Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0531 | 0.8479 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0445 | 0.3225 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0392 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0445 | 0.3225 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0445 | 0.3225 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 13 % | Inhibition of recombinant His-tagged SIRT3 (unknown origin) using Fluor de Lys acetylated KI179 as substrate at 200 uM incubated for 5 mins followed by enzyme addition measured after 1 hr by fluorescence assay relative to control | ChEMBL. | 23562596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.