Detailed information for compound 904426

Basic information

Technical information
  • TDR Targets ID: 904426
  • Name: N-(furan-2-ylmethyl)-2-(4-methylphenoxy)aceta mide
  • MW: 245.274 | Formula: C14H15NO3
  • H donors: 1 H acceptors: 1 LogP: 2.2 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccco1)COc1ccc(cc1)C
  • InChi: 1S/C14H15NO3/c1-11-4-6-12(7-5-11)18-10-14(16)15-9-13-3-2-8-17-13/h2-8H,9-10H2,1H3,(H,15,16)
  • InChiKey: FSPLLUZSJRDMAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-furylmethyl)-2-(4-methylphenoxy)acetamide
  • N-(furan-2-ylmethyl)-2-(4-methylphenoxy)ethanamide
  • BAS 00441438
  • N-Furan-2-ylmethyl-2-p-tolyloxy-acetamide
  • ZINC00063658
  • Oprea1_545278
  • ST5002628
  • Oprea1_640353

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0149 0.0919
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0081 0.0093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0093
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0172 0.1391
Loa Loa (eye worm) hypothetical protein 0.0269 0.211 0.2629
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0243 0.5126
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0052 0.0331 0.0405
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0081 0.0074
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0081 0.0074
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0172 0.1391
Brugia malayi Calcitonin receptor-like protein seb-1 0.0269 0.211 0.2629
Brugia malayi RNA binding protein 0.0062 0.0406 0.05
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0101 0.0757
Onchocerca volvulus 0.0022 0.0081 0.0481
Trichomonas vaginalis apoptosis inducing factor, putative 0.0014 0.0016 0.0193
Echinococcus multilocularis smad 0.0067 0.0454 0.0448
Mycobacterium ulcerans polyketide synthase Pks9 0.002 0.0062 0.1486
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0172 0.1391
Plasmodium falciparum thioredoxin reductase 0.0151 0.114 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0406 0.04
Trichomonas vaginalis ran, putative 0.0024 0.0101 0.204
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0081 0.0074
Trichomonas vaginalis glutamate synthase, putative 0.0014 0.0016 0.0193
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0093
Toxoplasma gondii type I fatty acid synthase, putative 0.0031 0.016 0.1283
Echinococcus granulosus mothers against decapentaplegic 5 0.0067 0.0454 0.0448
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0101 0.0757
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0081 0.0481
Schistosoma mansoni chromobox protein 0.0069 0.0467 0.0461
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0085 0.0601 0.0742
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0081 0.0093
Echinococcus multilocularis transcription factor btf3 0.0034 0.018 0.0174
Loa Loa (eye worm) acetyltransferase 0.0142 0.1067 0.1326
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0031 0.016 0.0526
Toxoplasma gondii NADPH-glutathione reductase 0.0052 0.0331 0.2803
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0081 0.0093
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0014 0.0016 0.0051
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0052 0.0331 1
Echinococcus multilocularis glutamate synthase 0.0014 0.0016 0.0009
Brugia malayi MH1 domain containing protein 0.0037 0.0207 0.0251
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0052 0.0331 1
Brugia malayi TAR-binding protein 0.0062 0.0406 0.05
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0081 0.0093
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0172 0.0165
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0081 0.0074
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0081 0.0074
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0014 0.0016 0.0425
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0052 0.0331 0.2803
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0331 0.2803
Loa Loa (eye worm) glutathione reductase 0.0151 0.114 0.1416
Schistosoma mansoni Smad4 0.003 0.0149 0.0142
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0081 0.0074
Schistosoma mansoni ran 0.0024 0.0101 0.0094
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0014 0.0016 0.0193
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.018 0.1465
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0059 0.0389
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0052 0.0331 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0189 0.0182
Mycobacterium tuberculosis Probable oxidoreductase 0.0383 0.304 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0201 0.155 1
Echinococcus granulosus snurportin 1 0.0352 0.2787 0.2782
Brugia malayi MH2 domain containing protein 0.0989 0.8006 1
Entamoeba histolytica hypothetical protein 0.0035 0.0189 0.8704
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0101 0.0117
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0031 0.016 0.4577
Onchocerca volvulus 0.0052 0.0325 0.206
Schistosoma mansoni hypothetical protein 0.0085 0.0601 0.0594
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0081 0.0074
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0014 0.0016 0.0193
Echinococcus multilocularis thioredoxin glutathione reductase 0.0151 0.114 0.1134
Schistosoma mansoni smad1 5 8 and 0.0067 0.0454 0.0448
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0121 0.0937
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0052 0.0331 0.2803
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0126 0.2593
Echinococcus multilocularis snurportin 1 0.0352 0.2787 0.2782
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0053 0.1005
Brugia malayi N-terminal motif family protein 0.0201 0.155 0.1929
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0053 0.0332
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0149 0.0177
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0081 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0467 1
Loa Loa (eye worm) thioredoxin reductase 0.0151 0.114 0.1416
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.018 0.1465
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0081 0.0074
