Detailed information for compound 902936

Basic information

Technical information
  • TDR Targets ID: 902936
  • Name: 2-(4-cyano-2-ethoxyphenoxy)-N-(phenylmethyl)a cetamide
  • MW: 310.347 | Formula: C18H18N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.79 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C#N)ccc1OCC(=O)NCc1ccccc1
  • InChi: 1S/C18H18N2O3/c1-2-22-17-10-15(11-19)8-9-16(17)23-13-18(21)20-12-14-6-4-3-5-7-14/h3-10H,2,12-13H2,1H3,(H,20,21)
  • InChiKey: FOAHAPCACCBBJG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-cyano-2-ethoxy-phenoxy)-N-(phenylmethyl)acetamide
  • N-(benzyl)-2-(4-cyano-2-ethoxy-phenoxy)acetamide
  • 2-(4-cyano-2-ethoxy-phenoxy)-N-(phenylmethyl)ethanamide
  • ZINC04858000

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0037 0.0032 0.0053
Loa Loa (eye worm) hypothetical protein 0.0075 0.0255 0.028
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0118 0.0499 0.0823
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0034 0.0012 0.0012
Echinococcus multilocularis PWWP domain containing protein 2A 0.0118 0.0499 0.0823
Schistosoma mansoni methylthioadenosine phosphorylase 0.0858 0.4796 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Schistosoma mansoni protein arginine n-methyltransferase 0.016 0.0742 0.1547
Mycobacterium ulcerans spermidine synthase 0.0849 0.4741 0.9865
Plasmodium falciparum purine nucleoside phosphorylase 0.0159 0.0739 0.1212
Brugia malayi NNMT/PNMT/TEMT family protein 0.0986 0.5536 0.6089
Loa Loa (eye worm) hypothetical protein 0.0065 0.0195 0.0215
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0205 0.0225
Brugia malayi SET domain containing protein 0.0054 0.0129 0.0141
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Echinococcus granulosus PWWP domain containing protein 2A 0.0118 0.0499 0.0823
Trichomonas vaginalis set domain proteins, putative 0.1755 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0739 0.0739
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0025
Entamoeba histolytica hypothetical protein 0.0065 0.0195 0.0677
Brugia malayi PHD-finger family protein 0.0032 0.0005 0.0005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0172 0.0814 0.2112
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0133 0.0588 0.097
Echinococcus granulosus uridine phosphorylase 1 0.0159 0.0739 0.1219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0032
Schistosoma mansoni histone J3 methyltransferase 0.0779 0.4333 0.9036
Schistosoma mansoni purine nucleoside phosphorylase 0.0159 0.0739 0.154
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0739 0.2562
Brugia malayi SET domain containing protein 0.0151 0.069 0.0759
Brugia malayi SET domain containing protein 0.0134 0.0592 0.0651
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0055 0.0114
Brugia malayi MTAP 0.0858 0.4796 0.5274
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0005 0.001
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0099 0.039 0.0644
Brugia malayi ELM2 domain containing protein 0.0037 0.0029 0.0032
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0363 0.1922 0.2114
Echinococcus multilocularis disco interacting protein 2 0.0317 0.1654 0.2729
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0159 0.0739 0.2562
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0159 0.0739 0.1219
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.016 0.0742 0.1224
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0078 0.0129
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Leishmania major methylthioadenosine phosphorylase, putative 0.0858 0.4796 0.7912
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Treponema pallidum uridine phosphorylase (udp) 0.0159 0.0739 0.5
Schistosoma mansoni bromo adjacent homology domain containing 0.0037 0.0029 0.006
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0528 0.2882 0.4756
Brugia malayi polybromodomain protein 0.0037 0.0029 0.0032
Schistosoma mansoni enhancer of zeste ezh 0.0313 0.1633 0.3406
Loa Loa (eye worm) SET domain-containing protein 0.0313 0.1633 0.1796
Brugia malayi SET domain containing protein 0.0313 0.1633 0.1796
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0037 0.0029 0.0047
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0779 0.4333 0.4766
Echinococcus multilocularis histone h3 methyltransferase 0.0779 0.4333 0.7149
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.0432 0.0713
Echinococcus granulosus histone arginine methyltransferase CARMER 0.016 0.0742 0.1224
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0077 0.0266 0.0439
Brugia malayi hypothetical protein 0.0363 0.1922 0.2114
Schistosoma mansoni suppressor of variegation 4-20-related 0.0151 0.069 0.1439
Mycobacterium leprae probable uridine phosphorylase 0.0159 0.0739 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1599 0.9092 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0159 0.0739 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0237 0.1193 0.1968
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0151 0.069 0.1139
Toxoplasma gondii Purine nucleoside phosphorylase 0.0159 0.0739 0.1917
Loa Loa (eye worm) hypothetical protein 0.0037 0.0032 0.0035
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0151 0.069 0.1139
