Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.108 | 1 | 0.5 | |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0304 | 0.2502 | 0.5 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase superfamily protein | 0.0304 | 0.2502 | 1 |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0304 | 0.2502 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.108 | 1 | 1 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0304 | 0.2502 | 1 |
Mycobacterium ulcerans | dehydratase | 0.0089 | 0.0423 | 0.1689 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0304 | 0.2502 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0304 | 0.2502 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0304 | 0.2502 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.108 | 1 | 0.5 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0304 | 0.2502 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.108 | 1 | 0.5 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0304 | 0.2502 | 0.5 |
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0304 | 0.2502 | 0.5 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0304 | 0.2502 | 0.5 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.108 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0089 | 0.0423 | 0.1689 |
Toxoplasma gondii | 4'-phosphopantetheinyl transferase domain-containing protein | 0.0304 | 0.2502 | 1 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0089 | 0.0423 | 0.1689 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0304 | 0.2502 | 1 |
Brugia malayi | maoC like domain containing protein | 0.0089 | 0.0423 | 0.0423 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0079 | 0.0335 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0423 | 0.0423 |
Entamoeba histolytica | hypothetical protein | 0.0304 | 0.2502 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0089 | 0.0423 | 0.1689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.