TDR Targets

Basic information

Technical information

TDR Targets ID: 902114
Name: dimethyl 1,2,6-trimethyl-4-(4-methyl-3-nitrop henyl)-4H-pyridine-3,5-dicarboxylate
MW: 374.388 | Formula: C19H22N2O6
H donors: 0 H acceptors: 4 LogP: 2.89 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C1=C(C)N(C(=C(C1c1ccc(c(c1)[N+](=O)[O-])C)C(=O)OC)C)C
InChi: 1S/C19H22N2O6/c1-10-7-8-13(9-14(10)21(24)25)17-15(18(22)26-5)11(2)20(4)12(3)16(17)19(23)27-6/h7-9,17H,1-6H3
InChiKey: WKBPEDQFGAOFIG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

dimethyl 1,2,6-trimethyl-4-(4-methyl-3-nitro-phenyl)-4H-pyridine-3,5-dicarboxylate
1,2,6-trimethyl-4-(4-methyl-3-nitrophenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
1,2,6-trimethyl-4-(4-methyl-3-nitro-phenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
CBMicro_044318
BIM-0044419.P001
A2437/0103284
ZINC01214796
EU-0005254
Oprea1_441981

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.0395	0.0371
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	acetylcholinesterase 1	0.0418	1	1
Echinococcus granulosus	neuropeptide s receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	hypothetical protein	0.0035	0.0395	0.0395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus granulosus	hypothetical protein	0.0035	0.0395	0.0395
Schistosoma mansoni	growth hormone secretagogue receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0642	0.0642
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0035	0.0395	0.0268
Brugia malayi	Carboxylesterase family protein	0.0071	0.1291	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Brugia malayi	G-protein coupled receptor	0.0035	0.0395	0.0268
Brugia malayi	Dopamine receptor protein 2	0.0035	0.0395	0.0268
Entamoeba histolytica	hypothetical protein	0.0035	0.0402	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0035	0.0395	0.0395
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0418	1	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1291	0.1268
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0035	0.0395	0.0371
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Brugia malayi	Carboxylesterase family protein	0.0071	0.1291	0.1175
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1291	0.1268
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus granulosus	sex peptide receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.0395	0.0395
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0035	0.0395	0.0268
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	sex peptide receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1291	0.1291
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0642	0.0518
Schistosoma mansoni	hypothetical protein	0.0166	0.3676	0.3676
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0071	0.1291	0.5
Brugia malayi	putative neuropeptide receptor	0.0035	0.0395	0.0268
Echinococcus granulosus	carboxylesterase 5A	0.0418	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1291	0.1268
Schistosoma mansoni	opsin-like receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0035	0.0395	0.0395
Schistosoma mansoni	amine GPCR	0.0211	0.4816	0.4816
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	neuropeptide receptor A26	0.0035	0.0395	0.0395
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0642	0.0642
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0073	0.0073
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0071	0.1291	0.5
Schistosoma mansoni	opsin-like receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	amine GPCR	0.0035	0.0395	0.0395
Onchocerca volvulus		0.0071	0.1291	1
Brugia malayi	G-protein coupled receptor	0.0035	0.0395	0.0268
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	neuropeptide FF receptor 2	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0035	0.0395	0.0268
Schistosoma mansoni	amine GPCR	0.0035	0.0395	0.0395
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0395	0.0395
Brugia malayi	G protein-coupled receptor F59B2.13	0.0035	0.0395	0.0268
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.0395	0.0395
Brugia malayi	Serotonin receptor	0.0035	0.0395	0.0268
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0035	0.0395	0.0395
Brugia malayi	Dopamine receptor	0.0035	0.0395	0.0268
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0402	0.0402
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0984	0.0984
Schistosoma mansoni	biogenic amine receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0642	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0035	0.0395	0.0268
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1291	0.1268
Brugia malayi	ORL1-like opioid receptor	0.0035	0.0395	0.0268
Loa Loa (eye worm)	G-protein coupled receptor	0.0035	0.0395	0.0371
Schistosoma mansoni	histamine h1 receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	G protein coupled receptor 139	0.0035	0.0395	0.0395
Trichomonas vaginalis	spcc417.12 protein, putative	0.0071	0.1291	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0035	0.0395	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0071	0.1291	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.0395	0.0395
