TDR Targets

Basic information

Technical information

TDR Targets ID: 90396
Name: (2R,3R,4S,5R)-2-[6-[(2-chloro-6-fluorophenyl) methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)o xolane-3,4-diol
MW: 426.85 | Formula: C17H16ClFN4O4S
H donors: 3 H acceptors: 6 LogP: 1.51 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2SCc1c(F)cccc1Cl
InChi: 1S/C17H16ClFN4O4S/c18-9-2-1-3-10(19)8(9)5-28-16-12-15(20-6-21-16)23(7-22-12)17-14(26)13(25)11(4-24)27-17/h1-3,6-7,11,13-14,17,24-26H,4-5H2/t11-,13-,14-,17-/m1/s1
InChiKey: AFCSRSLSUATDRN-LSCFUAHRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R,3R,4S,5R)-2-[6-[(2-chloro-6-fluoro-phenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-[6-[(2-chloro-6-fluorophenyl)methylthio]-9-purinyl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-[6-[(2-chloro-6-fluoro-phenyl)methylsulfanyl]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4S,5R)-2-[6-[(2-chloro-6-fluoro-benzyl)thio]purin-9-yl]-5-methylol-tetrahydrofuran-3,4-diol
AIDS210783
9H-Purine, 6-[[(2-chloro-6-fluorophenyl)methyl]thio]-9-beta-D-ribofuranosyl-
AIDS-210783

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 29 (equilibrative nucleoside transporter), member 1	Starlite/ChEMBL	References
Toxoplasma gondii	kinase, pfkB family protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_128398	All targets in OG5_128398
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Giardia lamblia	Hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Toxoplasma gondii	kinase, pfkB family protein	Get druggable targets OG5_128398	All targets in OG5_128398
Candida albicans	adenosine kinase	Get druggable targets OG5_128398	All targets in OG5_128398
Echinococcus granulosus	adenosine kinase	Get druggable targets OG5_128398	All targets in OG5_128398
Trypanosoma brucei	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Schistosoma japonicum	Equilibrative nucleoside transporter 3, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Leishmania donovani	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	Get druggable targets OG5_127378	All targets in OG5_127378
Trypanosoma cruzi	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Trypanosoma brucei	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Leishmania major	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Schistosoma mansoni	adenosine kinase	Get druggable targets OG5_128398	All targets in OG5_128398
Echinococcus multilocularis	equilibrative nucleoside transporter protein	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus multilocularis	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Babesia bovis	adenosine kinase	Get druggable targets OG5_128398	All targets in OG5_128398
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Brugia malayi	Adenosine kinase-like	Get druggable targets OG5_128398	All targets in OG5_128398
Cryptosporidium parvum	adenosine kinase like ribokinase	Get druggable targets OG5_128398	All targets in OG5_128398
Leishmania braziliensis	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Trypanosoma brucei gambiense	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Leishmania mexicana	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Neospora caninum	GG10762, related	Get druggable targets OG5_128398	All targets in OG5_128398
Trypanosoma brucei gambiense	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Echinococcus granulosus	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128398	All targets in OG5_128398
Leishmania infantum	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Candida albicans	putative adenosine kinase	Get druggable targets OG5_128398	All targets in OG5_128398
Echinococcus multilocularis	adenosine kinase	Get druggable targets OG5_128398	All targets in OG5_128398
Brugia malayi	hypothetical protein	Get druggable targets OG5_127378	All targets in OG5_127378
Schistosoma mansoni	adenosine kinase	Get druggable targets OG5_128398	All targets in OG5_128398
Candida albicans	possible nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus granulosus	equilibrative nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Trypanosoma congolense	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Brugia malayi	Nucleoside transporter family protein	Get druggable targets OG5_127378	All targets in OG5_127378
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	Get druggable targets OG5_127378	All targets in OG5_127378
Trypanosoma cruzi	adenosine kinase, putative	Get druggable targets OG5_128398	All targets in OG5_128398
Candida albicans	possible nucleoside transporter	Get druggable targets OG5_127378	All targets in OG5_127378
Echinococcus multilocularis	equilibrative nucleoside transporter 3	Get druggable targets OG5_127378	All targets in OG5_127378
Entamoeba histolytica	nucleoside transporter, putative	Get druggable targets OG5_127378	All targets in OG5_127378
Schistosoma japonicum	ko:K00856 adenosine kinase [EC2.7.1.20], putative	Get druggable targets OG5_128398	All targets in OG5_128398

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	purine nucleoside transporter	solute carrier family 29 (equilibrative nucleoside transporter), member 1	456 aa	396 aa	24.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.014	0.0926	0.5875
