Detailed information for compound 901430

Basic information

Technical information
  • TDR Targets ID: 901430
  • Name: 6-bromo-N-butyl-N-ethylquinazolin-4-amine
  • MW: 308.217 | Formula: C14H18BrN3
  • H donors: 0 H acceptors: 2 LogP: 4.31 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(c1ncnc2c1cc(Br)cc2)CC
  • InChi: 1S/C14H18BrN3/c1-3-5-8-18(4-2)14-12-9-11(15)6-7-13(12)16-10-17-14/h6-7,9-10H,3-5,8H2,1-2H3
  • InChiKey: XGTDEUHICAOTRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-bromo-N-butyl-N-ethyl-quinazolin-4-amine
  • 6-bromo-N-butyl-N-ethyl-4-quinazolinamine
  • (6-bromoquinazolin-4-yl)-butyl-ethyl-amine
  • Oprea1_635744
  • ST5182435
  • IDI1_002689
  • N4-butyl-N4-methyl-6-bromo-4-quinazolinamine 6-bromo-4-quinazolinyl(butyl)methylamine
  • NSC727845
  • ZINC01766180
  • ChemDiv2_003974

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0289 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0086 0.0086
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0296 0.7992
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0289 1 1
Echinococcus multilocularis GPCR, family 2 0.0011 0.014 0.014
Brugia malayi CXXC zinc finger family protein 0.0023 0.0578 0.0695
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0296 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0086 0.0086
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0141 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0086 0.0086
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0011 0.014 0.014
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0086 0.0086
Schistosoma mansoni smad1 5 8 and 0.0016 0.033 0.033
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0335 1
Trypanosoma brucei PAB1-binding protein , putative 0.0016 0.0335 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0736 0.0736
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.4624 0.5699
Brugia malayi Pre-SET motif family protein 0.0189 0.6442 0.7947
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0296 0.7992
Brugia malayi TAR-binding protein 0.0137 0.4624 0.5699
Schistosoma mansoni hypothetical protein 0.0011 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0009 0.0086 0.0086
Brugia malayi nuclear receptor NHR-88 0.0009 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0023 0.0579 0.0579
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0086 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.005 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0086 0.0086
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0086 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0023 0.0579 0.0696
Schistosoma mansoni smad 0.0007 0.0016 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0086 0.0086
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.1528 0.1528
Onchocerca volvulus Huntingtin homolog 0.0111 0.3684 0.4993
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0736 0.4947
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0086 0.0086
Brugia malayi nuclear hormone receptor 0.0009 0.0086 0.0086
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0086 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0086 0.0086
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0296 0.0347
Brugia malayi RNA binding protein 0.0137 0.4624 0.5699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0086 0.0086
Brugia malayi MH2 domain containing protein 0.0016 0.033 0.0389
Schistosoma mansoni tar DNA-binding protein 0.0137 0.4624 0.4624
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0289 1 1
Echinococcus multilocularis smad 0.0016 0.033 0.033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0296 0.7992
Schistosoma mansoni coup transcription factor 0.0009 0.0086 0.0086
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0015 0.0296 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0296 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0086 0.0086
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0086 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0086 0.0086
Echinococcus multilocularis tar DNA binding protein 0.0137 0.4624 0.4624
Loa Loa (eye worm) hypothetical protein 0.0009 0.0086 0.0086
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0086 0.0086
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0296 0.7992
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0047 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0009 0.0076 0.0075
Brugia malayi hypothetical protein 0.001 0.0132 0.0144
Schistosoma mansoni Smad4 0.0016 0.033 0.033
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0335 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0086 0.0086
Echinococcus granulosus tar DNA binding protein 0.0137 0.4624 0.4624
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0086 0.0095
Echinococcus granulosus GPCR family 2 0.0011 0.014 0.014
Plasmodium vivax ataxin-2 like protein, putative 0.0016 0.0335 0.3271
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0296 0.2614
Brugia malayi MH1 domain containing protein 0.0016 0.033 0.0389
Brugia malayi Latrophilin receptor protein 2 0.0011 0.014 0.0154
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0086 0.0086
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0086 0.0086
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.033 0.033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0683 0.0683
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0296 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.014 0.0154
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0034 0.0957 0.1164
Schistosoma mansoni tar DNA-binding protein 0.0137 0.4624 0.4624
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0086 0.0086
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.033 0.033
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0086 0.0086
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0016 0.0016
Schistosoma mansoni Smad4 0.0007 0.0016 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0189 0.6442 0.7947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0086 0.0086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0141 0.0141
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0086 0.0086
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.8102 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0086 0.0086
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0016 0.0016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0011 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0028 0.0736 0.089
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0141 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0137 0.4624 0.4624
Toxoplasma gondii LsmAD domain-containing protein 0.0016 0.0335 0.1618
Schistosoma mansoni cpg binding protein 0.0023 0.0578 0.0578
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0086 0.0086
Brugia malayi MH2 domain containing protein 0.0016 0.033 0.0389
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0086 0.0086
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0736 0.0736
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0009 0.0086 0.0086
