Detailed information for compound 90052

Basic information

Technical information
  • TDR Targets ID: 90052
  • Name: 7-methyl-1,2,3,4-tetrahydroacridin-9-amine
  • MW: 212.29 | Formula: C14H16N2
  • H donors: 1 H acceptors: 1 LogP: 3.1 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c(N)c1c(n2)CCCC1
  • InChi: 1S/C14H16N2/c1-9-6-7-13-11(8-9)14(15)10-4-2-3-5-12(10)16-13/h6-8H,2-5H2,1H3,(H2,15,16)
  • InChiKey: ZZKQNBNYCRCFCW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (7-methyl-1,2,3,4-tetrahydroacridin-9-yl)amine
  • 7-Methyl-1,2,3,4-tetrahydro-acridin-9-ylamine
  • BAS 00232284
  • Oprea1_790166
  • Oprea1_733107

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica prolyl oligopeptidase family protein 0.122576 0.10692 0.313993
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0211766 0.0168185 0.0488957
Trypanosoma cruzi Aph-1 protein, putative 0.00304659 0.000708564 0.000785086
Toxoplasma gondii hypothetical protein 0.122576 0.10692 0.240656
Loa Loa (eye worm) carboxylesterase 0.00818585 0.00527521 0.00527521
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.022848 0.0183037 0.0181076
Schistosoma mansoni notch 0.00943005 0.00638078 0.00618226
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.238446 0.209879 0.209721
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0212553 0.0168884 0.0491014
Echinococcus multilocularis Mastin 0.019933 0.0157135 0.0155168
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.00481222 0.00227747 0.00320589
Echinococcus multilocularis proteasome (prosome, macropain) 0.0903901 0.0783202 0.0781361
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0162699 0.0124585 0.0124585
Plasmodium vivax hypothetical protein, conserved 0.122576 0.10692 0.313993
Giardia lamblia 20S proteasome alpha subunit 6 0.0201755 0.015929 0.144437
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.019933 0.0157135 0.0155168
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0162699 0.0124585 0.0122613
Echinococcus granulosus proteasome subunit alpha type 6 0.0212553 0.0168884 0.016692
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0201755 0.015929 0.02427
Brugia malayi cathepsin B-like cysteine proteinase 0.00261328 0.000323539 0.000265095
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.00777054 0.00490618 0.00490618
Toxoplasma gondii PCI domain-containing protein 0.00315268 0.000802838 0.00180703
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.017321 0.0133925 0.0203563
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.731832 0.648292 1
Brugia malayi histone deacetylase 1 (HD1) 0.0222759 0.0177954 0.0177379
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.00288805 0.00056769 0.000368009
Trypanosoma brucei histone deacetylase, putative 0.032938 0.0272695 0.0417683
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0610033 0.0522077 0.153018
Brugia malayi PCI domain containing protein 0.00287507 0.00055616 0.00049773
Brugia malayi proteasome subunit beta type 1 0.0610033 0.0522077 0.0521523
Echinococcus granulosus histone deacetylase 6 0.0336673 0.0279175 0.0277233
Echinococcus granulosus histone deacetylase 6 0.032938 0.0272695 0.0270751
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.00247398 0.000199755 0.000415547
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.00264256 0.000349559 0.000231146
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0211766 0.0168185 0.0168185
Giardia lamblia Proteasome subunit beta type 2 0.022848 0.0183037 0.166766
Onchocerca volvulus 0.019933 0.0157135 0.00939262
Toxoplasma gondii proteasome subunit 0.0200842 0.0158478 0.0356703
Brugia malayi Proteasome A-type and B-type family protein 0.0194314 0.0152678 0.0152102
Brugia malayi PCI domain containing protein 0.00263867 0.000346096 0.000287653
Echinococcus multilocularis carboxylesterase 5A 0.00818585 0.00527521 0.00507647
Brugia malayi Histone deacetylase family protein 0.032938 0.0272695 0.0272126
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Brugia malayi thymidylate synthase 0.0149883 0.0113197 0.0112619
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.00341134 0.00103268 0.00128519
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.00350579 0.00111661 0.000917034
Echinococcus multilocularis prolyl endopeptidase 0.238446 0.209879 0.209721
Leishmania major histone deacetylase, putative 0.0222759 0.0177954 0.0271498
Plasmodium vivax proteasome subunit beta type-5, putative 0.0903901 0.0783202 0.229846
Echinococcus multilocularis histone deacetylase 3 0.0222759 0.0177954 0.0175991
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0195702 0.0153911 0.0446959
Giardia lamblia Histone deacetylase 0.0222759 0.0177954 0.161986
Trypanosoma cruzi histone deacetylase, putative 0.0109979 0.00777398 0.0116869
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.00315268 0.000802838 0.00177439
Leishmania major proteasome alpha 1 subunit, putative 0.0212553 0.0168884 0.0257505
Plasmodium falciparum cysteine repeat modular protein 1 0.0385033 0.0322147 0.0941944
Trypanosoma cruzi histone deacetylase, putative 0.032938 0.0272695 0.0417683
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.00288805 0.00056769 0.00149764
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.00315268 0.000802838 0.000930551
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.00264256 0.000349559 0.000440754
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Brugia malayi Serine protease Z688.6 precursor 0.03016 0.024801 0.024744
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0200842 0.0158478 0.0158478
Onchocerca volvulus 0.0149883 0.0113197 0.00497062
Loa Loa (eye worm) hypothetical protein 0.122576 0.10692 0.10692
Schistosoma mansoni hypothetical protein 0.00943005 0.00638078 0.00618226
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.00288805 0.00056769 0.000368009
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.019098 0.0149715 0.0434614
Brugia malayi Kringle domain containing protein 0.0385033 0.0322147 0.0321582
Toxoplasma gondii histone deacetylase HDAC5 0.0109979 0.00777398 0.0174977
Brugia malayi prolyl oligopeptidase family protein 0.238446 0.209879 0.209833
Echinococcus multilocularis histone deacetylase 6 0.0336673 0.0279175 0.0277233
Echinococcus granulosus proteasome subunit beta type 6 0.0200842 0.0158478 0.0156512
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0202165 0.0159654 0.0463858
Onchocerca volvulus Notchless protein homolog 0.0203521 0.0160859 0.00976742
Loa Loa (eye worm) hypothetical protein 0.0109979 0.00777398 0.00777398
Echinococcus multilocularis tissue type plasminogen activator 0.0385033 0.0322147 0.0320214
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.00713033 0.0043373 0.00638419
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.00263867 0.000346096 0.000225803
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0196449 0.0154575 0.0152608
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0243323 0.0196226 0.0196226
Echinococcus multilocularis gamma secretase subunit aph 1 0.00777054 0.00490618 0.00470736
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0047954 0.00226253 0.00220419
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0202165 0.0159654 0.0157688
Echinococcus multilocularis cathepsin b 0.00261328 0.000323539 0.000123809
Loa Loa (eye worm) prolyl oligopeptidase 1.12764 1 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 1.12764 1 1
Toxoplasma gondii histone deacetylase HDAC1 0.032938 0.0272695 0.0613781
Trichomonas vaginalis 26S proteasome subunit, putative 0.00263867 0.000346096 0.000845932
Trypanosoma brucei oligopeptidase b 0.148085 0.129587 0.199642
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0243323 0.0196226 0.0575378
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0903901 0.0783202 0.731082
Loa Loa (eye worm) hypothetical protein 0.0222759 0.0177954 0.0177954
Plasmodium falciparum proteasome subunit beta type-7, putative 0.019098 0.0149715 0.0434614
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0194314 0.0152678 0.0232497
Brugia malayi EGF-like domain containing protein 0.00943005 0.00638078 0.00632269
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0211766 0.0168185 0.0378551
