Detailed information for compound 89823

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 336.919 | Formula: C20H31ClNO-
  • H donors: 1 H acceptors: 1 LogP: 5.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1.[Cl-]
  • InChi: 1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H/p-1
  • InChiKey: QDWJJTJNXAKQKD-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0122 0.0231
Brugia malayi nuclear hormone receptor 0.0024 0.0223 0.0423
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0223 0.0423
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0562 0.1064
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0259 0.0259
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Brugia malayi Dopamine receptor protein 1 0.0016 0.0122 0.0231
Onchocerca volvulus 0.0024 0.0223 0.0371
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0257 0.3033 0.492
Echinococcus granulosus tyrosine protein kinase Srms 0.0007 0.0013 0.0013
Onchocerca volvulus 0.0157 0.1827 0.3033
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0122 0.0198
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0007 0.0013 0.0013
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0148 0.0281
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0159 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0085 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0122 0.0122
Echinococcus granulosus serotonin receptor 0.0016 0.0122 0.0122
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0553 0.0553
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0122 0.0122
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0553 0.1047
Loa Loa (eye worm) HMP-2 protein 0.0313 0.3711 0.602
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Echinococcus multilocularis expressed conserved protein 0.0096 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0122 0.0122
Onchocerca volvulus 0.0016 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0148 0.117
Onchocerca volvulus 0.0016 0.0122 0.0203
Schistosoma mansoni hypothetical protein 0.0016 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0259 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0553 0.0897
Onchocerca volvulus 0.0007 0.0013 0.0022
Echinococcus granulosus g protein coupled receptor 0.0016 0.0122 0.0122
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0461 0.0461
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0122 0.0122
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0095 0.5974
Brugia malayi hypothetical protein 0.0006 0.0004 0.0008
Brugia malayi Dopamine receptor protein 2 0.0016 0.0122 0.0231
Schistosoma mansoni hypothetical protein 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.0897
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Schistosoma mansoni neuropeptide receptor 0.0016 0.0122 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0122 0.0122
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0122 0.0203
Echinococcus granulosus expressed conserved protein 0.0096 0.1094 0.1094
Onchocerca volvulus 0.0016 0.0122 0.0203
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0007 0.0013 0.0013
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0223 0.0423
Brugia malayi nuclear receptor NHR-88 0.0024 0.0223 0.0423
Loa Loa (eye worm) HMG box family protein 0.0142 0.165 0.2677
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Plasmodium vivax SET domain protein, putative 0.0064 0.0697 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.0897
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0142 0.165 0.165
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0223 0.0362
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0223 0.0223
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0223 0.0223
Onchocerca volvulus 0.0016 0.0122 0.0203
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0148 0.931
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0461 0.0461
Brugia malayi Patched protein homolog 1 0.0006 0.0004 0.0008
Brugia malayi hypothetical protein 0.0006 0.0004 0.0008
Brugia malayi nuclear hormone receptor 0.0052 0.0553 0.1047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Onchocerca volvulus 0.0504 0.6022 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0553 0.1047
Schistosoma mansoni tyrosine kinase 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0553 0.0918
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0553 0.0553
Echinococcus granulosus orexin receptor type 2 0.0016 0.0122 0.0122
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0122 0.0122
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0148 0.2131
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0223 0.0223
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0727 0.0727
Echinococcus granulosus tyrosine protein kinase ABL1 0.0007 0.0013 0.0013
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0122 0.0122
Echinococcus granulosus g protein coupled receptor 0.0016 0.0122 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0553 0.0553
Toxoplasma gondii patched family protein 0.0006 0.0004 0.0059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0259 0.0419
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.1701 0.1701
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0057 0.0057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0553 0.0553
Schistosoma mansoni hypothetical protein 0.0519 0.6198 0.6198
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0148 0.0241
Loa Loa (eye worm) RecQ helicase 0.0026 0.024 0.039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Brugia malayi hypothetical protein 0.0007 0.0013 0.0025
Loa Loa (eye worm) TK/ABL protein kinase 0.0007 0.0013 0.0022
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0122 0.0198
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.1169 0.2213
