Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Smad1 | 0.0008 | 0.0355 | 0.0316 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0557 | 0.0519 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0323 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0355 | 0.0316 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0323 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.2621 | 0.2591 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0569 | 0.0879 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0355 | 0.0316 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0388 | 0.0135 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0355 | 0.0316 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0076 | 0.0127 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0355 | 0.0316 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0323 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.279 | 0.4688 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0355 | 0.0316 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0388 | 0.0135 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0569 | 0.0879 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0323 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0323 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0355 | 0.0596 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0355 | 0.0316 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.279 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0355 | 0.0316 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0323 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0388 | 0.0135 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0323 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0323 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.5951 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0355 | 0.0596 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.279 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.5278 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.279 | 0.4688 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0323 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0388 | 0.0135 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.2621 | 0.2591 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0388 | 0.0651 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0355 | 0.0596 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Onchocerca volvulus | 0.0033 | 0.2621 | 0.5 | |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0569 | 0.0531 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0323 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0355 | 0.0596 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0355 | 0.0596 |
Schistosoma mansoni | smad | 0.0008 | 0.0355 | 0.0596 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.2621 | 0.4403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.