TDR Targets

Basic information

Technical information

TDR Targets ID: 901979
Name: N-[4-[(4-diethylamino-6-methylpyrimidin-2-yl) amino]phenyl]-3-methoxybenzamide
MW: 405.493 | Formula: C23H27N5O2
H donors: 2 H acceptors: 3 LogP: 4.47 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C(=O)Nc1ccc(cc1)Nc1nc(C)cc(n1)N(CC)CC
InChi: 1S/C23H27N5O2/c1-5-28(6-2)21-14-16(3)24-23(27-21)26-19-12-10-18(11-13-19)25-22(29)17-8-7-9-20(15-17)30-4/h7-15H,5-6H2,1-4H3,(H,25,29)(H,24,26,27)
InChiKey: KUJCDCGPVKDLPK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[(4-diethylamino-6-methyl-pyrimidin-2-yl)amino]phenyl]-3-methoxy-benzamide
N-[4-[(4-diethylamino-6-methyl-2-pyrimidinyl)amino]phenyl]-3-methoxybenzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0164	0.0146
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0234	0.0662
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0164	0.0447
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0234	0.0662
Loa Loa (eye worm)	hypothetical protein	0.001	0.0234	0.0217
Schistosoma mansoni	hypothetical protein	0.0016	0.0559	0.1701
Mycobacterium leprae	putative cytochrome p450	0.0007	0.0057	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0234	0.0662
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0007	0.0057	0.5
Echinococcus granulosus	GPCR family 2	0.0016	0.0559	0.1656
Loa Loa (eye worm)	hypothetical protein	0.001	0.0234	0.0217
Brugia malayi	MH2 domain containing protein	0.0008	0.0121	0.0103
Schistosoma mansoni	hypothetical protein	0.0016	0.0559	0.1701
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Schistosoma mansoni	dishevelled	0.0009	0.0164	0.0499
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.0018	0.0054
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.3285	0.3273
Brugia malayi	MH1 domain containing protein	0.0008	0.0121	0.0103
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0234	0.0217
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0234	0.0712
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0559	0.1656
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0234	0.0662
Echinococcus granulosus	tar DNA binding protein	0.0063	0.3285	1
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0164	0.0447
Trypanosoma cruzi	cytochrome P450, putative	0.0024	0.1054	1
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0164	0.0447
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0234	0.0217
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Echinococcus granulosus	Smad4	0.0008	0.0121	0.0316
Brugia malayi	Cytochrome P450 family protein	0.0024	0.1054	0.1038
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0234	0.0662
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0234	0.0217
Leishmania major	cytochrome p450-like protein	0.0024	0.1054	1
Brugia malayi	DIX domain containing protein	0.0009	0.0164	0.0146
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0234	0.0217
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0121	0.0103
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0234	0.0712
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0007	0.0057	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0234	0.0217
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.2512	0.2498
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0234	0.0217
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0234	0.0662
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3285	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0121	0.0368
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.1054	0.1038
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0164	0.0146
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0007	0.0057	0.0382
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0164	0.0499
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0234	0.0662
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0234	0.0662
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0234	0.0662
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0164	0.0447
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0121	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0651	0.0635
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3285	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0164	0.0447
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0007	0.0057	0.5
Echinococcus multilocularis		0.0007	0.0057	0.0121
Loa Loa (eye worm)	Smad1	0.0008	0.0121	0.0103
Loa Loa (eye worm)	hypothetical protein	0.001	0.0234	0.0217
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0559	0.1656
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0559	0.1656
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0007	0.0057	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3285	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0007	0.0057	0.5
Brugia malayi	MH2 domain containing protein	0.0008	0.0121	0.0103
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.0018	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0007	0.0057	0.5
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0121	0.0368
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.6496	0.649
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0234	0.0662
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0234	0.0217
Brugia malayi	MH1 domain containing protein	0.0008	0.0121	0.0103
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0234	0.0712
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0121	0.0316
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0024	0.1054	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1608	0.1593
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0164	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0559	0.0542
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0234	0.0712
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0007	0.0057	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0007	0.0057	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0164	0.0447
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0234	0.0712
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0559	0.0542
Schistosoma mansoni	dep domain containing protein	0.0009	0.0164	0.0499
Brugia malayi	TAR-binding protein	0.0063	0.3285	0.3273
Brugia malayi	nuclear receptor NHR-88	0.001	0.0234	0.0217
Onchocerca volvulus		0.0009	0.0164	0.0146
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0234	0.0217
Trypanosoma brucei	cytochrome P450, putative	0.0024	0.1054	1
Schistosoma mansoni	smad	0.0008	0.0121	0.0368
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0234	0.0662
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0234	0.0217
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0559	0.1656
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0018	0.0054
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0559	0.0542
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0234	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0164	0.0146
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0164	0.0447
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0007	0.0057	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0234	0.0712
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0234	0.0662
Schistosoma mansoni	coup transcription factor	0.001	0.0234	0.0712
Brugia malayi	ecdysteroid receptor	0.001	0.0234	0.0217
