TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.44 | Formula: C21H23N5O
H donors: 2 H acceptors: 3 LogP: 4.13 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1nc(Nc2ccc(cc2)NC(=O)c2ccc(cc2)C)nc(c1)N(C)C
InChi: 1S/C21H23N5O/c1-14-5-7-16(8-6-14)20(27)23-17-9-11-18(12-10-17)24-21-22-15(2)13-19(25-21)26(3)4/h5-13H,1-4H3,(H,23,27)(H,22,24,25)
InChiKey: FSDRWIDORVJTGV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0087	0.0721	0.0346
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0071	0.0421	0.0463
Echinococcus granulosus	neuropeptide receptor	0.0087	0.0721	0.0774
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.3359	0.3685
Echinococcus granulosus	rhodopsin orphan GPCR	0.0087	0.0721	0.0774
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0106	0.1077	0.106
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0087	0.0721	0.0346
Onchocerca volvulus		0.0087	0.0721	1
Echinococcus granulosus	neuropeptide receptor A26	0.0531	0.9002	0.991
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0099	0.0955	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0087	0.0721	0.0346
Onchocerca volvulus		0.0087	0.0721	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.0463
Trypanosoma cruzi	cytochrome P450, putative	0.0199	0.281	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0087	0.0721	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0071	0.0421	0.0402
Echinococcus granulosus	geminin	0.017	0.2274	0.2488
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.05	0.8426	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0099	0.0955	1
Echinococcus multilocularis	sex peptide receptor	0.0087	0.0721	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0087	0.0721	0.0703
Echinococcus granulosus	dro:myosuppressin receptor	0.0087	0.0721	0.0774
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0099	0.0955	0.2236
Brugia malayi	Cytochrome P450 family protein	0.0099	0.0955	0.1051
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0099	0.0955	1
Brugia malayi	G protein-coupled receptor	0.0087	0.0721	0.0793
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0071	0.0421	0.5
Treponema pallidum	cyclic nucleotide binding protein	0.0071	0.0421	0.5
Loa Loa (eye worm)	hypothetical protein	0.01	0.0958	0.1054
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0099	0.0955	0.2236
Schistosoma mansoni	neuropeptide receptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	cytochrome P450 family protein	0.0099	0.0955	0.1051
Onchocerca volvulus		0.0087	0.0721	1
Schistosoma mansoni	myosin xvIII	0.0087	0.0721	0.0703
Onchocerca volvulus		0.0087	0.0721	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0099	0.0955	1
Echinococcus granulosus	g protein coupled receptor	0.0087	0.0721	0.0774
Schistosoma mansoni	hypothetical protein	0.017	0.2274	0.2259
Schistosoma mansoni	hypothetical protein	0.0087	0.0721	0.0703
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0099	0.0955	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0071	0.0421	0.0402
Onchocerca volvulus		0.0087	0.0721	1
Echinococcus granulosus	voltage gated potassium channel	0.0155	0.1994	0.2179
Onchocerca volvulus		0.0087	0.0721	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0155	0.1994	0.2196
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0087	0.0721	0.0774
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0099	0.0955	1
Brugia malayi	ORL1-like opioid receptor	0.0087	0.0721	0.0793
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0099	0.0955	0.2236
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0071	0.0421	0.0402
Echinococcus granulosus	tm gpcr rhodopsin	0.0087	0.0721	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0087	0.0721	0.0346
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0536	0.9083	1
Onchocerca volvulus		0.0087	0.0721	1
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0099	0.0955	0.2236
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0087	0.0721	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0087	0.0721	0.0346
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0087	0.0721	0.0346
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0071	0.0421	0.0443
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0087	0.0721	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Brugia malayi	Serotonin receptor	0.0087	0.0721	0.0793
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0099	0.0955	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0155	0.1994	0.1816
Echinococcus multilocularis	g protein coupled receptor	0.0087	0.0721	0.0346
Onchocerca volvulus		0.0087	0.0721	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0087	0.0721	0.0703
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0087	0.0721	0.0703
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Echinococcus multilocularis	neuropeptide Y receptor	0.0087	0.0721	0.0346
Schistosoma mansoni	hypothetical protein	0.017	0.2274	0.2259
Mycobacterium leprae	Conserved hypothetical protein	0.0071	0.0421	0.4288
Onchocerca volvulus		0.0087	0.0721	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Treponema pallidum	catabolite gene activator (Crp)	0.0071	0.0421	0.5
