TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.556 | Formula: C24H28N2O3S
H donors: 0 H acceptors: 2 LogP: 3.56 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(N1CC[C@@H]2[C@H](C1)CCCN2C(=O)C=Cc1cccs1)CCOc1ccccc1
InChi: 1S/C24H28N2O3S/c27-23(13-16-29-20-7-2-1-3-8-20)25-15-12-22-19(18-25)6-4-14-26(22)24(28)11-10-21-9-5-17-30-21/h1-3,5,7-11,17,19,22H,4,6,12-16,18H2/b11-10+/t19-,22+/m1/s1
InChiKey: LIZYQXRAAXZNAL-MIYJXHNBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	ferritin	0.0009	0.0001	0.0001
Onchocerca volvulus		0.0095	0.1886	0.3107
Onchocerca volvulus		0.0054	0.0984	0.1121
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1104	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.1847	0.1847
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0619	0.0619
Trichomonas vaginalis	esterase, putative	0.0037	0.0619	0.1234
Brugia malayi	Pre-SET motif family protein	0.0031	0.0476	0.0439
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.008	0.1551	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.008	0.1551	1
Schistosoma mansoni	hypothetical protein	0.0023	0.0311	0.0884
Schistosoma mansoni	lamin	0.0054	0.0984	0.2796
Echinococcus granulosus	peptidase Clp S14 family	0.0052	0.095	0.095
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0619	0.1759
Schistosoma mansoni	apoferritin-2	0.0009	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0963	0.0925
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1104	0.2208
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0619	0.3991
Onchocerca volvulus		0.0037	0.0619	0.0316
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0052	0.095	0.1899
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0168	0.0168
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0476	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0619	0.058
Schistosoma mansoni	cpg binding protein	0.0033	0.0527	0.1497
Brugia malayi	intermediate filament protein	0.0054	0.0984	0.0949
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.008	0.1551	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0932	0.4585
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0619	0.1238
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.008	0.1551	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0168	0.0129
Brugia malayi	RNA recognition motif domain containing protein	0.0126	0.2572	0.2543
Brugia malayi	beta-lactamase	0.0037	0.0619	0.0583
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0619	0.1759
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0619	0.058
Brugia malayi	Pre-SET motif family protein	0.0209	0.4384	0.4362
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0984	0.0949
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0437	0.0437
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0619	0.0583
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0476	0.1352
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.1391	0.395
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.1847	0.1815
Echinococcus granulosus	expressed protein	0.0009	0.0001	0.0001
Echinococcus multilocularis	lamin dm0	0.0054	0.0984	0.0984
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.1847	0.1847
Brugia malayi	hypothetical protein	0.0072	0.1391	0.1357
Schistosoma mansoni	ferritin	0.0009	0.0001	0.0002
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1104	0.712
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1104	0.3136
Echinococcus granulosus	lamin	0.0054	0.0984	0.0984
Echinococcus granulosus	lamin dm0	0.0054	0.0984	0.0984
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.1847	0.1813
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.5014	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0168	0.0477
Echinococcus multilocularis	geminin	0.017	0.3521	0.3521
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0619	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0619	0.058
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0156	0.3227	0.3199
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0948	0.0913
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1104	0.3136
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0932	1
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2572	0.7305
Schistosoma mansoni	hypothetical protein	0.017	0.3521	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.1122	0.6248
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0168	0.0127
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.1391	0.1391
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.008	0.1551	0.1551
Schistosoma mansoni	survival motor neuron protein	0.0095	0.1886	0.5356
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0126	0.2572	0.2541
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2572	0.7305
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0587	0.0548
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0168	0.0168
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1847	0.5245
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0932	0.4585
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0168	0.0168
Echinococcus multilocularis	expressed protein	0.0009	0.0001	0.0001
Brugia malayi	Probable ClpP-like protease	0.008	0.1551	0.1518
Schistosoma mansoni	ferritin	0.0009	0.0001	0.0002
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0619	0.1238
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0619	0.1238
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0488	0.0451
Echinococcus multilocularis	muscleblind protein 1	0.0156	0.3227	0.3227
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0984	0.0947
Brugia malayi	beta-lactamase family protein	0.0037	0.0619	0.0583
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0168	0.0127
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0476	0.1352
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0619	0.3991
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.1391	0.1391
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.1847	0.1847
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1104	0.6096
Onchocerca volvulus		0.0054	0.0984	0.1121
Brugia malayi	Muscleblind-like protein	0.0156	0.3227	0.3201
Schistosoma mansoni	hypothetical protein	0.0036	0.0587	0.1667
Schistosoma mansoni	hypothetical protein	0.0016	0.0168	0.0477
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.4384	0.436
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2572	0.7305
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.008	0.1551	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0619	0.1238
Toxoplasma gondii	ABC1 family protein	0.0037	0.0619	0.1853
Echinococcus multilocularis	lamin	0.0054	0.0984	0.0984
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.008	0.1551	0.5
Schistosoma mansoni	hypothetical protein	0.0016	0.0168	0.0477
Schistosoma mansoni	hypothetical protein	0.0016	0.0168	0.0477
Echinococcus multilocularis	survival motor neuron protein 1	0.0466	1	1
Schistosoma mansoni	ferritin	0.0009	0.0001	0.0002
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.008	0.1551	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0932	0.4585
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0619	0.058
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0619	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0932	0.0894
Onchocerca volvulus		0.0031	0.0488	0.0027