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.00341134 0.00103268 0.000833088
Entamoeba histolytica proteasome regulatory subunit, putative 0.00263867 0.000346096 0.000430564
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.017321 0.0133925 0.0789537
Loa Loa (eye worm) hypothetical protein 0.03016 0.024801 0.024801
Onchocerca volvulus 0.019933 0.0157135 0.00939262
Brugia malayi Dihydrofolate reductase 0.00611171 0.00343217 0.00337391
Plasmodium vivax histone deacetylase 1, putative 0.0222759 0.0177954 0.0517697
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Giardia lamblia Alanyl dipeptidyl peptidase 0.122576 0.10692 1
Leishmania major histone deacetylase, putative 0.032938 0.0272695 0.0417683
Plasmodium vivax 26S proteasome regulatory subunit RPN13, putative 0.00481222 0.00227747 0.00611304
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0903901 0.0783202 0.120539
Leishmania major agmatinase-like protein 0.110822 0.0964755 0.148552
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0200842 0.0158478 0.0241448
Loa Loa (eye worm) proteasome regulatory particle 0.00315268 0.000802838 0.000802838
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.00247398 0.000199755 0.000415547
Onchocerca volvulus 0.053854 0.045855 0.0397277
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0903901 0.0783202 0.120539
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0212553 0.0168884 0.016692
Toxoplasma gondii proteasome subunit beta type 2, putative 0.022848 0.0183037 0.0411981
Leishmania major proteasome beta 2 subunit, putative 0.022848 0.0183037 0.0279342
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0903901 0.0783202 0.120539
Entamoeba histolytica hypothetical protein 0.00259901 0.000310861 0.000326895
Schistosoma mansoni notch 0.00943005 0.00638078 0.00618226
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.00261328 0.000323539 0.000123809
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0385033 0.0322147 0.0941944
Brugia malayi Proteasome A-type and B-type family protein 0.0200842 0.0158478 0.0157903
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.00288805 0.00056769 0.00127776
Schistosoma mansoni hypothetical protein 0.0385033 0.0322147 0.0320214
Leishmania major proteasome beta 3 subunit, putative 0.0195702 0.0153911 0.0234401
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Giardia lamblia Hypothetical protein 0.00315268 0.000802838 0.00221102
Trypanosoma brucei ATP-dependent protease subunit HslV 0.017321 0.0133925 0.0203563
Schistosoma mansoni hypothetical protein 0.00943005 0.00638078 0.00618226
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.00315268 0.000802838 0.000744423
Brugia malayi Cadherin domain containing protein 0.00943005 0.00638078 0.00632269
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0212553 0.0168884 0.0257505
Trypanosoma cruzi histone deacetylase 1, putative 0.0222759 0.0177954 0.0271498
Loa Loa (eye worm) hypothetical protein 0.0385033 0.0322147 0.0322147
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0610033 0.0522077 0.153018
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.019933 0.0157135 0.0155168
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0211 0.0167504 0.0377019
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Echinococcus multilocularis proteasome subunit alpha type 6 0.0212553 0.0168884 0.016692
Brugia malayi dihydrofolate reductase family protein 0.00611171 0.00343217 0.00337391
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.238446 0.209879 0.209721
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.00259901 0.000310861 0.000111128
Plasmodium falciparum histone deacetylase 1 0.0222759 0.0177954 0.0517697
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.019933 0.0157135 0.0155168
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.00259901 0.000310861 0.000111128
Echinococcus multilocularis histone deacetylase 6 0.032938 0.0272695 0.0270751
Echinococcus granulosus cathepsin b 0.00261328 0.000323539 0.000123809
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0162699 0.0124585 0.0124585
Trypanosoma brucei proteasome beta 7 subunit 0.0194314 0.0152678 0.0232497
Trichomonas vaginalis histone deacetylase, putative 0.0222759 0.0177954 0.0521638
Trichomonas vaginalis histone deacetylase, putative 0.0222759 0.0177954 0.0521638
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.022848 0.0183037 0.0181076
Schistosoma mansoni notch 0.00943005 0.00638078 0.00618226
Echinococcus multilocularis fibropellin Ia 0.00943005 0.00638078 0.00618226
Echinococcus granulosus proteasome subunit beta type 7 0.0386254 0.0323232 0.0321298
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.00288805 0.00056769 0.00056772
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.00263867 0.000346096 0.00014637
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Loa Loa (eye worm) acetylcholinesterase 1 0.00818585 0.00527521 0.00527521
Loa Loa (eye worm) hypothetical protein 0.00818585 0.00527521 0.00527521
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0903901 0.0783202 0.229846
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.00288805 0.00056769 0.00050926
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.019098 0.0149715 0.0149715
Echinococcus multilocularis neural cadherin 0.00943005 0.00638078 0.00618226
Loa Loa (eye worm) trypsin family protein 0.019933 0.0157135 0.0157135
Brugia malayi Serine protease Z688.6 precursor 0.03016 0.024801 0.024744
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.122576 0.10692 0.240656
Schistosoma mansoni slit 0.00943005 0.00638078 0.00618226
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.00341134 0.00103268 0.00245062
Onchocerca volvulus 0.03016 0.024801 0.0185385
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.019933 0.0157135 0.0155168
Echinococcus granulosus acylamino acid releasing enzyme 0.122576 0.10692 0.106742
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0047954 0.00226253 0.00318283
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.441477 0.390289 0.390167
Echinococcus granulosus prolyl endopeptidase 0.238446 0.209879 0.209721
Onchocerca volvulus 0.019933 0.0157135 0.00939262
Loa Loa (eye worm) hypothetical protein 0.0219401 0.0174969 0.0174969
Echinococcus granulosus thymidylate synthase 0.0149883 0.0113197 0.0111222
Echinococcus multilocularis proteasome subunit beta type 7 0.0386254 0.0323232 0.0321298
Toxoplasma gondii proteasome subunit alpha type, putative 0.0202165 0.0159654 0.035935
Echinococcus granulosus Mastin 0.019933 0.0157135 0.0155168
Schistosoma mansoni hypothetical protein 0.0178103 0.0138273 0.0136303
Echinococcus multilocularis histone deacetylase 8 0.0109979 0.00777398 0.00757574
Plasmodium vivax histone deacetylase, putative 0.0109979 0.00777398 0.0222849
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0178103 0.0138273 0.0137696
Onchocerca volvulus Arrow homolog 0.0162699 0.0124585 0.0061168
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.148085 0.129587 0.199642
Entamoeba histolytica hypothetical protein, conserved 0.122576 0.10692 0.313993
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0202165 0.0159654 0.0157688
Trypanosoma cruzi hypothetical protein, conserved 0.122576 0.10692 0.164669
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.00264256 0.000349559 0.000440754
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.148085 0.129587 0.199642
Giardia lamblia 20S proteasome alpha subunit 2 0.0206296 0.0163325 0.148231
Trypanosoma cruzi Aph-1 protein, putative 0.00304659 0.000708564 0.000785086
Leishmania major proteasome alpha 7 subunit, putative 0.0243323 0.0196226 0.0299693
Trypanosoma brucei proteasome beta 2 subunit, putative 0.019098 0.0149715 0.0227927
Toxoplasma gondii kringle domain-containing protein 0.0385033 0.0322147 0.0725089
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.017321 0.0133925 0.5
Loa Loa (eye worm) hypothetical protein 0.03016 0.024801 0.024801
Echinococcus multilocularis histone deacetylase 1 0.0222759 0.0177954 0.0175991
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0194314 0.0152678 0.0232497
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0206296 0.0163325 0.0161359