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0041	0.0044
Onchocerca volvulus		0.0067	0.0369	0.1022
Echinococcus granulosus	para nitrobenzyl esterase	0.0067	0.0369	0.0348
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0575	0.4212	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.0844	0.1962
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0738	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0054	0.027	0.0591
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0129	0.0107
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0021	0.0022	0.0141
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0408	0.4267
Schistosoma mansoni	cellular tumor antigen P53	0.0196	0.1346	0.316
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Trichomonas vaginalis	esterase, putative	0.0035	0.013	0.0115
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0636	0.0652
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.1623	0.1605
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0237	0.0215
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0129	0.0113
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0067	0.0369	0.2343
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0129	0.0113
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0408	0.6065
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.013	0.0258
Schistosoma mansoni	hypothetical protein	0.0362	0.2602	0.6158
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0227	0.0205
Echinococcus granulosus	neuroligin	0.0067	0.0369	0.0348
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0408	0.6065
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0022	0.0141
Brugia malayi	glutathione reductase	0.0048	0.0227	0.0488
Trypanosoma brucei	adenosine kinase, putative	0.0105	0.0658	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0108	0.0953
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0072	0.0408	0.1911
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0024	0.0041	0.0292
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0054	0.027	0.274
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Loa Loa (eye worm)	TAR-binding protein	0.0575	0.4212	1
Trypanosoma cruzi	adenosine kinase, putative	0.0105	0.0658	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0606	0.1393
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.013	0.0108
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0067	0.0369	0.2343
Onchocerca volvulus		0.0072	0.0408	0.1136
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.1575	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0137	0.1809
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0408	0.4267
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0227	0.3219
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0159	0.1065	0.1045
Schistosoma mansoni	tar DNA-binding protein	0.0575	0.4212	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0412	0.2984	0.707
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0024	0.0041	0.0292
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0072	0.0408	0.1911
Echinococcus multilocularis	adenosine kinase	0.0105	0.0658	0.0637
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.011	0.0694	0.7437
Mycobacterium tuberculosis	Conserved protein	0.0035	0.013	0.0827
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0247	0.1571
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0369	0.0828
Brugia malayi	hypothetical protein	0.0095	0.0584	0.1341
Schistosoma mansoni	kinase	0.0052	0.0256	0.0557
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.2039	0.2142
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0129	0.0113
Echinococcus granulosus	adenosine kinase	0.0105	0.0658	0.0637
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0137	0.0122
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0369	0.0828
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.2039	0.2142
Brugia malayi	T-complex protein 1, beta subunit	0.0024	0.0041	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0408	0.092
Onchocerca volvulus		0.0047	0.0221	0.0587
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0237	0.0512
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.013	0.0844	0.1962
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.013	0.0827
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0067	0.0369	0.0368
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0369	0.0828
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0024	0.0041	0.0019
Onchocerca volvulus		0.0092	0.0558	0.1578
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.0787	0.8465
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0237	0.0512
Leishmania major	hypothetical protein, conserved	0.0035	0.013	0.17
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0129	0.0113
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.2039	0.2142
Entamoeba histolytica	nucleoside transporter, putative	0.0098	0.0606	0.2894
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0021	0.0022	0.0141
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0137	0.1809
Onchocerca volvulus		0.0035	0.013	0.0318
Onchocerca volvulus		0.0196	0.1346	0.3901
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0892	0.6613	0.6605