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0052 0.0331 0.2803
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0101 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0081 0.0093
Mycobacterium ulcerans polyketide synthase 0.0031 0.016 0.4577
Loa Loa (eye worm) MH2 domain-containing protein 0.0067 0.0454 0.0559
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0081 0.0074
Loa Loa (eye worm) programmed cell death 8 0.0014 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0207 0.0251
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0345 0.2725 0.8964
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0298 0.2346 0.234
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0038 0.0217 0.0263
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0081 0.0074
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0216 0.1782
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0016 0.0193
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0331 0.2803
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0149 0.0142
Schistosoma mansoni Smad4 0.003 0.0149 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0081 0.0093
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0149 0.0177
Leishmania major importin beta-1 subunit, putative 0.0027 0.0121 0.0937
Onchocerca volvulus 0.0014 0.0016 0.0058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0081 0.0074
Brugia malayi Heterochromatin protein 1 0.0069 0.0467 0.0575
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0406 0.04
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0014 0.0016 0.0011
Brugia malayi MH2 domain containing protein 0.003 0.0149 0.0177
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0052 0.0331 0.2803
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.018 0.1465
Brugia malayi MH1 domain containing protein 0.0067 0.0454 0.0559
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0081 0.0093
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0406 0.05
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0081 0.0093
Echinococcus granulosus Smad4 0.0067 0.0454 0.0448
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.018 0.1465
Plasmodium falciparum glutathione reductase 0.0151 0.114 1
Loa Loa (eye worm) acyl carrier protein 0.0014 0.0013 0.0008
Mycobacterium ulcerans polyketide synthase Pks13 0.0044 0.0265 0.7911
Trypanosoma brucei trypanothione reductase 0.0151 0.114 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0056 0.0362 0.0444
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0014 0.0016 0.0011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0016 0.0193
Mycobacterium ulcerans thioesterase 0.0025 0.0104 0.2812
Loa Loa (eye worm) latrophilin receptor protein 2 0.0085 0.0601 0.0742
Brugia malayi latrophilin 2 splice variant baaae 0.0184 0.1411 0.1756
Loa Loa (eye worm) hypothetical protein 0.0532 0.4266 0.5324
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0149 0.0142
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.004 0.0131
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0129 0.0423
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.0145 0.0172
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.002 0.0062 0.1486
Loa Loa (eye worm) hypothetical protein 0.0033 0.0172 0.0207
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0085 0.0601 0.0594
Echinococcus granulosus smad 0.0067 0.0454 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0081 0.0093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0093
Plasmodium falciparum importin beta, putative 0.0033 0.0172 0.1391
Schistosoma mansoni hypothetical protein 0.0184 0.1411 0.1406
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0085 0.0601 0.0594
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0216 1
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0121 0.248
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0052 0.0331 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0014 0.0016 0.0009
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0016 0.0193
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0243 0.5126
Schistosoma mansoni ran 0.0024 0.0101 0.0094
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0101 0.0757
Entamoeba histolytica hypothetical protein 0.0035 0.0189 0.8704
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0014 0.0016 0.0009
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0081 0.0481
Echinococcus granulosus microtubule associated protein 2 0.0677 0.5451 0.5447
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0081 0.0093
Schistosoma mansoni smad1 5 8 and 0.0067 0.0454 0.0448
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0081 0.0074
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0052 0.0331 0.2803
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0052 0.0331 1
Echinococcus granulosus transcription factor btf3 0.0034 0.018 0.0174
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0101 0.2699
Plasmodium vivax importin-beta 2, putative 0.0033 0.0172 0.1391
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0081 0.0074
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0145 0.4098
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0053 0.1005
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0137 0.0451
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0052 0.0331 0.1088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0053 0.0332
Brugia malayi Importin beta-1 subunit 0.0033 0.0172 0.0207
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0081 0.0074
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0345 0.2725 0.8964
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0053 0.0046
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0075 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0081 0.0093
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0014 0.0016 0.0051
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0101 0.0757
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0101 0.0757
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0269 0.211 0.2629
