Detailed information for compound 898165

Basic information

Technical information
  • TDR Targets ID: 898165
  • Name: N-[(Z)-3-[(4-methoxyphenyl)amino]-1-(3-nitrop henyl)-3-oxoprop-1-en-2-yl]cyclohexanecarboxa mide
  • MW: 423.462 | Formula: C23H25N3O5
  • H donors: 2 H acceptors: 4 LogP: 4.45 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)C(=Cc1cccc(c1)[N+](=O)[O-])NC(=O)C1CCCCC1
  • InChi: 1S/C23H25N3O5/c1-31-20-12-10-18(11-13-20)24-23(28)21(25-22(27)17-7-3-2-4-8-17)15-16-6-5-9-19(14-16)26(29)30/h5-6,9-15,17H,2-4,7-8H2,1H3,(H,24,28)(H,25,27)/b21-15-
  • InChiKey: RZQZRNHCXBOHGZ-QNGOZBTKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(Z)-1-[(4-methoxyphenyl)carbamoyl]-2-(3-nitrophenyl)vinyl]cyclohexanecarboxamide
  • N-[(Z)-1-[[(4-methoxyphenyl)amino]-oxomethyl]-2-(3-nitrophenyl)vinyl]cyclohexanecarboxamide
  • N-[(Z)-3-[(4-methoxyphenyl)amino]-1-(3-nitrophenyl)-3-oxo-prop-1-en-2-yl]cyclohexanecarboxamide
  • ZINC01828497

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni gamma-secretase subunit aph-1 0.0252 0.5222 0.5931
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0146 0.2911 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0173 0.0532
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0413 0.8753 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0064 0.0073
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0173 0.0196
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.6425 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1986 0.227
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.1619 0.4986
Plasmodium falciparum thioredoxin reductase 0.0038 0.0547 0.1879
Trypanosoma brucei unspecified product 0.0015 0.0029 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.2816 0.3198
Schistosoma mansoni hypothetical protein 0.0165 0.3312 0.3762
Trichomonas vaginalis ornithine decarboxylase, putative 0.0052 0.0853 0.0853
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0027 0.0302 0.0471
Brugia malayi Common central domain of tyrosinase family protein 0.0236 0.4877 0.5571
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0064 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0945 0.0945
Onchocerca volvulus 0.006 0.1019 0.0695
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0173 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0173 0.0196
Onchocerca volvulus 0.0236 0.4877 0.4691
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.1832 0.5642
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0029 0.0045
Schistosoma mansoni smad1 5 8 and 0.0025 0.0253 0.0287
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0349 0.0387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2816 0.3198
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0173 0.0269
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0173 0.0197
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0027 0.0302 0.0345
Brugia malayi hypothetical protein 0.0166 0.3334 0.3809
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Echinococcus granulosus cpg binding protein 0.0031 0.0385 0.0437
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0027 0.0302 0.0343
Echinococcus multilocularis smad 0.0025 0.0253 0.0287
Trichomonas vaginalis ornithine decarboxylase, putative 0.0146 0.2911 0.2911
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0253 0.0287
Schistosoma mansoni smad 0.0025 0.0253 0.0287
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0252 0.5222 0.5961
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1112 0.1263
Onchocerca volvulus 0.0236 0.4877 0.4691
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1152 0.1308
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.2816 0.3198
Loa Loa (eye worm) hypothetical protein 0.0236 0.4877 0.5566
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0064 0.022
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0236 0.4877 0.5571
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Brugia malayi Thioredoxin reductase 0.0038 0.0547 0.0625
Plasmodium vivax glutathione reductase, putative 0.0038 0.0547 0.1879
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0263 0.0904
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.2888 0.4495
Brugia malayi MH2 domain containing protein 0.0025 0.0253 0.0289
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1019 0.1157
Schistosoma mansoni smad1 5 8 and 0.0025 0.0253 0.0287
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0 0.5
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0263 0.0409
Loa Loa (eye worm) hypothetical protein 0.0071 0.1266 0.1437
Loa Loa (eye worm) hypothetical protein 0.0025 0.0263 0.0289
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0027 0.0302 0.1037
Brugia malayi MH2 domain containing protein 0.0025 0.0253 0.0289
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0263 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1019 0.1157
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.6425 1
Schistosoma mansoni hypothetical protein 0.0071 0.1266 0.1438
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.1019 0.1157
Brugia malayi Pre-SET motif family protein 0.006 0.1019 0.1164
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0547 0.1879
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0 0.5
Brugia malayi Carboxylesterase family protein 0.0066 0.1152 0.1316
Brugia malayi Pre-SET motif family protein 0.0413 0.8753 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.4877 0.5566
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.043 0.0489
Brugia malayi Smad1 0.0025 0.0253 0.0289
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0064 0.0073
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0173 0.0196
Giardia lamblia DINP protein human, muc B family 0.0021 0.0173 0.0594
Trypanosoma cruzi Aph-1 protein, putative 0.0098 0.1858 0.2891
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.6425 1
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0236 0.4877 0.5571
Trypanosoma brucei ornithine decarboxylase 0.0146 0.2911 0.453
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0173 0.0269
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0236 0.4877 0.5571
Schistosoma mansoni cpg binding protein 0.0031 0.0385 0.0437
Mycobacterium tuberculosis Probable reductase 0.0087 0.1619 0.4986
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0173 0.0186
Echinococcus multilocularis geminin 0.0165 0.3312 0.3762