Echinococcus granulosus	acetylcholinesterase	0.0067	0.0369	0.0348
Mycobacterium tuberculosis	Probable dehydrogenase	0.011	0.0694	0.4405
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0024	0.0041	0.0645
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.013	0.17
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0059	0.031	0.4527
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.011	0.0694	0.4405
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0237	0.0215
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0237	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0658	0.1517
Brugia malayi	Latrophilin receptor protein 2	0.013	0.0844	0.1962
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0041	0.0044
Schistosoma mansoni	hypothetical protein	0.028	0.1984	0.4683
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0021	0.0022	0.0141
Trypanosoma cruzi	adenosine kinase, putative	0.0105	0.0658	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.013	0.0258
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0072	0.0408	0.4267
Echinococcus granulosus	GPCR family 2	0.013	0.0844	0.0824
Echinococcus granulosus	BC026374 protein S09 family	0.0067	0.0369	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.1265	0.9439	1
Echinococcus granulosus	equilibrative nucleoside transporter	0.0098	0.0606	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Trypanosoma brucei	glucosidase, putative	0.0035	0.0129	0.168
Echinococcus granulosus	carboxylesterase 5A	0.0067	0.0369	0.0348
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0137	0.1809
Loa Loa (eye worm)	acetylcholinesterase 1	0.0067	0.0369	0.0828
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0072	0.0408	0.4267
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0021	0.0022	0.0141
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0098	0.0606	0.0585
Trypanosoma brucei	trypanothione reductase	0.0048	0.0227	0.3219
Brugia malayi	MH2 domain containing protein	0.0116	0.0738	0.1709
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0738	0.1709
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0227	0.711
Schistosoma mansoni	alpha-glucosidase	0.0137	0.0897	0.2089
Mycobacterium tuberculosis	Conserved protein	0.0035	0.013	0.0827
Echinococcus multilocularis	geminin	0.0362	0.2602	0.2586
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.0258
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0636	0.0652
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0606	0.1393
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.2039	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0606	0.1393
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.2039	0.2142
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0057	0.0293	0.0272
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0369	0.0828
Brugia malayi	serine/threonine-protein kinase plk-2	0.0102	0.0636	0.1465
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.0787	0.4995
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.013	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.0258
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0227	0.711
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0237	0.0512
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0072	0.0408	0.2588
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0072	0.0408	0.4267
Trypanosoma cruzi	polo-like protein kinase, putative	0.0102	0.0636	0.9662
Leishmania major	adenosine kinase, putative	0.0105	0.0658	1
Schistosoma mansoni	adenosine kinase	0.0105	0.0658	0.1517
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.013	0.17
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0137	0.057
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.013	0.0827
Brugia malayi	RNA recognition motif domain containing protein	0.0575	0.4212	1
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0022	0.0141
Mycobacterium leprae	Probable lipase LipE	0.0035	0.013	0.1196
Echinococcus multilocularis	neuroligin	0.0067	0.0369	0.0348
Brugia malayi	Carboxylesterase family protein	0.0067	0.0369	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0584	0.1341
Schistosoma mansoni	acetylcholinesterase	0.0067	0.0369	0.0828
Schistosoma mansoni	hypothetical protein	0.013	0.0844	0.1962
Schistosoma mansoni	tar DNA-binding protein	0.0575	0.4212	1
Brugia malayi	Carboxylesterase family protein	0.0067	0.0369	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0196	0.1346	0.316
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.041	0.2966	0.7027
Onchocerca volvulus		0.0059	0.031	0.0848
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0072	0.0408	0.4267
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0022	0.0141
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.013	0.0844	0.0824
Echinococcus multilocularis	carboxylesterase 5A	0.0067	0.0369	0.0348
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0408	0.092
Loa Loa (eye worm)	RNA binding protein	0.0575	0.4212	1
Schistosoma mansoni	hypothetical protein	0.0362	0.2602	0.6158
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0247	0.1571
Echinococcus multilocularis	tumor protein p63	0.1339	1	1
Trypanosoma brucei	polo-like protein kinase	0.0102	0.0636	0.9662
Brugia malayi	Carboxylesterase family protein	0.0067	0.0369	0.0828
