Detailed information for compound 901223

Basic information

Technical information
  • TDR Targets ID: 901223
  • Name: 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-(2-me thylprop-2-enylsulfanyl)-6-oxo-4,5-dihydro-1H -pyridine-3-carbonitrile
  • MW: 409.297 | Formula: C17H17BrN2O3S
  • H donors: 2 H acceptors: 3 LogP: 3.13 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(SCC(=C)C)NC(=O)CC1c1cc(Br)c(c(c1)OC)O
  • InChi: 1S/C17H17BrN2O3S/c1-9(2)8-24-17-12(7-19)11(6-15(21)20-17)10-4-13(18)16(22)14(5-10)23-3/h4-5,11,22H,1,6,8H2,2-3H3,(H,20,21)
  • InChiKey: FYPIBCKBNMLIAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(3-bromo-4-hydroxy-5-methoxy-phenyl)-2-(2-methylprop-2-enylsulfanyl)-6-oxo-4,5-dihydro-1H-pyridine-3-carbonitrile
  • 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-(2-methylprop-2-enylthio)-6-oxo-4,5-dihydro-1H-pyridine-3-carbonitrile
  • 4-(3-bromo-4-hydroxy-5-methoxy-phenyl)-6-keto-2-(2-methylprop-2-enylthio)-4,5-dihydro-1H-pyridine-3-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0093 0.0356 0.0584
Brugia malayi CXXC zinc finger family protein 0.0271 0.1378 0.1516
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0422 0.2253 0.3722
Schistosoma mansoni hypothetical protein 0.009 0.0339 0.071
Brugia malayi Pre-SET motif family protein 0.1609 0.9092 1
Loa Loa (eye worm) hypothetical protein 0.0364 0.1918 0.211
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0766 0.4236 0.7003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0735 0.0735
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.01 0.0393 0.0648
Loa Loa (eye worm) hypothetical protein 0.0119 0.0503 0.0553
Echinococcus granulosus disco interacting protein 2 0.0275 0.14 0.2315
Echinococcus granulosus SET and MYND domain containing protein 3 0.0078 0.0267 0.0441
Brugia malayi NNMT/PNMT/TEMT family protein 0.0992 0.5537 0.609
Schistosoma mansoni hypothetical protein 0.009 0.0339 0.071
Leishmania major methylthioadenosine phosphorylase, putative 0.086 0.4774 0.7892
Echinococcus multilocularis PWWP domain containing protein 2A 0.009 0.0339 0.0561
Brugia malayi PWWP domain containing protein 0.009 0.0339 0.0373
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0052 0.0087
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0034 0.0013 0.0016
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Treponema pallidum uridine phosphorylase (udp) 0.0159 0.0735 0.5
Loa Loa (eye worm) spermidine synthase 0.1081 0.6049 0.6653
Trypanosoma brucei histone-lysine n-methyltransferase 0.01 0.0393 0.0648
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0003 0.0005
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0735 0.0735
Echinococcus multilocularis methylthioadenosine phosphorylase 0.086 0.4774 0.7893
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0173 0.0814 0.1346
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0003 0.0007
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0766 0.4236 0.4659
Brugia malayi hypothetical protein 0.0364 0.1918 0.211
Entamoeba histolytica hypothetical protein 0.0066 0.0196 0.0867
Brugia malayi hypothetical protein 0.009 0.0339 0.0373
Schistosoma mansoni enhancer of zeste ezh 0.0315 0.1634 0.3422
Brugia malayi Pre-SET motif family protein 0.021 0.103 0.1133
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0766 0.4236 0.7003
Brugia malayi hypothetical protein 0.0364 0.1918 0.211
Trypanosoma cruzi transcription elongation factor s-II, putative 0.009 0.0339 0.056
Echinococcus granulosus microtubule associated protein 2 0.0766 0.4234 0.7
Brugia malayi Spermidine synthase 0.1081 0.6049 0.6653
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0034 0.0013 0.0016
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0013 0.0013
Leishmania major histone-lysine N-methyltransferase, putative 0.01 0.0393 0.0648
Trypanosoma cruzi spermidine synthase, putative 0.1081 0.6049 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0239 0.1194 0.25
Toxoplasma gondii Purine nucleoside phosphorylase 0.0159 0.0735 0.223
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Brugia malayi Protein arginine N-methyltransferase 0.0032 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0106 0.0429 0.0708
Leishmania major nucleoside phosphorylase-like protein 0.0159 0.0735 0.1214
Onchocerca volvulus 0.0129 0.056 0.0557
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0003 0.0006
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0735 0.3261
Schistosoma mansoni hepatoma derived growth factor 0.009 0.0339 0.071
Schistosoma mansoni hypothetical protein 0.0187 0.0895 0.1875
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0735 0.0735
Echinococcus multilocularis geminin 0.0187 0.0895 0.148
Loa Loa (eye worm) hypothetical protein 0.009 0.0339 0.0373
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0009 0.0019
Schistosoma mansoni cpg binding protein 0.0272 0.1388 0.2908
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.016 0.0743 0.1228
Loa Loa (eye worm) hypothetical protein 0.0055 0.0135 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0735 0.0735