Brugia malayi	hypothetical protein	0.0035	0.0402	0.0275
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0402	0.0402
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	7tm_1 domain containing protein	0.0035	0.0395	0.0395
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0035	0.0395	0.0395
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.0395	0.0395
Echinococcus multilocularis	neuropeptide Y receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	opsin-like receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0071	0.1291	0.1291
Brugia malayi	Serotonin receptor	0.0035	0.0395	0.0268
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0071	0.1291	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Brugia malayi	Melatonin receptor type 1A	0.0035	0.0395	0.0268
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0073	0.0073
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Brugia malayi	putative neuropeptide receptor NPR1	0.0035	0.0395	0.0268
Brugia malayi	Carboxylesterase family protein	0.0071	0.1291	0.1175
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Onchocerca volvulus		0.0071	0.1291	1
Schistosoma mansoni	hypothetical protein	0.0166	0.3676	0.3676
Echinococcus multilocularis	somatostatin receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus granulosus	neuropeptide receptor A26	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1291	0.1291
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0395	0.0395
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0035	0.0395	0.0268
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0395	0.0395
Brugia malayi	Bromodomain containing protein	0.0073	0.1359	0.1245
Echinococcus granulosus	acetylcholinesterase	0.0418	1	1
Schistosoma mansoni	amine GPCR	0.0035	0.0395	0.0395
Onchocerca volvulus		0.0071	0.1291	1
Echinococcus multilocularis	acetylcholinesterase	0.0418	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0035	0.0395	0.0371
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Schistosoma mansoni	hypothetical protein	0.0035	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1254	0.1232
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	g-protein coupled receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus multilocularis	para nitrobenzyl esterase	0.0071	0.1291	0.1291
Schistosoma mansoni	hypothetical protein	0.002	0.0026	0.0026
Echinococcus granulosus	g-protein coupled receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	BC026374 protein (S09 family)	0.0071	0.1291	0.1291
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	dro:myosuppressin receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	biogenic amine 5HT receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Onchocerca volvulus		0.0071	0.1291	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0642	0.0642
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.0395	0.0395
Brugia malayi	sulfakinin receptor protein	0.0035	0.0395	0.0268
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0035	0.0395	0.0371
Schistosoma mansoni	neuropeptide f receptor 76f	0.0035	0.0395	0.0395
Echinococcus multilocularis	carboxylesterase 5A	0.0418	1	1
Onchocerca volvulus		0.0071	0.1291	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0035	0.0395	0.0395
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Echinococcus granulosus	para nitrobenzyl esterase	0.0071	0.1291	0.1291
Brugia malayi	neuropeptide F receptor	0.0035	0.0395	0.0268
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Schistosoma mansoni	hypothetical protein	0.0035	0.0395	0.0395
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus granulosus	allatostatin A receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0035	0.0395	0.0371
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0073	0.0073
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0642	0.0642
Brugia malayi	Dopamine receptor protein 1	0.0035	0.0395	0.0268
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0035	0.0395	0.0395
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus multilocularis	geminin	0.0166	0.3676	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	dro:myosuppressin receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	neuropeptide F-like receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Schistosoma mansoni	acetylcholinesterase	0.0071	0.1291	0.1291
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0401	0.0401
Loa Loa (eye worm)	carboxylesterase	0.0071	0.1291	0.1268
Loa Loa (eye worm)	carboxylesterase	0.0418	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1291	0.1268
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.0395	0.0395
Brugia malayi	larval opioid receptor	0.0035	0.0395	0.0268
Entamoeba histolytica	hypothetical protein	0.0035	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	bromodomain containing protein	0.0062	0.1072	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0461	0.0436
Echinococcus granulosus	acetylcholinesterase	0.0418	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1291	0.1268
