Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1735 | 0.1963 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.031 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0206 | 0.8837 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1735 | 0.1963 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0206 | 0.8837 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0206 | 0.8837 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0157 | 0.0906 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.8837 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.1735 | 0.1963 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.8837 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0206 | 0.8837 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0206 | 0.8837 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0206 | 0.8837 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.8837 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0206 | 0.8837 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0206 | 0.8837 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.031 | 0.1787 |
Echinococcus granulosus | acetylcholinesterase | 0.0206 | 0.8837 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0157 | 0.0178 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0157 | 0.0178 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1735 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1735 | 0.1963 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.031 | 0.1787 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1735 | 0.1963 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1735 | 0.1963 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1735 | 0.1963 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0157 | 0.507 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0157 | 0.0906 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0 | 0.5 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.1735 | 0.1963 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0206 | 0.8837 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1735 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.