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0292 0.15 0.3142
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0003 0.0003
Toxoplasma gondii hypothetical protein 0.0603 0.3294 1
Mycobacterium leprae probable uridine phosphorylase 0.0159 0.0735 0.5
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0422 0.2253 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0293 0.0613
Plasmodium vivax SET domain protein, putative 0.0173 0.0814 0.1342
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.01 0.0393 0.0648
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.086 0.4774 0.7892
Schistosoma mansoni hypothetical protein 0.0057 0.0148 0.0311
Schistosoma mansoni cpg binding protein 0.0272 0.1388 0.2908
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0422 0.2253 0.3722
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.009 0.0339 0.056
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0159 0.0735 0.1214
Schistosoma mansoni purine nucleoside phosphorylase 0.0159 0.0735 0.154
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0036
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0013 0.0026
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0052 0.011
Mycobacterium ulcerans spermidine synthase 0.0852 0.4729 0.9887
Brugia malayi jmjC domain containing protein 0.0105 0.0425 0.0467
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0425 0.0702
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.009 0.0339 0.056
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0159 0.0735 0.1211
Echinococcus multilocularis spermidine synthase 0.1081 0.6049 1
Schistosoma mansoni microtubule-associated protein tau 0.0766 0.4234 0.8869
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.01 0.0393 0.0648
Loa Loa (eye worm) hypothetical protein 0.0992 0.5537 0.609
Leishmania major spermidine synthase 0.1081 0.6049 1
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0093 0.0356 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0735 0.0735
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0159 0.0735 1
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0034 0.0013 0.0021
Echinococcus granulosus DNA methyltransferase 2, putative 0.0422 0.2253 0.3725
Loa Loa (eye worm) hypothetical protein 0.0033 0.001 0.0012
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0159 0.0735 0.0809
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0013 0.0026
Loa Loa (eye worm) hypothetical protein 0.0992 0.5537 0.609
Echinococcus multilocularis microtubule associated protein 2 0.0766 0.4234 0.7
Loa Loa (eye worm) hypothetical protein 0.0032 0.0003 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.02 0.022
Toxoplasma gondii phosphorylase family protein 0.0159 0.0735 0.223
Loa Loa (eye worm) hypothetical protein 0.0364 0.1918 0.211
Toxoplasma gondii DNA methyltransferase 2, putative 0.0422 0.2253 0.6839
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0173 0.0814 0.1706
Entamoeba histolytica hypothetical protein 0.009 0.0339 0.1503
Schistosoma mansoni hypothetical protein 0.0187 0.0895 0.1875
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0003 0.0005
Echinococcus multilocularis cpg binding protein 0.0272 0.1388 0.2295
Loa Loa (eye worm) hypothetical protein 0.0364 0.1918 0.211
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.01 0.0393 0.0648
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0735 0.0735
Schistosoma mansoni phd finger protein 0.009 0.0339 0.071
Onchocerca volvulus 0.009 0.0339 0.0336
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0422 0.2253 0.472
Brugia malayi hypothetical protein 0.0066 0.0196 0.0215
Loa Loa (eye worm) uridine phosphorylase 0.0159 0.0735 0.0809
Treponema pallidum pfs protein (pfs) 0.0159 0.0735 0.5
Schistosoma mansoni hepatoma derived growth factor 0.009 0.0339 0.071
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0766 0.4236 0.7003
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0151 0.0691 0.1142
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0013 0.0013
Echinococcus granulosus histone arginine methyltransferase CARMER 0.016 0.0743 0.1228
Brugia malayi hypothetical protein 0.009 0.0339 0.0373
Leishmania major S-adenosylmethionine decarboxylase 0.0766 0.4236 0.7003
Chlamydia trachomatis AMP nucleosidase 0.0159 0.0735 0.5
Trypanosoma brucei transcription elongation factor s-II, putative 0.009 0.0339 0.056
Loa Loa (eye worm) hypothetical protein 0.0786 0.435 0.4785
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0159 0.0735 0.1214
Echinococcus granulosus spermidine synthase 0.1081 0.6049 1
Brugia malayi MTAP 0.086 0.4774 0.5251
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0034 0.0013 0.0036
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0422 0.2253 0.6839
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0159 0.0735 1
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0766 0.4236 0.7003
Brugia malayi PHD-finger family protein 0.0032 0.0003 0.0003
Schistosoma mansoni purine nucleoside phosphorylase 0.0159 0.0735 0.154
Echinococcus multilocularis PWWP domain containing protein 2A 0.009 0.0339 0.0561
