Detailed information for compound 904234

Basic information

Technical information
  • TDR Targets ID: 904234
  • Name: 4-bromo-N-(2,4,6-trimethylphenyl)benzamide
  • MW: 318.208 | Formula: C16H16BrNO
  • H donors: 1 H acceptors: 1 LogP: 4.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c(c(c1)C)NC(=O)c1ccc(cc1)Br
  • InChi: 1S/C16H16BrNO/c1-10-8-11(2)15(12(3)9-10)18-16(19)13-4-6-14(17)7-5-13/h4-9H,1-3H3,(H,18,19)
  • InChiKey: OOHBFEBQBRQAPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ZINC00114852
  • BAS 00117517
  • 4-Bromo-N-(2,4,6-trimethyl-phenyl)-benzamide
  • ST025558
  • Oprea1_714108
  • Oprea1_226263

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0139 0.2881 0.2871
Leishmania major DNA damage repair protein, putative 0.0029 0.0426 0.0557
Leishmania major hypothetical protein, conserved 0.0026 0.0372 0.0472
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Onchocerca volvulus 0.0164 0.3435 0.6441
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0171 0.3607 0.5
Schistosoma mansoni hypothetical protein 0.0418 0.9116 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0594 0.0581
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0206 0.0195
Loa Loa (eye worm) hypothetical protein 0.0135 0.2793 0.2783
Echinococcus granulosus cpg binding protein 0.0031 0.0478 0.0511
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0049 0.0038
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0013 0.0079 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.4 0.438
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0092 0.1849 0.2017
Schistosoma mansoni hypothetical protein 0.002 0.0236 0.0258
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0079 0.0022
Plasmodium vivax phosphoglycerate kinase, putative 0.0171 0.3607 1
Leishmania major DNA polymerase kappa, putative 0.0029 0.0426 0.0557
Loa Loa (eye worm) RecQ helicase 0.0046 0.0804 0.0791
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.1188 0.1729
Trypanosoma brucei DNA polymerase eta, putative 0.0145 0.3021 0.4547
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0886 0.0959
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0236 0.0244
Plasmodium falciparum DNA repair protein REV1, putative 0.0029 0.0426 0.1021
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0164 0.3435 0.3768
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0013 0.0079 0.0086
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0804 0.0868
Brugia malayi CXXC zinc finger family protein 0.0029 0.0441 0.043
Mycobacterium ulcerans phosphoglycerate kinase 0.0171 0.3607 0.5786
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.1188 0.1729
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0236 0.0483
Echinococcus granulosus dna polymerase kappa 0.0119 0.2446 0.2673
Schistosoma mansoni cpg binding protein 0.0031 0.0478 0.0525
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.3607 0.5448
Loa Loa (eye worm) hypothetical protein 0.0055 0.1023 0.1011
Mycobacterium ulcerans DNA polymerase IV 0.0119 0.2446 0.3675
Brugia malayi hypothetical protein 0.0135 0.2793 0.2785
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0079 0.0218
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0426 0.0557
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0594 0.0904
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0372 0.0472
Plasmodium falciparum phosphoglycerate kinase 0.0171 0.3607 1
Schistosoma mansoni hypothetical protein 0.0343 0.7431 0.8152
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.495 1
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0079 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0594 0.0815
Schistosoma mansoni lipoxygenase 0.0056 0.1045 0.1146
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.3607 0.5448
Schistosoma mansoni lipoxygenase 0.002 0.0236 0.0258
Schistosoma mansoni hypothetical protein 0.0049 0.0886 0.0972
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.1188 0.1729
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0426 0.0557
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.068 0.1738
Mycobacterium ulcerans glutaminase 0.0275 0.5923 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.1188 0.1729
Schistosoma mansoni hypothetical protein 0.0049 0.0886 0.0972
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0594 0.0652
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.033 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Loa Loa (eye worm) pip kinase 1 0.0013 0.0079 0.0065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0886 0.0959
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0079 0.0022
Entamoeba histolytica recQ family helicase, putative 0.0024 0.033 0.0914
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.4 0.3993
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0171 0.3607 0.6916
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0594 0.0652
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0064 0.0054
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.3607 0.5448
Leishmania major DNA polymerase kappa, putative 0.0099 0.1997 0.2973
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0372 0.103
Brugia malayi Pip kinase protein 1 0.0013 0.0079 0.0068
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0594 0.0638
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.2995 0.4507
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0426 0.0557
Giardia lamblia Hypothetical protein 0.0013 0.0079 0.004
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0948 0.1359
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0164 0.3435 0.3768
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0594 0.0305
Loa Loa (eye worm) beta-lactamase 0.0036 0.0594 0.0581
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.6566 1
Echinococcus multilocularis dna polymerase eta 0.0145 0.3021 0.3304
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0206 0.04