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0014 0.0016 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0081 0.0074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0085 0.0601 0.0594
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0016 0.0193
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0052 0.0331 0.0324
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0383 0.304 1
Schistosoma mansoni hypothetical protein 0.0035 0.0189 0.0182
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0101 0.0117
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0406 0.05
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0014 0.0016 0.0425
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0345 0.2725 0.8964
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0067 0.0454 0.0448
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0189 0.0182
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0467 0.0575
Schistosoma mansoni hypothetical protein 0.1232 1 1
Toxoplasma gondii thioredoxin reductase 0.0151 0.114 1
Toxoplasma gondii NAC domain-containing protein 0.0034 0.018 0.1465
Schistosoma mansoni disulfide oxidoreductase 0.0014 0.0016 0.0009
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0014 0.0016 0.0011
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0014 0.0016 0.0009
Schistosoma mansoni sulfide quinone reductase 0.0014 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0081 0.0093
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0053 0.0332
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0024 0.01 0.033
Loa Loa (eye worm) hypothetical protein 0.0085 0.0601 0.0742
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0081 0.0074
Mycobacterium leprae Probable polyketide synthase Pks1 0.0031 0.016 0.0477
Schistosoma mansoni coup transcription factor 0.0022 0.0081 0.0074
Schistosoma mansoni hypothetical protein 0.0352 0.2787 0.2782
Brugia malayi RNA, U transporter 1 0.0094 0.067 0.0829
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0081 0.0093
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0053 0.1186
Plasmodium vivax glutathione reductase, putative 0.0151 0.114 1
Entamoeba histolytica hypothetical protein 0.0035 0.0189 0.8704
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0331 0.2803
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0219 0.1373
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0081 0.0074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0121 0.248
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.018 0.3771
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0031 0.016 0.0477
Leishmania major GTP-binding protein, putative 0.0024 0.0101 0.0757
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0014 0.0016 0.0425
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0053 0.0174
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0025 0.008
Mycobacterium tuberculosis Probable reductase 0.0345 0.2725 0.8964
Brugia malayi MH1 domain containing protein 0.0037 0.0207 0.0251
Brugia malayi MH1 domain containing protein 0.0067 0.0454 0.0559
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0406 0.04
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0016 0.0193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0298 0.2346 0.234
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0052 0.0331 0.2803
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.2787 0.3475
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0081 0.0093
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.0145 0.0427
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0406 0.04
Loa Loa (eye worm) hypothetical protein 0.003 0.015 0.0179
Schistosoma mansoni hypothetical protein 0.1232 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0189 0.8704
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0031 0.016 0.0526
Brugia malayi ecdysteroid receptor 0.0022 0.0081 0.0093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0093
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0053 0.1186
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0052 0.0331 0.2803
Schistosoma mansoni hypothetical protein 0.0014 0.0016 0.0009
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0149 0.0142
Entamoeba histolytica Ran family GTPase 0.0024 0.0101 0.4489
Loa Loa (eye worm) hypothetical protein 0.0039 0.0219 0.0265
Brugia malayi Smad1 0.0067 0.0454 0.0559
Brugia malayi nuclear hormone receptor 0.0022 0.0081 0.0093
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0104 0.2812
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0014 0.0016 0.0051
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0052 0.0331 0.2803
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0244 0.0238
Entamoeba histolytica disulphide oxidoreductase, putative 0.0014 0.0016 0.0425
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0298 0.2346 0.234
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0406 0.04
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0244 0.5165
Brugia malayi glutamate synthase 0.0014 0.0016 0.0011
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0053 0.0332
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0298 0.2346 0.234
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0219 0.4603
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0145 0.4098
Brugia malayi nuclear receptor NHR-88 0.0022 0.0081 0.0093
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0145 0.0476
Brugia malayi beta-NAC-like protein 0.0034 0.018 0.0217
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1067 0.1061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0081 0.0093
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0097 0.027
Schistosoma mansoni hypothetical protein 0.0085 0.0601 0.0594
Toxoplasma gondii exonuclease III APE 0.0018 0.0053 0.0332
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0052 0.0331 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0014 0.0016 0.0009
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0014 0.0016 0.0425
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0097 0.2591
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0044 0.0265 0.0871