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0195 0.094 0.1555
Brugia malayi SET domain containing protein 0.0134 0.0592 0.0652
Trypanosoma cruzi spermidine synthase, putative 0.1081 0.6049 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0735 0.3261
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Toxoplasma gondii histone lysine methyltransferase SET1 0.0075 0.0251 0.076
Leishmania major arginine N-methyltransferase-like protein 0.0034 0.0013 0.002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0271 0.1378 0.1516
Onchocerca volvulus 0.009 0.0339 0.0336
Echinococcus multilocularis uridine phosphorylase 1 0.0159 0.0735 0.1215
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0013 0.0026
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.086 0.4774 0.7892
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0159 0.0735 0.0733
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0766 0.4236 0.7003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0735 0.0735
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0037 0.0033 0.0054
Leishmania major hypothetical protein, conserved 0.009 0.0339 0.056
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0603 0.3294 0.5444
Trypanosoma cruzi hypothetical protein, conserved 0.009 0.0339 0.056
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Echinococcus multilocularis disco interacting protein 2 0.0275 0.14 0.2315
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0066 0.0196 0.0323
Loa Loa (eye worm) hypothetical protein 0.0125 0.0538 0.0591
Trypanosoma brucei spermidine synthase 0.1081 0.6049 1
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0315 0.1634 0.2701
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0422 0.2253 0.3725
Loa Loa (eye worm) PWWP domain-containing protein 0.009 0.0339 0.0373
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0019 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0239 0.1194 0.25
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0373 0.197 0.3253
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0766 0.4236 0.7003
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0275 0.14 0.2933
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0042 0.0069
Trypanosoma cruzi spermidine synthase, putative 0.1081 0.6049 1
Echinococcus granulosus PWWP domain containing protein 2A 0.009 0.0339 0.0561
Onchocerca volvulus 0.0271 0.1378 0.1376
Schistosoma mansoni jumonji domain containing protein 0.0084 0.03 0.0628
Echinococcus granulosus methyltransferase protein 5 0.0032 0.0001 0.0001
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0766 0.4236 0.4659
Echinococcus granulosus methylthioadenosine phosphorylase 0.086 0.4774 0.7893
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0159 0.0735 0.0735
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0052 0.0058
Giardia lamblia UPL-1 0.0159 0.0735 1
Onchocerca volvulus 0.0292 0.15 0.1498
Schistosoma mansoni uridine phosphorylase 0.0159 0.0735 0.154
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0422 0.2253 0.3724
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0159 0.0735 0.5
Brugia malayi Bromodomain containing protein 0.0032 0.0003 0.0003
Schistosoma mansoni uridine phosphorylase 0.0159 0.0735 0.154
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0052 0.011
Echinococcus granulosus histone lysine methyltransferase setb 0.0239 0.1194 0.1973
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0003 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.009 0.0339 0.056
Echinococcus multilocularis histone h3 methyltransferase 0.0786 0.435 0.7192
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0766 0.4236 0.7003
Loa Loa (eye worm) hypothetical protein 0.0066 0.0196 0.0215
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0075 0.0125
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.01 0.0393 0.0648
Toxoplasma gondii phosphorylase family protein 0.0159 0.0735 0.223
Echinococcus granulosus cpg binding protein 0.0272 0.1388 0.2295
Echinococcus granulosus geminin 0.0187 0.0895 0.148
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0315 0.1634 0.2701
Toxoplasma gondii hypothetical protein 0.01 0.0393 0.1191
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Plasmodium vivax spermidine synthase, putative 0.1081 0.6049 1
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.086 0.4774 1
Schistosoma mansoni hypothetical protein 0.009 0.0339 0.071
Plasmodium falciparum purine nucleoside phosphorylase 0.0159 0.0735 0.1211
Schistosoma mansoni methylthioadenosine phosphorylase 0.086 0.4774 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0159 0.0735 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0425 0.0702
Echinococcus granulosus PWWP domain containing protein 2A 0.009 0.0339 0.0561
Trypanosoma cruzi spermidine synthase, putative 0.1081 0.6049 1
Loa Loa (eye worm) SET domain-containing protein 0.0315 0.1634 0.1797
Trypanosoma brucei Histone methylation protein DOT1, putative 0.01 0.0393 0.0648
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0701 0.3857 0.7816
Plasmodium falciparum spermidine synthase 0.1081 0.6049 1
