Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.6737 | 0.6737 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.6737 | 0.6421 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.2595 | 0.2595 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.2595 | 0.2595 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2595 | 0.2595 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 1 | 1 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.001 | 0.2452 | 0.9449 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.6737 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.2595 | 0.2595 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.2595 | 1 |
Onchocerca volvulus | 0.0023 | 1 | 1 | |
Trypanosoma cruzi | ABC transporter, putative | 0.001 | 0.2452 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0883 | 0.0546 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.2595 | 0.2595 |
Entamoeba histolytica | ABC transporter, putative | 0.001 | 0.2452 | 0.1721 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.2595 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0883 | 0.0546 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.6737 | 0.6617 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0883 | 0.0546 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.2595 | 0.2595 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | ABC transporter | 0.0008 | 0.1638 | 0.1638 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.2595 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.2595 | 0.1878 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2595 | 0.2595 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.2595 | 1 |
Toxoplasma gondii | ATP-binding cassette G family transporter ABCG84 | 0.001 | 0.2452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0883 | 0.0883 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0007 | 0.0883 | 0.3402 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.2595 | 0.2595 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.001 | 0.2452 | 0.9449 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.2595 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0883 | 0.0546 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0883 | 0.0546 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.2595 | 0.2595 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.2595 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.2595 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.2595 | 0.2595 |
Schistosoma mansoni | ABC transporter | 0.0008 | 0.1638 | 0.631 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.2595 | 0.2595 |
Trypanosoma brucei | ABC transporter, putative | 0.001 | 0.2452 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0883 | 0.0883 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.2595 | 0.2595 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.6737 | 0.6737 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.001 | 0.2452 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 1 | 1 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.001 | 0.2452 | 0.1721 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.2595 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.001 | 0.2452 | 0.9449 |
Plasmodium falciparum | ABC transporter G family member 2 | 0.001 | 0.2452 | 0.2681 |
Mycobacterium tuberculosis | Probable conserved transmembrane ATP-binding protein ABC transporter | 0.0008 | 0.1575 | 0.1264 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0883 | 0.0883 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.6211 | 0.6071 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0883 | 0.0883 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.2595 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.2595 | 0.1878 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.2595 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.001 | 0.2452 | 0.1721 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.2595 | 0.2595 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0883 | 0.0883 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2595 | 0.2595 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 1 | 1 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0883 | 0.0883 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0883 | 0.5 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.6211 | 0.6071 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.2595 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.6737 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.2595 | 0.2595 |
Schistosoma mansoni | ATP-binding cassette sub-family g2 (white protein) (abcg2) | 0.001 | 0.2452 | 0.9449 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.2595 | 0.2595 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2595 | 0.2595 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0883 | 0.0546 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0883 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.1575 | 0.6069 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 1 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0883 | 0.0546 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.001 | 0.2452 | 0.1721 |
Giardia lamblia | ABC transporter | 0.001 | 0.239 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0883 | 0.0883 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0883 | 0.0883 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.2595 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.6737 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.6737 | 0.6737 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.6211 | 0.6071 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0883 | 0.0883 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2595 | 0.2595 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0883 | 0.0546 |
Onchocerca volvulus | 0.001 | 0.2595 | 0.1878 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.2595 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.2595 | 0.2595 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.2595 | 1 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.001 | 0.2452 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 1 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0883 | 0.0546 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.2595 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.2595 | 0.2595 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.2595 | 0.1878 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.2595 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0883 | 0.0883 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.001 | 0.2452 | 0.9449 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.6211 | 0.6071 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.2595 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0883 | 0.0546 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0007 | 0.0883 | 0.3402 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.6737 | 0.6737 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.2595 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.2595 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.2595 | 0.2595 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2595 | 0.2595 |
Echinococcus granulosus | ATP binding cassette sub family G | 0.001 | 0.2452 | 0.9449 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.6737 | 0.6737 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2595 | 0.2595 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.2595 | 0.2595 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.2595 | 0.2595 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.001 | 0.2452 | 0.1721 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0883 | 0.3402 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.2595 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 1 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family G | 0.001 | 0.2452 | 0.9449 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0883 | 0.0883 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.2595 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.2595 | 0.2595 |
Brugia malayi | ABC transporter family protein | 0.0008 | 0.1638 | 0.1638 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.0883 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.2595 | 0.2595 |
Plasmodium vivax | ABC transporter G family member 2, putative | 0.001 | 0.2452 | 0.2681 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.2595 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.001 | 0.2452 | 0.1721 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.