Onchocerca volvulus 0.0128 0.0559 0.0554
Leishmania major histone-lysine N-methyltransferase, putative 0.0099 0.039 0.0644
Trypanosoma cruzi spermidine synthase, putative 0.1076 0.6061 1
Brugia malayi Disco-interacting protein 2 homolog 0.0317 0.1654 0.1819
Trypanosoma brucei transcription elongation factor s-II, putative 0.0118 0.0499 0.0823
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0739 0.0739
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0657 0.3627 0.3989
Schistosoma mansoni phd finger protein 0.0118 0.0499 0.104
Brugia malayi Bromodomain containing protein 0.0032 0.0005 0.0005
Echinococcus multilocularis spermidine synthase 0.1076 0.6061 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0537 0.0591
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0005 0.0008
Schistosoma mansoni uridine phosphorylase 0.0159 0.0739 0.154
Loa Loa (eye worm) hypothetical protein 0.0118 0.0502 0.0553
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0317 0.1654 0.3449
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0858 0.4796 0.7912
Trypanosoma cruzi spermidine synthase, putative 0.1076 0.6061 1
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0739 0.0739
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0858 0.4796 0.7912
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0099 0.039 0.0644
Toxoplasma gondii phosphorylase family protein 0.0159 0.0739 0.1917
Entamoeba histolytica hypothetical protein 0.0159 0.0739 0.2562
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0037 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.0237 0.1193 0.1312
Loa Loa (eye worm) Carm1-pending protein 0.016 0.0742 0.0816
Onchocerca volvulus 0.029 0.15 0.1496
Leishmania major modification methylase-like protein 0.0528 0.2882 0.4756
Brugia malayi uridine phosphorylase family protein 0.0159 0.0739 0.0812
Schistosoma mansoni purine nucleoside phosphorylase 0.0159 0.0739 0.154
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0037 0.0029 0.006
Brugia malayi jmjC domain containing protein 0.0041 0.0055 0.006
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0159 0.0739 0.1219
Onchocerca volvulus 0.0317 0.1654 0.165
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0159 0.0739 0.1212
Loa Loa (eye worm) hypothetical protein 0.0118 0.0499 0.0549
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0078 0.0129
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0739 0.2562
Schistosoma mansoni hypothetical protein 0.0188 0.0909 0.1895
Schistosoma mansoni cpg binding protein 0.0309 0.1609 0.3356
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0034 0.0012 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0237 0.1193 0.2488
Echinococcus granulosus histone h3 methyltransferase 0.0779 0.4333 0.7149
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0099 0.039 0.0644
Echinococcus granulosus microtubule associated protein 2 0.0761 0.4233 0.6984
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0159 0.0739 0.0739
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0065 0.0195 0.0322
Echinococcus granulosus PWWP domain containing protein 2A 0.0118 0.0499 0.0823
Trypanosoma cruzi spermidine synthase, putative 0.1076 0.6061 1
Schistosoma mansoni jumonji domain containing protein 0.0084 0.0306 0.0637
Loa Loa (eye worm) hypothetical protein 0.0032 0.0005 0.0005
Onchocerca volvulus 0.0307 0.1599 0.1595
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0237 0.1193 0.1968
Schistosoma mansoni hypothetical protein 0.0037 0.0029 0.006
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0696 0.3853 0.6354
Brugia malayi hypothetical protein 0.0363 0.1922 0.2114
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0044 0.0073
Echinococcus multilocularis cpg binding protein 0.0309 0.1609 0.2655
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0055 0.009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0029 0.0032
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0657 0.3627 0.5984
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0858 0.4796 0.7912
Loa Loa (eye worm) hypothetical protein 0.0038 0.0039 0.0043
Leishmania major S-adenosylmethionine decarboxylase 0.0657 0.3627 0.5984
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Toxoplasma gondii hypothetical protein 0.0118 0.0499 0.1295
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0657 0.3627 0.5984
Brugia malayi hypothetical protein 0.0118 0.0499 0.0549
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0037 0.0029 0.006
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0858 0.4796 1
Schistosoma mansoni uridine phosphorylase 0.0159 0.0739 0.154
Schistosoma mansoni SET domain protein 0.0135 0.0599 0.1248
Echinococcus granulosus disco interacting protein 2 0.0317 0.1654 0.2729
Trypanosoma cruzi spermidine synthase, putative 0.1076 0.6061 1
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0528 0.2882 1
Schistosoma mansoni hepatoma derived growth factor 0.0118 0.0499 0.104
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0159 0.0739 1
Echinococcus granulosus cpg binding protein 0.0309 0.1609 0.2655
Brugia malayi hypothetical protein 0.0065 0.0195 0.0215
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0657 0.3627 0.5984
Loa Loa (eye worm) uridine phosphorylase 0.0159 0.0739 0.0812