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.008	0.1551	0.1551
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0948	0.0913
Schistosoma mansoni	hypothetical protein	0.0095	0.1886	0.5356
Loa Loa (eye worm)	TAR-binding protein	0.0126	0.2572	0.2541
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0619	0.058
Brugia malayi	hypothetical protein	0.0051	0.0932	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0466	1	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0168	0.0129
Brugia malayi	TAR-binding protein	0.0126	0.2572	0.2543
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0375	0.0335
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0476	0.0476
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1847	0.5245
Echinococcus granulosus	tar DNA binding protein	0.0126	0.2572	0.2572
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0619	0.1234
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0619	0.3991
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0052	0.095	0.095
Schistosoma mansoni	ferritin	0.0009	0.0001	0.0002
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0932	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0168	0.0168
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0619	0.3991
Schistosoma mansoni	cpg binding protein	0.0033	0.0527	0.1497
Leishmania major	hypothetical protein, conserved	0.0051	0.0932	0.644
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0375	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0948	0.091
Entamoeba histolytica	hypothetical protein	0.0072	0.1391	0.5
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.008	0.1551	1
Schistosoma mansoni	hypothetical protein	0.0072	0.1391	0.395
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0168	0.0168
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0619	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0619	0.058
Onchocerca volvulus		0.0037	0.0619	0.0316
Schistosoma mansoni	cpg binding protein	0.0031	0.0488	0.1386
Loa Loa (eye worm)	RNA binding protein	0.0126	0.2572	0.2541
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0476	0.1352
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0984	0.2796
Echinococcus multilocularis	musashi	0.0054	0.0984	0.0984
Schistosoma mansoni	ferritin light chain	0.0009	0.0001	0.0002
Entamoeba histolytica	hypothetical protein	0.0072	0.1391	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0476	0.0436
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.2424	0.2392
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0932	0.4585
Brugia malayi	hypothetical protein	0.0033	0.0533	0.0496
Plasmodium vivax	SET domain protein, putative	0.0031	0.0476	0.0598
Echinococcus granulosus	muscleblind protein	0.0156	0.3227	0.3227
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0619	0.1238
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0476	0.0476
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.1847	0.1847
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0476	0.1352
Echinococcus granulosus	cpg binding protein	0.0033	0.0527	0.0527
Mycobacterium ulcerans	lipase LipD	0.0037	0.0619	0.3991
Echinococcus granulosus	survival motor neuron protein 1	0.0466	1	1
Entamoeba histolytica	hypothetical protein	0.0072	0.1391	0.5
Echinococcus multilocularis	cpg binding protein	0.0033	0.0527	0.0527
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0488	0.0448
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0619	0.1238
Entamoeba histolytica	hypothetical protein	0.0072	0.1391	0.5
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.008	0.1551	1
Schistosoma mansoni	lamin	0.0054	0.0984	0.2796
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0052	0.095	0.6123
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0042	0.0042
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1104	0.712
Echinococcus granulosus	GPCR family 2	0.0016	0.0168	0.0168
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0948	0.091
Schistosoma mansoni	ferritin light chain	0.0009	0.0001	0.0002
Schistosoma mansoni	hypothetical protein	0.017	0.3521	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0619	0.1234
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0353	0.0313
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0619	0.3991
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.1847	0.5245
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.2424	0.2392
Loa Loa (eye worm)	hypothetical protein	0.0156	0.3227	0.3199
Onchocerca volvulus		0.0238	0.5014	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0095	0.1886	0.1854
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0619	0.058
Onchocerca volvulus		0.0037	0.0619	0.0316
Brugia malayi	beta-lactamase family protein	0.0037	0.0619	0.0583
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0619	0.1238
Echinococcus multilocularis	tar DNA binding protein	0.0126	0.2572	0.2572
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1104	0.1104
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1104	0.712
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.008	0.1551	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0619	0.3991
Schistosoma mansoni	peptidase Clp (S14 family)	0.008	0.1551	0.4404
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0587	0.055
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0984	0.0947
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0932	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0984	0.0947
Brugia malayi	MH2 domain containing protein	0.012	0.2424	0.2394
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0438	0.04
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0407	0.2624
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0619	0.1234
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0619	0.1853
Echinococcus granulosus	geminin	0.017	0.3521	0.3521
Brugia malayi	RNA binding protein	0.0126	0.2572	0.2543
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1104	0.1104
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0375	0.0375
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0052	0.095	0.1899
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0619	0.1238
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0353	0.0313
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2572	0.7305
Schistosoma mansoni	tar DNA-binding protein	0.0126	0.2572	0.7305
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0619	0.1234
Echinococcus multilocularis	ferritin	0.0009	0.0001	0.0001
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.008	0.1551	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.008	0.1551	0.1515
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0042	0.0042
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0027	0.0407	0.2624
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0619	0.058
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.1276	0.3624
Echinococcus granulosus	intermediate filament protein	0.0054	0.0984	0.0984
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0237	0.4998	1
Schistosoma mansoni	apoferritin-2	0.0009	0.0001	0.0002
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0438	0.0398
Echinococcus multilocularis	muscleblind protein	0.0156	0.3227	0.3227
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0619	0.0619

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 904648