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0372 0.0867
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0481 0.0528
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0739 0.1038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.4 0.438
Mycobacterium ulcerans lipase LipD 0.0036 0.0594 0.0305
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0426 0.0557
Loa Loa (eye worm) hypothetical protein 0.0107 0.2163 0.2152
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0804 0.1262
Giardia lamblia Phosphoglycerate kinase 0.0171 0.3607 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0441 0.0428
Schistosoma mansoni DNA helicase recq5 0.0019 0.0206 0.0226
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0886 0.0876
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.1357 0.1988
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0164 0.3435 0.3759
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0064 0.0056
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0236 0.0244
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.3263 0.3256
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0099 0.1997 0.3221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.4 0.438
Leishmania major DNA polymerase eta, putative 0.0081 0.1598 0.2358
Brugia malayi Doublecortin family protein 0.002 0.0236 0.0225
Loa Loa (eye worm) hypothetical protein 0.0036 0.0594 0.0581
Trichomonas vaginalis set domain proteins, putative 0.0243 0.5203 0.8771
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0594 0.1495
Onchocerca volvulus 0.0029 0.0441 0.0413
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0013 0.0079 0.0024
Schistosoma mansoni polycystin 1-related 0.002 0.0236 0.0258
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0594 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Brugia malayi hypothetical protein 0.0017 0.0164 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.1357 0.1988
Schistosoma mansoni loxhd1 0.002 0.0236 0.0258
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.12 0.1317
Trypanosoma brucei DNA damage repair protein, putative 0.0029 0.0426 0.0557
Loa Loa (eye worm) hypothetical protein 0.002 0.0236 0.0222
Giardia lamblia DINP protein human, muc B family 0.0099 0.1997 0.5457
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0458 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0594 0.0904
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0426 0.0557
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0079 0.004
Schistosoma mansoni cpg binding protein 0.0029 0.0441 0.0484
Onchocerca volvulus 0.0243 0.5203 1
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0079 0.004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0442 0.047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0481 0.0514
Brugia malayi Pre-SET motif family protein 0.0213 0.4547 0.4541
Echinococcus multilocularis GPCR, family 2 0.0049 0.0886 0.0959
Schistosoma mansoni DNA polymerase eta 0.0145 0.3021 0.3314
Trichomonas vaginalis esterase, putative 0.0036 0.0594 0.0904
Loa Loa (eye worm) hypothetical protein 0.0049 0.0886 0.0874
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.6566 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.4 0.438
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0013 0.0079 0.004
Loa Loa (eye worm) glutaminase 2 0.0275 0.5923 0.5918
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0013 0.0079 0.0086
Toxoplasma gondii ABC1 family protein 0.0036 0.0594 0.1647
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0594 0.0581
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.1188 0.1729
Leishmania major DNA polymerase eta, putative 0.0145 0.3021 0.4547
Echinococcus multilocularis geminin 0.0343 0.7431 0.8149
Loa Loa (eye worm) hypothetical protein 0.0031 0.0481 0.0468
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0594 0.0904
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0171 0.3607 1
Echinococcus multilocularis dna polymerase kappa 0.0119 0.2446 0.2673
Trypanosoma brucei DNA polymerase IV, putative 0.0113 0.2298 0.3435
Trichomonas vaginalis DNA polymerase eta, putative 0.0119 0.2446 0.4065
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0079 0.0072
Brugia malayi hypothetical protein 0.002 0.0236 0.0225
Brugia malayi hypothetical protein 0.0026 0.0372 0.0361
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.1045 0.1133
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0886 0.0959
Loa Loa (eye worm) hypothetical protein 0.0171 0.3607 0.3598
Entamoeba histolytica deoxycytidyl transferase, putative 0.0092 0.1849 0.5127
Chlamydia trachomatis phosphoglycerate kinase 0.0171 0.3607 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0481 0.1334
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0035 0.0574 0.1592
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Trypanosoma cruzi DNA polymerase eta, putative 0.0145 0.3021 0.4547
Loa Loa (eye worm) FYVE zinc finger family protein 0.0013 0.0079 0.0065
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0079 0.0022
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0236 0.0244
Loa Loa (eye worm) doublecortin family protein 0.002 0.0236 0.0222
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0092 0.1849 0.1838
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.2995 0.4507
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.2995 0.4507
Brugia malayi Pip kinase protein 2 0.0164 0.3435 0.3428
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.033 0.0408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.4 0.4388
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0206 0.0571
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0013 0.0079 0.0065
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0092 0.1849 0.2017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0081 0.1598 0.4429
Brugia malayi beta-lactamase family protein 0.0036 0.0594 0.0584