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0159 0.0739 0.1219
Schistosoma mansoni polybromo-1 0.0037 0.0029 0.006
Onchocerca volvulus 0.0118 0.0499 0.0495
Echinococcus granulosus methylthioadenosine phosphorylase 0.0858 0.4796 0.7912
Trypanosoma brucei spermidine synthase 0.1076 0.6061 1
Brugia malayi GATA zinc finger family protein 0.0037 0.0029 0.0032
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0528 0.2882 0.7481
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.029 0.15 0.3127
Echinococcus granulosus bromo adjacent y domain containing 1 0.0037 0.0029 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0499 0.0823
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0159 0.0739 0.0812
Echinococcus granulosus peregrin 0.015 0.0687 0.1133
Loa Loa (eye worm) spermidine synthase 0.1076 0.6061 0.6666
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0194 0.094 0.1551
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0739 0.0739
Giardia lamblia UPL-1 0.0159 0.0739 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0075 0.025 0.065
Echinococcus multilocularis metastasis associated protein MTA1 0.0037 0.0029 0.0047
Trypanosoma brucei histone-lysine n-methyltransferase 0.0099 0.039 0.0644
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0159 0.0739 1
Schistosoma mansoni microtubule-associated protein tau 0.0761 0.4233 0.8828
Loa Loa (eye worm) SET domain-containing protein 0.0151 0.069 0.0759
Leishmania major hypothetical protein, conserved 0.0099 0.039 0.0644
Loa Loa (eye worm) hypothetical protein 0.0779 0.4333 0.4766
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0005 0.0005
Brugia malayi Carm1-pending protein 0.016 0.0742 0.0816
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0657 0.3627 0.5984
Leishmania major hypothetical protein, conserved 0.0099 0.039 0.0644
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0739 0.0739
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0012 0.0012
Echinococcus granulosus geminin 0.0188 0.0909 0.1499
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0093 0.0356 0.0579
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.002 0.0022
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.032 0.1673 0.2754
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0005 0.0008
Schistosoma mansoni cpg binding protein 0.0307 0.1599 0.3334
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0118 0.0499 0.0823
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0528 0.2882 0.6011
Trypanosoma brucei uridine phosphorylase 0.0159 0.0739 0.1219
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0065 0.0195 0.0677
Loa Loa (eye worm) PWWP domain-containing protein 0.0118 0.0499 0.0549
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0739 0.0739
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0093 0.0356 0.0579
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0739 0.0739
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0037 0.0029 0.0047
Echinococcus granulosus DNA methyltransferase 2, putative 0.0528 0.2882 0.4756
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0034 0.0012 0.002
Echinococcus multilocularis PWWP domain containing protein 2A 0.0118 0.0499 0.0823
Loa Loa (eye worm) hypothetical protein 0.0986 0.5536 0.6089
Plasmodium vivax spermidine synthase, putative 0.1076 0.6061 1
Schistosoma mansoni hepatoma derived growth factor 0.0118 0.0499 0.104
Toxoplasma gondii hypothetical protein 0.0696 0.3853 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Plasmodium falciparum spermidine synthase 0.1076 0.6061 1
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0118 0.0499 0.0823
Leishmania major nucleoside phosphorylase-like protein 0.0159 0.0739 0.1219
Echinococcus granulosus protein arginine N methyltransferase 8 0.0034 0.0012 0.002
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0065 0.0195 0.0322
Onchocerca volvulus 0.0363 0.1922 0.1919
Plasmodium vivax SET domain protein, putative 0.0172 0.0814 0.1336
Toxoplasma gondii DNA methyltransferase 2, putative 0.0528 0.2882 0.7481
Echinococcus multilocularis polybromo 1 0.0037 0.0029 0.0047
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0986 0.5536 0.6089
Schistosoma mansoni methylthioadenosine phosphorylase 0.0159 0.0739 0.154
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0037 0.0032 0.0053
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0699 0.3874 0.7834
Schistosoma mansoni hypothetical protein 0.0057 0.0148 0.0308
Schistosoma mansoni cpg binding protein 0.0309 0.1609 0.3356
Brugia malayi hypothetical protein 0.0118 0.0499 0.0549
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0528 0.2882 0.4752
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0739 0.2562
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0009 0.0019
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0172 0.0814 0.1343
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0082 0.0292 0.0609
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0858 0.4796 0.7912
Schistosoma mansoni hypothetical protein 0.0118 0.0499 0.104
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0849 0.4741 1
Entamoeba histolytica hypothetical protein 0.0118 0.0499 0.1731
Leishmania major hypothetical protein, conserved 0.0118 0.0499 0.0823