Brugia malayi isocitrate dehydrogenase 0.0019 0.0159 0.0302
Onchocerca volvulus Protein patched homolog 0.0006 0.0004 0.0007
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0035 0.0035
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0159 0.0159
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0122 0.0122
Brugia malayi Melatonin receptor type 1A 0.0016 0.0122 0.0231
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0085 0.0085
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0175 0.0175
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0122 0.0122
Onchocerca volvulus 0.0052 0.0553 0.0918
Loa Loa (eye worm) hypothetical protein 0.0007 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.1169 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0007 0.0013 0.0013
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0122 0.0122
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.024 0.0399
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0036 0.0358 0.0358
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0256 0.3023 0.3023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0553 0.0553
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0122 0.0122
Brugia malayi GnHR receptor homolog 0.0016 0.0122 0.0231
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0035 0.0035
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0432 0.0717
Schistosoma mansoni hypothetical protein 0.0042 0.0442 0.0442
Toxoplasma gondii patched family protein 0.0006 0.0004 0.0059
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0085 0.0085
Schistosoma mansoni tyrosine kinase 0.0238 0.28 0.28
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0128 0.0242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0484 0.0484
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Schistosoma mansoni nuclear receptor 0.0024 0.0223 0.0223
Schistosoma mansoni hypothetical protein 0.0016 0.0122 0.0122
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0223 0.0423
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0148 0.0148
Echinococcus granulosus tyrosine protein kinase Fyn 0.0007 0.0013 0.0013
Echinococcus granulosus tyrosine kinase 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.0897
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0085 0.0161
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0122 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0553 0.0553
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0223 0.0223
Loa Loa (eye worm) patched family protein 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0142 0.165 0.165
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0085 0.0085
Onchocerca volvulus 0.0016 0.0122 0.0203
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0148 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Loa Loa (eye worm) hypothetical protein 0.0052 0.0557 0.0903
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0035 0.0035
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0159 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0007 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0553 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0553 0.1047
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0057 0.387
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Toxoplasma gondii patched family protein 0.0006 0.0004 0.0059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0148 0.7332
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Brugia malayi G protein-coupled receptor 0.0016 0.0122 0.0231
Schistosoma mansoni 60S ribosomal protein L21 0.0007 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0103 0.1169 0.1896
Onchocerca volvulus 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0122 0.0122
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0007 0.0013 0.0013
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0484 0.0785
Schistosoma mansoni neuropeptide receptor 0.0016 0.0122 0.0122
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0223 0.0423
Onchocerca volvulus 0.0007 0.0013 0.0022
Echinococcus granulosus tar DNA binding protein 0.0066 0.0727 0.0727
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0122 0.0122
Loa Loa (eye worm) SRC-1 0.0007 0.0013 0.0022
Trichomonas vaginalis set domain proteins, putative 0.0504 0.6022 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Brugia malayi Myosin head containing protein 0.0006 0.0004 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0122 0.0122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus granulosus hypothetical protein 0.0016 0.0122 0.0122
Echinococcus granulosus neuropeptide receptor 0.0016 0.0122 0.0122
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.1169 0.1169
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0016 0.0128 0.0128
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0122 0.0122
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.3033 0.3033
Schistosoma mansoni biogenic amine receptor 0.0016 0.0122 0.0122
Echinococcus multilocularis sex peptide receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0484 0.0484
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0122 0.0231
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0122 0.0122
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0122 0.0122
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0553 0.0918
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus multilocularis protein patched 0.0044 0.0461 0.0461
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0085 0.0085
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0057 0.0057
Brugia malayi protein-tyrosine kinase 0.0007 0.0013 0.0025
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0517 0.0517
Echinococcus multilocularis GPCR, family 2 0.0016 0.0128 0.0128
Schistosoma mansoni neuropeptide receptor 0.0016 0.0122 0.0122