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0086 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0009 0.0086 0.0086
Brugia malayi Calcitonin receptor-like protein seb-1 0.0034 0.0957 0.1164
Treponema pallidum exodeoxyribonuclease (exoA) 0.0015 0.0296 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0086 0.0095
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0007 0.0019 0.0019
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0086 0.0086
Loa Loa (eye worm) histone methyltransferase 0.0008 0.005 0.0042
Brugia malayi MH2 domain containing protein 0.0236 0.8102 1
Schistosoma mansoni Smad4 0.0007 0.0016 0.0016
Brugia malayi MH1 domain containing protein 0.0016 0.033 0.0389
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0086 0.0086
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0141 0.0141
Schistosoma mansoni hypothetical protein 0.0011 0.014 0.014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0011 0.014 0.014
Plasmodium vivax SET domain protein, putative 0.0028 0.0736 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0296 0.0347
Brugia malayi ecdysteroid receptor 0.0009 0.0086 0.0086
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0007 0.0019 0.0019
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0016 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0086 0.0086
Schistosoma mansoni ap endonuclease 0.0015 0.0296 0.0296
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0736 0.0736
Loa Loa (eye worm) hypothetical protein 0.0011 0.014 0.0154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0086 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0736 0.0736
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0086 0.0086
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0086 0.0086
Loa Loa (eye worm) CXXC zinc finger family protein 0.0023 0.0578 0.0695
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0335 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0086 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0016 0.0335 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0086 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0137 0.4624 0.4624
Toxoplasma gondii exonuclease III APE 0.0015 0.0296 0.1293
Loa Loa (eye worm) hypothetical protein 0.0009 0.0086 0.0086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0034 0.0957 0.1164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0086 0.0086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0141 0.0141
Loa Loa (eye worm) TAR-binding protein 0.0137 0.4624 0.5699
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0086 0.0086
Schistosoma mansoni cpg binding protein 0.0024 0.0624 0.0624
Onchocerca volvulus 0.0215 0.7363 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0011 0.014 0.014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0736 0.0736
Schistosoma mansoni smad1 5 8 and 0.0016 0.033 0.033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.005 0.005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0086 0.0086
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0011 0.014 0.014
Loa Loa (eye worm) Smad1 0.0016 0.033 0.0389
Loa Loa (eye worm) hypothetical protein 0.0111 0.3684 0.4536
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.1343 1
Echinococcus granulosus smad 0.0016 0.033 0.033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0296 1
Onchocerca volvulus Huntingtin homolog 0.0111 0.3684 0.4993
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0086 0.0086
Onchocerca volvulus 0.0009 0.0086 0.0095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0086 0.0086
Brugia malayi steroid hormone receptor 0.0009 0.0086 0.0086
Brugia malayi MH1 domain containing protein 0.0009 0.0076 0.0075
Trichomonas vaginalis set domain proteins, putative 0.0215 0.7363 1
Schistosoma mansoni smad 0.0016 0.033 0.033
Echinococcus granulosus Smad4 0.0016 0.033 0.033
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0086 0.0095
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.8102 1
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.4624 0.5699
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.014 0.0154
Echinococcus multilocularis Smad4 0.0016 0.033 0.033
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0034 0.0957 0.1164
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0086 0.0086
Schistosoma mansoni smad1 5 8 and 0.0016 0.033 0.033
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0086 0.0086
Onchocerca volvulus 0.0028 0.0736 0.0979
Loa Loa (eye worm) hypothetical protein 0.0016 0.0335 0.0395
Onchocerca volvulus 0.0023 0.0578 0.0765
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0086 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0736 0.0736
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0086 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0137 0.4624 0.4624
Loa Loa (eye worm) hypothetical protein 0.0009 0.0086 0.0086
Schistosoma mansoni ap endonuclease 0.0015 0.0296 0.0296
Schistosoma mansoni hypothetical protein 0.0011 0.014 0.014
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0086 0.0086
Brugia malayi Pre-SET motif family protein 0.0028 0.0736 0.089
Loa Loa (eye worm) nuclear factor I 0.0009 0.0076 0.0075
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.033 0.0389
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0086 0.0086
Schistosoma mansoni cpg binding protein 0.0024 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0111 0.3684 0.4536
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0141 0.0141
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0296 0.7992
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0086 0.0086
Brugia malayi Smad1 0.0016 0.033 0.0389
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.033 0.0389
Leishmania major hypothetical protein, conserved 0.0016 0.0335 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0141 0.0141
Brugia malayi hypothetical protein 0.0016 0.0335 0.0395
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0016 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0141 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0736 0.0736
Echinococcus granulosus cpg binding protein 0.0024 0.0624 0.0624
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.033 0.033
Brugia malayi latrophilin 2 splice variant baaae 0.0023 0.0579 0.0696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0086 0.0086
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0015 0.0296 0.5
Brugia malayi MH1 domain containing protein 0.0009 0.0076 0.0075
Brugia malayi hypothetical protein 0.0111 0.3684 0.4536
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0296 0.0296
Schistosoma mansoni hypothetical protein 0.0007 0.0019 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0086 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0009 0.0086 0.0086
Brugia malayi isocitrate dehydrogenase 0.0011 0.0141 0.0154
Echinococcus multilocularis cpg binding protein 0.0024 0.0624 0.0624
Loa Loa (eye worm) RNA binding protein 0.0137 0.4624 0.5699

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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