Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0271 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0031 | 0.0016 |
Onchocerca volvulus | 0.0164 | 0.4184 | 1 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0136 | 0.3352 | 0.5833 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0031 | 0.0016 |
Brugia malayi | Amidase family protein | 0.0026 | 0.0183 | 0.0282 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0061 | 0.0039 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0026 | 0.0183 | 0.0161 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0026 | 0.0183 | 0.0183 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0026 | 0.0183 | 1 |
Brugia malayi | amidase | 0.0218 | 0.5731 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0218 | 0.5731 | 0.5721 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0032 | 0.0342 | 0.056 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0342 | 0.032 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0218 | 0.5731 | 0.5721 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0029 | 0.0271 | 0.025 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0365 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0026 | 0.0183 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0241 | 0.0219 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0136 | 0.3352 | 0.5833 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0098 | 0.225 | 0.225 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0218 | 0.5731 | 0.5721 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3352 | 0.3337 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3352 | 0.3337 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0026 | 0.0183 | 0.0183 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0026 | 0.0183 | 0.5 |
Brugia malayi | putative amidase | 0.0026 | 0.0183 | 0.0282 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0022 | 0.0061 | 0.0061 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0026 | 0.0183 | 1 |
Schistosoma mansoni | patched 1 | 0.0029 | 0.0271 | 0.025 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0241 | 0.0219 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0061 | 0.0069 |
Echinococcus multilocularis | expressed conserved protein | 0.0064 | 0.1281 | 0.1262 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0032 | 0.0342 | 0.0342 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0069 | 0.1432 | 0.1413 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0029 | 0.0271 | 0.0271 |
Loa Loa (eye worm) | amidase | 0.0026 | 0.0183 | 0.0282 |
Brugia malayi | TAR-binding protein | 0.0136 | 0.3352 | 0.5833 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0218 | 0.5731 | 0.5731 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0246 | 0.6537 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0033 | 0.0391 | 0.037 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.012 | 0.2897 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1401 | 0.2416 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0026 | 0.0183 | 0.0161 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0241 | 0.0219 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3352 | 0.3337 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Brugia malayi | RNA binding protein | 0.0136 | 0.3352 | 0.5833 |
Trichomonas vaginalis | set domain proteins, putative | 0.0164 | 0.4184 | 0.6245 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.1401 | 0.1382 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0032 | 0.0342 | 0.032 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0068 | 0.1401 | 0.2416 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0026 | 0.0183 | 0.0161 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0218 | 0.5731 | 0.5731 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3352 | 0.3337 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0136 | 0.3352 | 0.5833 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0342 | 0.032 |
Trypanosoma cruzi | amidase, putative | 0.0026 | 0.0183 | 1 |
Brugia malayi | CHE-14 protein | 0.0029 | 0.0271 | 0.0437 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0026 | 0.0183 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0145 | 0.3606 | 0.6278 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0029 | 0.0271 | 0.0271 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0068 | 0.1401 | 0.2069 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0032 | 0.0342 | 0.032 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.5731 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0136 | 0.3352 | 0.3337 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.012 | 0.2897 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0032 | 0.0342 | 0.056 |
Loa Loa (eye worm) | amidase | 0.0026 | 0.0183 | 0.0282 |
Schistosoma mansoni | amidase | 0.0218 | 0.5731 | 0.5721 |
Brugia malayi | Amidase family protein | 0.0026 | 0.0183 | 0.0282 |
Echinococcus multilocularis | protein patched | 0.0029 | 0.0271 | 0.025 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0145 | 0.3606 | 0.6278 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0241 | 0.0219 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0136 | 0.3352 | 0.3352 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0183 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0022 | 0.0061 | 0.0039 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0246 | 0.6537 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0021 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | RNA binding protein | 0.0136 | 0.3352 | 0.5833 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0032 | 0.0342 | 0.032 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0109 | 0.2581 | 0.8836 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0109 | 0.2581 | 0.8836 |
Trypanosoma cruzi | amidase, putative | 0.0026 | 0.0183 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0029 | 0.0271 | 0.0437 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0026 | 0.0183 | 0.0161 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0246 | 0.6537 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.012 | 0.2897 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0021 | 0.0031 | 0.0555 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.1401 | 0.1401 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0462 | 0.0771 |
Echinococcus multilocularis | tar DNA binding protein | 0.0136 | 0.3352 | 0.3337 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0098 | 0.225 | 0.2233 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0032 | 0.0342 | 0.0342 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0021 | 0.0031 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0064 | 0.1281 | 0.1281 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0022 | 0.0061 | 0.0039 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0365 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.