TDR Targets

Basic information

Technical information

TDR Targets ID: 902462
Name: N-[5-(pentanoylamino)naphthalen-1-yl]pentanam ide
MW: 326.433 | Formula: C20H26N2O2
H donors: 2 H acceptors: 2 LogP: 4.26 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC(=O)Nc1cccc2c1cccc2NC(=O)CCCC
InChi: 1S/C20H26N2O2/c1-3-5-13-19(23)21-17-11-7-10-16-15(17)9-8-12-18(16)22-20(24)14-6-4-2/h7-12H,3-6,13-14H2,1-2H3,(H,21,23)(H,22,24)
InChiKey: AYECQZGFKHIBTK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[5-(pentanoylamino)-1-naphthyl]pentanamide
N-[5-(1-oxopentylamino)-1-naphthyl]pentanamide
N-[5-(valerylamino)-1-naphthyl]valeramide
AH-034/32473037
ZINC02023685

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0675	0.1598
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0113	0.3012	0.7127
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0328	0.0776
Echinococcus multilocularis	cathepsin b	0.0113	0.3012	0.2882
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0328	0.0776
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0026	0.0328	0.0776
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0312	0.8907
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0675	0.9034
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0026	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0153	0.4226	1
Loa Loa (eye worm)	cysteine protease	0.0021	0.0182	0.043
Brugia malayi	Inositol-1	0.0037	0.0675	0.1598
Entamoeba histolytica	hypothetical protein	0.0036	0.0646	0.956
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0026	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0328	0.0776
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0026	0.0328	0.0776
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0026	0.0328	0.5
Onchocerca volvulus		0.0021	0.0182	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0675	0.2242
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0026	0.0328	0.2583
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0328	0.0776
Trypanosoma cruzi	cysteine peptidase, putative	0.0021	0.0182	0.0603
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0555	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0312	0.2301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Loa Loa (eye worm)	hypothetical protein	0.0153	0.4226	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0026	0.0328	0.2583
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0037	0.0675	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Treponema pallidum	sodium- and chloride- dependent transporter	0.0153	0.4226	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.0153	0.4226	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0113	0.3012	0.7127
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0675	0.1598
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0675	0.0503
Entamoeba histolytica	cysteine proteinase, putative	0.0021	0.0182	0.269
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0026	0.0328	0.0776
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0021	0.0182	0.0182
Loa Loa (eye worm)	fibroinase	0.0021	0.0182	0.043
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0026	0.0328	0.0776
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0646	0.0472
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Echinococcus multilocularis	cathepsin b	0.0113	0.3012	0.2882
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0153	0.4226	1
Onchocerca volvulus		0.0021	0.0182	0.043
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0646	0.1528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Echinococcus multilocularis	serotonin transporter	0.0153	0.4226	0.4119
Onchocerca volvulus		0.0021	0.0182	0.043
Trypanosoma brucei	cysteine peptidase C (CPC)	0.004	0.0747	1
Brugia malayi	hypothetical protein	0.0016	0.0035	0.0083
Schistosoma mansoni	cathepsin F (C01 family)	0.0021	0.0182	0.043
Echinococcus granulosus	serotonin transporter	0.0153	0.4226	0.4226
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0312	0.8907
Leishmania major	hypothetical protein, conserved	0.0025	0.0312	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0182	0.043
Giardia lamblia	Cathepsin B precursor	0.004	0.0747	0.5
Entamoeba histolytica	hypothetical protein	0.0036	0.0646	0.956
Trypanosoma cruzi	cysteine peptidase, putative	0.0021	0.0182	0.0603
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0026	0.0328	0.0149
Echinococcus granulosus	cathepsin b	0.0113	0.3012	0.3012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0021	0.0182	0.043
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0182	0.043
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0328	0.0776
Loa Loa (eye worm)	hypothetical protein	0.005	0.1063	0.2516
Toxoplasma gondii	hypothetical protein	0.0026	0.0328	0.2583
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0113	0.3012	1
Entamoeba histolytica	cysteine protease, putative	0.0021	0.0182	0.269
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0026	0.0328	0.0149
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0312	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Brugia malayi	hypothetical protein	0.0036	0.0646	0.1528
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0026	0.0328	0.0776
Onchocerca volvulus	Cathepsin L homolog	0.0021	0.0182	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Schistosoma mansoni	hypothetical protein	0.0036	0.0646	0.1528
Schistosoma mansoni	cathepsin F (C01 family)	0.0021	0.0182	0.043
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0026	0.0328	0.0776
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0021	0.0182	0.243
Onchocerca volvulus	Cathepsin L homolog	0.0021	0.0182	0.043
Loa Loa (eye worm)	serotonin transporter b	0.0153	0.4226	1
Toxoplasma gondii	cathepsin B	0.004	0.0747	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0328	0.0776