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.013	0.17
Loa Loa (eye worm)	hypothetical protein	0.0054	0.027	0.0591
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0108	0.0688
Trichomonas vaginalis	set domain proteins, putative	0.0469	0.3416	0.3604
Mycobacterium tuberculosis	Conserved protein	0.0035	0.013	0.0827
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0054	0.027	0.1712
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.013	0.1196
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0102	0.0636	0.1809
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0098	0.0606	0.172
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0137	0.0115
Schistosoma mansoni	eyes absent homolog	0.0095	0.0584	0.1341
Plasmodium falciparum	acyl-CoA synthetase	0.0054	0.027	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0137	0.0115
Onchocerca volvulus		0.0067	0.0369	0.1022
Loa Loa (eye worm)	hypothetical protein	0.0054	0.027	0.0591
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0129	0.0529
Schistosoma mansoni	hypothetical protein	0.0047	0.0221	0.0475
Trypanosoma cruzi	polo-like protein kinase, putative	0.0102	0.0636	0.9662
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0102	0.0636	0.1465
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0098	0.0606	0.062
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.2039	0.2142
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0137	0.0122
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0021	0.0022	0.0141
Schistosoma mansoni	gliotactin	0.0067	0.0369	0.0828
Brugia malayi	Pre-SET motif family protein	0.0412	0.2984	0.707
Brugia malayi	hypothetical protein	0.0098	0.0606	0.1393
Schistosoma mansoni	hypothetical protein	0.013	0.0844	0.1962
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0129	0.0113
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0137	0.1272
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.013	0.0844	0.0824
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0024	0.0041	0.002
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0636	0.0652
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0245	0.0237
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.013	0.0827
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0408	0.092
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0102	0.0636	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Giardia lamblia	Fructose-bisphosphate aldolase	0.0288	0.2039	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.013	0.0258
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0227	0.0488
Schistosoma mansoni	BC026374 protein (S09 family)	0.0067	0.0369	0.0828
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0369	0.0828
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0369	0.0828
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0024	0.0041	0.0019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0237	0.0215
Echinococcus granulosus	geminin	0.0362	0.2602	0.2586
Treponema pallidum	fructose-bisphosphate aldolase	0.0288	0.2039	0.5
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.013	0.0827
Echinococcus multilocularis	GPCR, family 2	0.013	0.0844	0.0824
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0137	0.1809
Loa Loa (eye worm)	inositol-1	0.0036	0.0137	0.0274
Brugia malayi	Inositol-1	0.0036	0.0137	0.0274
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0102	0.0636	0.9662
Loa Loa (eye worm)	hypothetical protein	0.041	0.2966	0.7027
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0102	0.0636	0.3044
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0098	0.0606	0.062
Schistosoma mansoni	tar DNA-binding protein	0.0575	0.4212	1
Brugia malayi	Carboxylesterase family protein	0.0067	0.0369	0.0828
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0059	0.031	0.0687
Brugia malayi	beta-lactamase	0.0035	0.013	0.0258
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0237	0.0512
Plasmodium falciparum	glutathione reductase	0.0048	0.0227	0.8265
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0072	0.0408	0.4267
Onchocerca volvulus		0.0067	0.0369	0.1022
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.013	0.0827
Toxoplasma gondii	t-complex protein beta subunit	0.0024	0.0041	0.0292
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0035	0.0129	0.0529
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.031	0.0687
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0129	0.0113
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0021	0.0022	0.0141
Brugia malayi	Calcitonin receptor-like protein seb-1	0.041	0.2966	0.7027
Loa Loa (eye worm)	hypothetical protein	0.0054	0.027	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.0258
Brugia malayi	RNA binding protein	0.0575	0.4212	1
Onchocerca volvulus		0.0035	0.013	0.0318
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.0787	0.4995
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.013	0.0115
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.013	0.0844	0.0824
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0024	0.0041	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0233	0.1623	0.3822
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0584	0.1341
