Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0037 | 0.1024 | 0.1024 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.1092 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.1092 | 0.0425 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0037 | 0.1024 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0072 | 0.2641 | 0.2641 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0037 | 0.1024 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1092 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0072 | 0.2641 | 0.2641 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0037 | 0.1024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0967 | 0.0967 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0037 | 0.1024 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.1092 | 0.0425 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1092 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.1092 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.611 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1092 | 0.0425 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.7204 | 0.7204 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0037 | 0.1024 | 0.0487 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0037 | 0.1024 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1092 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0037 | 0.1024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0542 | 0.0542 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.1092 | 0.1092 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1024 | 0.0829 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.1092 | 0.056 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0037 | 0.1024 | 0.5 |
Mycobacterium leprae | putative cytochrome p450 | 0.0037 | 0.1024 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0037 | 0.1024 | 0.5 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.1092 | 0.056 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.7204 | 0.7204 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0037 | 0.1024 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0564 | 0.0564 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0037 | 0.1024 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0564 | 0.0564 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0037 | 0.1024 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0037 | 0.1024 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1092 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1092 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.7204 | 0.7037 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.1092 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0072 | 0.2641 | 0.2641 |
Brugia malayi | Cytochrome P450 family protein | 0.0072 | 0.2641 | 0.2641 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.1092 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.1092 | 0.1092 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.1522 | 0.1522 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1092 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0564 | 0.0564 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.1024 | 0.1024 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0037 | 0.1024 | 0.5 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.1092 | 0.0953 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0037 | 0.1024 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0037 | 0.1024 | 0.1024 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0037 | 0.1024 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.611 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0037 | 0.1024 | 0.1024 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.1092 | 0.0425 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.1522 | 0.1727 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0564 | 0.0564 |
Leishmania major | cytochrome p450-like protein | 0.0072 | 0.2641 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0072 | 0.2641 | 0.2641 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0072 | 0.2641 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0037 | 0.1024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0037 | 0.1024 | 0.5 |
Echinococcus multilocularis | 0.0037 | 0.1024 | 0.0487 | |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0037 | 0.1024 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0037 | 0.1024 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.7204 | 0.7037 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0037 | 0.1024 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1522 | 0.1727 |
Onchocerca volvulus | 0.0048 | 0.1522 | 0.2878 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.1092 | 0.5 |
Onchocerca volvulus | 0.0099 | 0.3892 | 1 | |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0072 | 0.2641 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.7204 | 0.7037 |
Loa Loa (eye worm) | cytochrome P450 | 0.0037 | 0.1024 | 0.1024 |
Trypanosoma brucei | cytochrome P450, putative | 0.0072 | 0.2641 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.1092 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0564 | 0.0564 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0037 | 0.1024 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0037 | 0.1024 | 0.0829 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0072 | 0.2641 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.