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0106 0.0429 0.0708
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0032 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0271 0.1378 0.2886
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.016 0.0743 0.2253
Loa Loa (eye worm) hypothetical protein 0.0239 0.1194 0.1313
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0037 0.0033 0.0054
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0159 0.0735 0.1214
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0159 0.0735 0.3261
Loa Loa (eye worm) hypothetical protein 0.0275 0.14 0.154
Echinococcus granulosus protein arginine N methyltransferase 8 0.0034 0.0013 0.0021
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Schistosoma mansoni histone J3 methyltransferase 0.0786 0.435 0.9112
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0786 0.435 0.4785
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0078 0.0267 0.0441
Loa Loa (eye worm) Carm1-pending protein 0.016 0.0743 0.0817
Echinococcus granulosus hepatoma derived growth factor protein 0.009 0.0339 0.0561
Schistosoma mansoni methylthioadenosine phosphorylase 0.086 0.4774 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Echinococcus granulosus protein arginine methyltransferase 0.0034 0.0013 0.0021
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0735 0.0735
Brugia malayi Disco-interacting protein 2 homolog 0.0275 0.14 0.154
Echinococcus multilocularis protein arginine methyltransferase 0.0034 0.0013 0.0021
Leishmania major modification methylase-like protein 0.0422 0.2253 0.3724
Onchocerca volvulus 0.0275 0.14 0.1398
Brugia malayi SET domain containing protein 0.0151 0.0691 0.076
Schistosoma mansoni hypothetical protein 0.0032 0.0001 0.0001
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Schistosoma mansoni suppressor of variegation 4-20-related 0.0151 0.0691 0.1447
Schistosoma mansoni SET domain protein 0.0108 0.0439 0.0919
Trypanosoma brucei uridine phosphorylase 0.0159 0.0735 0.1214
Onchocerca volvulus 0.0364 0.1918 0.1916
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0151 0.0691 0.1142
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0735 0.0735
Brugia malayi uridine phosphorylase family protein 0.0159 0.0735 0.0809
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1609 0.9092 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0239 0.1194 0.1973
Loa Loa (eye worm) SET domain-containing protein 0.0151 0.0691 0.076
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.086 0.4774 0.7892
Brugia malayi jmjC domain containing protein 0.0041 0.0052 0.0058
Echinococcus multilocularis peregrin 0.0123 0.0525 0.0867
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0013 0.0013
Toxoplasma gondii hypothetical protein 0.009 0.0339 0.1028
Schistosoma mansoni methylthioadenosine phosphorylase 0.0159 0.0735 0.154
Echinococcus granulosus histone h3 methyltransferase 0.0786 0.435 0.7192
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0735 0.3261
Schistosoma mansoni protein arginine n-methyltransferase 0.016 0.0743 0.1556
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0075 0.0125
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0373 0.197 0.3253
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0001 0.0001
Brugia malayi SET domain containing protein 0.0315 0.1634 0.1797
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0159 0.0735 0.5
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0032 0.0001 0.0001
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.086 0.4774 0.5251
Leishmania major hypothetical protein, conserved 0.01 0.0393 0.0648
Brugia malayi Carm1-pending protein 0.016 0.0743 0.0817
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0735 0.1215
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0735 0.3261
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0852 0.4729 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0001 0.0001
Echinococcus multilocularis hepatoma derived growth factor protein 0.009 0.0339 0.0561
Loa Loa (eye worm) hypothetical protein 0.0076 0.0255 0.0281
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0735 0.3261
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0066 0.0196 0.0867
Schistosoma mansoni hypothetical protein 0.0032 0.0003 0.0006
Echinococcus granulosus peregrin 0.0123 0.0525 0.0867
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0173 0.0814 0.2471
Echinococcus granulosus protein arginine N methyltransferase 7 0.0032 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0159 0.0735 0.3261
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0992 0.5537 0.609
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0066 0.0196 0.0323
Echinococcus granulosus uridine phosphorylase 1 0.0159 0.0735 0.1215
Brugia malayi SET domain containing protein 0.0049 0.01 0.011
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.01 0.0393 0.0648
Trichomonas vaginalis set domain proteins, putative 0.1766 1 1
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0066 0.0196 0.0323

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.