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0675	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Brugia malayi	hypothetical protein	0.0026	0.0328	0.0776
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0026	0.0328	0.0328
Onchocerca volvulus		0.0026	0.0328	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0328	0.0776
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0153	0.4226	1
Echinococcus granulosus	cathepsin b	0.0113	0.3012	0.3012
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0328	0.0776
Loa Loa (eye worm)	ctsf protein	0.0021	0.0182	0.043
Onchocerca volvulus		0.0026	0.0328	0.0776
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.004	0.0747	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.004	0.0747	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0113	0.3012	0.7127
Onchocerca volvulus		0.0021	0.0182	0.043
Echinococcus multilocularis	tumor protein p63	0.0341	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0113	0.3012	0.7127
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0328	0.0776
Brugia malayi	Papain family cysteine protease containing protein	0.0021	0.0182	0.043
Loa Loa (eye worm)	norepinephrine transporter	0.0153	0.4226	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0021	0.0182	0.0603
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0646	0.0646
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0182	0.043
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0113	0.3012	0.7127
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0675	0.8723
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0328	0.0776
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0675	0.2242
Onchocerca volvulus		0.0021	0.0182	0.043
Echinococcus granulosus	sodium and chloride dependent glycine	0.0026	0.0328	0.0328
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0021	0.0182	0.243
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0328	0.0776
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0026	0.0328	0.0149
Plasmodium vivax	amine transporter, putative	0.0026	0.0328	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0026	0.0328	0.0328
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0312	0.1035
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0675	0.8723
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0675	0.9034
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0555	0.5
Brugia malayi	hypothetical protein	0.0025	0.0312	0.0738
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0675	0.0675
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.1063	0.2516
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.004	0.0747	0.2482
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0113	0.3012	0.7127
Echinococcus granulosus	cathepsin l1	0.0021	0.0182	0.0182
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0182	0.043
Plasmodium falciparum	amino acid transporter, putative	0.0026	0.0328	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0328	0.0776
Toxoplasma gondii	hypothetical protein	0.0026	0.0328	0.2583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0328	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0021	0.0182	0.243
Onchocerca volvulus	Cathepsin F homolog	0.0021	0.0182	0.043
Loa Loa (eye worm)	inositol-1	0.0037	0.0675	0.1598
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0182	0.043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Onchocerca volvulus		0.0021	0.0182	0.043
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0021	0.0182	0.0182
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.004	0.0747	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0312	0.1035
Entamoeba histolytica	hypothetical protein	0.0036	0.0646	0.956
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0182	0.243
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0021	0.0182	0.043
Giardia lamblia	Cathepsin B precursor	0.004	0.0747	0.5
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0328	0.0776
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0675	0.5
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0026	0.0328	0.0149
Onchocerca volvulus		0.005	0.1063	0.2516
Trypanosoma cruzi	cysteine peptidase, putative	0.0021	0.0182	0.0603
Entamoeba histolytica	hypothetical protein	0.0036	0.0646	0.956
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0312	0.0738
Onchocerca volvulus		0.0021	0.0182	0.043
Schistosoma mansoni	sodium/chloride dependent transporter	0.0026	0.0328	0.0776
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0328	0.0776
Onchocerca volvulus		0.0153	0.4226	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0026	0.0328	0.0149
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0026	0.0328	0.2583
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0328	0.0776
Loa Loa (eye worm)	cathepsin B	0.004	0.0747	0.1769
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0182	0.043
Giardia lamblia	Cathepsin B precursor	0.004	0.0747	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.0026	0.0328	0.0776
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0182	0.043
Trypanosoma cruzi	cysteine peptidase, putative	0.0021	0.0182	0.0603
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0153	0.4226	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0675	0.9034
Loa Loa (eye worm)	hypothetical protein	0.0153	0.4226	1
Echinococcus granulosus	sodium and chloride dependent glycine	0.0026	0.0328	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0328	0.0776
Plasmodium falciparum	transporter, putative	0.0026	0.0328	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0675	0.8723
Entamoeba histolytica	cysteine proteinase, putative	0.0021	0.0182	0.269
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0312	0.8907
Onchocerca volvulus		0.0026	0.0328	0.0776

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 902462