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0099	0.0955	0.2236
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0099	0.0955	0.2236
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0087	0.0721	0.0703
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0099	0.0955	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0087	0.0721	0.0346
Schistosoma mansoni	amine GPCR	0.0087	0.0721	0.0703
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0087	0.0721	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	amine GPCR	0.0087	0.0721	0.0703
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0087	0.0721	0.0774
Schistosoma mansoni	voltage-gated potassium channel	0.0155	0.1994	0.1979
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0087	0.0721	1
Echinococcus granulosus	cytochrome P450 2K1	0.0099	0.0955	0.1032
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0099	0.0955	1
Trypanosoma brucei	cytochrome P450, putative	0.0199	0.281	1
Echinococcus multilocularis	neuropeptide receptor	0.0087	0.0721	0.0346
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0071	0.0421	0.0477
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0071	0.0421	0.0443
Brugia malayi	Dopamine receptor	0.0087	0.0721	0.0793
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0087	0.0721	0.0774
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0071	0.0421	0.0477
Schistosoma mansoni	opsin-like receptor	0.0087	0.0721	0.0703
Echinococcus granulosus	neuropeptides capa receptor	0.0087	0.0721	0.0774
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0099	0.0955	1
Schistosoma mansoni	biogenic amine receptor	0.0087	0.0721	0.0703
Echinococcus multilocularis	serotonin receptor	0.0087	0.0721	0.0346
Schistosoma mansoni	voltage-gated potassium channel	0.0585	1	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0087	0.0721	0.0793
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Leishmania major	cytochrome p450-like protein	0.0199	0.281	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0087	0.0721	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0087	0.0721	0.0774
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0099	0.0955	1
Echinococcus multilocularis	somatostatin receptor	0.0087	0.0721	0.0346
Brugia malayi	GnHR receptor homolog	0.0087	0.0721	0.0793
Schistosoma mansoni	neuropeptide receptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0087	0.0721	0.0793
Loa Loa (eye worm)	melatonin receptor type 1A	0.0087	0.0721	0.0793
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0106	0.1077	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0106	0.1077	0.106
Schistosoma mansoni	opsin-like receptor	0.0087	0.0721	0.0703
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0071	0.0421	0.0463
Trypanosoma cruzi	cytochrome P450, putative	0.0199	0.281	1
Echinococcus multilocularis	neuropeptide s receptor	0.0531	0.9002	0.9906
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0049	0.002	0.0022
Echinococcus granulosus	cGMP dependent protein kinase	0.0071	0.0421	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0099	0.0955	0.2236
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0071	0.0421	0.0477
Brugia malayi	sulfakinin receptor protein	0.0087	0.0721	0.0793
Loa Loa (eye worm)	TYRA-2 protein	0.0087	0.0721	0.0793
Echinococcus granulosus	g protein coupled receptor	0.0087	0.0721	0.0774
Echinococcus granulosus	rhodopsin orphan GPCR	0.0087	0.0721	0.0774
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0087	0.0721	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	neuropeptides capa receptor	0.0087	0.0721	0.0346
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0099	0.0955	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.3359	0.3392
Schistosoma mansoni	histamine h1 receptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0106	0.1077	0.106
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0087	0.0721	0.0793
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Brugia malayi	G-protein coupled receptor	0.0087	0.0721	0.0793
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0106	0.1077	0.1258
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0099	0.0955	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	hypothetical protein	0.0087	0.0721	0.0774
Loa Loa (eye worm)	cytochrome P450 family protein	0.0199	0.281	0.3094
Schistosoma mansoni	hypothetical protein	0.0087	0.0721	0.0703
Brugia malayi	putative neuropeptide receptor	0.0087	0.0721	0.0793
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0421	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Trypanosoma brucei	protein kinase A regulatory subunit	0.0071	0.0421	0.1438
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0106	0.1077	0.1258
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0099	0.0955	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0531	0.9002	0.9906
Echinococcus multilocularis	dro:myosuppressin receptor	0.0087	0.0721	0.0346
Echinococcus granulosus	G protein coupled receptor 139	0.0087	0.0721	0.0774
Schistosoma mansoni	neuropeptide receptor	0.0087	0.0721	0.0703