Brugia malayi Protein kinase domain containing protein 0.0007 0.0013 0.0025
Loa Loa (eye worm) TK protein kinase 0.0007 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0484 0.0484
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0122 0.0122
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0122 0.0231
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0467 0.0467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0553 0.1047
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Schistosoma mansoni amine GPCR 0.0016 0.0122 0.0122
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Onchocerca volvulus 0.0016 0.0122 0.0203
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0007 0.0013 0.0013
Echinococcus granulosus neuropeptide receptor 0.0016 0.0122 0.0122
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0122 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0157 0.1827 0.3458
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus multilocularis geminin 0.0175 0.2043 0.2043
Brugia malayi Tyrosine-protein kinase abl-1 0.0007 0.0013 0.0025
Schistosoma mansoni DNA helicase recq5 0.0011 0.0057 0.0057
Echinococcus granulosus hypothetical protein 0.066 0.7904 0.7904
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0122 0.0122
Echinococcus granulosus somatostatin receptor 0.0016 0.0122 0.0122
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0095 0.5974
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0014 0.0014
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Echinococcus granulosus tyrosine protein kinase shark 0.0238 0.28 0.28
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0122 0.0122
Plasmodium falciparum lipid/sterol:H+ symporter 0.0006 0.0004 0.0203
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0159 0.0159
Echinococcus granulosus tyrosine kinase 0.0007 0.0013 0.0013
Echinococcus granulosus pangolin 0.0142 0.165 0.165
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0122 0.0122
Echinococcus granulosus tyrosine protein kinase Src64B 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0177 0.0288
Brugia malayi follicle stimulating hormone receptor 0.0254 0.2993 0.5666
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0148 1
Onchocerca volvulus 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Brugia malayi SRC-1 0.0007 0.0013 0.0025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0553 0.1047
Schistosoma mansoni tyrosine kinase 0.0232 0.2735 0.2735
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0553 0.0553
Schistosoma mansoni hypothetical protein 0.0175 0.2043 0.2043
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0223 0.0223
Schistosoma mansoni coup transcription factor 0.0052 0.0553 0.0553
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0697 0.0697
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0203 1
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0122 0.0122
Echinococcus granulosus tyrosine protein kinase Src42A 0.0007 0.0013 0.0013
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0727 0.1179
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0467 0.0467
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0553 0.0553
Schistosoma mansoni hypothetical protein 0.0042 0.0442 0.0442
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0517 0.0517
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0467 0.0758
Brugia malayi Serotonin receptor 0.0016 0.0122 0.0231
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0148 0.931
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0122 0.0122
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0148 0.931
Brugia malayi nuclear receptor NHR-88 0.0052 0.0553 0.1047
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0223 0.0223
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0259 0.049
Plasmodium vivax patched family protein, putative 0.0006 0.0004 0.0059
Toxoplasma gondii hypothetical protein 0.0006 0.0004 0.0059
Onchocerca volvulus 0.0016 0.0122 0.0203
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Echinococcus granulosus tyrosine protein kinase Fyn 0.0007 0.0013 0.0013
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0358 0.0581
Brugia malayi Serotonin receptor 0.0016 0.0122 0.0231
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0057 0.2838
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.2993 0.4854
Brugia malayi ecdysone receptor 0.0024 0.0223 0.0423
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0553 0.1047
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.0897
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0137 0.1966
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0057 0.0057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0159 0.0159
Echinococcus multilocularis serotonin receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus granulosus bloom syndrome protein 0.0026 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0159 0.0159
Echinococcus multilocularis c src tyrosine kinase 0.0007 0.0013 0.0013
Echinococcus granulosus fmrfamide receptor 0.0016 0.0122 0.0122
Schistosoma mansoni opsin-like receptor 0.0016 0.0122 0.0122
Onchocerca volvulus 0.0006 0.0004 0.0007
Schistosoma mansoni myosin xvIII 0.0016 0.0122 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0553 0.0897
Onchocerca volvulus 0.0016 0.0122 0.0203
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0122 0.0122
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0122 0.0122
Brugia malayi G-protein coupled receptor 0.0016 0.0122 0.0231
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0095 0.5974
Schistosoma mansoni thyroid hormone receptor 0.0308 0.3647 0.3647
Loa Loa (eye worm) hypothetical protein 0.0039 0.0396 0.0643
Onchocerca volvulus 0.0007 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0035 0.0057