Schistosoma mansoni gamma-secretase subunit aph-1 0.00777054 0.00490618 0.00470736
Plasmodium vivax proteasome subunit beta type-2, putative 0.022848 0.0183037 0.0532655
Echinococcus granulosus acetylcholinesterase 0.00818585 0.00527521 0.00507647
Schistosoma mansoni histone deacetylase 0.0222759 0.0177954 0.0175991
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Plasmodium falciparum arginase 0.384974 0.340082 1
Echinococcus granulosus enteropeptidase 0.019933 0.0157135 0.0155168
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0195702 0.0153911 0.0151944
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.00287507 0.00055616 0.000549929
Giardia lamblia Proteasome subunit beta type 1 0.0610033 0.0522077 0.485554
Brugia malayi histone deacetylase 11 0.0109979 0.00777398 0.00771597
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0162699 0.0124585 0.0124008
Toxoplasma gondii heat shock protein hslv, putative 0.017321 0.0133925 0.0301439
Plasmodium vivax proteasome subunit beta type-6, putative 0.0200842 0.0158478 0.0460397
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0243323 0.0196226 0.057146
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0302237 0.0248576 0.0248006
Echinococcus granulosus histone deacetylase 3 0.0222759 0.0177954 0.0175991
Echinococcus multilocularis protein jagged 1 0.00943005 0.00638078 0.00618226
Plasmodium falciparum proteasome subunit beta type-5 0.0903901 0.0783202 0.229846
Loa Loa (eye worm) hypothetical protein 0.0162699 0.0124585 0.0124585
Toxoplasma gondii proteasome subunit alpha type, putative 0.00701133 0.00423156 0.00952439
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.00259901 0.000310861 0.000326895
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0243323 0.0196226 0.0299693
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0211766 0.0168185 0.0488957
Echinococcus granulosus arginase 2 mitochondrial 0.384974 0.340082 0.33995
Schistosoma mansoni hypothetical protein 0.019933 0.0157135 0.0155168
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.00263867 0.000346096 0.000845932
Brugia malayi hypothetical protein 0.00713033 0.0043373 0.00427909
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.00287507 0.00055616 0.000356476
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0047954 0.00226253 0.00206318
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.00315268 0.000802838 0.00177439
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.03016 0.024801 0.0246061
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0212553 0.0168884 0.0494966
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0203521 0.0160859 0.0158893
Brugia malayi Trypsin-like protease protein 5 0.019933 0.0157135 0.0156559
Echinococcus multilocularis laminin 0.0162699 0.0124585 0.0122613
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0194314 0.0152678 0.0232497
Trypanosoma brucei proteasome subunit beta type-2, putative 0.022848 0.0183037 0.0279342
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Echinococcus multilocularis slit 2 protein 0.00943005 0.00638078 0.00618226
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0206296 0.0163325 0.0248926
Brugia malayi proteasome subunit alpha type 6 0.0212553 0.0168884 0.016831
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.03016 0.024801 0.0379594
Echinococcus granulosus proteasome prosome macropain subunit beta 0.022848 0.0183037 0.0181076
Leishmania major proteasome alpha 3 subunit, putative 0.0202165 0.0159654 0.0243263
Schistosoma mansoni egf-like domain protein 0.0162699 0.0124585 0.0122613
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.03016 0.024801 0.0727671
Plasmodium vivax histone deacetylase 2, putative 0.032938 0.0272695 0.0796444
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Mycobacterium tuberculosis Probable peptidase 0.148085 0.129587 1
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.122576 0.10692 0.164669
Trichomonas vaginalis conserved hypothetical protein 0.384974 0.340082 1
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0211766 0.0168185 0.0488957
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243323 0.0196226 0.0194268
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0194314 0.0152678 0.0152678
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 1.12764 1 1
Echinococcus multilocularis transmembrane protease serine 3 0.019933 0.0157135 0.0155168
Brugia malayi EGF-like domain containing protein 0.00943005 0.00638078 0.00632269
Trypanosoma cruzi arginase, putative 0.110822 0.0964755 0.148552
Trypanosoma cruzi arginase, putative 0.110822 0.0964755 0.148552
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.00287507 0.00055616 0.000356476
Trypanosoma cruzi hypothetical protein, conserved 0.122576 0.10692 0.164669
Giardia lamblia 20S proteasome alpha subunit 3 0.0202165 0.0159654 0.14478
Toxoplasma gondii histone deacetylase HDAC2 0.0222759 0.0177954 0.0400538
Trypanosoma brucei carbonic anhydrase-like protein 0.0047954 0.00226253 0.00318283
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0903901 0.0783202 0.0781361
Onchocerca volvulus 0.033921 0.0281429 0.0219019
Trypanosoma cruzi agmatinase, putative 0.110822 0.0964755 0.148552
Loa Loa (eye worm) proteasome subunit beta type 1 0.0610033 0.0522077 0.0522077
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0211766 0.0168185 0.0256426
Mycobacterium ulcerans thymidylate synthase 0.0149883 0.0113197 0.0625227
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.00350579 0.00111661 0.000917034
Trypanosoma cruzi 20S proteasome subunit 0.022848 0.0183037 0.0279342
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.00264256 0.000349559 0.000786788
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.122576 0.10692 0.314278
Mycobacterium ulcerans hypothetical protein 0.019933 0.0157135 0.0973514
Echinococcus granulosus acetylcholinesterase 0.00818585 0.00527521 0.00507647
Toxoplasma gondii calcium binding egf domain-containing protein 0.0162699 0.0124585 0.0280417
Loa Loa (eye worm) hypothetical protein 0.0162699 0.0124585 0.0124585
Echinococcus multilocularis neurogenic locus notch protein 0.00943005 0.00638078 0.00618226
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.03016 0.024801 0.0723817
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.441477 0.390289 0.390167
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0211766 0.0168185 0.0166221
Brugia malayi Proteasome A-type and B-type family protein 0.0386254 0.0323232 0.0322666
Schistosoma mansoni histone deacetylase hda2 0.0109979 0.00777398 0.00757574
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0201755 0.015929 0.035853
Trichomonas vaginalis proteasome regulatory subunits, putative 0.00287507 0.00055616 0.00146373
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0206296 0.0163325 0.0163325
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0202165 0.0159654 0.046782
Onchocerca volvulus 0.019933 0.0157135 0.00939262
Brugia malayi hypothetical protein 0.019933 0.0157135 0.0156559
Leishmania major proteasome beta 5 subunit, putative 0.0903901 0.0783202 0.120539
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.00288805 0.00056769 0.00056772
Giardia lamblia 20S proteasome alpha subunit 1 0.0212553 0.0168884 0.153459
Echinococcus granulosus carboxylesterase 5A 0.00818585 0.00527521 0.00507647
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0212553 0.0168884 0.0257505
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.00264256 0.000349559 0.000149834
Brugia malayi Proteasome A-type and B-type family protein 0.0903901 0.0783202 0.0782663
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0200842 0.0158478 0.0460397
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0200842 0.0158478 0.143674
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00261328 0.000323539 0.000123809
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0188526 0.0147535 0.0432177
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0610033 0.0522077 0.0520183
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0200842 0.0158478 0.0241448
Brugia malayi notch-like transmembrane receptor 0.00943005 0.00638078 0.00632269
