Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.2058 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0895 | 0.3794 | 0.8911 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0184 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0895 | 0.3794 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0982 | 0.4258 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0895 | 0.3794 | 0.8911 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.1874 | 0.9017 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.2058 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1874 | 0.9017 | 0.9017 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.1874 | 0.9017 | 0.9017 |
Loa Loa (eye worm) | hypothetical protein | 0.0885 | 0.3738 | 0.9853 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0192 | 0.0041 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0184 | 0 | 0.5 |
Onchocerca volvulus | 0.0184 | 0 | 0.5 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0184 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0192 | 0.0041 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.