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Schistosoma mansoni zinc finger protein 0.0024 0.0223 0.0223
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0122 0.0122
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Schistosoma mansoni thyroid hormone receptor 0.0308 0.3647 0.3647
Echinococcus granulosus c src tyrosine kinase 0.0007 0.0013 0.0013
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0035 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0553 0.0553
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0553 0.0553
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0122 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Onchocerca volvulus Protein patched homolog 0.0006 0.0004 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0148 0.931
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0122 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Schistosoma mansoni patched 1 0.0044 0.0461 0.0461
Brugia malayi Protein kinase domain containing protein 0.0007 0.0013 0.0025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0122 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0727 0.0727
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0159 1
Schistosoma mansoni tyrosine kinase 0.0007 0.0013 0.0013
Brugia malayi Patched related family protein 10 0.0006 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi RE15519p 0.0016 0.0122 0.0231
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0223 0.0362
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0122 0.0198
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0148 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0122 0.0122
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0484 0.0916
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0223 0.0223
Onchocerca volvulus 0.0016 0.0122 0.0203
Loa Loa (eye worm) patched family protein 0.0006 0.0004 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Brugia malayi Protein kinase domain containing protein 0.0007 0.0013 0.0025
Schistosoma mansoni adenoreceptor 0.0016 0.0122 0.0122
Schistosoma mansoni tyrosine kinase 0.0007 0.0013 0.0013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0122 0.0122
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0148 0.0247
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus multilocularis tyrosine protein kinase Srms 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) patched family protein 0.0006 0.0004 0.0007
Schistosoma mansoni histamine h1 receptor 0.0016 0.0122 0.0122
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0122 0.0122
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0727 0.1376
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0159 0.7876
Onchocerca volvulus 0.0016 0.0122 0.0203
Schistosoma mansoni tyrosine kinase 0.0007 0.0013 0.0013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0553 0.0553
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.3033 0.3033
Onchocerca volvulus 0.0007 0.0013 0.0022
Schistosoma mansoni amine GPCR 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Loa Loa (eye worm) patched family protein 0.0006 0.0004 0.0007
Brugia malayi hypothetical protein 0.0027 0.0259 0.049
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0052 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0027 0.0259 0.0419
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0122 0.0122
Brugia malayi larval opioid receptor 0.0016 0.0122 0.0231
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0122 0.0231
Schistosoma mansoni opsin-like receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0013 0.0085 0.0138
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0122 0.0122
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0007 0.0013 0.0013
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0128 0.0242
Onchocerca volvulus 0.0016 0.0122 0.0203
Onchocerca volvulus Cirhin homolog 0.0311 0.3686 0.6121
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0122 0.0198
Brugia malayi Pre-SET motif family protein 0.0064 0.0697 0.1319
Brugia malayi Dopamine receptor 0.0016 0.0122 0.0231
Onchocerca volvulus 0.0007 0.0013 0.0022
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0122 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0727 0.0727
Schistosoma mansoni pangolin 0.0142 0.165 0.165
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.0897
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Brugia malayi SH2 domain containing protein 0.0007 0.0013 0.0025
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0159 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0553 0.1047
Schistosoma mansoni DNA helicase recq1 0.0011 0.0057 0.0057
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0553 0.0553
Schistosoma mansoni biogenic amine receptor 0.0016 0.0122 0.0122
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0553 0.0553
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.024 0.0455
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0223 0.0371
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.1169 0.1169
Onchocerca volvulus 0.0007 0.0013 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0484 0.0484
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0553 0.1047
Echinococcus granulosus allatostatin A receptor 0.0016 0.0122 0.0122
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0122 0.0231
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0697 0.0697
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0159 0.2289
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Onchocerca volvulus 0.0016 0.0122 0.0203
Toxoplasma gondii patched family protein 0.0006 0.0004 0.0059
Brugia malayi Pre-SET motif family protein 0.0443 0.5282 1
Schistosoma mansoni biogenic amine receptor 0.0016 0.0122 0.0122
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0122 0.0122
