Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0192 | 0.314 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0144 | 0.0144 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0121 | 0.0121 |
Echinococcus multilocularis | hexokinase | 0.1659 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0197 | 0.0197 |
Onchocerca volvulus | 0.1659 | 1 | 1 | |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0179 | 0.0179 |
Echinococcus multilocularis | expressed conserved protein | 0.0089 | 0.044 | 0.044 |
Brugia malayi | Hexokinase family protein | 0.1041 | 0.6235 | 0.6235 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.0484 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Plasmodium falciparum | hexokinase | 0.1659 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0144 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1131 | 0.6787 | 0.6787 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hexokinase | 0.1041 | 0.6235 | 0.6235 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0136 | 0.0723 | 0.0723 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0197 | 0.4744 |
Loa Loa (eye worm) | hexokinase type II | 0.1659 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0893 | 0.0893 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.0356 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0144 | 0.0144 |
Onchocerca volvulus | 0.0049 | 0.0192 | 0.0013 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0049 | 0.0192 | 0.314 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0315 | 0.0315 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.1287 | 0.1287 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0192 | 0.0192 |
Brugia malayi | hypothetical protein | 0.0228 | 0.1287 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0192 | 0.0192 |
Loa Loa (eye worm) | hexokinase | 0.1659 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0315 | 0.0315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0144 | 0.0144 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.0527 | 0.3108 | 0.3108 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.0117 | 0.5934 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0315 | 0.0315 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0144 | 0.0144 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.0356 |
Treponema pallidum | hexokinase (hxk) | 0.1659 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0356 | 0.0356 |
Echinococcus granulosus | hexokinase type 2 | 0.1659 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0356 | 1 |
Brugia malayi | Hexokinase family protein | 0.1659 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0192 | 0.0192 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0197 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0225 | 0.0225 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0197 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0192 | 0.0192 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0192 | 0.0192 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0049 | 0.0192 | 0.9738 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0054 | 0.0054 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0049 | 0.0192 | 0.9738 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0095 | 0.0475 | 0.0475 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0144 | 0.0144 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.0192 | 0.4572 |
Toxoplasma gondii | hexokinase | 0.1659 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0527 | 0.3108 | 0.3108 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0054 | 0.0054 |
Echinococcus granulosus | geminin | 0.0164 | 0.0893 | 0.0893 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0475 | 0.0475 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0117 | 0.0117 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0315 | 0.0315 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0049 | 0.0192 | 0.4572 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0121 | 0.0121 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0192 | 0.314 |
Onchocerca volvulus | Hexokinase homolog | 0.1041 | 0.6235 | 0.6166 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0225 | 0.0225 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0049 | 0.0192 | 0.314 |
Trypanosoma cruzi | hexokinase, putative | 0.1659 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0513 | 0.3022 | 0.3022 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0356 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0893 | 0.0893 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0315 | 0.0315 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0356 | 0.0356 |
Trypanosoma brucei | hexokinase | 0.1659 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0192 | 0.0192 |
Echinococcus granulosus | expressed conserved protein | 0.0089 | 0.044 | 0.044 |
Trypanosoma brucei | hexokinase | 0.1659 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0315 | 0.0315 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0136 | 0.0723 | 0.0723 |
Echinococcus granulosus | hexokinase | 0.1659 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0315 | 0.0315 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0144 | 0.0144 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0105 | 0.532 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.1287 | 0.1287 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0197 | 0.0197 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0095 | 0.0475 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0527 | 0.3108 | 0.3108 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0095 | 0.0475 | 0.0475 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0049 | 0.0192 | 0.314 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0095 | 0.0475 | 0.0475 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.1287 | 0.1287 |
Echinococcus multilocularis | hexokinase | 0.1659 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0315 | 0.0315 |
Onchocerca volvulus | 0.1041 | 0.6235 | 0.6166 | |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0356 | 0.0356 |
Trypanosoma brucei | hexokinase, putative | 0.1659 | 1 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0105 | 0.532 |
Onchocerca volvulus | 0.1659 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.1659 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Entamoeba histolytica | hexokinase 1 | 0.1659 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.1659 | 1 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0049 | 0.0192 | 0.314 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0144 | 0.0144 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.0117 | 0.0117 |
Echinococcus granulosus | hexokinase | 0.1659 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0179 | 0.0179 |
Onchocerca volvulus | 0.1659 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0513 | 0.3022 | 0.3022 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0179 | 0.0179 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.0117 | 0.0117 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0105 | 0.532 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0356 | 0.0356 |
Brugia malayi | AMP-binding enzyme family protein | 0.0049 | 0.0192 | 0.0192 |
Echinococcus multilocularis | hexokinase | 0.1659 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0049 | 0.0192 | 0.314 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0026 | 0.0054 | 0.0054 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.162 | 0.9763 | 0.9763 |
Leishmania major | hexokinase, putative | 0.1659 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.1659 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1659 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.1659 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.1659 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0144 | 0.0144 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0049 | 0.0192 | 0.0192 |
Trypanosoma cruzi | hexokinase, putative | 0.1659 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.02 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0192 | 0.0192 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 0.0303 |
Schistosoma mansoni | hexokinase | 0.1659 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0105 | 0.532 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0049 | 0.0192 | 0.314 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0356 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0315 | 0.0315 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0225 | 0.0225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.