Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0211 | 0.1349 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.018 | 0.0161 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0519 | 0.3761 |
Plasmodium vivax | importin-beta 2, putative | 0.0031 | 0.044 | 0.8484 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.2641 | 0.3509 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0254 | 0.2179 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.1031 | 0.1031 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.2641 | 0.3509 |
Trichomonas vaginalis | importin beta-1, putative | 0.0025 | 0.0254 | 0.2179 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0062 | 0.144 | 0.144 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0211 | 0.0192 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.2641 | 0.2627 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.044 | 0.0422 |
Schistosoma mansoni | ran | 0.0023 | 0.018 | 0.018 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0519 | 0.3606 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0211 | 0.1349 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0211 | 0.1349 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.3649 | 0.3649 |
Schistosoma mansoni | importin beta-1 | 0.0031 | 0.044 | 0.044 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0461 | 0.0461 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.044 | 0.7682 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0519 | 0.0519 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0243 | 0.7192 | 0.7192 |
Brugia malayi | hypothetical protein | 0.0243 | 0.7192 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0243 | 0.7192 | 0.7192 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3649 | 0.3649 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0519 | 0.0484 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0519 | 1 |
Brugia malayi | RNA binding protein | 0.0132 | 0.3649 | 0.4947 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0519 | 0.0501 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0023 | 0.018 | 0.1248 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0519 | 0.0501 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0519 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0519 | 0.0519 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0915 | 0.0915 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0519 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0519 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.144 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3649 | 0.3649 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0685 | 0.0685 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0031 | 0.044 | 0.7682 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1632 | 0.1616 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.1031 | 0.1031 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0519 | 0.3761 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0196 | 0.0178 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0019 | 0.0365 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.3649 | 0.3637 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0519 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0211 | 0.0044 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0019 | 0.0365 |
Onchocerca volvulus | 0.005 | 0.1031 | 1 | |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.0196 | 0.0178 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0461 | 0.0461 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0915 | 0.0915 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0025 | 0.0254 | 0.2179 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0685 | 0.0685 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.1031 | 0.1214 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.7192 | 0.7187 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0685 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0062 | 0.144 | 0.144 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0685 | 0.0685 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.3649 | 0.4947 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3649 | 0.3649 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0025 | 0.0254 | 0.2179 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0211 | 0.0246 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0519 | 0.352 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0211 | 0.1349 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.018 | 0.346 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.3649 | 0.4947 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0519 | 0.0519 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0062 | 0.144 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0685 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.3649 | 0.3637 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0331 | 1 | 1 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0023 | 0.018 | 0.018 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0519 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.1632 | 0.1632 |
Mycobacterium ulcerans | pyruvate kinase | 0.0033 | 0.0519 | 0.352 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.3649 | 0.3649 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0519 | 0.0501 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3649 | 0.3649 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0211 | 0.1349 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0915 | 0.0915 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0062 | 0.144 | 1 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.018 | 0.346 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0519 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0519 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0211 | 0.0246 |
Echinococcus multilocularis | snurportin 1 | 0.0331 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.0196 | 0.0332 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.0461 | 0.0461 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0211 | 0.1349 |
Brugia malayi | Importin beta-1 subunit | 0.0031 | 0.044 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0461 | 0.0443 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0519 | 0.2694 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0461 | 0.0443 |
Plasmodium falciparum | importin beta, putative | 0.0031 | 0.044 | 0.8484 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.0461 | 0.0461 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.0461 | 0.0461 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.144 | 0.144 |
Schistosoma mansoni | ran | 0.0023 | 0.018 | 0.018 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0685 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0211 | 0.0246 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.3649 | 0.3649 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.0294 | 0.0294 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0211 | 0.0613 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0031 | 0.044 | 0.044 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.144 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0211 | 0.0044 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0519 | 0.0519 |
Echinococcus granulosus | importin subunit beta 1 | 0.0031 | 0.044 | 0.044 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0915 | 0.0915 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0685 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0211 | 0.1349 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0519 | 0.0519 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.0461 | 0.0461 |
Brugia malayi | RNA, U transporter 1 | 0.0088 | 0.2262 | 0.297 |
Leishmania major | importin beta-1 subunit, putative | 0.0025 | 0.0254 | 0.0587 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0461 | 0.0402 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0685 | 0.0685 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0915 | 0.0898 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0062 | 0.144 | 0.144 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0211 | 0.0192 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0023 | 0.018 | 0.018 |
Entamoeba histolytica | hypothetical protein | 0.0025 | 0.0254 | 0.1464 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0211 | 0.1349 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0519 | 0.2694 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0211 | 0.0192 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0685 | 0.0721 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.3649 | 0.3637 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0062 | 0.144 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0211 | 0.1349 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0062 | 0.144 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0211 | 0.0044 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0915 | 0.1049 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0023 | 0.018 | 0.346 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2641 | 0.2627 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0211 | 0.1349 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0031 | 0.044 | 0.3059 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0519 | 0.0501 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0461 | 0.0402 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0915 | 0.0915 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0033 | 0.0519 | 0.3761 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0211 | 0.0613 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0461 | 0.0461 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0068 | 0.1632 | 0.2071 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0519 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0211 | 0.0613 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0519 | 0.0484 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0915 | 0.0915 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0461 | 0.0461 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0915 | 0.0915 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0461 | 0.0461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.