Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine deaminase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | adenosine deaminase-related growth factor | Adenosine deaminase | 363 aa | 299 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | adenosine deaminase | 0.0104 | 0.2696 | 1 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.0114 | 0.35 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.0104 | 0.2696 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0104 | 0.2696 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.0104 | 0.2696 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2696 | 0.7702 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0195 | 1 | 1 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0114 | 0.35 | 1 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.0114 | 0.35 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0104 | 0.2696 | 0.5 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.0114 | 0.35 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0104 | 0.2696 | 0.5 |
Brugia malayi | Adenosine/AMP deaminase family protein | 0.0104 | 0.2696 | 0.2458 |
Brugia malayi | Bm-MIF-1, identical | 0.0114 | 0.35 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.01 | 0.2433 | 0.6953 |
Treponema pallidum | adenosine deaminase | 0.0104 | 0.2696 | 0.5 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.0114 | 0.35 | 1 |
Echinococcus granulosus | adenosine deaminase | 0.0104 | 0.2696 | 0.0347 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.0114 | 0.35 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0104 | 0.2696 | 0.5 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.0114 | 0.35 | 1 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.0114 | 0.35 | 1 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.0114 | 0.35 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0114 | 0.35 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(binding) | 0 | Compound was tested for inhibition of Adenylate deaminase (AMPDA) in rabbit muscle | Starlite. | 10450967 |
(binding) | 0 | Compound was tested for inhibition of Adenylate deaminase (AMPDA) in pea enzyme | Starlite. | 10450967 |
(binding) | 0 | Compound was tested for inhibition of Adenylate deaminase deaminase (AMPDA) in rabbit muscle | Starlite. | 10450967 |
ATP level (functional) | = 423 nM (g frozen weight)-1 | Amount of ATP was determined using a luciferase based assay after 4 hours | Starlite. | 10450967 |
ATP level (functional) | = 450 nM (g frozen weight)-1 | Amount of ATP was determined using a luciferase based assay after 4 hours | Starlite. | 10450967 |
ATP level (functional) | = 693 nM (g frozen weight)-1 | Amount of ATP was determined using a luciferase based assay after 24 hours | Starlite. | 10450967 |
IC50 (binding) | = 70 nM | Compound was tested for inhibition of adenosine 5'-monophosphate deaminase (AMPDA) in rabbit muscle | Starlite. | 10450967 |
IC50 (binding) | = 100 nM | Compound was tested for inhibition of adenosine 5'-monophosphate deaminase (AMPDA) in pea enzyme | Starlite. | 10450967 |
IC50 (binding) | = 5 uM | Inhibition of Bos taurus (calf) intestinal mucosa adenylate deaminase | ChEMBL. | 10450967 |
Km (binding) | = 35 uM | Binding affinity to Bos taurus (calf) intestinal mucosa adenylate deaminase | ChEMBL. | 10450967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.