Schistosoma mansoni rab6-interacting 0.002 0.0236 0.0258
Schistosoma mansoni hypothetical protein 0.0049 0.0886 0.0972
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0739 0.1038
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0739 0.1038
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0886 0.0876
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0049 0.0038
Echinococcus granulosus bloom syndrome protein 0.0046 0.0804 0.0868
Mycobacterium ulcerans hypothetical protein 0.016 0.3357 0.5332
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.1598 0.2358
Echinococcus granulosus dnaJ subfamily B 0.0418 0.9116 1
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0804 0.0794
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0013 0.0079 0.0072
Echinococcus granulosus dna polymerase eta 0.0145 0.3021 0.3304
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0064 0.0178
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0064 0.0071
Schistosoma mansoni cpg binding protein 0.0031 0.0478 0.0525
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.3357 0.6343
Leishmania major phosphoglycerate kinase C, glycosomal 0.0171 0.3607 0.5448
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0029 0.0426 0.1182
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0481 0.0528
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0372 0.0472
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.033 0.0408
Treponema pallidum phosphoglycerate kinase 0.0171 0.3607 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.6566 1
Echinococcus granulosus geminin 0.0343 0.7431 0.8149
Entamoeba histolytica phosphoinositide kinase, putative 0.0013 0.0079 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0013 0.0079 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.1023 0.1475
Trypanosoma brucei DNA polymerase kappa, putative 0.0055 0.1023 0.1475
Loa Loa (eye worm) hypothetical protein 0.0036 0.0594 0.0581
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0013 0.0079 0.0218
Brugia malayi beta-lactamase family protein 0.0036 0.0594 0.0584
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0206 0.0195
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0236 0.0244
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0236 0.0244
Mycobacterium ulcerans hypothetical protein 0.0036 0.0594 0.0305
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.1188 0.1729
Mycobacterium tuberculosis Conserved hypothetical protein 0.0092 0.1849 0.2881
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.2446 0.3663
Onchocerca volvulus 0.0036 0.0594 0.0722
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.1188 0.1729
Mycobacterium ulcerans DNA polymerase IV 0.0119 0.2446 0.3675
Onchocerca volvulus 0.0036 0.0594 0.0722
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0013 0.0079 0.0022
Schistosoma mansoni hypothetical protein 0.0107 0.2163 0.2373
Trypanosoma cruzi DNA damage repair protein, putative 0.0029 0.0426 0.0557
Echinococcus multilocularis RUN 0.002 0.0236 0.0244
Schistosoma mansoni hypothetical protein 0.0012 0.0049 0.0053
Onchocerca volvulus Huntingtin homolog 0.0135 0.2793 0.5147
Schistosoma mansoni terminal deoxycytidyl transferase 0.0092 0.1849 0.2029
Brugia malayi hypothetical protein 0.002 0.0236 0.0225
Loa Loa (eye worm) hypothetical protein 0.0145 0.3021 0.3011
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.3607 0.3957
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0804 0.1262
Echinococcus multilocularis phosphoglycerate kinase 1 0.0171 0.3607 0.3948
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0064 0.0056
Echinococcus multilocularis 0.0012 0.0064 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0481 0.0528
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.9116 1
Echinococcus granulosus phosphoglycerate kinase 1 0.0171 0.3607 0.3948
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0594 0.0584
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Loa Loa (eye worm) hypothetical protein 0.0164 0.3435 0.3426
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0171 0.3607 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0594 0.0581
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.1188 0.1729
Mycobacterium ulcerans beta-lactamase 0.0036 0.0594 0.0305
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.003 0.0466 0.1292
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0064 0.0056
Brugia malayi glutaminase DH11.1 0.0275 0.5923 0.5919
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0206 0.0212
Brugia malayi ImpB/MucB/SamB family protein 0.0145 0.3021 0.3013
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0013 0.0079 0.0218
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0013 0.0079 0.0022
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0481 0.0514
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0079 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.4 0.3992
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0013 0.0079 0.0022
Plasmodium vivax SET domain protein, putative 0.0031 0.0481 0.1176
Brugia malayi polk-prov protein 0.0055 0.1023 0.1013
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0426 0.0557
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.033 0.0408
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0594 0.0815
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0206 0.0193
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0099 0.1997 0.2973
Echinococcus granulosus RUN 0.002 0.0236 0.0244
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.4547 0.454
Trypanosoma cruzi DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Trypanosoma brucei unspecified product 0.0064 0.1209 0.176
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0594 0.0904
Trichomonas vaginalis glutaminase, putative 0.0275 0.5923 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.3607 0.6046