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Loa Loa (eye worm) RNA binding protein 0.0066 0.0727 0.1179
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0128 0.0128
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0007 0.0013 0.0013
Echinococcus granulosus tyrosine protein kinase Blk 0.0007 0.0013 0.0013
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0159 1
Schistosoma mansoni hypothetical protein 0.0042 0.0442 0.0442
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0159 0.0159
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0035 0.0035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0259 0.0259
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0122 0.0122
Onchocerca volvulus 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0128 0.0207
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0553 0.0553
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0035 0.0057
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0313 0.3711 0.7026
Schistosoma mansoni neuropeptide receptor 0.0016 0.0122 0.0122
Echinococcus multilocularis thyroid hormone receptor alpha 0.0308 0.3647 0.3647
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0259 0.0259
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0122 0.0231
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0122 0.0122
Schistosoma mansoni tyrosine kinase 0.0007 0.0013 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0128 0.0128
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0085 0.0085
Onchocerca volvulus 0.0016 0.0122 0.0203
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0553 0.0553
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0223 0.0223
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0057 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0553 0.1047
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0727 0.0727
Echinococcus multilocularis serotonin receptor 0.0016 0.0122 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Onchocerca volvulus 0.0156 0.1813 0.3011
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0035 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Schistosoma mansoni beta-catenin 0.0313 0.3711 0.3711
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Onchocerca volvulus 0.0006 0.0004 0.0007
Schistosoma mansoni ap endonuclease 0.0018 0.0148 0.0148
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0553 0.1047
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0122 0.0122
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0035 0.0035
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0223 0.0223
Brugia malayi sulfakinin receptor protein 0.0016 0.0122 0.0231
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0223 0.0223
Brugia malayi Protein kinase domain containing protein 0.0007 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Schistosoma mansoni hypothetical protein 0.0016 0.0128 0.0128
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0223 0.0362
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Schistosoma mansoni hypothetical protein 0.0016 0.0122 0.0122
Brugia malayi nuclear receptor NHR-67 0.0024 0.0223 0.0423
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Schistosoma mansoni ap endonuclease 0.0018 0.0148 0.0148
Brugia malayi protein C24B5.3 0.0006 0.0004 0.0008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0122 0.0122
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0057 0.0825
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0122 0.0122
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0122 0.0122
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0223 0.0371
Loa Loa (eye worm) hypothetical protein 0.0157 0.1827 0.2963
Brugia malayi CHE-14 protein 0.0044 0.0461 0.0873
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0175 0.2043 0.2043
Schistosoma mansoni amine GPCR 0.0016 0.0122 0.0122
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0007 0.0013 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Brugia malayi G-protein coupled receptor 0.0016 0.0122 0.0231
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0006 0 0.5
Toxoplasma gondii exonuclease III APE 0.0018 0.0148 0.2131
Brugia malayi SH2 domain containing protein 0.0007 0.0013 0.0025
Echinococcus multilocularis somatostatin receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.0897
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0727 0.0727
Schistosoma mansoni amine GPCR 0.0016 0.0122 0.0122
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0122 0.0122
Brugia malayi hypothetical protein 0.0006 0.0004 0.0008
Echinococcus multilocularis tyrosine protein kinase Blk 0.0007 0.0013 0.0013
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0027 0.0259 0.0419
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0122 0.0122
Brugia malayi RNA binding protein 0.0066 0.0727 0.1376
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0122 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0358 0.0678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0553 0.0897
Onchocerca volvulus 0.0006 0.0004 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0557 0.0903
Echinococcus multilocularis bloom syndrome protein 0.0026 0.024 0.024
Echinococcus granulosus GPCR family 2 0.0016 0.0128 0.0128
Echinococcus multilocularis protein pangolin J 0.0142 0.165 0.165
Schistosoma mansoni survival motor neuron protein 0.0052 0.0562 0.0562
Mycobacterium leprae Conserved hypothetical protein 0.0006 0 0.5
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0223 0.0423
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0122 0.0122
Brugia malayi hypothetical protein 0.0027 0.0259 0.049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0007 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0256 0.3023 0.3023