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Echinococcus multilocularis histone deacetylase 0.032938 0.0272695 0.0270751
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0610033 0.0522077 0.0802477
Loa Loa (eye worm) hypothetical protein 0.019933 0.0157135 0.0157135
Onchocerca volvulus 0.0385033 0.0322147 0.0259998
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0903901 0.0783202 0.230166
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.00264256 0.000349559 0.000231146
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0610033 0.0522077 0.0520183
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.00259901 0.000310861 0.000699686
Schistosoma mansoni hypothetical protein 0.00943005 0.00638078 0.00618226
Loa Loa (eye worm) hypothetical protein 0.03016 0.024801 0.024801
Brugia malayi EGF-like domain containing protein 0.00943005 0.00638078 0.00632269
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.00341134 0.00103268 0.00128519
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.00481222 0.00227747 0.00320589
Leishmania major proteasome alpha 1 subunit, putative 0.0201755 0.015929 0.02427
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.03016 0.024801 0.0723817
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0302237 0.0248576 0.0559495
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.00263867 0.000346096 0.000225803
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0212553 0.0168884 0.0491014
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.00315268 0.000802838 0.000603204
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.053854 0.045855 0.0456643
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.00264256 0.000349559 0.000291117
Leishmania major proteasome beta-1 subunit, putative 0.0200842 0.0158478 0.0241448
Plasmodium vivax proteasome subunit beta type-1, putative 0.0610033 0.0522077 0.153018
Schistosoma mansoni 26S proteasome subunit S9 0.00315268 0.000802838 0.000603204
Leishmania major proteasome alpha 2 subunit, putative 0.0206296 0.0163325 0.0248926
Brugia malayi prolyl oligopeptidase family protein 1.12764 1 1
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.03016 0.024801 0.0379594
Loa Loa (eye worm) hypothetical protein 0.00247398 0.000199755 0.000199755
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0201755 0.015929 0.02427
Loa Loa (eye worm) histone deacetylase 1 0.0222759 0.0177954 0.0177954
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.731832 0.648292 0.648222
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0194314 0.0152678 0.0232497
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.019098 0.0149715 0.0227927
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.00263867 0.000346096 0.000430564
Loa Loa (eye worm) hypothetical protein 0.0162699 0.0124585 0.0124585
Loa Loa (eye worm) notch protein 0.00943005 0.00638078 0.00638078
Trypanosoma brucei agmatinase, putative 0.110822 0.0964755 0.148552
Trichomonas vaginalis histone deacetylase, putative 0.0222759 0.0177954 0.0521638
Echinococcus granulosus tissue type plasminogen activator 0.0385033 0.0322147 0.0320214
Schistosoma mansoni histone deacetylase 1 2 3 0.0109979 0.00777398 0.00757574
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243323 0.0196226 0.0194268
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0203521 0.0160859 0.0158893
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243323 0.0196226 0.0299693
Echinococcus multilocularis acylamino acid releasing enzyme 0.122576 0.10692 0.106742
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0243323 0.0196226 0.057146
Schistosoma mansoni histone deacetylase 4 5 0.032938 0.0272695 0.0270751
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0203521 0.0160859 0.0467401
Schistosoma mansoni dihydrofolate reductase 0.00611171 0.00343217 0.00323306
Echinococcus multilocularis histone deacetylase 7 0.032938 0.0272695 0.0270751
Plasmodium vivax histone deacetylase, putative 0.032938 0.0272695 0.0796444
Schistosoma mansoni hypothetical protein 0.00943005 0.00638078 0.00618226
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.03016 0.024801 0.0727671
Trypanosoma brucei prolyl endopeptidase 0.238446 0.209879 0.323533
Brugia malayi Calcium binding EGF domain containing protein 0.00943005 0.00638078 0.00632269
Brugia malayi proteasome subunit alpha type 3 0.0203521 0.0160859 0.0160284
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0243323 0.0196226 0.0194268
Loa Loa (eye worm) hypothetical protein 0.019933 0.0157135 0.0157135
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.00350579 0.00111661 0.00111661
Loa Loa (eye worm) Notch2 0.00943005 0.00638078 0.00638078
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0203521 0.0160859 0.0160859
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0162699 0.0124585 0.0124585
Echinococcus multilocularis arginase 2, mitochondrial 0.384974 0.340082 0.33995
Leishmania major carbonic anhydrase-like protein 0.0047954 0.00226253 0.00318283
Toxoplasma gondii histone deacetylase HDAC3 0.0222759 0.0177954 0.0400538
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.019933 0.0157135 0.0155168
Giardia lamblia Proteasome subunit beta type 3 0.0195702 0.0153911 0.13938
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 1.12764 1 1
Echinococcus granulosus neurogenic locus notch protein 0.00943005 0.00638078 0.00618226
Toxoplasma gondii 26s proteasome subunit p55, putative 0.00287507 0.00055616 0.00125181
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.019933 0.0157135 0.0155168
Echinococcus granulosus adhesion regulating molecule 1 0.0302237 0.0248576 0.0246628
Onchocerca volvulus 0.019933 0.0157135 0.00939262
Trypanosoma cruzi histone deacetylase 1, putative 0.0222759 0.0177954 0.0271498
Brugia malayi Trypsin family protein 0.019933 0.0157135 0.0156559
Trypanosoma cruzi oligopeptidase b 0.148085 0.129587 0.199642
Loa Loa (eye worm) hypothetical protein 0.03016 0.024801 0.024801
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0149883 0.0113197 0.0625227
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.022848 0.0183037 0.0532655
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Echinococcus granulosus histone deacetylase 7 0.032938 0.0272695 0.0270751
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0206296 0.0163325 0.0474657
Echinococcus multilocularis Tolloid protein 1 0.0162699 0.0124585 0.0122613
Brugia malayi Trypsin family protein 0.019933 0.0157135 0.0156559
Loa Loa (eye worm) hypothetical protein 0.019933 0.0157135 0.0157135
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0222759 0.0177954 0.0521638
Toxoplasma gondii PCI domain-containing protein 0.00263867 0.000346096 0.000778993
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.00264256 0.000349559 0.000349559
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.00350579 0.00111661 0.000917034
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0149883 0.0113197 0.0625227
Echinococcus granulosus laminin 0.0162699 0.0124585 0.0122613
Loa Loa (eye worm) histone deacetylase 3 0.0222759 0.0177954 0.0177954
Echinococcus multilocularis carbonic anhydrase II 0.0047954 0.00226253 0.00206318
Trypanosoma brucei proteasome beta 6 subunit 0.0610033 0.0522077 0.0802477
Echinococcus multilocularis neurogenic locus protein delta 0.00943005 0.00638078 0.00618226
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0211766 0.0168185 0.0256426
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0203521 0.0160859 0.0245121
Echinococcus multilocularis fat cadherin tumor suppressor 0.00943005 0.00638078 0.00618226
Loa Loa (eye worm) hypothetical protein 0.0178103 0.0138273 0.0138273
Schistosoma mansoni hypothetical protein 0.00943005 0.00638078 0.00618226
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0386254 0.0323232 0.0321298
Giardia lamblia Thymus-specific serine protease precursor 0.03016 0.024801 0.227858
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.00264256 0.000349559 0.000231146
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0212553 0.0168884 0.0168884
Brugia malayi proteasome subunit beta type 2 0.022848 0.0183037 0.0182464
Schistosoma mansoni hypothetical protein 0.00263867 0.000346096 0.00014637