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0007	0.0057	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.1608	0.4894
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0234	0.0217
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0121	0.0316
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0234	0.0217
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0057	0.004
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0164	0.0146
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.0018	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3285	1
Brugia malayi	RNA binding protein	0.0063	0.3285	0.3273
Brugia malayi	nuclear hormone receptor	0.001	0.0234	0.0217
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0559	0.0542
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.2512	0.2498
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0234	0.0217
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0234	0.0712
Brugia malayi	hypothetical protein	0.0009	0.0164	0.0146
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0007	0.0057	0.5
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0164	0.0447
Echinococcus granulosus	cytochrome P450 2K1	0.0007	0.0057	0.0121
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0121	0.0316
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.018	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0234	0.0217
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0234	0.0662
Brugia malayi	Cytochrome P450 family protein	0.0007	0.0057	0.004
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0234	0.0217
Brugia malayi	MH2 domain containing protein	0.0119	0.6496	0.649
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0234	0.0217
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0234	0.0662
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0164	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0164	0.0146
Trichomonas vaginalis	ras GTP exchange factor, son of sevenless, putative	0.0006	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.2512	0.2498
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0007	0.0057	0.5
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0164	0.0447
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0234	0.0217
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0234	0.0712
Loa Loa (eye worm)	hypothetical protein	0.018	1	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0007	0.0057	0.0382
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0234	0.0217
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0234	0.0217
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0121	0.0103
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0234	0.0662
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0007	0.0057	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0234	0.0217
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0018	0.0054
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Toxoplasma gondii	hypothetical protein	0.0009	0.0164	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.2512	0.2498
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0164	0.0499
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0007	0.0057	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0007	0.0057	0.004
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Echinococcus granulosus	smad	0.0008	0.0121	0.0316
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0234	0.0712
Trichomonas vaginalis	guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0164	0.0146
Loa Loa (eye worm)	cytochrome P450 family protein	0.0024	0.1054	0.1038
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1608	0.1593
Schistosoma mansoni	hypothetical protein	0.0007	0.0057	0.0174
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.3285	0.3273
Loa Loa (eye worm)	cytochrome P450	0.0007	0.0057	0.004
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0234	0.0217
Schistosoma mansoni	hypothetical protein	0.0016	0.0559	0.1701
Brugia malayi	hypothetical protein	0.0009	0.0164	0.0146
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0007	0.0057	0.0382
Loa Loa (eye worm)	hypothetical protein	0.001	0.0234	0.0217
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0559	0.1656
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0164	0.0146
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0007	0.0057	0.5
Brugia malayi	Smad1	0.0008	0.0121	0.0103
Loa Loa (eye worm)	CYP4Cod1	0.0024	0.1054	0.1038
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0234	0.0217
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0234	0.0712
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0234	0.0662
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0234	0.0712
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0007	0.0057	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Loa Loa (eye worm)	RNA binding protein	0.0063	0.3285	0.3273
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.3285	0.3273
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0018	0.5
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.0018	0.0054
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0007	0.0057	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0234	0.0712
Loa Loa (eye worm)	hypothetical protein	0.001	0.0234	0.0217
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.3285	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0007	0.0057	0.5
Echinococcus multilocularis	smad	0.0008	0.0121	0.0316
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0164	0.0146
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0164	0.0447
Loa Loa (eye worm)	hypothetical protein	0.001	0.0234	0.0217
Loa Loa (eye worm)	hypothetical protein	0.001	0.0234	0.0217
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0234	0.0662
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0234	0.0217
Brugia malayi	Cytochrome P450 family protein	0.0024	0.1054	0.1038
Loa Loa (eye worm)	hypothetical protein	0.001	0.0234	0.0217
Schistosoma mansoni	dishevelled	0.0009	0.0164	0.0499
Schistosoma mansoni	Smad4	0.0008	0.0121	0.0368
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0234	0.0217
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0121	0.0368
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0007	0.0057	0.5
Schistosoma mansoni	cytochrome P450	0.0007	0.0057	0.0174
Echinococcus multilocularis	Smad4	0.0008	0.0121	0.0316
Onchocerca volvulus		0.001	0.0234	0.0217
Trypanosoma cruzi	cytochrome P450, putative	0.0024	0.1054	1
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0007	0.0057	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0234	0.0217
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0121	0.0316
Mycobacterium leprae	Conserved hypothetical protein	0.0007	0.0057	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.6496	0.649
Brugia malayi	cytochrome P450	0.0007	0.0057	0.004
Schistosoma mansoni	hypothetical protein	0.0016	0.0559	0.1701
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0018	0.0054
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0234	0.0217
Brugia malayi	steroid hormone receptor	0.001	0.0234	0.0217
Entamoeba histolytica	hypothetical protein	0.0006	0.0018	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3285	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0234	0.0662
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0234	0.0217

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 901979