Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | DNA topoisomerase 1 | 0.0604 | 0.3552 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0446 | 0.1093 | 0.3078 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0452 | 0.1193 | 0.336 |
Plasmodium vivax | topoisomerase I, putative | 0.0604 | 0.3552 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0452 | 0.1193 | 0.336 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0452 | 0.1193 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0986 | 0.9484 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0604 | 0.3552 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0604 | 0.3552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0982 | 0.9423 | 0.9896 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0604 | 0.3552 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0452 | 0.1193 | 0.5 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0452 | 0.1193 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0446 | 0.1093 | 0.3078 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0986 | 0.9484 | 0.92 |
Schistosoma mansoni | thyroid hormone receptor | 0.0446 | 0.1093 | 0.3078 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0986 | 0.9484 | 0.92 |
Plasmodium falciparum | topoisomerase I | 0.0604 | 0.3552 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.