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.019098 0.0149715 0.0336979
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0194314 0.0152678 0.0343647
Brugia malayi Calcium binding EGF domain containing protein 0.00943005 0.00638078 0.00632269
Echinococcus granulosus cathepsin b 0.00261328 0.000323539 0.000123809
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0047954 0.00226253 0.00318283
Brugia malayi EGF-like domain containing protein 0.00943005 0.00638078 0.00632269
Echinococcus granulosus neurogenic locus notch protein 0.00943005 0.00638078 0.00618226
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.00264256 0.000349559 0.000856118
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.00287507 0.00055616 0.000549929
Loa Loa (eye worm) hypothetical protein 0.00818585 0.00527521 0.00527521
Echinococcus granulosus proteasome subunit alpha type 2 0.0206296 0.0163325 0.0161359
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.019098 0.0149715 0.0227927
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.00350579 0.00111661 0.00269756
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.00264256 0.000349559 0.000149834
Plasmodium vivax proteasome subunit beta type-7, putative 0.019098 0.0149715 0.0434614
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.238446 0.209879 0.323533
Entamoeba histolytica proteasome regulatory subunit, putative 0.00341134 0.00103268 0.00245062
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0222759 0.0177954 0.0521638
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.00231496 0.0000584594 0.0000584594
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.019933 0.0157135 0.0155168
Leishmania major hypothetical protein, conserved 0.0158705 0.0121036 0.0183676
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.00315268 0.000802838 0.000930551
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.00264256 0.000349559 0.000291117
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.00259901 0.000310861 0.000326895
Schistosoma mansoni notch 0.00943005 0.00638078 0.00618226
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.03016 0.024801 0.0379594
Plasmodium falciparum histone deacetylase, putative 0.032938 0.0272695 0.0796444
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0194314 0.0152678 0.044333
Echinococcus multilocularis enteropeptidase 0.019933 0.0157135 0.0155168
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.00263867 0.000346096 0.00014637
Brugia malayi 26S proteasome regulatory complex subunit p97 0.00350579 0.00111661 0.00105821
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0203521 0.0160859 0.0471363
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.00264256 0.000349559 0.000440754
Echinococcus granulosus Proteasome subunit alpha type 7 0.0243323 0.0196226 0.0194268
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.00315268 0.000802838 0.000930551
Echinococcus multilocularis adhesion regulating molecule 1 0.0302237 0.0248576 0.0246628
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.019933 0.0157135 0.0155168
Trypanosoma cruzi prolyl endopeptidase 0.238446 0.209879 0.323533
Entamoeba histolytica proteasome regulatory subunit, putative 0.00288805 0.00056769 0.00108254
Plasmodium falciparum histone deacetylase 2 0.032938 0.0272695 0.0796444
Toxoplasma gondii proteasome subunit alpha1, putative 0.0212553 0.0168884 0.0380125
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.03016 0.024801 0.0727671
Leishmania major proteasome beta 7 subunit, putative 0.0194314 0.0152678 0.0232497
Toxoplasma gondii SAC3/GANP family protein 0.00247398 0.000199755 0.000449609
Echinococcus multilocularis neurogenic locus notch protein 4 0.00943005 0.00638078 0.00618226
Toxoplasma gondii EGF family domain-containing protein 0.00943005 0.00638078 0.0143619
Loa Loa (eye worm) hypothetical protein 0.0302237 0.0248576 0.0248576
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0903901 0.0783202 0.593623
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.00264256 0.000349559 0.000149834
Brugia malayi prolyl oligopeptidase family protein 0.122576 0.10692 0.106868
Echinococcus multilocularis fibrillin 1 0.0162699 0.0124585 0.0122613
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.019933 0.0157135 0.0155168
Toxoplasma gondii proteasome beta subunit 0.0195702 0.0153911 0.0346423
Echinococcus granulosus fibropellin Ia 0.00943005 0.00638078 0.00618226
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0203521 0.0160859 0.0245121
Echinococcus granulosus proteasome subunit beta t family 0.0195702 0.0153911 0.0151944
Trichomonas vaginalis histone deacetylase, putative 0.0222759 0.0177954 0.0521638
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0203521 0.0160859 0.0467401
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0202165 0.0159654 0.0463858
Schistosoma mansoni hypothetical protein 0.00943005 0.00638078 0.00618226
Mycobacterium ulcerans proteasome PrcA 0.017321 0.0133925 0.0789537
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.00350579 0.00111661 0.00269756
Loa Loa (eye worm) hypothetical protein 0.053854 0.045855 0.045855
Giardia lamblia Proteasome subunit beta type 7 precursor 0.019098 0.0149715 0.135434
Schistosoma mansoni histone deacetylase 0.0222759 0.0177954 0.0175991
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.017321 0.0133925 0.0388157
Entamoeba histolytica proteasome regulatory subunit, putative 0.00315268 0.000802838 0.00177439
Toxoplasma gondii peptidase, T1 family protein 0.0203521 0.0160859 0.0362061
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0212553 0.0168884 0.0257505
Trypanosoma brucei prolyl oligopeptidase, putative 0.148085 0.129587 0.199642
Echinococcus multilocularis proteasome subunit beta type 6 0.0200842 0.0158478 0.0156512
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.148085 0.129587 1
Brugia malayi Proteasome subunit alpha type 7-1 0.0243323 0.0196226 0.0195653
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.122576 0.10692 0.314278
Loa Loa (eye worm) hypothetical protein 0.238446 0.209879 0.209879
Echinococcus granulosus subfamily T1A non peptidase ue 0.0211766 0.0168185 0.0166221
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.502245 0.444286 1
Chlamydia trachomatis dihydrofolate reductase 0.00611171 0.00343217 0.5
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.00287507 0.00055616 0.00104861
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.022848 0.0183037 0.0536589
Loa Loa (eye worm) hypothetical protein 0.352163 0.310926 0.310926
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0211 0.0167504 0.0255375
Loa Loa (eye worm) hypothetical protein 0.00261328 0.000323539 0.000323539
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.00288805 0.00056769 0.000368009
Schistosoma mansoni septate junction protein 0.00943005 0.00638078 0.00618226
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0212553 0.0168884 0.0491014
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Trypanosoma cruzi hypothetical protein, conserved 0.0385033 0.0322147 0.0493988
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0047954 0.00226253 0.00206318
Schistosoma mansoni notch 0.00943005 0.00638078 0.00618226
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.00264256 0.000349559 0.000149834
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0211766 0.0168185 0.0492909
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.019933 0.0157135 0.0156559
Echinococcus granulosus protein jagged 1 0.00943005 0.00638078 0.00618226
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0158705 0.0121036 0.0350236
Echinococcus multilocularis glycoprotein Antigen 5 0.019933 0.0157135 0.0155168
Loa Loa (eye worm) proteasome subunit beta type 2 0.022848 0.0183037 0.0183037
Loa Loa (eye worm) hypothetical protein 0.019933 0.0157135 0.0157135
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.019933 0.0157135 0.0155168
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.00341134 0.00103268 0.00128519
Trichomonas vaginalis conserved hypothetical protein 0.03016 0.024801 0.0727671
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Echinococcus granulosus proteasome prosome macropain 0.0903901 0.0783202 0.0781361
