Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.007 | 0.4717 | 0.4717 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0063 | 0.4083 | 0.4083 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0133 | 1 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.4717 | 0.4717 |
Schistosoma mansoni | nuclear hormone receptor | 0.0063 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.007 | 0.4717 | 0.4717 |
Brugia malayi | nuclear receptor NHR-67 | 0.0063 | 0.4083 | 0.4083 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.1833 | 0.1833 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0063 | 0.4083 | 0.4083 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0014 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0063 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.4717 | 0.4717 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0133 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0133 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.4717 | 0.4717 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0063 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0063 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0133 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0133 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0071 | 0.4801 | 0.4801 |
Schistosoma mansoni | coup transcription factor | 0.0133 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0133 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0063 | 0.4083 | 0.4083 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0063 | 0.4083 | 0.4083 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0063 | 0.4083 | 0.4083 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0133 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.007 | 0.4717 | 0.4717 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.007 | 0.4717 | 0.4717 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.007 | 0.4717 | 0.4717 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0133 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0133 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.007 | 0.4717 | 0.4717 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0063 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Brugia malayi | nuclear hormone receptor | 0.0133 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.1833 | 0.1833 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0133 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0063 | 0.4083 | 0.4083 |
Schistosoma mansoni | nuclear receptor | 0.0063 | 0.4083 | 0.4083 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0133 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.1833 | 0.1833 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0133 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0063 | 0.4083 | 0.4083 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0133 | 1 | 1 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0014 | 0 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0014 | 0 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0133 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.007 | 0.4717 | 0.4717 |
Schistosoma mansoni | zinc finger protein | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0014 | 0 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.1633 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0063 | 0.4083 | 0.4083 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0133 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.4717 | 0.4717 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0063 | 0.4083 | 0.4083 |
Trypanosoma brucei | cytochrome P450, putative | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0014 | 0 | 0.5 |
Brugia malayi | ecdysone receptor | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0014 | 0 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0014 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0133 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0063 | 0.4083 | 0.4083 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0133 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0014 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1432 | 0.1432 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0133 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0133 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0014 | 0 | 0.5 |
Brugia malayi | tailless protein | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0063 | 0.4083 | 0.4083 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0063 | 0.4083 | 0.4083 |
Onchocerca volvulus | 0.0133 | 1 | 1 | |
Brugia malayi | nuclear hormone receptor | 0.0063 | 0.4083 | 0.4083 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0133 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0014 | 0 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.1833 | 0.1833 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0014 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0063 | 0.4083 | 0.4083 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0133 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.2111 | 0.2111 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0133 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0063 | 0.4083 | 0.4083 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.1633 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.007 | 0.4717 | 0.4717 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.2111 | 0.2111 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0133 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.4717 | 0.4717 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0063 | 0.4083 | 0.4083 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.007 | 0.4717 | 0.4717 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0014 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.007 | 0.4717 | 0.4717 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0071 | 0.4801 | 0.4801 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0133 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0133 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0014 | 0 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0133 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0133 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0133 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0063 | 0.4083 | 0.4083 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0133 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0063 | 0.4083 | 0.4083 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0133 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0133 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0063 | 0.4083 | 0.4083 |
Echinococcus granulosus | FTZ F1 alpha | 0.0133 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0063 | 0.4083 | 0.4083 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0133 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0133 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0063 | 0.4083 | 0.4083 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0063 | 0.4083 | 0.4083 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0063 | 0.4083 | 0.4083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.