Brugia malayi	Carboxylesterase family protein	0.0067	0.0369	0.0828
Echinococcus granulosus	acetylcholinesterase	0.0067	0.0369	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Trichomonas vaginalis	conserved hypothetical protein	0.1265	0.9439	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.014	0.0926	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0067	0.0369	0.0348
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.011	0.0694	0.4405
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.013	0.1196
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0021	0.0022	0.0141
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0129	0.0113
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0159	0.1065	0.2489
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0159	0.1065	0.2489
Onchocerca volvulus	Equilibrative nucleoside transporter, putative homolog	0.0098	0.0606	0.172
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.0787	0.4995
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0137	0.1809
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0636	0.0652
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0245	0.0237
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0227	0.8265
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.0258
Mycobacterium tuberculosis	Probable reductase	0.011	0.0694	0.4405
Echinococcus multilocularis	equilibrative nucleoside transporter protein	0.0098	0.0606	0.0585
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0024	0.0041	0.0749
Schistosoma mansoni	serine/threonine protein kinase	0.0102	0.0636	0.1465
Onchocerca volvulus		0.0067	0.0369	0.1022
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0098	0.0606	0.062
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0067	0.0369	0.2343
Brugia malayi	Adenosine kinase-like	0.0105	0.0658	0.1517
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.013	0.0827
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.0129	0.168
Trichomonas vaginalis	spcc417.12 protein, putative	0.0067	0.0369	0.0368
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0137	0.0274
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0221	0.0475
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0067	0.0369	0.0348
Onchocerca volvulus		0.0093	0.0567	0.1605
Echinococcus multilocularis	tar DNA binding protein	0.0575	0.4212	0.4199
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0129	0.0255
Toxoplasma gondii	kinase, pfkB family protein	0.0105	0.0658	1
Schistosoma mansoni	alpha glucosidase	0.0035	0.0129	0.0255
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0408	0.4267
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0408	0.092
Echinococcus multilocularis	acetylcholinesterase	0.0067	0.0369	0.0348
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0129	0.0107
Brugia malayi	Thioredoxin reductase	0.0048	0.0227	0.0488
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0227	0.3219
Brugia malayi	hypothetical protein	0.0233	0.1623	0.3822
Brugia malayi	TAR-binding protein	0.0575	0.4212	1
Schistosoma mansoni	hypothetical protein	0.013	0.0844	0.1962
Schistosoma mansoni	adenosine kinase	0.0105	0.0658	0.1517
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.013	0.3754
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.013	0.0258
Brugia malayi	Pre-SET motif family protein	0.0059	0.031	0.0687
Brugia malayi	latrophilin 2 splice variant baaae	0.028	0.1984	0.4683
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.013	0.0844	0.0824
Plasmodium vivax	acyl-CoA synthetase, putative	0.0054	0.027	0.8603
Loa Loa (eye worm)	T-complex protein 1	0.0024	0.0041	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0059	0.031	0.0687
Echinococcus granulosus	lysosomal alpha glucosidase	0.0159	0.1065	0.1045
Toxoplasma gondii	ABC1 family protein	0.0035	0.013	0.17
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0636	0.0652
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0054	0.027	0.5
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0137	0.0122
Mycobacterium ulcerans	acyl-CoA synthetase	0.0072	0.0408	0.4267
Schistosoma mansoni	hypothetical protein	0.013	0.0844	0.1962
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0021	0.0022	0.0141
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0288	0.2039	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0221	0.0475
Leishmania major	4-coumarate:coa ligase-like protein	0.0072	0.0408	0.6065
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0227	0.144
Echinococcus granulosus	tar DNA binding protein	0.0575	0.4212	0.4199
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0227	0.0205
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.014	0.0926	1
Echinococcus multilocularis	equilibrative nucleoside transporter 3	0.0081	0.0477	0.0455
Brugia malayi	Nucleoside transporter family protein	0.0098	0.0606	0.1393
Schistosoma mansoni	tar DNA-binding protein	0.0575	0.4212	1
Brugia malayi	AMP-binding enzyme family protein	0.0072	0.0408	0.092
Brugia malayi	hypothetical protein	0.0067	0.0369	0.0828
Loa Loa (eye worm)	hypothetical protein	0.028	0.1984	0.4683
Schistosoma mansoni	tar DNA-binding protein	0.0575	0.4212	1
Onchocerca volvulus		0.0469	0.3416	1
Brugia malayi	Carboxylesterase family protein	0.0067	0.0369	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.0258