Brugia malayi Fibulin-1 precursor 0.0162699 0.0124585 0.0124008
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.00350579 0.00111661 0.00516128
Trypanosoma cruzi oligopeptidase b 0.148085 0.129587 0.199642
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0047954 0.00226253 0.00226253
Loa Loa (eye worm) hypothetical protein 0.379669 0.335367 0.335367
Brugia malayi Proteasome subunit alpha type 1 0.0186439 0.014568 0.0145104
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.122576 0.10692 0.106742
Trypanosoma brucei histone deacetylase 4 0.032938 0.0272695 0.0417683
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0243323 0.0196226 0.0299693
Leishmania major oligopeptidase b 0.148085 0.129587 0.199642
Echinococcus multilocularis notch 0.00943005 0.00638078 0.00618226
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.00350579 0.00111661 0.00141469
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0243323 0.0196226 0.0194268
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00261328 0.000323539 0.000123809
Trichomonas vaginalis conserved hypothetical protein 0.03016 0.024801 0.0727671
Toxoplasma gondii histone deacetylase HDAC4 0.0109979 0.00777398 0.0174977
Loa Loa (eye worm) prolyl oligopeptidase 0.122576 0.10692 0.10692
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.00249855 0.000221594 0.0000336973
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0200842 0.0158478 0.0460397
Leishmania major histone deacetylase, putative 0.032938 0.0272695 0.0417683
Echinococcus multilocularis dihydrofolate reductase 0.00611171 0.00343217 0.00323306
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0211766 0.0168185 0.0166221
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0201755 0.015929 0.015929
Leishmania major hypothetical protein, conserved 0.0385033 0.0322147 0.0493988
Loa Loa (eye worm) PCI domain-containing protein 0.00287507 0.00055616 0.00055616
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.00263867 0.000346096 0.000225803
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0201755 0.015929 0.0462785
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0302237 0.0248576 0.0246628
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.03016 0.024801 0.0723817
Echinococcus granulosus slit 2 protein 0.00943005 0.00638078 0.00618226
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.017321 0.0133925 0.0131954
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.03016 0.024801 0.0246061
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0610033 0.0522077 0.0802477
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.148085 0.129587 1
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0201755 0.015929 0.0462785
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0202165 0.0159654 0.0157688
Schistosoma mansoni laminin gamma-3 chain 0.00943005 0.00638078 0.00618226
Echinococcus granulosus histone deacetylase 6 0.032938 0.0272695 0.0270751
Plasmodium falciparum proteasome subunit beta type-2, putative 0.022848 0.0183037 0.0532655
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0200842 0.0158478 0.0464362
Brugia malayi Histone deacetylase 1 0.0222759 0.0177954 0.0177379
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.00943005 0.00638078 0.00632269
Leishmania major arginase 0.384974 0.340082 0.524434
Toxoplasma gondii proteasome regulatory subunit 0.00264256 0.000349559 0.000786788
Trypanosoma brucei Aph-1 protein, putative 0.00304659 0.000708564 0.000785086
Giardia lamblia 20S proteasome alpha subunit 7 0.0203521 0.0160859 0.145912
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00261328 0.000323539 0.000123809
Echinococcus multilocularis protein jagged 1 0.00943005 0.00638078 0.00618226
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0202165 0.0159654 0.0243263
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0610033 0.0522077 0.0802477
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.053854 0.045855 0.0456643
Loa Loa (eye worm) hypothetical protein 0.053854 0.045855 0.045855
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0211766 0.0168185 0.0256426
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Trypanosoma brucei histone deacetylase 3 0.032938 0.0272695 0.0417683
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.00264256 0.000349559 0.000440754
Trypanosoma cruzi histone deacetylase, putative 0.032938 0.0272695 0.0417683
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.00481222 0.00227747 0.00320589
Leishmania major proteasome beta 2 subunit, putative 0.019098 0.0149715 0.0227927
Brugia malayi proteasome subunit alpha type 2 0.0206296 0.0163325 0.016275
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0200842 0.0158478 0.0241448
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Loa Loa (eye worm) dihydrofolate reductase 0.00611171 0.00343217 0.00343217
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0202165 0.0159654 0.0463858
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0149883 0.0113197 0.0111222
Brugia malayi Carboxylesterase family protein 0.00818585 0.00527521 0.00521705
Toxoplasma gondii calcium binding egf domain-containing protein 0.0162699 0.0124585 0.0280417
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0610033 0.0522077 0.117509
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.00341134 0.00103268 0.000833088
Brugia malayi 26S proteasome regulatory subunit rpn11 0.00264256 0.000349559 0.000291117
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Loa Loa (eye worm) histone deacetylase 0.032938 0.0272695 0.0272695
Brugia malayi Delta serrate ligand family protein 0.00943005 0.00638078 0.00632269
Brugia malayi Calcium binding EGF domain containing protein 0.00943005 0.00638078 0.00632269
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.00943005 0.00638078 0.00618226
Echinococcus multilocularis Dipeptidyl peptidase 9 0.731832 0.648292 0.648222
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.00341134 0.00103268 0.000833088
Trypanosoma brucei histone deacetylase 1 0.0222759 0.0177954 0.0271498
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.148085 0.129587 0.199642
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.384974 0.340082 0.33995
Brugia malayi EGF-like domain containing protein 0.00943005 0.00638078 0.00632269
Trypanosoma cruzi agmatinase, putative 0.110822 0.0964755 0.148552
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0201755 0.015929 0.0157324
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0191654 0.0150314 0.00870619
Brugia malayi proteasome subunit alpha type 1 0.0201755 0.015929 0.0158715
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.022848 0.0183037 0.0536589
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.017321 0.0133925 0.0388157
Loa Loa (eye worm) carbonic anhydrase 3 0.0047954 0.00226253 0.00226253
Plasmodium vivax proteasome subunit beta type-3, putative 0.0195702 0.0153911 0.0446959
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0206296 0.0163325 0.0248926
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.00247398 0.000199755 0.000415547
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.00481222 0.00227747 0.00320589
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.00287507 0.00055616 0.00104861
Entamoeba histolytica prolyl oligopeptidase family protein 0.122576 0.10692 0.313993
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0206296 0.0163325 0.0474657
Plasmodium vivax proteasome subunit beta type-4, putative 0.0194314 0.0152678 0.044333
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.148085 0.129587 1
Giardia lamblia High cysteine protein 0.00943005 0.00638078 0.0546586
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0203521 0.0160859 0.0467401
Schistosoma mansoni proteasome regulatory subunit-related 0.00287507 0.00055616 0.000356476
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.00729799 0.00448628 0.00428738
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0202165 0.0159654 0.0463858
Trypanosoma cruzi histone deacetylase, putative 0.032938 0.0272695 0.0417683
Giardia lamblia Alanyl dipeptidyl peptidase 0.122576 0.10692 1