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0099	0.0955	0.2236
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0071	0.0421	0.0443
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0071	0.0421	0.0402
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0071	0.0421	0.0463
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0087	0.0721	0.0346
Schistosoma mansoni	60S ribosomal protein L21	0.0084	0.0676	0.0658
Leishmania major	cytochrome p450-like protein	0.0099	0.0955	0.2236
Schistosoma mansoni	neuropeptide receptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	G-protein coupled receptor	0.0087	0.0721	0.0793
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0536	0.9083	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0099	0.0955	0.2236
Echinococcus granulosus	fmrfamide receptor	0.0087	0.0721	0.0774
Echinococcus granulosus	hyperpolarization activated cyclic	0.0106	0.1077	0.1167
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0099	0.0955	0.2236
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0099	0.0955	0.2236
Brugia malayi	follicle stimulating hormone receptor	0.0087	0.0721	0.0793
Schistosoma mansoni	amine GPCR	0.0087	0.0721	0.0703
Onchocerca volvulus		0.0087	0.0721	1
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0071	0.0421	0.0443
Echinococcus multilocularis	geminin	0.017	0.2274	0.214
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0087	0.0721	0.0774
Echinococcus granulosus	rhodopsin orphan GPCR	0.0087	0.0721	0.0774
Echinococcus granulosus	neuropeptide Y receptor	0.0087	0.0721	0.0774
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0106	0.1077	0.1186
Brugia malayi	Dopamine receptor protein 1	0.0087	0.0721	0.0793
Treponema pallidum	cyclic nucleotide binding protein	0.0071	0.0421	0.5
Schistosoma mansoni	biogenic amine receptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Trypanosoma brucei	Flagellar Member 6	0.0071	0.0421	0.1438
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0087	0.0721	0.0346
Echinococcus granulosus	somatostatin receptor	0.0087	0.0721	0.0774
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0099	0.0955	0.2236
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0087	0.0721	0.0346
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0099	0.0955	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Trypanosoma brucei	cAMP binding protein, putative	0.0071	0.0421	0.1438
Echinococcus granulosus	rhodopsin orphan GPCR	0.0087	0.0721	0.0774
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0099	0.0955	0.3352
Schistosoma mansoni	cytochrome P450	0.0099	0.0955	0.0937
Plasmodium falciparum	cGMP-dependent protein kinase	0.0071	0.0421	0.5
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0087	0.0721	0.0346
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0421	0.0402
Schistosoma mansoni	neuropeptide F-like receptor	0.0087	0.0721	0.0703
Echinococcus granulosus	serotonin receptor	0.0087	0.0721	0.0774
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0087	0.0721	0.0703
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0087	0.0721	0.0793
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0106	0.1077	0.1167
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0155	0.1994	0.2179
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0071	0.0421	0.0402
Loa Loa (eye worm)	neuropeptide F receptor	0.0087	0.0721	0.0793
Brugia malayi	larval opioid receptor	0.0087	0.0721	0.0793
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0099	0.0955	0.2236
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0087	0.0721	0.0703
Echinococcus granulosus	g protein coupled receptor	0.0087	0.0721	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0106	0.1077	0.106
Treponema pallidum	catabolite gene activator	0.0071	0.0421	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0087	0.0721	0.0774
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0087	0.0721	0.0703
Schistosoma mansoni	hypothetical protein	0.0099	0.0955	0.0937
Brugia malayi	Cytochrome P450 family protein	0.0199	0.281	0.3094
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0087	0.0721	0.0346
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0071	0.0421	0.0402
Echinococcus granulosus	g-protein coupled receptor	0.0087	0.0721	0.0774
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0099	0.0955	1
Onchocerca volvulus		0.0087	0.0721	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0087	0.0721	0.0774
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0087	0.0721	0.0346
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0087	0.0721	0.0703
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0087	0.0721	0.0346
Echinococcus multilocularis	voltage gated potassium channel	0.0155	0.1994	0.1816
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	rhodopsin orphan GPCR	0.0087	0.0721	0.0774
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0087	0.0721	0.0703
Schistosoma mansoni	adenoreceptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	G protein coupled receptor 139	0.0087	0.0721	0.0346
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0106	0.1077	0.0758
