TDR Targets

Basic information

Technical information

TDR Targets ID: 904516
Name: 3-chloro-N-(2-chlorophenyl)benzamide
MW: 266.123 | Formula: C13H9Cl2NO
H donors: 1 H acceptors: 1 LogP: 4.01 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)C(=O)Nc1ccccc1Cl
InChi: 1S/C13H9Cl2NO/c14-10-5-3-4-9(8-10)13(17)16-12-7-2-1-6-11(12)15/h1-8H,(H,16,17)
InChiKey: RJMQLXUUFGSMFM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC00126153
BAS 00579818
ST014446
3-Chloro-N-(2-chloro-phenyl)-benzamide
AF-399/11380404

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0177	0.2926	0.2926
Loa Loa (eye worm)	hypothetical protein	0.019	0.3173	0.3173
Schistosoma mansoni	nuclear hormone receptor	0.0029	0.0197	0.0204
Brugia malayi	ecdysteroid receptor	0.0029	0.0197	0.0197
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0197	0.0306
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0262	0.4495	0.4495
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0029	0.0197	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0559	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0029	0.0197	0.0197
Schistosoma mansoni	hypothetical protein	0.0177	0.2926	0.4299
Echinococcus multilocularis	tar DNA binding protein	0.0262	0.4495	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0029	0.0197	0.0204
Echinococcus granulosus	FTZ F1 alpha	0.0029	0.0197	0.0306
Schistosoma mansoni	coup transcription factor	0.0029	0.0197	0.0204
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0129	0.2033	0.4448
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0029	0.0197	0.0197
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0029	0.0197	0.0197
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0029	0.0197	0.0197
Schistosoma mansoni	hypothetical protein	0.0177	0.2926	0.4299
Echinococcus multilocularis	smad	0.0034	0.0281	0.0496
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0034	0.0281	0.0496
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0204	0.343	0.7598
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0029	0.0197	0.0197
Brugia malayi	Nuclear hormone receptor-like 1	0.0029	0.0197	0.0197
Echinococcus granulosus	ecdysone induced protein 78C	0.0029	0.0197	0.0306
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0029	0.0197	0.0197
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0281	0.0281
Toxoplasma gondii	isocitrate dehydrogenase	0.0129	0.2033	1
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0129	0.2033	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0029	0.0197	0.0306
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0029	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0197	0.0197
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0034	0.0281	0.0496
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0281	0.033
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0129	0.2033	1
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0129	0.2033	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0029	0.0197	0.0204
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0029	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0197	0.0197
Schistosoma mansoni	thyroid hormone receptor	0.0029	0.0197	0.0204
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0029	0.0197	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0198	0.3321	0.3321
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0197	0.0306
Schistosoma mansoni	hypothetical protein	0.0177	0.2926	0.4299
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0177	0.2926	0.2926
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0029	0.0197	0.0204
Brugia malayi	RNA binding protein	0.0262	0.4495	0.4495
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0177	0.2926	0.6462
Loa Loa (eye worm)	MH2 domain-containing protein	0.0499	0.8878	0.8878
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.4495	0.6652
Echinococcus multilocularis	Smad4	0.0034	0.0281	0.0496
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0129	0.2033	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0029	0.0197	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0197	0.0197
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0559	1	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0029	0.0197	0.0204
Brugia malayi	Smad1	0.0034	0.0281	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0564	0.0564
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0177	0.2926	0.6462
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.4495	0.6652
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.4495	0.6652
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0029	0.0197	0.0197
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0129	0.2033	0.4448
Echinococcus multilocularis	isocitrate dehydrogenase	0.0129	0.2033	0.4448
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0029	0.0197	0.0197
Loa Loa (eye worm)	transcription factor SMAD2	0.0499	0.8878	0.8878
Brugia malayi	MH2 domain containing protein	0.0034	0.0281	0.0281
Echinococcus granulosus	Smad4	0.0034	0.0281	0.0496
Brugia malayi	Steroid receptor seven-up type 2	0.0204	0.343	0.343
Brugia malayi	photoreceptor-specific nuclear receptor	0.0258	0.4421	0.4421
Brugia malayi	RNA recognition motif domain containing protein	0.0262	0.4495	0.4495
Brugia malayi	N-terminal motif family protein	0.0198	0.3321	0.3321
Echinococcus granulosus	smad	0.0034	0.0281	0.0496