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0007 0.0013 0.0013
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0007 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0095 0.071
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0122 0.0122
Brugia malayi nuclear receptor RXR 0.0027 0.0259 0.049
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0461 0.0461
Schistosoma mansoni hypothetical protein 0.0016 0.0122 0.0122
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0122 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0697 0.0697
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0697 0.0697
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0035 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Onchocerca volvulus 0.0052 0.0562 0.0933
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0122 0.0122
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0035 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0259 0.0419
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0557 0.1054
Brugia malayi HMG box family protein 0.0142 0.165 0.3124
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0159 0.0159
Echinococcus multilocularis protein dispatched 1 0.005 0.0536 0.0536
Schistosoma mansoni nuclear receptor 0.0024 0.0223 0.0223
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0035 0.0035
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi putative neuropeptide receptor 0.0016 0.0122 0.0231
Loa Loa (eye worm) hypothetical protein 0.0516 0.6165 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0259 0.0259
Brugia malayi nuclear receptor RXR 0.0024 0.0223 0.0423
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Onchocerca volvulus 0.0016 0.0122 0.0203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0553 0.0897
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0122 0.0122
Brugia malayi neuropeptide F receptor 0.0016 0.0122 0.0231
Echinococcus multilocularis beta catenin 0.0313 0.3711 0.3711
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0553 0.0897
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0553 0.1047
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.0035 0.0067
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0035 0.0059
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0159 0.2289
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0727 0.1179
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0122 0.0122
Echinococcus multilocularis tyrosine protein kinase Abl 0.0007 0.0013 0.0013
Schistosoma mansoni amine GPCR 0.0016 0.0122 0.0122
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0697 0.0697
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0553 0.0553
Loa Loa (eye worm) hypothetical protein 0.0054 0.0581 0.0942
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0259 0.0419
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0057 0.0093
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0159 0.0259
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0553 0.0553
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0122 0.0122
Onchocerca volvulus 0.0006 0.0004 0.0007
Onchocerca volvulus 0.0016 0.0122 0.0203
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0223 0.0223
Echinococcus granulosus g protein coupled receptor 0.0016 0.0122 0.0122
Onchocerca volvulus 0.0016 0.0122 0.0203
Onchocerca volvulus 0.0016 0.0122 0.0203
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.024 0.0399
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0148 0.931
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0553 0.1047
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0057 0.0109
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0668 0.0668
Brugia malayi protein C24B5.3 0.0006 0.0004 0.0008
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0223 0.0223
Brugia malayi Protein kinase domain containing protein 0.0007 0.0013 0.0025
Brugia malayi hypothetical protein 0.0024 0.0223 0.0423
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0557 0.1054
Brugia malayi TAR-binding protein 0.0066 0.0727 0.1376
Loa Loa (eye worm) patched family protein 0.0006 0.0004 0.0007
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.1701 0.1701
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Brugia malayi conserved hypotetical protein 0.0024 0.0223 0.0423
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi hypothetical protein 0.0016 0.0122 0.0231
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.0897
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0093
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0057 0.0825
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0122 0.0122
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0139 0.2002
Loa Loa (eye worm) hypothetical protein 0.0052 0.0553 0.0897
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0007 0.0013 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0697 0.0697
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0223 0.0423
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0727 0.0727
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0697 0.0697
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0122 0.0122
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0122 0.0203
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0223 0.0223
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0095 0.0158
Brugia malayi ORL1-like opioid receptor 0.0016 0.0122 0.0231
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0057 0.0057
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0553 0.0897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0484 0.0484
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0122 0.0122
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0122 0.0122
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.9396 0.9396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0484 0.0484
