Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0866 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0023 | 0.0866 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0059 | 0.4565 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4565 | 0.921 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.009 | 0.7807 | 0.7807 |
Brugia malayi | RNA binding protein | 0.0059 | 0.4565 | 0.4565 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1391 | 0.0575 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0028 | 0.1391 | 0.1391 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0023 | 0.0866 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0059 | 0.4565 | 0.4565 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0866 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0059 | 0.4565 | 0.405 |
Echinococcus multilocularis | tar DNA binding protein | 0.0059 | 0.4565 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.7807 | 0.7599 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0061 | 0.4837 | 0.4837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4565 | 0.921 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0028 | 0.1391 | 0.0575 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0028 | 0.1391 | 0.1391 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4565 | 0.921 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0023 | 0.0866 | 0.5 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0866 | 0.0866 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.4837 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0059 | 0.4565 | 0.4565 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0111 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0059 | 0.4565 | 0.405 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0023 | 0.0866 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.009 | 0.7807 | 0.7599 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4565 | 0.921 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.009 | 0.7807 | 0.7807 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0023 | 0.0866 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.4837 | 0.4348 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0059 | 0.4565 | 0.405 |
Schistosoma mansoni | tar DNA-binding protein | 0.0059 | 0.4565 | 0.921 |
Leishmania major | hypothetical protein, conserved | 0.0023 | 0.0866 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.