Echinococcus multilocularis	ecdysone induced protein 78C	0.0029	0.0197	0.0306
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0029	0.0197	0.0197
Loa Loa (eye worm)	nuclear hormone receptor	0.0189	0.3142	0.3142
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0029	0.0197	0.0306
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0029	0.0197	0.0197
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0029	0.0197	0.0197
Echinococcus multilocularis	FTZ F1 alpha	0.0029	0.0197	0.0306
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0281	0.033
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0129	0.2033	0.5
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0197	0.0197
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0029	0.0197	0.0197
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0029	0.0197	0.0306
Brugia malayi	MH1 domain containing protein	0.0034	0.0281	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0197	0.0197
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0029	0.0197	0.0197
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0034	0.0281	0.033
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0029	0.0197	0.0306
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0029	0.0197	0.0306
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0129	0.2033	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0129	0.2033	0.4448
Loa Loa (eye worm)	Smad1	0.0034	0.0281	0.0281
Schistosoma mansoni	retinoic acid receptor RXR	0.0029	0.0197	0.0204
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0177	0.2926	0.6462
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0029	0.0197	0.0197
Schistosoma mansoni	hypothetical protein	0.0177	0.2926	0.4299
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0029	0.0197	0.0306
Schistosoma mansoni	Smad4	0.0034	0.0281	0.033
Brugia malayi	MH2 domain containing protein	0.0499	0.8878	0.8878
Echinococcus granulosus	GPCR family 2	0.0177	0.2926	0.6462
Loa Loa (eye worm)	RNA binding protein	0.0262	0.4495	0.4495
Brugia malayi	Latrophilin receptor protein 2	0.0177	0.2926	0.2926
Brugia malayi	hypothetical protein	0.0049	0.0564	0.0564
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0281	0.0281
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0034	0.0281	0.0496
Brugia malayi	nuclear hormone receptor	0.0029	0.0197	0.0197
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0129	0.2033	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0177	0.2926	0.2926
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0029	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0197	0.0197
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0198	0.3321	1
Brugia malayi	steroid hormone receptor	0.0029	0.0197	0.0197
Schistosoma mansoni	thyroid hormone receptor	0.0029	0.0197	0.0204
Brugia malayi	latrophilin 2 splice variant baaae	0.0382	0.6726	0.6726
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0029	0.0197	0.0197
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0129	0.2033	0.4448
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0129	0.2033	0.2033
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0029	0.0197	0.0204
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0177	0.2926	0.6462
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0029	0.0197	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0258	0.4421	0.4421
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0204	0.343	0.7598
Brugia malayi	MH1 domain containing protein	0.0034	0.0281	0.0281
Brugia malayi	Isocitrate dehydrogenase	0.0129	0.2033	0.2033
Echinococcus multilocularis	GPCR, family 2	0.0177	0.2926	0.6462
Loa Loa (eye worm)	hypothetical protein	0.0382	0.6726	0.6726
Echinococcus granulosus	mothers against decapentaplegic 5	0.0034	0.0281	0.0496
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0029	0.0197	0.0204
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0029	0.0197	0.0306
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0281	0.033
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.4495	0.6652
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0029	0.0197	0.0306
Echinococcus granulosus	tar DNA binding protein	0.0262	0.4495	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0559	1	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0129	0.2033	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0197	0.0197
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0129	0.2033	0.2959
Schistosoma mansoni	smad	0.0034	0.0281	0.033
Toxoplasma gondii	isocitrate dehydrogenase	0.0129	0.2033	1
Schistosoma mansoni	hypothetical protein	0.0382	0.6726	1
Brugia malayi	TAR-binding protein	0.0262	0.4495	0.4495
Schistosoma mansoni	tar DNA-binding protein	0.0262	0.4495	0.6652
Brugia malayi	MH2 domain containing protein	0.0034	0.0281	0.0281
Brugia malayi	hypothetical protein	0.0032	0.0241	0.0241
Loa Loa (eye worm)	steroid hormone receptor	0.0029	0.0197	0.0197
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0029	0.0197	0.0197
Brugia malayi	isocitrate dehydrogenase	0.0129	0.2033	0.2033
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0129	0.2033	0.4448
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0029	0.0197	0.0197
Loa Loa (eye worm)	TAR-binding protein	0.0262	0.4495	0.4495
Brugia malayi	nuclear receptor NHR-88	0.0029	0.0197	0.0197

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 904516