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0122 0.0122
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0159 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0461 0.0766
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0122 0.0122
Echinococcus granulosus beta catenin 0.0313 0.3711 0.3711
Echinococcus granulosus tyrosine protein kinase Fyn 0.0007 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0042 0.0442 0.0442
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0432 0.0717
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Onchocerca volvulus 0.0064 0.0697 0.1157
Loa Loa (eye worm) hypothetical protein 0.0516 0.6165 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.1188 0.1188
Brugia malayi steroid hormone receptor 0.0052 0.0553 0.1047
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0122 0.0122
Brugia malayi hypothetical protein 0.0257 0.3033 0.5742
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0064 0.0697 0.113
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi ecdysteroid receptor 0.0052 0.0553 0.1047
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0122 0.0122
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0007 0.0013 0.0013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0443 0.5282 0.8568
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0553 0.0918
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0128 0.0128
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0035 0.0035
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Brugia malayi Patched related family protein 12 0.0006 0.0004 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0553 0.0897
Brugia malayi hypothetical protein 0.0006 0.0004 0.0008
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0035 0.0035
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0122 0.0122
Echinococcus granulosus tyrosine protein kinase Lyn 0.0007 0.0013 0.0013
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0122 0.0198
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0035 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0553 0.0553
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0553 0.0553
Brugia malayi Patched family protein 0.0006 0.0004 0.0008
Brugia malayi neuropeptide F receptor 0.0016 0.0122 0.0231
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198
Echinococcus multilocularis tyrosine protein kinase shark 0.0238 0.28 0.28
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0159 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0035 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0259 0.049
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0553 0.1047
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0223 0.0362
Echinococcus granulosus sex peptide receptor 0.0016 0.0122 0.0122
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0122 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0122 0.0198
Onchocerca volvulus 0.0024 0.0223 0.0371
Brugia malayi Patched related family protein 4 0.0006 0.0004 0.0008
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0148 0.0247
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0044 0.0461 0.0748
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0148 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0159 0.2289
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0007 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0553 0.1047
Loa Loa (eye worm) TK/FER protein kinase 0.0007 0.0013 0.0022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0223 0.0223
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0159 0.0302
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0553 0.0897
Echinococcus multilocularis tyrosine kinase 0.0007 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0016 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0007
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0467 0.0885
Echinococcus granulosus geminin 0.0175 0.2043 0.2043
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0122 0.0122
Brugia malayi hypothetical protein 0.0024 0.0223 0.0423
Loa Loa (eye worm) DR-78 0.0024 0.0223 0.0362
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0461 0.0748
Brugia malayi tailless protein 0.0024 0.0223 0.0423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0122 0.0122
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0256 0.3023 0.3023
Schistosoma mansoni opsin-like receptor 0.0016 0.0122 0.0122
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0122 0.0122
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0007 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0553 0.1047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0128 0.0207
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0697 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0122 0.0122
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0553 0.0553
Brugia malayi AKH receptor 0.0016 0.0122 0.0231
Loa Loa (eye worm) hypothetical protein 0.0016 0.0122 0.0198

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.3 nM Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]-NMS binding using membranes in transfected chinese hamster ovarian cell ChEMBL. 9873472
IC50 (binding) = 6.7 nM Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell ChEMBL. 9873472
IC50 (binding) = 10.3 nM Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell ChEMBL. 9873472
IC50 (binding) = 18.6 nM Evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell ChEMBL. 9873472
IC50 (binding) = 26.3 nM Evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]-NMS binding using membranes from transfected chinese hamster ovarian cell ChEMBL. 9873472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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