Onchocerca volvulus		0.0087	0.0721	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0087	0.0721	0.0793
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0087	0.0721	0.0346
Brugia malayi	Cytochrome P450 family protein	0.0199	0.281	0.3094
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0536	0.9083	1
Echinococcus multilocularis	g-protein coupled receptor	0.0087	0.0721	0.0346
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0106	0.1077	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0465	0.7765	0.8549
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Brugia malayi	Egg laying defective protein 4	0.0071	0.0421	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	amine GPCR	0.0087	0.0721	0.0703
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0099	0.0955	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0106	0.1077	0.0758
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0071	0.0421	0.5
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0099	0.0955	0.2236
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0087	0.0721	0.0703
Brugia malayi	neuropeptide F receptor	0.0087	0.0721	0.0793
Echinococcus granulosus	hyperpolarization activated cyclic	0.0106	0.1077	0.1167
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0071	0.0421	0.5
Loa Loa (eye worm)	hypothetical protein	0.0228	0.3359	0.3698
Schistosoma mansoni	growth hormone secretagogue receptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	opsin-like receptor	0.0087	0.0721	0.0703
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0087	0.0721	0.0774
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0087	0.0721	0.0774
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0087	0.0721	0.0703
Brugia malayi	AKH receptor	0.0087	0.0721	0.0793
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0099	0.0955	0.2236
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0099	0.0955	0.2236
Echinococcus granulosus	rhodopsin orphan GPCR	0.0087	0.0721	0.0774
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0099	0.0955	0.2236
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0087	0.0721	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Trypanosoma brucei	cAMP response protein 1, putative	0.0071	0.0421	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0087	0.0721	0.0703
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0106	0.1077	0.106
Echinococcus multilocularis	fmrfamide receptor	0.0087	0.0721	0.0346
Schistosoma mansoni	hypothetical protein	0.0087	0.0721	0.0703
Plasmodium falciparum	cAMP-dependent protein kinase regulatory subunit	0.0071	0.0421	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0087	0.0721	0.0346
Echinococcus granulosus	allatostatin A receptor	0.0087	0.0721	0.0774
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0099	0.0955	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0087	0.0721	0.0346
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0087	0.0721	0.0793
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	g protein coupled receptor	0.0087	0.0721	0.0346
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0106	0.1077	0.0758
Echinococcus multilocularis	fmrfamide receptor	0.0087	0.0721	0.0346
Echinococcus granulosus	biogenic amine 5HT receptor	0.0087	0.0721	0.0774
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	voltage-gated potassium channel	0.0155	0.1994	0.1979
Echinococcus multilocularis	serotonin receptor	0.0087	0.0721	0.0346
Echinococcus granulosus	7TM GPCR rhodopsin	0.0087	0.0721	0.0774
Echinococcus granulosus	neuropeptide receptor	0.0087	0.0721	0.0774
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0099	0.0955	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0106	0.1077	0.0758
Onchocerca volvulus		0.0087	0.0721	1
Brugia malayi	N-terminal motif family protein	0.0071	0.0421	0.0463
Mycobacterium leprae	Conserved hypothetical protein	0.0099	0.0955	1
Brugia malayi	G-protein coupled receptor	0.0087	0.0721	0.0793
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0071	0.0421	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1077	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0536	0.9083	1
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0099	0.0955	0.2236
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0087	0.0721	0.0346
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0071	0.0421	0.0443
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0087	0.0721	0.0774
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0071	0.0421	0.0402
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0071	0.0421	0.0463
Echinococcus granulosus	rhodopsin orphan GPCR	0.0087	0.0721	0.0774
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0199	0.281	1
Onchocerca volvulus		0.0087	0.0721	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0087	0.0721	0.0774
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0099	0.0955	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0087	0.0721	0.0793
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0087	0.0721	0.0346
Echinococcus multilocularis	g protein coupled receptor	0.0087	0.0721	0.0346
Loa Loa (eye worm)	neuropeptide F receptor	0.0087	0.0721	0.0793
