Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1315 | 0.1315 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.6775 | 1 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.6775 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.6742 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.6775 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.6742 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.205 | 0.3041 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3096 | 0.3096 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0198 | 0.0788 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1315 | 0.1315 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0198 | 0.0788 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.205 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.5992 | 0.8837 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0198 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0198 | 0.0198 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0198 | 0.0235 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.2218 | 0.3289 |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.205 | 0.3041 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.205 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.205 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3096 | 0.4591 |
Echinococcus multilocularis | geminin | 0.0166 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.004 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0198 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0198 | 0.0788 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3096 | 0.3096 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0198 | 0.0294 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3096 | 0.3096 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3096 | 0.3096 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0198 | 0.0198 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0016 | 0.004 | 0.004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3096 | 0.3096 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.2218 | 0.3289 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0198 | 0.0788 |
Leishmania major | trypanothione reductase | 0.0046 | 0.205 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0198 | 0.0788 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1315 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1315 | 0.1315 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.205 | 0.2985 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.205 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1315 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.004 | 0.0059 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.6742 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0198 | 0.0788 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.2218 | 0.3289 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1191 | 0.1767 |
Brugia malayi | glutathione reductase | 0.0046 | 0.205 | 0.3041 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.205 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0016 | 0.004 | 0.004 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3096 | 0.4591 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.6775 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3096 | 0.4591 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.5992 | 0.8837 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0198 | 0.0788 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.5992 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.5992 | 0.8837 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0198 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0198 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.205 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3096 | 0.4591 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1191 | 0.1191 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0198 | 0.0198 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.5992 | 0.8837 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0016 | 0.004 | 0.004 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3096 | 0.3096 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0198 | 0.0294 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0198 | 0.0198 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.205 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0198 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1315 | 0.1315 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1315 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3096 | 0.4591 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.205 | 0.205 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3096 | 0.4591 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1191 | 0.1767 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3096 | 0.3096 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1315 | 0.195 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.205 | 0.205 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.5992 | 0.8837 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2218 | 0.3289 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.205 | 0.3041 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1315 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0198 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.