Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0063 | 0.0633 | 1 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0063 | 0.0633 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0063 | 0.0633 | 0.0681 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0543 | 0.6088 | 0.6553 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0063 | 0.0633 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0063 | 0.0633 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0063 | 0.0633 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0063 | 0.0633 | 0.0633 |
Echinococcus multilocularis | 0.0063 | 0.0633 | 1 | |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0063 | 0.0633 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0826 | 0.929 | 1 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0007 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0063 | 0.0633 | 1 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0063 | 0.0633 | 0.0633 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0063 | 0.0633 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0063 | 0.0633 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0007 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0063 | 0.0633 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0063 | 0.0633 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0063 | 0.0633 | 0.0633 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0063 | 0.0633 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0063 | 0.0633 | 1 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.0543 | 0.6088 | 0.6088 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0633 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0063 | 0.0633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0633 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0063 | 0.0633 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0063 | 0.0633 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0063 | 0.0633 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0063 | 0.0633 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0063 | 0.0633 | 0.0681 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0888 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0633 | 1 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0633 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0063 | 0.0633 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0633 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0063 | 0.0633 | 0.0633 |
Brugia malayi | SWIRM domain containing protein | 0.0063 | 0.0633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0633 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0063 | 0.0633 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0063 | 0.0633 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0633 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0063 | 0.0633 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0063 | 0.0633 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0063 | 0.0633 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.