Entamoeba histolytica	hypothetical protein	0.0035	0.0402	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0035	0.0395	0.0268
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0071	0.1291	0.1291
Schistosoma mansoni	hypothetical protein	0.0035	0.0395	0.0395
Echinococcus granulosus	orexin receptor type 2	0.0035	0.0395	0.0395
Loa Loa (eye worm)	carboxylesterase	0.0071	0.1291	0.1268
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0395	0.0395
Entamoeba histolytica	hypothetical protein	0.0035	0.0402	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0035	0.0395	0.0395
Schistosoma mansoni	hypothetical protein	0.0035	0.0395	0.0395
Echinococcus multilocularis	neuropeptide receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0566	0.0541
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0642	0.0642
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Echinococcus granulosus	serotonin receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.0395	0.0395
Mycobacterium ulcerans	carboxylesterase, LipT	0.0071	0.1291	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0035	0.0395	0.0395
Echinococcus multilocularis	fmrfamide receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	BC026374 protein S09 family	0.0071	0.1291	0.1291
Echinococcus multilocularis	serotonin receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	fmrfamide receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	neuropeptides capa receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	melatonin receptor type 1A	0.0035	0.0395	0.0371
Echinococcus granulosus	neuropeptide receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Brugia malayi	neuropeptide F receptor	0.0035	0.0395	0.0268
Echinococcus multilocularis	orexin receptor type 2	0.0035	0.0395	0.0395
Brugia malayi	GnHR receptor homolog	0.0035	0.0395	0.0268
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0402	0.0402
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Brugia malayi	Carboxylesterase family protein	0.0418	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.0395	0.0395
Echinococcus granulosus	neuropeptides capa receptor	0.0035	0.0395	0.0395
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Brugia malayi	Carboxylesterase family protein	0.0071	0.1291	0.1175
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0071	0.1291	0.1291
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1291	0.1291
Schistosoma mansoni	adenoreceptor	0.0035	0.0395	0.0395
Brugia malayi	G protein-coupled receptor	0.0035	0.0395	0.0268
Schistosoma mansoni	myosin xvIII	0.0035	0.0395	0.0395
Echinococcus granulosus	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	tm gpcr rhodopsin	0.0035	0.0395	0.0395
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus granulosus	neuroligin	0.0071	0.1291	0.1291
Schistosoma mansoni	gliotactin	0.0071	0.1291	0.1291
Loa Loa (eye worm)	hypothetical protein	0.0418	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Schistosoma mansoni	amine GPCR	0.0035	0.0395	0.0395
Brugia malayi	Bromodomain containing protein	0.0037	0.0459	0.0333
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Echinococcus granulosus	7TM GPCR rhodopsin	0.0035	0.0395	0.0395
Echinococcus granulosus	g protein coupled receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	geminin	0.0166	0.3676	0.3676
Brugia malayi	hypothetical protein	0.0071	0.1291	0.1175
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	acetylcholinesterase	0.0418	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0519	0.0494
Brugia malayi	hypothetical protein	0.0035	0.0395	0.0268
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0035	0.0395	0.0395
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0035	0.0395	0.0395
Echinococcus granulosus	neuropeptide receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0401	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0418	1	1
Echinococcus multilocularis	serotonin receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	allatostatin A receptor	0.0035	0.0395	0.0395
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0642	0.0642
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0035	0.0395	0.0395
Brugia malayi	RE15519p	0.0035	0.0395	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Brugia malayi	AKH receptor	0.0035	0.0395	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1291	0.1268
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	neuroligin	0.0071	0.1291	0.1291
Echinococcus granulosus	G protein coupled receptor 139	0.0035	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0984	0.0984
Echinococcus granulosus	somatostatin receptor	0.0035	0.0395	0.0395
Loa Loa (eye worm)	neuropeptide F receptor	0.0035	0.0395	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0395	0.0371
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0035	0.0395	0.0395
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	g protein coupled receptor	0.0035	0.0395	0.0395
Echinococcus multilocularis	neuropeptide s receptor	0.0035	0.0395	0.0395
Schistosoma mansoni	neuropeptide receptor	0.0035	0.0395	0.0395
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0071	0.1291	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 902114