Toxoplasma gondii phosphorylase family protein 0.0159 0.0739 0.1917
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0037 0.0029 0.006
Echinococcus granulosus metastasis associated protein 1 mta1 0.0037 0.0029 0.0047
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0055 0.006
Echinococcus granulosus polybromo 1 0.0037 0.0029 0.0047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0307 0.1599 0.1758
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.016 0.0742 0.1926
Loa Loa (eye worm) hypothetical protein 0.0056 0.0139 0.0153
Chlamydia trachomatis AMP nucleosidase 0.0159 0.0739 0.5
Brugia malayi jmjC domain containing protein 0.0106 0.0432 0.0475
Schistosoma mansoni hypothetical protein 0.0188 0.0909 0.1895
Echinococcus granulosus purine nucleoside phosphorylase 0.0159 0.0739 0.1219
Brugia malayi PWWP domain containing protein 0.0118 0.0499 0.0549
Echinococcus multilocularis geminin 0.0188 0.0909 0.1499
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0657 0.3627 0.3989
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0528 0.2882 0.4756
Treponema pallidum pfs protein (pfs) 0.0159 0.0739 0.5
Echinococcus multilocularis uridine phosphorylase 1 0.0159 0.0739 0.1219
Trichomonas vaginalis origin recognition complex subunit, putative 0.0037 0.0029 0.0029
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0313 0.1633 0.2695
Leishmania major spermidine synthase 0.1076 0.6061 1
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0657 0.3627 0.5984
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0037 0.0029 0.0047
Echinococcus granulosus metastasis associated protein MTA1 0.0037 0.0029 0.0047
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0065 0.0195 0.0322
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0099 0.039 0.0644
Brugia malayi Pre-SET motif family protein 0.0209 0.1029 0.1132
Loa Loa (eye worm) hypothetical protein 0.0317 0.1654 0.1819
Loa Loa (eye worm) hypothetical protein 0.0363 0.1922 0.2114
Toxoplasma gondii hypothetical protein 0.0099 0.039 0.1013
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0657 0.3627 0.5984
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0739 0.0739
Echinococcus granulosus hepatoma derived growth factor protein 0.0118 0.0499 0.0823
Trichomonas vaginalis CDC6, putative 0.0037 0.0029 0.0029
Echinococcus multilocularis peregrin 0.015 0.0687 0.1133
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0005 0.0012
Leishmania major arginine N-methyltransferase-like protein 0.0034 0.0012 0.002
Onchocerca volvulus 0.0118 0.0499 0.0495
Schistosoma mansoni hypothetical protein 0.0032 0.0005 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0237 0.1193 0.2488
Brugia malayi Spermidine synthase 0.1076 0.6061 0.6666
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0159 0.0739 0.0734
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0739 0.2562
Echinococcus multilocularis hepatoma derived growth factor protein 0.0118 0.0499 0.0823
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0005 0.0012
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0037 0.0029 0.0047
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0055 0.0114
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0159 0.0739 1
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0099 0.039 0.0644
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0099 0.039 0.0644
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0858 0.4796 0.5274
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0012 0.0025
Echinococcus granulosus protein arginine methyltransferase 0.0034 0.0012 0.002
Echinococcus multilocularis microtubule associated protein 2 0.0761 0.4233 0.6984
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.032 0.1673 0.2754
Echinococcus granulosus spermidine synthase 0.1076 0.6061 1
Schistosoma mansoni hypothetical protein 0.0118 0.0499 0.104
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0159 0.0739 0.2562
Schistosoma mansoni methylthioadenosine phosphorylase 0.0858 0.4796 1
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0034 0.0012 0.0012
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0159 0.0739 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0172 0.0814 0.1697
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.0499 0.0823
Brugia malayi CXXC zinc finger family protein 0.0307 0.1599 0.1758
Brugia malayi Pre-SET motif family protein 0.1599 0.9092 1
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0528 0.2882 0.4752
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.0432 0.0713
Echinococcus multilocularis protein arginine methyltransferase 0.0034 0.0012 0.002
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0313 0.1633 0.2695
Echinococcus granulosus SET and MYND domain containing protein 3 0.0077 0.0266 0.0439
Loa Loa (eye worm) hypothetical protein 0.0986 0.5536 0.6089
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0657 0.3627 0.5984
Loa Loa (eye worm) hypothetical protein 0.0363 0.1922 0.2114
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0133 0.0588 0.097
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0159 0.0739 0.0739
Schistosoma mansoni hypothetical protein 0.0118 0.0499 0.104

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.