Detailed information for compound 900110

Basic information

Technical information
  • TDR Targets ID: 900110
  • Name: 2-[6-chloro-2-(4-chlorophenyl)-4-phenyl-4H-qu inazolin-3-yl]acetohydrazide
  • MW: 425.311 | Formula: C22H18Cl2N4O
  • H donors: 2 H acceptors: 1 LogP: 4.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=O)CN1C(=Nc2c(C1c1ccccc1)cc(cc2)Cl)c1ccc(cc1)Cl
  • InChi: 1S/C22H18Cl2N4O/c23-16-8-6-15(7-9-16)22-26-19-11-10-17(24)12-18(19)21(14-4-2-1-3-5-14)28(22)13-20(29)27-25/h1-12,21H,13,25H2,(H,27,29)
  • InChiKey: HMSZIOSVYSHCJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[6-chloro-2-(4-chlorophenyl)-4-phenyl-4H-quinazolin-3-yl]ethanehydrazide
  • IDI1_020738
  • ChemDiv3_001772

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0069 0.3247 0.2948
Brugia malayi nuclear hormone receptor family member nhr-6 0.0069 0.3247 0.2948
Loa Loa (eye worm) nuclear receptor NHR-67 0.0069 0.3247 0.3247
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0147 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0069 0.3247 0.3247
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.3247 0.2948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Brugia malayi orphan nuclear receptor NR2E1 0.0069 0.3247 0.2948
Echinococcus multilocularis nuclear receptor nhr 48 0.0069 0.3247 0.2948
Brugia malayi hypothetical protein 0.0069 0.3247 0.2948
Brugia malayi ecdysone receptor 0.0069 0.3247 0.2948
Schistosoma mansoni nuclear hormone receptor 0.0147 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0147 1 1
Brugia malayi hypothetical protein 0.0078 0.397 0.3703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0147 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.397 0.397
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0147 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0147 1 1
Loa Loa (eye worm) DR-78 0.0069 0.3247 0.3247
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.1721 0.1721
Brugia malayi nuclear receptor RXR 0.0078 0.397 0.3703
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Echinococcus multilocularis ecdysone induced protein 78C 0.0147 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0069 0.3247 0.2724
Brugia malayi steroid hormone receptor 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0212 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0147 1 1
Schistosoma mansoni nuclear receptor 0.0069 0.3247 0.2724
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Brugia malayi Cytochrome P450 family protein 0.0052 0.1721 0.1354
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0147 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Loa Loa (eye worm) hypothetical protein 0.0078 0.397 0.397
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0147 1 1
Brugia malayi Nuclear hormone receptor E75 0.0069 0.3247 0.2948
Brugia malayi nuclear hormone receptor 0.0069 0.3247 0.2948
Onchocerca volvulus Bile acid receptor homolog 0.0147 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0147 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0147 1 1
Schistosoma mansoni zinc finger protein 0.0069 0.3247 0.2724
Loa Loa (eye worm) hypothetical protein 0.0078 0.397 0.397
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0147 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0147 1 1
Brugia malayi hypothetical protein 0.0078 0.397 0.3703
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Brugia malayi Nuclear hormone receptor E75 0.0069 0.3247 0.2948
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0078 0.397 0.3703
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0147 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0069 0.3247 0.2948
Echinococcus granulosus thyroid hormone receptor alpha 0.0069 0.3247 0.2948
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.397 0.397
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.397 0.3703
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.3247 0.2948
Brugia malayi Nuclear hormone receptor-like 1 0.0147 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0147 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0147 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0147 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0147 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0147 1 1
Brugia malayi nuclear receptor RXR 0.0069 0.3247 0.2948
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0069 0.3247 0.2948
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0147 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.3247 0.2948
Echinococcus granulosus ecdysone induced protein 78C 0.0147 1 1
Schistosoma mansoni thyroid hormone receptor 0.0147 1 1
Schistosoma mansoni coup transcription factor 0.0147 1 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0069 0.3247 0.2948
Onchocerca volvulus 0.0147 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0147 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0069 0.3247 0.3247
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0147 1 1
Schistosoma mansoni thyroid hormone receptor 0.0147 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0147 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0147 1 1
Schistosoma mansoni nuclear hormone receptor 0.0069 0.3247 0.2724
Schistosoma mansoni nuclear receptor nhr-48 0.0069 0.3247 0.2724
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0078 0.397 0.3703
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0069 0.3247 0.2724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0147 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0147 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0147 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0078 0.397 0.397
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0147 1 1
Schistosoma mansoni nuclear hormone receptor 0.0069 0.3247 0.2724
Echinococcus granulosus FTZ F1 alpha 0.0147 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.397 0.3504
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0423 0.0423
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0069 0.3247 0.2948
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.397 0.3703
Brugia malayi tailless protein 0.0069 0.3247 0.2948
Loa Loa (eye worm) hypothetical protein 0.0078 0.397 0.397
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0147 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0147 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.3247 0.2948
Echinococcus multilocularis FTZ F1 alpha 0.0147 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0147 1 1
Brugia malayi conserved hypotetical protein 0.0069 0.3247 0.2948
Brugia malayi nuclear receptor NHR-67 0.0069 0.3247 0.2948
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0147 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0147 1 1
Schistosoma mansoni nuclear receptor 0.0069 0.3247 0.2724
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Brugia malayi photoreceptor-specific nuclear receptor 0.0147 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Brugia malayi nuclear receptor NHR-88 0.0147 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0069 0.3247 0.2948
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0069 0.3247 0.2948
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0147 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0147 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0069 0.3247 0.2948
Schistosoma mansoni steroid hormone receptor ad4bp 0.0147 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0069 0.3247 0.2948
Brugia malayi nuclear hormone receptor 0.0147 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0147 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0078 0.397 0.3504
Loa Loa (eye worm) hypothetical protein 0.0069 0.3247 0.3247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0147 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0147 1 1
Brugia malayi nuclear receptor NHR-88 0.0069 0.3247 0.2948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0147 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0212 0.5
Loa Loa (eye worm) hypothetical protein 0.0147 1 1
Loa Loa (eye worm) hypothetical protein 0.0147 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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