Brugia malayi	beta-lactamase family protein	0.0035	0.013	0.0258
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0067	0.0369	0.0348
Trichomonas vaginalis	chaperonin, putative	0.0024	0.0041	0.002
Loa Loa (eye worm)	beta-lactamase	0.0035	0.013	0.0258
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0067	0.0369	0.0348
Mycobacterium ulcerans	carboxylesterase, LipT	0.0067	0.0369	0.384
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.2039	0.2142
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0129	0.0113
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0247	0.1571
Entamoeba histolytica	acyl-coA synthetase, putative	0.0072	0.0408	0.1911
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0227	0.0488
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0237	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0408	0.092
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0129	0.0113
Onchocerca volvulus		0.0035	0.013	0.0318
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.011	0.0694	0.4405
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0051	0.0247	0.1571
Mycobacterium ulcerans	beta-lactamase	0.0035	0.013	0.1196
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0159	0.1065	0.1045
Onchocerca volvulus		0.0067	0.0369	0.1022
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0369	0.0828
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.041	0.2966	0.7027
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0129	0.168
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0059	0.031	0.0288
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0636	0.0652
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0129	0.168
Giardia lamblia	Hypothetical protein	0.0098	0.0606	0.2828
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0129	0.168
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.013	0.0115
Mycobacterium ulcerans	lipase LipD	0.0035	0.013	0.1196
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.031	0.0687
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0288	0.2039	0.2142
Echinococcus granulosus	histone lysine methyltransferase setb	0.0059	0.031	0.0288
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.1623	0.1605
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0102	0.0636	0.0615
Mycobacterium ulcerans	hypothetical protein	0.0035	0.013	0.1196
Trichomonas vaginalis	CAMK family protein kinase	0.0102	0.0636	0.0652
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0024	0.0041	0.0092
Leishmania major	trypanothione reductase	0.0048	0.0227	0.3219
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0129	0.0255
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.013	0.0827
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0059	0.031	0.0288
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0288	0.2039	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0369	0.0828
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0072	0.0408	0.4267
Loa Loa (eye worm)	hypothetical protein	0.0054	0.027	0.0591
Brugia malayi	T-complex protein 1, beta subunit	0.0024	0.0041	0.0044
Echinococcus granulosus	equilibrative nucleoside transporter 3	0.0098	0.0606	0.0585
Trichomonas vaginalis	equilibrative nucleoside transporter, putative	0.0098	0.0606	0.062
Echinococcus multilocularis	acetylcholinesterase	0.0067	0.0369	0.0348
Schistosoma mansoni	alpha-glucosidase	0.0137	0.0897	0.2089
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.013	0.0108
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.031	0.0687
Leishmania major	T-complex protein 1, beta subunit, putative	0.0024	0.0041	0.0292
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.013	0.1196
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0067	0.0369	0.0828
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0072	0.0408	0.2588
Giardia lamblia	Kinase, PLK	0.0102	0.0636	0.298
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0137	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.013	0.0258
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.013	0.0115
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.013	0.0115
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.011	0.0694	0.4405
Loa Loa (eye worm)	latrophilin receptor protein 2	0.013	0.0844	0.1962
Brugia malayi	beta-lactamase family protein	0.0035	0.013	0.0258
Plasmodium vivax	SET domain protein, putative	0.0059	0.031	1
Trypanosoma brucei	adenosine kinase, putative	0.0105	0.0658	1
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0137	0.0274

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.06	Inhibition of Toxoplasma gondii adenosine kinase	ChEMBL.	No reference
IC50 (binding)	= 8.7 uM	Inhibition of Toxoplasma gondii adenosine kinase	ChEMBL.	No reference
Ki (binding)	= 7.06	Inhibition of human ENT1	ChEMBL.	19091561
Ki (binding)	= 37.7 uM	Inhibition of Toxoplasma gondii adenosine kinase	ChEMBL.	No reference
Km (binding)	= 37.7 uM	Binding affinity at Toxoplasma gondii adenosine kinase.	ChEMBL.	15055998
Km (binding)	= 37.7 uM	Binding affinity at Toxoplasma gondii adenosine kinase.	ChEMBL.	15055998

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL59683
PubChem: 3009579

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 90396