Trichomonas vaginalis conserved hypothetical protein 0.384974 0.340082 1
Trichomonas vaginalis histone deacetylase, putative 0.0222759 0.0177954 0.0521638
Trypanosoma cruzi proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.00481222 0.00227747 0.00320589
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.019098 0.0149715 0.0438589
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.00350579 0.00111661 0.00141469
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Loa Loa (eye worm) RPN-3 protein 0.00341134 0.00103268 0.00103268
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.731832 0.648292 1
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0194314 0.0152678 0.13822
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.00264256 0.000349559 0.000231146
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.00264256 0.000349559 0.000349559
Trypanosoma brucei histone deacetylase 2 0.0109979 0.00777398 0.0116869
Toxoplasma gondii PCI domain-containing protein 0.00341134 0.00103268 0.00232435
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.017321 0.0133925 0.0203563
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0201755 0.015929 0.0157324
Schistosoma mansoni arginase 0.384974 0.340082 0.33995
Echinococcus multilocularis protein jagged 2 0.00943005 0.00638078 0.00618226
Brugia malayi EGF-like domain containing protein 0.00943005 0.00638078 0.00632269
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00818585 0.00527521 0.00507647
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0194314 0.0152678 0.015071
Toxoplasma gondii proteasome subunit beta type, putative 0.0903901 0.0783202 0.176283
Trichomonas vaginalis conserved hypothetical protein 0.00713033 0.0043373 0.012584
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.00287507 0.00055616 0.000549929
Echinococcus multilocularis histone deacetylase 6 0.032938 0.0272695 0.0270751
Loa Loa (eye worm) proteasome subunit beta type 3 0.0195702 0.0153911 0.0153911
Trypanosoma brucei proteasome alpha 7 subunit 0.0203521 0.0160859 0.0245121
Echinococcus multilocularis acetylcholinesterase 0.00818585 0.00527521 0.00507647
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0211 0.0167504 0.0255375
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0194314 0.0152678 0.0232497
Trypanosoma brucei proteasome complex subunit Rpn13 ubiquitin receptor, putative 0.00481222 0.00227747 0.00320589
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.017321 0.0133925 0.0789537
Brugia malayi proteasome subunit alpha type 4 0.0186849 0.0146045 0.0145468
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0206296 0.0163325 0.0367612
Onchocerca volvulus Prolyl endopeptidase homolog 0.238446 0.209879 0.204805
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.00315268 0.000802838 0.000603204
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0195702 0.0153911 0.0450929
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0195702 0.0153911 0.0234401
Loa Loa (eye worm) thymidylate synthase 0.0149883 0.0113197 0.0113197
Echinococcus granulosus protein jagged 1 0.00943005 0.00638078 0.00618226
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0222759 0.0177954 0.0521638
Echinococcus granulosus dihydrofolate reductase 0.00611171 0.00343217 0.00323306
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.00263867 0.000346096 0.000430564
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 1.12764 1 1
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0195702 0.0153911 0.0234401
Echinococcus multilocularis proteasome subunit alpha type 2 0.0206296 0.0163325 0.0161359
Brugia malayi hypothetical protein 0.379669 0.335367 0.335328
Schistosoma mansoni histone deacetylase hda2 0.0336673 0.0279175 0.0277233
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.00264256 0.000349559 0.000856118
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.115869 0.10096 0.773086
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.731832 0.648292 1
Onchocerca volvulus Histone deacetylase 10 homolog 0.0109979 0.00777398 0.00140215
Trichomonas vaginalis Arginase, putative 0.384974 0.340082 1
Echinococcus granulosus gamma secretase subunit aph 1 0.00777054 0.00490618 0.00470736
Echinococcus granulosus Proteasome subunit alpha beta 0.0203521 0.0160859 0.0158893
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0200842 0.0158478 0.0156512
Leishmania major proteasome alpha 7 subunit, putative 0.0203521 0.0160859 0.0245121
Echinococcus granulosus delta-like protein 1 0.00943005 0.00638078 0.00618226
Plasmodium falciparum peptidase, putative 0.122576 0.10692 0.313993
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.017321 0.0133925 0.0388157
Loa Loa (eye worm) histone deacetylase 11 0.0109979 0.00777398 0.00777398
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.00729799 0.00448628 0.00428738
Giardia lamblia 20S proteasome alpha subunit 5 0.0211766 0.0168185 0.152801
Loa Loa (eye worm) PAS-3 protein 0.0186849 0.0146045 0.0146045
Echinococcus granulosus protein jagged 2 0.00943005 0.00638078 0.00618226
Echinococcus granulosus histone deacetylase 1 0.0222759 0.0177954 0.0175991
Brugia malayi Calcium binding EGF domain containing protein 0.0162699 0.0124585 0.0124008
Brugia malayi EGF-like domain containing protein 0.00943005 0.00638078 0.00632269
Brugia malayi Histone deacetylase family protein 0.032938 0.0272695 0.0272126
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0195702 0.0153911 0.0151944
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.00315268 0.000802838 0.0021892
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.731832 0.648292 1
Brugia malayi Trypsin family protein 0.053854 0.045855 0.0457992
Echinococcus granulosus neural cadherin 0.00943005 0.00638078 0.00618226
Echinococcus granulosus glycoprotein Antigen 5 0.019933 0.0157135 0.0155168
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0903901 0.0783202 0.593623
Echinococcus granulosus histone deacetylase 0.032938 0.0272695 0.0270751
Echinococcus granulosus Dipeptidyl peptidase 9 0.731832 0.648292 0.648222
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.022848 0.0183037 0.0181076
Echinococcus multilocularis cathepsin b 0.00261328 0.000323539 0.000123809
Brugia malayi Cadherin domain containing protein 0.00943005 0.00638078 0.00632269
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0195702 0.0153911 0.0446959
Schistosoma mansoni hypothetical protein 0.019933 0.0157135 0.0155168
Mycobacterium tuberculosis Hypothetical protein 0.00713033 0.0043373 0.00717474
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.017321 0.0133925 0.0203563
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0047954 0.00226253 0.00220419
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0202165 0.0159654 0.0243263
Loa Loa (eye worm) hypothetical protein 0.0162699 0.0124585 0.0124585
Loa Loa (eye worm) hypothetical protein 0.019933 0.0157135 0.0157135
Loa Loa (eye worm) TK/ROR protein kinase 0.0385033 0.0322147 0.0322147
Loa Loa (eye worm) hypothetical protein 0.00247398 0.000199755 0.000199755
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0211766 0.0168185 0.0488957
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.00288805 0.00056769 0.00108254
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.022848 0.0183037 0.0279342
Brugia malayi Protein kinase domain containing protein 0.0385033 0.0322147 0.0321582
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0211 0.0167504 0.0486954
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Loa Loa (eye worm) hypothetical protein 0.0226693 0.0181449 0.0181449
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0194314 0.0152678 0.0447301
Giardia lamblia Serine peptidase, putative 0.03016 0.024801 0.227858
Schistosoma mansoni hypothetical protein 0.00943005 0.00638078 0.00618226
Entamoeba histolytica dipeptidyl-peptidase, putative 0.122576 0.10692 0.313993
Plasmodium falciparum proteasome subunit beta type-4 0.0194314 0.0152678 0.044333
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.00350579 0.00111661 0.00311198
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0195702 0.0153911 0.0234401
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0194314 0.0152678 0.015071