Echinococcus granulosus acetylcholinesterase 0.0066 0.1152 0.1308
Schistosoma mansoni cpg binding protein 0.0029 0.0349 0.0396
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.1619 0.7598
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.1019 0.1157
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0263 0.0904
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0654 0.1018
Echinococcus multilocularis gamma secretase subunit aph 1 0.0252 0.5222 0.5931
Toxoplasma gondii thioredoxin reductase 0.0038 0.0547 0.1879
Echinococcus granulosus dna polymerase eta 0.0021 0.0173 0.0196
Loa Loa (eye worm) MH2 domain-containing protein 0.0364 0.7678 0.8771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2816 0.3198
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.2816 0.3209
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1986 0.227
Echinococcus granulosus dnaJ subfamily B 0.0415 0.8805 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.1619 0.4986
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.1619 0.4986
Plasmodium vivax SET domain protein, putative 0.006 0.1019 0.35
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0029 0.0045
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.043 0.048
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0027 0.0302 0.1037
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0064 0.0198
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.1619 0.4986
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Mycobacterium tuberculosis Diaminopimelate decarboxylase LysA (DAP decarboxylase) 0.0146 0.2911 0.8965
Loa Loa (eye worm) tyrosinase 1 0.0236 0.4877 0.5566
Loa Loa (eye worm) Smad1 0.0025 0.0253 0.0278
Treponema pallidum NADH oxidase 0.0013 0 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.1019 0.1154
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0064 0.01
Echinococcus granulosus dna polymerase kappa 0.0021 0.0173 0.0196
Brugia malayi ShTK domain containing protein 0.0236 0.4877 0.5571
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.2888 0.4495
Echinococcus granulosus Smad4 0.0025 0.0253 0.0287
Trichomonas vaginalis pyridoxal-dependent decarboxylase, putative 0.0146 0.2911 0.2911
Schistosoma mansoni hypothetical protein 0.0033 0.043 0.0489
Giardia lamblia Ornithine decarboxylase 0.0146 0.2911 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.1019 0.1157
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0263 0.0409
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.2816 0.3198
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0064 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Echinococcus granulosus smad 0.0025 0.0253 0.0287
Brugia malayi glutathione reductase 0.0038 0.0547 0.0625
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0253 0.0278
Brugia malayi MH2 domain containing protein 0.0364 0.7678 0.8772
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0173 0.0197
Loa Loa (eye worm) transcription factor SMAD2 0.0364 0.7678 0.8771
Schistosoma mansoni tyrosinase precursor 0.0236 0.4877 0.5539
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0253 0.0287
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.1152 0.1308
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0027 0.0302 0.047
Schistosoma mansoni tyrosinase precursor 0.0236 0.4877 0.5539
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0146 0.2911 1
Entamoeba histolytica ornithine decarboxylase, putative 0.0146 0.2911 1
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1152 0.1308
Onchocerca volvulus 0.0236 0.4877 0.4691
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0064 0.0073
Schistosoma mansoni hypothetical protein 0.0033 0.043 0.0489
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0027 0.0302 0.047
Trypanosoma cruzi Aph-1 protein, putative 0.0098 0.1858 0.2891
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0173 0.0269
Trypanosoma brucei unspecified product 0.0015 0.0029 0.0045
Loa Loa (eye worm) hypothetical protein 0.0033 0.043 0.048
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0064 0.01
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0173 0.0269
Leishmania major trypanothione reductase 0.0038 0.0547 0.0851
Loa Loa (eye worm) carboxylesterase 0.0066 0.1152 0.1306
Brugia malayi hypothetical protein 0.0025 0.0263 0.0301
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0027 0.0302 0.047
Schistosoma mansoni Smad4 0.0025 0.0253 0.0287
Loa Loa (eye worm) hypothetical protein 0.0104 0.1986 0.226
Schistosoma mansoni hypothetical protein 0.0165 0.3312 0.3762
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0064 0.0073
Echinococcus multilocularis Smad4 0.0025 0.0253 0.0287
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0064 0.01
Schistosoma mansoni hypothetical protein 0.0033 0.043 0.0489
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0027 0.0302 0.0302
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0558 0.0634
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0654 0.1018
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0146 0.2911 0.2911
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.043 0.0489
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0027 0.0302 0.1037
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0263 0.0904
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.043 0.0492
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Brugia malayi Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein 0.0146 0.2911 0.3326
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0173 0.0532
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.1019 0.1157
Loa Loa (eye worm) pyridoxal-dependent decarboxylase 0.0146 0.2911 0.3318
Leishmania major hypothetical protein, conserved 0.0025 0.0263 0.0409
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.2888 0.4495
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0957 0.1087
Echinococcus granulosus gamma secretase subunit aph 1 0.0252 0.5222 0.5931
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0654 0.1018
Brugia malayi MH1 domain containing protein 0.0014 0.001 0.0012
Loa Loa (eye worm) ShTK domain-containing protein 0.0236 0.4877 0.5566
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0027 0.0302 0.0302
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0253 0.0287
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.1832 1