Loa Loa (eye worm) Smad1 0.0067 0.0454 0.0559
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0145 0.4098
Entamoeba histolytica thioredoxin reductase, putative 0.0014 0.0016 0.0425
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0298 0.2346 0.2924
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0097 0.2591
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0081 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0406 0.04
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0052 0.0331 0.2803
Onchocerca volvulus Fatty acid synthase homolog 0.0053 0.034 0.2158
Onchocerca volvulus 0.0028 0.0129 0.0791
Echinococcus multilocularis chromobox protein 1 0.0069 0.0467 0.0461
Echinococcus multilocularis chromobox protein 1 0.0069 0.0467 0.0461
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0137 0.0451
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1067 0.1326
Schistosoma mansoni hypothetical protein 0.0085 0.0601 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0081 0.0093
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0081 0.0093
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0129 0.0153
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0298 0.2346 0.234
Loa Loa (eye worm) RNA binding protein 0.0062 0.0406 0.05
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0269 0.211 0.2629
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0014 0.0016 0.0193
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0031 0.016 0.4577
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.018 0.1465
Echinococcus multilocularis mothers against decapentaplegic 5 0.0067 0.0454 0.0448
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0093
Loa Loa (eye worm) hypothetical protein 0.005 0.031 0.0379
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0244 0.2036
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0085 0.0601 0.0594
Echinococcus multilocularis geminin 0.1232 1 1
Mycobacterium leprae Polyketide synthase Pks13 0.0044 0.0265 0.0824
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0052 0.0331 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0081 0.0093
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0053 0.0058
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0014 0.0016 0.0009
Loa Loa (eye worm) MH1 domain-containing protein 0.0067 0.0454 0.0559
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0014 0.0016 0.0009
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0104 0.0343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0331 0.2803
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0244 0.2036
Schistosoma mansoni ap endonuclease 0.0018 0.0053 0.0046
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0244 0.2036
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0219 0.4603
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0052 0.0331 0.0324
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0216 0.6357
Echinococcus multilocularis GPCR, family 2 0.0085 0.0601 0.0594
Loa Loa (eye worm) MH2 domain-containing protein 0.0989 0.8006 1
Schistosoma mansoni importin beta-1 0.0033 0.0172 0.0165
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0189 0.0182
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0151 0.114 0.3748
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0081 0.0074
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0383 0.304 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0053 0.0332
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0081 0.0481
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0038 0.0217 0.0263
Loa Loa (eye worm) nuclear factor I 0.0037 0.0207 0.0251
Schistosoma mansoni hypothetical protein 0.0085 0.0601 0.0594
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0052 0.0331 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0532 0.4266 0.5324
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0014 0.0016 0.0425
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0298 0.2346 0.2924
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0014 0.0016 0.0009
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0345 0.2725 0.8958
Echinococcus granulosus importin subunit beta 1 0.0033 0.0172 0.0165
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0052 0.0331 0.0324
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0053 0.0046
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.0145 0.0476
Giardia lamblia NADH oxidase lateral transfer candidate 0.0052 0.0331 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0014 0.0016 0.0009
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0052 0.0331 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0014 0.0016 0.0193
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0014 0.0016 0.0011
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0014 0.0016 0.0051
Entamoeba histolytica hypothetical protein 0.0027 0.0121 0.5457
Echinococcus granulosus TGF beta signal transducer SmadC 0.0067 0.0454 0.0448
Echinococcus multilocularis Smad4 0.0067 0.0454 0.0448
Brugia malayi MH2 domain containing protein 0.0067 0.0454 0.0559
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0081 0.0074
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1067 0.1061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0081 0.0093
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0044 0.0265 0.0871
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0014 0.0016 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0126 0.2593
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.002 0.0062 0.0155
Plasmodium falciparum glutathione reductase 0.0052 0.0331 0.2803
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.0145 0.0427
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0052 0.0331 0.2803
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0076 0.0251
Brugia malayi Latrophilin receptor protein 2 0.0085 0.0601 0.0742
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0244 0.5165
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0149 0.0177
Trichomonas vaginalis glutamate synthase, putative 0.0014 0.0016 0.0193
Brugia malayi hypothetical protein 0.0035 0.0189 0.0228
