Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Giardia lamblia | High cysteine protein | 0.0122 | 0.2187 | 0.5 |
Brugia malayi | Cadherin domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Onchocerca volvulus | Peroxidasin homolog | 0.0377 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | Notch2 | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0122 | 0.2187 | 0.1498 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Schistosoma mansoni | notch | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Schistosoma mansoni | slit | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | Animal haem peroxidase family protein | 0.0377 | 1 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0122 | 0.2187 | 0.2187 |
Brugia malayi | EGF-like domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0377 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0377 | 1 | 1 |
Echinococcus multilocularis | fibropellin Ia | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | Animal haem peroxidase family protein | 0.0377 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0122 | 0.2187 | 0.2187 |
Brugia malayi | Animal haem peroxidase family protein | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Echinococcus granulosus | slit 2 protein | 0.0122 | 0.2187 | 0.2187 |
Onchocerca volvulus | Peroxidase homolog | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0377 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Onchocerca volvulus | Peroxidase homolog | 0.0377 | 1 | 1 |
Onchocerca volvulus | 0.0377 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.081 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | notch protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0377 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0377 | 1 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Schistosoma mansoni | septate junction protein | 0.0122 | 0.2187 | 0.1498 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Echinococcus multilocularis | notch | 0.0122 | 0.2187 | 0.2187 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0122 | 0.2187 | 0.2187 |
Brugia malayi | Peroxidasin | 0.0377 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | EGF-like domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Echinococcus granulosus | protein jagged 2 | 0.0122 | 0.2187 | 0.2187 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.5 |
Echinococcus granulosus | fibropellin Ia | 0.0122 | 0.2187 | 0.2187 |
Schistosoma mansoni | cell polarity protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | Animal haem peroxidase family protein | 0.0377 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0122 | 0.2187 | 0.2187 |
Echinococcus multilocularis | peroxidasin | 0.0377 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0122 | 0.2187 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.5 |
Brugia malayi | notch-like transmembrane receptor | 0.0122 | 0.2187 | 0.1498 |
Echinococcus multilocularis | protein jagged 1 | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Echinococcus granulosus | notch | 0.0122 | 0.2187 | 0.2187 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0377 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0377 | 1 | 1 |
Echinococcus granulosus | neural cadherin | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | Delta serrate ligand family protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Echinococcus granulosus | protein jagged 1 | 0.0122 | 0.2187 | 0.2187 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0122 | 0.2187 | 0.1498 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Schistosoma mansoni | notch | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Schistosoma mansoni | notch | 0.0122 | 0.2187 | 0.1498 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0122 | 0.2187 | 0.2187 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.5 |
Schistosoma mansoni | notch | 0.0122 | 0.2187 | 0.1498 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.081 |
Echinococcus granulosus | peroxidasin | 0.0377 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | Muscle positioning protein 4 | 0.0122 | 0.2187 | 0.1498 |
Echinococcus granulosus | delta-like protein 1 | 0.0122 | 0.2187 | 0.2187 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Schistosoma mansoni | notch | 0.0122 | 0.2187 | 0.1498 |
Schistosoma mansoni | peroxidasin | 0.0377 | 1 | 1 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | Animal haem peroxidase family protein | 0.0377 | 1 | 1 |
Onchocerca volvulus | 0.0377 | 1 | 1 | |
Echinococcus multilocularis | neural cadherin | 0.0122 | 0.2187 | 0.2187 |
Brugia malayi | EGF-like domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0122 | 0.2187 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Onchocerca volvulus | 0.0377 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Echinococcus multilocularis | slit 2 protein | 0.0122 | 0.2187 | 0.2187 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.081 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.081 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.081 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Echinococcus multilocularis | protein jagged 1 | 0.0122 | 0.2187 | 0.2187 |
Schistosoma mansoni | notch | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0377 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2187 | 0.1498 |
Brugia malayi | Cadherin domain containing protein | 0.0122 | 0.2187 | 0.1498 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.