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.1266 0.1447
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0547 0.1684
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.1152 0.1306
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.1619 0.4986
Toxoplasma gondii hypothetical protein 0.0049 0.0793 0.2725
Toxoplasma gondii diaminopimelate decarboxylase 0.0146 0.2911 1
Trichomonas vaginalis ornithine decarboxylase, putative 0.0146 0.2911 0.2911
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0654 0.1018
Brugia malayi hypothetical protein 0.0016 0.0067 0.0077
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0064 0.022
Brugia malayi gamma-secretase subunit aph-1 0.0252 0.5222 0.5966
Loa Loa (eye worm) ShTK domain-containing protein 0.0236 0.4877 0.5566
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0173 0.0269
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0064 0.022
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0173 0.0532
Echinococcus multilocularis dna polymerase eta 0.0021 0.0173 0.0196
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1986 0.226
Echinococcus granulosus geminin 0.0165 0.3312 0.3762
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0967 0.3323
Brugia malayi MH1 domain containing protein 0.0025 0.0253 0.0289
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0253 0.0278
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0547 0.0614
Loa Loa (eye worm) hypothetical protein 0.0066 0.1152 0.1306
Leishmania major ornithine decarboxylase, putative 0.0146 0.2911 0.453
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Mycobacterium ulcerans diaminopimelate decarboxylase LysA 0.0146 0.2911 0.8965
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0236 0.4877 0.5571
Echinococcus multilocularis GPCR, family 2 0.0033 0.043 0.0489
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.1832 0.5642
Loa Loa (eye worm) glutathione reductase 0.0038 0.0547 0.0614
Trypanosoma brucei trypanothione reductase 0.0038 0.0547 0.0851
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0173 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Echinococcus granulosus carboxylesterase 5A 0.0066 0.1152 0.1308
Trypanosoma brucei unspecified product 0.0021 0.0173 0.0269
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0064 0.0073
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0547 0.0851
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0027 0.0302 0.0345
Brugia malayi MH1 domain containing protein 0.0014 0.001 0.0012
Schistosoma mansoni smad1 5 8 and 0.0025 0.0253 0.0287
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0263 0.0904
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0027 0.0302 0.047
Brugia malayi CXXC zinc finger family protein 0.0029 0.0349 0.0398
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0064 0.0073
Loa Loa (eye worm) hypothetical protein 0.0166 0.3334 0.3802
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0064 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.3247 1
Leishmania major DNA polymerase eta, putative 0.0021 0.0173 0.0269
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1152 0.1308
Loa Loa (eye worm) hypothetical protein 0.0021 0.0173 0.0186
Brugia malayi Latrophilin receptor protein 2 0.0033 0.043 0.0492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.2816 0.3198
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.8805 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0385 0.0437
Schistosoma mansoni DNA polymerase eta 0.0021 0.0173 0.0196
Onchocerca volvulus 0.0146 0.2911 0.2655
Brugia malayi Carboxylesterase family protein 0.0066 0.1152 0.1316
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Schistosoma mansoni hypothetical protein 0.0415 0.8805 1
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0027 0.0302 0.0343
Plasmodium falciparum glutathione reductase 0.0038 0.0547 0.1879
Onchocerca volvulus 0.0166 0.3334 0.3093
Mycobacterium ulcerans hypothetical protein 0.0162 0.3247 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0173 0.0269
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.2816 0.3198
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0027 0.0302 0.0334
Echinococcus granulosus acetylcholinesterase 0.0066 0.1152 0.1308
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0027 0.0302 0.0334
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.043 0.0489
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0253 0.0287
Trypanosoma brucei Aph-1 protein, putative 0.0098 0.1858 0.2891
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0064 0.0073
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0173 0.0173
Onchocerca volvulus 0.0236 0.4877 0.4691
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0027 0.0302 0.0343
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0064 0.022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.1832 0.5642
Trichomonas vaginalis set domain proteins, putative 0.047 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.2816 0.3217
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Echinococcus granulosus GPCR family 2 0.0033 0.043 0.0489
Loa Loa (eye worm) hypothetical protein 0.0066 0.1152 0.1306
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0029 0.0045
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0146 0.2911 0.2911
Brugia malayi MH1 domain containing protein 0.0025 0.0253 0.0289
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0173 0.0173
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0173 0.0532
Schistosoma mansoni cpg binding protein 0.0031 0.0385 0.0437
Leishmania major DNA polymerase kappa, putative 0.0021 0.0173 0.0269
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.6425 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0064 0.01
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0064 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.1019 0.1157
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0253 0.0287
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0558 0.0634
Schistosoma mansoni hypothetical protein 0.0033 0.043 0.0489
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0861 0.134
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.043 0.0489
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.1019 0.35

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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