Brugia malayi Trypsin family protein 0.019933 0.0157135 0.0156559
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.00259901 0.000310861 0.000111128
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.00247398 0.000199755 0.000141304
Toxoplasma gondii serine carboxypeptidase s28 protein 0.03016 0.024801 0.055822
Brugia malayi Carboxylesterase family protein 0.00818585 0.00527521 0.00521705
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.441477 0.390289 0.390167
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.00350579 0.00111661 0.000917034
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.00264256 0.000349559 0.000440754
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0211 0.0167504 0.0255375
Echinococcus multilocularis 0.384974 0.340082 0.33995
Leishmania major histone deacetylase, putative 0.0222759 0.0177954 0.0271498
Entamoeba histolytica Arginase, putative 0.384974 0.340082 1
Loa Loa (eye worm) proteasome Regulatory Particle 0.00288805 0.00056769 0.00056769
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Entamoeba histolytica prolyl oligopeptidase family protein 0.122576 0.10692 0.313993
Loa Loa (eye worm) hypothetical protein 0.0162699 0.0124585 0.0124585
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.03016 0.024801 0.0727671
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.731832 0.648292 1
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0201755 0.015929 0.0462785
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.00261328 0.000323539 0.000190997
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0202165 0.0159654 0.0243263
Brugia malayi Serine carboxypeptidase S28 family protein 0.03016 0.024801 0.024744
Entamoeba histolytica proteasome regulatory subunit, putative 0.00287507 0.00055616 0.00104861
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.00350579 0.00111661 0.000917034
Schistosoma mansoni cercarial elastase (S01 family) 0.019933 0.0157135 0.0155168
Entamoeba histolytica histone deacetylase, putative 0.0222759 0.0177954 0.0517697
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0903901 0.0783202 0.0783202
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.00341134 0.00103268 0.000974275
Echinococcus granulosus protein jagged 2 0.00943005 0.00638078 0.00618226
Brugia malayi proteasome subunit beta type 3 0.0195702 0.0153911 0.0153335
Echinococcus granulosus Tolloid protein 1 0.0162699 0.0124585 0.0122613
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0610033 0.0522077 0.15337
Echinococcus granulosus transmembrane protease serine 3 0.019933 0.0157135 0.0155168
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0203521 0.0160859 0.0467401
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.00264256 0.000349559 0.000440754
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0211 0.0167504 0.0486954
Brugia malayi gamma-secretase subunit aph-1 0.00777054 0.00490618 0.004848
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.00247398 0.000199755 0.000141304
Brugia malayi GCC2 and GCC3 family protein 0.00943005 0.00638078 0.00632269
Echinococcus granulosus histone deacetylase 8 0.0109979 0.00777398 0.00757574
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0211766 0.0168185 0.0256426
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.019098 0.0149715 0.0438589
Mycobacterium ulcerans proteasome PrcB 0.0903901 0.0783202 0.593623
Loa Loa (eye worm) histone deacetylase 7A 0.032938 0.0272695 0.0272695
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Schistosoma mansoni notch 0.00943005 0.00638078 0.00618226
Trichomonas vaginalis histone deacetylase, putative 0.0222759 0.0177954 0.0521638
Plasmodium vivax arginase, putative 0.384974 0.340082 1
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Trichomonas vaginalis conserved hypothetical protein 0.122576 0.10692 0.314278
Toxoplasma gondii prolyl endopeptidase 0.238446 0.209879 0.472396
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0201755 0.015929 0.0466749
Schistosoma mansoni cell polarity protein 0.00943005 0.00638078 0.00618226
Trypanosoma cruzi histone deacetylase, putative 0.0109979 0.00777398 0.0116869
Echinococcus granulosus neurogenic locus protein delta 0.00943005 0.00638078 0.00618226
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.00288805 0.00056769 0.00056772
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0610033 0.0522077 0.0520183
Echinococcus granulosus carbonic anhydrase II 0.0047954 0.00226253 0.00206318
Echinococcus multilocularis neurogenic locus protein delta 0.00943005 0.00638078 0.00618226
Echinococcus multilocularis thymidylate synthase 0.0149883 0.0113197 0.0111222
Schistosoma mansoni hypothetical protein 0.00729799 0.00448628 0.00428738
Echinococcus granulosus neurogenic locus notch protein 4 0.00943005 0.00638078 0.00618226
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.148085 0.129587 0.199642
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.00341134 0.00103268 0.000833088
Brugia malayi prolyl oligopeptidase family protein 0.731832 0.648292 0.648272
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.122576 0.10692 0.106742
Echinococcus multilocularis acetylcholinesterase 0.00818585 0.00527521 0.00507647
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.00264256 0.000349559 0.000149834
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0211766 0.0168185 0.0166221
Loa Loa (eye worm) PCI domain-containing protein 0.00263867 0.000346096 0.000346096
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0194314 0.0152678 0.0232497
Loa Loa (eye worm) hypothetical protein 0.00943005 0.00638078 0.00638078
Brugia malayi prolyl oligopeptidase family protein 0.122576 0.10692 0.106868
Schistosoma mansoni histone deacetylase 4 5 0.032938 0.0272695 0.0270751
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0206296 0.0163325 0.0474657
Giardia lamblia 20S proteasome alpha subunit 4 0.0243323 0.0196226 0.179168
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0195702 0.0153911 0.0151944
Echinococcus multilocularis neurogenic locus notch protein 0.00943005 0.00638078 0.00618226
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.00259901 0.000310861 0.000171435
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0243323 0.0196226 0.057146
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0194314 0.0152678 0.015071
Brugia malayi 20S proteasome alpha5 subunit 0.0211766 0.0168185 0.016761
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0201755 0.015929 0.0157324
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0243323 0.0196226 0.057146
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.00288805 0.00056769 0.00108254
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0194314 0.0152678 0.0232497
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.03016 0.024801 0.0246061
Echinococcus granulosus notch 0.00943005 0.00638078 0.00618226
Entamoeba histolytica dipeptidyl-peptidase, putative 0.122576 0.10692 0.313993
Brugia malayi Muscle positioning protein 4 0.00943005 0.00638078 0.00632269
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.00350579 0.00111661 0.00141469
Brugia malayi histone deacetylase 3 (HD3) 0.0222759 0.0177954 0.0177379

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -5.09 Experimental pIC50 values for the inhibition of acetylcholinesterase ChEMBL. 10821713
IC50 (binding) = -5.09 Inhibitory activity against human erythrocyte acetylcholinesterase ChEMBL. 15317459
IC50 (binding) = 8100 nM Inhibition of AChE ChEMBL. 20053484
IC50 (functional) = 2.04 uM Antimalarial activity against chloroquine-sensitive ring-stage Plasmodium falciparum 3D7 assessed as parasite viability after 72 hrs by malstat assay ChEMBL. 27316542
IC50 (binding) = 8.1 uM Inhibitory activity against human erythrocyte acetylcholinesterase ChEMBL. 10821713
IC50 (binding) = 8.1 uM Inhibitory activity against human erythrocyte acetylcholinesterase ChEMBL. 10821713
Log IC50 (binding) = 5.09 Experimental pIC50 values for the inhibition of acetylcholinesterase ChEMBL. 10821713

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 27316542

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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