Trichomonas vaginalis xanthine dehydrogenase, putative 0.0167 0.2711 0.5932
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.0995 0.2177
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0552 1 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0251 0.0251
Entamoeba histolytica P-glycoprotein-5 0.0076 0.0995 0.2177
Brugia malayi Carboxylesterase family protein 0.0093 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0093 0.1313 0.1313
Trichomonas vaginalis ran, putative 0.0026 0.0033 0.0072
Trichomonas vaginalis ABC transporter, putative 0.0076 0.0995 0.2177
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0251 0.1829
Entamoeba histolytica Arginase, putative 0.0265 0.4571 1
Schistosoma mansoni acetylcholinesterase 0.0093 0.1313 0.1313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0419 0.0419
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0076 0.0995 0.2177
Echinococcus granulosus neuroligin 0.0093 0.1313 0.1313
Loa Loa (eye worm) hypothetical protein 0.0093 0.1313 0.1313
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0076 0.0995 0.2177
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0033 0.0238
Mycobacterium ulcerans carbon monoxide dehydrogenase 0.0111 0.1643 1
Leishmania major agmatinase-like protein 0.0096 0.1375 0.3008
Entamoeba histolytica P-glycoprotein-2, putative 0.0076 0.0995 0.2177
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL 0.0079 0.1039 0.6323
Echinococcus multilocularis arginase 2, mitochondrial 0.0265 0.4571 0.4571
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0076 0.0995 0.2177
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0076 0.0995 0.2177
Leishmania major p-glycoprotein 0.0076 0.0995 0.2177
Brugia malayi Carboxylesterase family protein 0.0093 0.1313 0.1313
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0093 0.1313 0.1313
Echinococcus granulosus snurportin 1 0.0372 0.6592 0.6592
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0076 0.0995 0.0995
Loa Loa (eye worm) carboxylesterase 0.0093 0.1313 0.1313
Brugia malayi multidrug resistance protein 3 0.0076 0.0995 0.0995
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0076 0.0979 0.0979
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0082 0.0597
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0251 0.0251

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 100 % Antischistosomal activity against Schistosoma mansoni Puerto Rican infected mouse assessed as infected mouse at 314 mg/kg/day, through diet for 14 days ChEMBL. 412964
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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