Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0083 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0181 | 0.1034 | 0.1034 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.074 | 0.4684 | 0.4684 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1034 | 0.1034 |
Brugia malayi | Probable ClpP-like protease | 0.0327 | 0.1989 | 0.1989 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0181 | 0.1034 | 0.2515 |
Schistosoma mansoni | tar DNA-binding protein | 0.0652 | 0.411 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0652 | 0.411 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0083 | 0.0201 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0182 | 0.0443 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0083 | 0.0083 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0158 | 0.0883 | 0.2147 |
Schistosoma mansoni | tar DNA-binding protein | 0.0652 | 0.411 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0113 | 0.059 | 0.059 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0327 | 0.1989 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0181 | 0.1034 | 0.2515 |
Schistosoma mansoni | tar DNA-binding protein | 0.0652 | 0.411 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.074 | 0.4684 | 0.4684 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0113 | 0.0589 | 0.2159 |
Loa Loa (eye worm) | pip kinase 2 | 0.0158 | 0.0883 | 0.0883 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1034 | 0.2515 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0113 | 0.059 | 0.1435 |
Schistosoma mansoni | phosphatidylinositol-4-phosphate 5-kinase type II | 0.0158 | 0.0883 | 0.2147 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0327 | 0.1989 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0182 | 0.0443 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0113 | 0.059 | 0.1435 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0572 | 0.3585 | 0.3585 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1034 | 0.2515 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 0.484 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0327 | 0.1989 | 0.484 |
Brugia malayi | Pip kinase protein 2 | 0.0158 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | RNA binding protein | 0.0652 | 0.411 | 0.411 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0113 | 0.059 | 0.1435 |
Brugia malayi | MH1 domain containing protein | 0.0028 | 0.0035 | 0.0035 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0215 | 0.1253 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0113 | 0.059 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0181 | 0.1034 | 0.2515 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0024 | 0.001 | 0.0024 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0083 | 0.5 |
Echinococcus granulosus | Smad4 | 0.005 | 0.0182 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 0.3585 | 0.3585 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0203 | 0.0203 |
Loa Loa (eye worm) | Smad1 | 0.005 | 0.0182 | 0.0182 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0113 | 0.059 | 0.1435 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.074 | 0.4684 | 0.4684 |
Brugia malayi | TAR-binding protein | 0.0652 | 0.411 | 0.411 |
Loa Loa (eye worm) | TAR-binding protein | 0.0652 | 0.411 | 0.411 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0652 | 0.411 | 0.411 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0113 | 0.059 | 0.2165 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0113 | 0.059 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0652 | 0.411 | 0.411 |
Brugia malayi | N-terminal motif family protein | 0.0175 | 0.0996 | 0.0996 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.005 | 0.0182 | 0.0443 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0113 | 0.059 | 0.1435 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0113 | 0.059 | 0.059 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0175 | 0.0996 | 0.0996 |
Echinococcus granulosus | smad | 0.005 | 0.0182 | 0.0443 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0572 | 0.3585 | 0.3585 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0083 | 0.0201 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0572 | 0.3585 | 0.3585 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0083 | 0.0201 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0391 | 0.2404 | 0.5849 |
Onchocerca volvulus | 0.0158 | 0.0883 | 0.0883 | |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.005 | 0.0182 | 0.0182 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0113 | 0.059 | 0.2165 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.005 | 0.0182 | 0.0443 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0113 | 0.059 | 0.2165 |
Echinococcus granulosus | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.0158 | 0.0883 | 0.2147 |
Echinococcus multilocularis | smad | 0.005 | 0.0182 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.1555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.0996 | 0.0996 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0215 | 0.1253 | 0.3049 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0083 | 0.0201 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.005 | 0.0182 | 0.0443 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0327 | 0.1989 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.001 | 0.0024 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0113 | 0.059 | 0.1435 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0113 | 0.059 | 0.1435 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0215 | 0.1253 | 1 |
Brugia malayi | MH1 domain containing protein | 0.005 | 0.0182 | 0.0182 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0215 | 0.1253 | 0.3049 |
Echinococcus multilocularis | Smad4 | 0.005 | 0.0182 | 0.0443 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0391 | 0.2404 | 0.2404 |
Brugia malayi | MH2 domain containing protein | 0.005 | 0.0182 | 0.0182 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0083 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0181 | 0.1034 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.1989 | 0.1989 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0181 | 0.1034 | 0.1034 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0083 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0113 | 0.059 | 1 |
Loa Loa (eye worm) | nuclear factor I | 0.0028 | 0.0035 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1034 | 0.2515 |
Echinococcus granulosus | tar DNA binding protein | 0.0652 | 0.411 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0181 | 0.1034 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.0391 | 0.2404 | 0.2404 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0079 | 0.0079 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 0.484 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1034 | 0.2515 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0035 | 0.0035 |
Schistosoma mansoni | Smad4 | 0.005 | 0.0182 | 0.0443 |
Brugia malayi | RNA binding protein | 0.0652 | 0.411 | 0.411 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.005 | 0.0182 | 0.0443 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0327 | 0.1989 | 1 |
Schistosoma mansoni | smad | 0.005 | 0.0182 | 0.0443 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0113 | 0.0589 | 0.2159 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0181 | 0.1034 | 0.2515 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0181 | 0.1034 | 0.1034 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0113 | 0.059 | 0.2165 |
Brugia malayi | MH1 domain containing protein | 0.005 | 0.0182 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0883 | 0.0883 |
Echinococcus multilocularis | tar DNA binding protein | 0.0652 | 0.411 | 1 |
Echinococcus multilocularis | phosphatidylinositol 5 phosphate 4 kinase type 2 | 0.0158 | 0.0883 | 0.2147 |
Schistosoma mansoni | tar DNA-binding protein | 0.0652 | 0.411 | 1 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0024 | 0.001 | 0.0024 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0215 | 0.1253 | 0.4744 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0327 | 0.1989 | 0.5 |
Brugia malayi | Isocitrate dehydrogenase | 0.0113 | 0.059 | 0.059 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0113 | 0.0589 | 0.2159 |
Brugia malayi | MH1 domain containing protein | 0.0028 | 0.0035 | 0.0035 |
Onchocerca volvulus | 0.1555 | 1 | 1 | |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.005 | 0.0182 | 0.0443 |
Schistosoma mansoni | smad1 5 8 and | 0.005 | 0.0182 | 0.0443 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0203 | 0.0203 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0113 | 0.059 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.005 | 0.0182 | 0.0182 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0113 | 0.059 | 1 |
Brugia malayi | MH2 domain containing protein | 0.005 | 0.0182 | 0.0182 |
Brugia malayi | Smad1 | 0.005 | 0.0182 | 0.0182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.