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0079 0.0072
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.3263 0.3256
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0206 0.0212
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0206 0.0212
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0013 0.0079 0.0068
Onchocerca volvulus Huntingtin homolog 0.0135 0.2793 0.5147
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0206 0.04
Loa Loa (eye worm) hypothetical protein 0.0156 0.3263 0.3254
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0481 0.0514
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0119 0.2446 0.4065
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0236 0.0244
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0206 0.0212
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0013 0.0079 0.0022
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0079 0.004
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0013 0.0079 0.0022
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0474 0.1157
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0064 0.0071
Brugia malayi beta-lactamase 0.0036 0.0594 0.0584
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1052 0.2916
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.2163 0.2154
Schistosoma mansoni DNA polymerase IV / kappa 0.0029 0.0426 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.007 0.1357 0.1988
Trypanosoma brucei unspecified product 0.0064 0.1209 0.176
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0594 0.0638
Loa Loa (eye worm) pip kinase 2 0.0164 0.3435 0.3426
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0079 0.0086
Onchocerca volvulus 0.0031 0.0481 0.0494
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.3607 0.5448
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0739 0.1038
Echinococcus granulosus GPCR family 2 0.0049 0.0886 0.0959
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0372 0.0867
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0013 0.0079 0.0072
Brugia malayi Pre-SET motif family protein 0.0031 0.0481 0.0471
Entamoeba histolytica phosphoglycerate kinase, putative 0.0171 0.3607 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.1997 0.2973
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0079 0.0022
Trypanosoma brucei unspecified product 0.0113 0.2298 0.3435
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0092 0.1849 0.2029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0206 0.0193
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0064 0.0178
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0013 0.0079 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0481 0.0528
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.3607 0.6046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.4 0.4388
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0594 0.0815
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0013 0.0079 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0119 0.2446 0.3663
Echinococcus multilocularis cpg binding protein 0.0031 0.0478 0.0511
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0013 0.0079 0.0022
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0013 0.0079 0.0022
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.1045 0.1133
Schistosoma mansoni DNA helicase recq1 0.0019 0.0206 0.0226
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0051
Loa Loa (eye worm) hypothetical protein 0.0135 0.2793 0.2783
Giardia lamblia DNA damage repair protein 0.0029 0.0426 0.1021
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0171 0.3607 1
Onchocerca volvulus 0.0036 0.0594 0.0722
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0013 0.0079 0.0024
Plasmodium vivax DNA repair protein REV1, putative 0.0029 0.0426 0.1021
Schistosoma mansoni hypothetical protein 0.0049 0.0886 0.0972
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0372 0.0867
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0372 0.0472
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0594 0.0581
Leishmania major hypothetical protein, conserved 0.0036 0.0594 0.0815
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.4 0.4388
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0594 0.0904
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0886 0.0959
Leishmania major phosphoglycerate kinase B, cytosolic 0.0171 0.3607 0.5448
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.6566 1
Schistosoma mansoni glutaminase 0.0275 0.5923 0.6498
Schistosoma mansoni hypothetical protein 0.0343 0.7431 0.8152
Loa Loa (eye worm) hypothetical protein 0.0036 0.0594 0.0581
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0013 0.0079 0.0086
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0206 0.0571
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.059 0.0647
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0164 0.3435 0.3759
Loa Loa (eye worm) hypothetical protein 0.0026 0.0372 0.0358
Brugia malayi ImpB/MucB/SamB family protein 0.0092 0.1849 0.184
Brugia malayi Phosphoglycerate kinase 0.0063 0.1188 0.1179
Brugia malayi Phosphoglycerate kinase 0.0171 0.3607 0.36
Loa Loa (eye worm) hypothetical protein 0.002 0.0236 0.0222
Toxoplasma gondii hypothetical protein 0.0049 0.0879 0.2438
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0236 0.0483
Loa Loa (eye worm) glutaminase 0.0275 0.5923 0.5918
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.3607 0.3957
Schistosoma mansoni hypothetical protein 0.0012 0.0061 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.2446 0.3663
Trypanosoma brucei chrX additional, unordered contigs 0.0029 0.0426 0.0557
Schistosoma mansoni rab6-interacting 0.002 0.0236 0.0258
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0886 0.0874
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.3263 0.3254

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.