Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0174 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.1278 | 0.6801 | 0.6801 |
Leishmania major | hexokinase, putative | 0.1874 | 1 | 0.5 |
Onchocerca volvulus | 0.1874 | 1 | 1 | |
Entamoeba histolytica | hexokinase 1 | 0.1874 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.1176 | 0.625 | 0.625 |
Loa Loa (eye worm) | hexokinase | 0.1874 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1874 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1874 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.0154 | 0.0154 |
Schistosoma mansoni | hexokinase | 0.1874 | 1 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.1874 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.1874 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.1874 | 1 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.004 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.3137 | 0.3137 |
Loa Loa (eye worm) | hexokinase | 0.058 | 0.3051 | 0.3051 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0044 | 0.0174 | 0.0174 |
Entamoeba histolytica | hexokinase 2 | 0.1874 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.1176 | 0.625 | 0.625 |
Toxoplasma gondii | hexokinase | 0.1874 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.1874 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.1874 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.1874 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1874 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1874 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.1874 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.1874 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 0.3137 | 0.3137 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0125 | 0.0125 |
Onchocerca volvulus | 0.1874 | 1 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | hexokinase type II | 0.1874 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1874 | 1 | 0.5 |
Brugia malayi | hexokinase type II | 0.0596 | 0.3137 | 0.3137 |
Echinococcus granulosus | hexokinase type 2 | 0.1874 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.1874 | 1 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.014 | 0.5 |
Trypanosoma brucei | hexokinase | 0.1874 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.058 | 0.3051 | 0.3051 |
Onchocerca volvulus | 0.1874 | 1 | 1 | |
Treponema pallidum | hexokinase (hxk) | 0.1874 | 1 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.004 | 0.0154 | 0.0154 |
Brugia malayi | Hexokinase family protein | 0.1874 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1874 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.