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0014 0.0016 0.0193
Trichomonas vaginalis mercuric reductase, putative 0.0052 0.0331 0.7038
Schistosoma mansoni chromobox protein 0.0069 0.0467 0.0461
Brugia malayi MH2 domain containing protein 0.0067 0.0454 0.0559
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0081 0.0074
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0101 0.0094
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0067 0.0454 0.0448
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0014 0.0016 0.0009
Leishmania major basic transcription factor 3a, putative 0.0034 0.018 0.1465
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0298 0.2346 0.234
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0145 0.4098
Treponema pallidum NADH oxidase 0.0052 0.0331 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.155 0.1929
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0081 0.0074
Loa Loa (eye worm) transcription factor SMAD2 0.0989 0.8006 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.018 0.3771
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0101 0.0757
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0081 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0467 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0031 0.016 0.0526
Schistosoma mansoni glutamate synthase 0.0014 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0011
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0145 0.0476
Schistosoma mansoni smad1 5 8 and 0.0067 0.0454 0.0448
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1034 0.1028
Loa Loa (eye worm) hypothetical protein 0.0184 0.1411 0.1756
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0081 0.0074
Echinococcus granulosus chromobox protein 1 0.0069 0.0467 0.0461
Schistosoma mansoni smad 0.003 0.0149 0.0142
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0177
Echinococcus granulosus glutamate synthase 0.0014 0.0016 0.0009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0053 0.0058
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0121 0.248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0081 0.0093
Echinococcus granulosus thioredoxin glutathione reductase 0.0151 0.114 0.1134
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0014 0.0016 0.0009
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0081 0.0074
Loa Loa (eye worm) hypothetical protein 0.0022 0.0081 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0298 0.2346 0.234
Schistosoma mansoni ap endonuclease 0.0018 0.0053 0.0046
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0406 0.05
Echinococcus granulosus tar DNA binding protein 0.0062 0.0406 0.04
Trypanosoma cruzi trypanothione reductase, putative 0.0151 0.114 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0081 0.0074
Onchocerca volvulus 0.003 0.015 0.0929
Schistosoma mansoni glutamate synthase 0.0014 0.0016 0.0009
Loa Loa (eye worm) ICD-1 protein 0.0034 0.018 0.0217
Schistosoma mansoni transcription factor btf3 0.0034 0.018 0.0174
Brugia malayi Thioredoxin reductase 0.0151 0.114 0.1416
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0081 0.0074
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0081 0.0074
Mycobacterium tuberculosis Probable dehydrogenase 0.0345 0.2725 0.8964
Loa Loa (eye worm) fatty acid synthase 0.0029 0.0141 0.0168
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0081 0.0093
Plasmodium falciparum thioredoxin reductase 0.0052 0.0331 0.2803
Brugia malayi chromobox protein homolog 3 0.0039 0.0219 0.0265
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.5451 0.5447
Echinococcus granulosus GPCR family 2 0.0085 0.0601 0.0594
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0053 0.1186
Brugia malayi glutathione reductase 0.0151 0.114 0.1416
Entamoeba histolytica hypothetical protein 0.0034 0.018 0.8297
Schistosoma mansoni glutamate synthase 0.0014 0.0016 0.0009
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0053 0.1186
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0052 0.0331 0.2803
Echinococcus granulosus chromobox protein 1 0.0069 0.0467 0.0461
Mycobacterium ulcerans polyketide synthase 0.003 0.0145 0.4098
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0081 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0331 0.2803
Plasmodium vivax thioredoxin reductase, putative 0.0151 0.114 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0104 0.0293
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0052 0.0331 0.2803
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0081 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.018 0.3771
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0014 0.0016 0.0051
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.5451 0.5447
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0345 0.2725 0.8964
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0053 0.2211
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0149 0.0142
Leishmania major trypanothione reductase 0.0151 0.114 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0014 0.0016 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0129 0.0153
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0039
Schistosoma mansoni Smad4 0.0067 0.0454 0.0448
Trichomonas vaginalis glutathione reductase, putative 0.0052 0.0331 0.7038
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.018 0.8297
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0053 0.0332
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0014 0.0016 0.0051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0383 0.304 1
Schistosoma mansoni smad 0.0067 0.0454 0.0448
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0243 0.1529
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0331 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0052 0.0331 0.2803
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0081 0.0093
Brugia malayi steroid hormone receptor 0.0022 0.0081 0.0093
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0031 0.016 0.0477

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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