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0071	0.0421	0.0477
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0106	0.1077	0.1186
Schistosoma mansoni	voltage-gated potassium channel	0.0084	0.0676	0.0658
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0099	0.0955	0.2236
Giardia lamblia	CAMP-dependent protein kinase regulatory chain	0.0071	0.0421	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0087	0.0721	0.0793
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0071	0.0421	0.0443
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Brugia malayi	hypothetical protein	0.0087	0.0721	0.0793
Onchocerca volvulus		0.0087	0.0721	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	neuropeptide Y receptor	0.0087	0.0721	0.0774
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0071	0.0421	0.1438
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0071	0.0421	0.0443
Loa Loa (eye worm)	cytochrome P450 family protein	0.0199	0.281	0.3094
Echinococcus granulosus	sex peptide receptor	0.0087	0.0721	0.0774
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0087	0.0721	0.0346
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0099	0.0955	0.2236
Echinococcus granulosus	orexin receptor type 2	0.0087	0.0721	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1994	0.2196
Brugia malayi	Dopamine receptor protein 2	0.0087	0.0721	0.0793
Schistosoma mansoni	neuropeptide f receptor 76f	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0421	0.0463
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0099	0.0955	1
Loa Loa (eye worm)	CYP4Cod1	0.0199	0.281	0.3094
Loa Loa (eye worm)	cytochrome P450	0.0099	0.0955	0.1051
Brugia malayi	Melatonin receptor type 1A	0.0087	0.0721	0.0793
Brugia malayi	hypothetical protein	0.0228	0.3359	0.3698
Echinococcus multilocularis	neuropeptides capa receptor	0.0087	0.0721	0.0346
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0071	0.0421	0.0402
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0087	0.0721	0.0793
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0421	0.0477
Schistosoma mansoni	amine GPCR	0.0087	0.0721	0.0703
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.05	0.8426	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0106	0.1077	0.1167
Onchocerca volvulus		0.0087	0.0721	1
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0099	0.0955	0.2236
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0106	0.1077	0.1167
Echinococcus granulosus	tm gpcr rhodopsin	0.0087	0.0721	0.0774
Brugia malayi	neuropeptide F receptor	0.0087	0.0721	0.0793
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0099	0.0955	0.2236
Echinococcus multilocularis		0.0099	0.0955	0.0617
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0087	0.0721	0.0346
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0071	0.0421	0.0463
Schistosoma mansoni	biogenic amine receptor	0.0087	0.0721	0.0703
Brugia malayi	G protein-coupled receptor F59B2.13	0.0087	0.0721	0.0793
Echinococcus multilocularis	neuropeptide receptor	0.0087	0.0721	0.0346
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0071	0.0421	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus multilocularis	orexin receptor type 2	0.0087	0.0721	0.0346
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0087	0.0721	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0087	0.0721	0.0703
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0099	0.0955	0.2236
Echinococcus granulosus	neuropeptide s receptor	0.0531	0.9002	0.991
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0087	0.0721	0.0793
Echinococcus granulosus	neuropeptide FF receptor 2	0.0087	0.0721	0.0774
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0087	0.0721	0.0346
Schistosoma mansoni	hypothetical protein	0.0087	0.0721	0.0703
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0421	0.0402
Brugia malayi	Cytochrome P450 family protein	0.0099	0.0955	0.1051
Leishmania major	cytochrome p450-like protein	0.0099	0.0955	0.2236
Brugia malayi	RE15519p	0.0087	0.0721	0.0793
Schistosoma mansoni	neuropeptide F-like receptor	0.0087	0.0721	0.0703
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0071	0.0421	0.0402
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0087	0.0721	0.0793
Mycobacterium leprae	putative cytochrome p450	0.0099	0.0955	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0071	0.0421	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	biogenic amine 5HT receptor	0.0087	0.0721	0.0774
Onchocerca volvulus		0.0087	0.0721	1
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0099	0.0955	0.2236
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0106	0.1077	0.1167
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0071	0.0421	0.0402
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0087	0.0721	0.0346
Schistosoma mansoni	voltage-gated potassium channel	0.0106	0.1077	0.106
Brugia malayi	cytochrome P450	0.0099	0.0955	0.1051
Brugia malayi	Serotonin receptor	0.0087	0.0721	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0721	0.0793
Schistosoma mansoni	hypothetical protein	0.0071	0.0421	0.0402

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 902043