TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 470.58 | Formula: C26H35FN4O3
H donors: 1 H acceptors: 3 LogP: 4.7 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CC(Cn1cc(C(=O)N2CCN(CC2)c2ccc(cc2)F)c(=O)c(c1)C(=O)NCCC(C)C)C
InChi: 1S/C26H35FN4O3/c1-18(2)9-10-28-25(33)22-16-29(15-19(3)4)17-23(24(22)32)26(34)31-13-11-30(12-14-31)21-7-5-20(27)6-8-21/h5-8,16-19H,9-15H2,1-4H3,(H,28,33)
InChiKey: BCBYWOYROFNGBA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	thyroid hormone receptor alpha	0.0067	0.0049	0.0049
Echinococcus granulosus	activin receptor type	0.339	0.4527	0.4535
Onchocerca volvulus		0.0142	0.015	0.8061
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0002	0.0002
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.1277	0.168	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0142	0.015	0.015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0142	0.015	0.015
Loa Loa (eye worm)	nuclear hormone receptor	0.0067	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0041	0.0014	0.0014
Trypanosoma cruzi	hypothetical protein	0.009	0.008	0.0375
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0142	0.015	0.015
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.0045	0.0046
Brugia malayi	coiled-coil like protein 1	0.009	0.008	0.008
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0032	0.0002	0.0002
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0142	0.015	0.015
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0061	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0447	0.056	1
Schistosoma mansoni	thyroid hormone receptor	0.1914	0.2539	0.2542
Schistosoma mansoni	nuclear hormone receptor	0.0142	0.015	0.0149
Schistosoma mansoni	protein kinase	0.0044	0.0018	0.0016
Brugia malayi	steroid hormone receptor	0.0142	0.015	0.015
Giardia lamblia	Giardia trophozoite antigen GTA-1	0.009	0.008	0.5
Brugia malayi	tailless protein	0.0067	0.0049	0.0049
Schistosoma mansoni	tyrosine kinase	0.0036	0.0007	0.0005
Onchocerca volvulus	Tyrosine kinase homolog	0.0169	0.0186	1
Onchocerca volvulus		0.009	0.008	0.4249
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0065	0.0045	0.0046
Brugia malayi	hypothetical protein	0.0067	0.0049	0.0049
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.009	0.008	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.0045	0.0046
Echinococcus multilocularis	activin receptor type	0.339	0.4527	0.4535
Schistosoma mansoni	sex comb on midleg homolog	0.009	0.008	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Schistosoma mansoni	tyrosine kinase	0.0065	0.0045	0.0044
Entamoeba histolytica	protein kinase domain containing protein	0.0044	0.0018	0.4681
Schistosoma mansoni	nuclear hormone receptor	0.0067	0.0049	0.0047
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0067	0.0049	0.2553
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0065	0.0045	0.0046
Echinococcus multilocularis	c src tyrosine kinase	0.0036	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.009	0.008	0.008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0142	0.015	0.015
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0065	0.0045	0.0046
Echinococcus granulosus	pdz domain containing protein	0.009	0.008	0.008
Brugia malayi	hypothetical protein	0.2854	0.3805	0.3805
Brugia malayi	Sphingomyelin synthase-related 1	0.009	0.008	0.008
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0065	0.0045	0.0046
Schistosoma mansoni	RAR-like nuclear receptor	0.0142	0.015	0.0149
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0142	0.015	0.015
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.1277	0.168	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0142	0.015	0.015
Entamoeba histolytica	protein kinase, putative	0.0057	0.0036	1
Echinococcus multilocularis	histone acetyltransferase myst3	0.009	0.008	0.008
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0067	0.0049	0.0049
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0142	0.015	0.0149
Onchocerca volvulus	Bile acid receptor homolog	0.0142	0.015	0.8061
Trypanosoma brucei	SAM domain (Sterile alpha motif), putative	0.009	0.008	0.0375
Echinococcus granulosus	tyrosine protein kinase Blk	0.0061	0.0041	0.0041
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0075	0.006	0.006
Brugia malayi	nuclear hormone receptor	0.0142	0.015	0.015
Brugia malayi	SRC-1	0.0065	0.0045	0.0045
Brugia malayi	nuclear receptor NHR-67	0.0067	0.0049	0.0049
Echinococcus granulosus	FTZ F1 alpha	0.0142	0.015	0.015
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0057	0.0036	0.0036
Schistosoma mansoni	lip-related protein (liprin) alpha	0.009	0.008	0.0078
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0142	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Loa Loa (eye worm)	TK protein kinase	0.0061	0.0041	0.0041
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0142	0.015	0.015
Brugia malayi	Cell death protein 3 precursor	0.0041	0.0014	0.0014
Echinococcus granulosus	polyhomeotic proximal chromatin protein	0.009	0.008	0.008
Schistosoma mansoni	protein kinase	0.3374	0.4507	0.4514
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Brugia malayi	nuclear receptor RXR	0.0075	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0142	0.015	0.015
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.1277	0.168	0.168
Echinococcus granulosus	tyrosine protein kinase Srms	0.0032	0.0002	0.0002
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.1277	0.168	1
Brugia malayi	hypothetical protein	0.009	0.008	0.008
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0142	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0075	0.006	0.006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0142	0.015	0.015
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0032	0.0002	0.0002
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0061	0.0041	0.0041
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.009	0.008	0.008
Brugia malayi	nuclear receptor NHR-88	0.0142	0.015	0.015
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0075	0.006	0.0058
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0142	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 24	0.009	0.008	0.0375
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0067	0.0049	0.0049
Schistosoma mansoni	polyhomeotic	0.009	0.008	0.0078
Schistosoma mansoni	hypothetical protein	0.1772	0.2347	0.235
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0142	0.015	0.015
Loa Loa (eye worm)	TK/ABL protein kinase	0.0032	0.0002	0.0002
Echinococcus granulosus	tyrosine kinase	0.0032	0.0002	0.0002
Onchocerca volvulus		0.0067	0.0049	0.2553
Brugia malayi	Nuclear hormone receptor E75	0.0067	0.0049	0.0049
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0142	0.015	0.015
Brugia malayi	Liprin-alpha 2	0.009	0.008	0.008
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.1277	0.168	1
Echinococcus multilocularis	tyrosine kinase	0.0032	0.0002	0.0002
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0044	0.0018	0.0018
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0075	0.006	0.006
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0142	0.015	0.0149
Schistosoma mansoni	Protein aveugle	0.009	0.008	0.0078
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0142	0.015	0.015
Echinococcus granulosus	c src tyrosine kinase	0.0036	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0067	0.0049	0.0049
Brugia malayi	ecdysone receptor	0.0067	0.0049	0.0049
Brugia malayi	hypothetical protein	0.0075	0.006	0.006
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0142	0.015	0.015
Schistosoma mansoni	hypothetical protein	0.009	0.008	0.0078
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0179	0.0199	0.0199
Brugia malayi	protein-tyrosine kinase	0.0061	0.0041	0.0041
Echinococcus granulosus	tyrosine protein kinase HCK	0.0057	0.0036	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0002	0.0002
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.1772	0.2347	0.2351
Brugia malayi	SH2 domain containing protein	0.0032	0.0002	0.0002
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0067	0.0049	0.0049
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.009	0.008	0.008
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0036	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0075	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.009	0.008	0.008
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0067	0.0049	0.0047
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.7449	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0065	0.0045	0.0046
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.0045	0.0046
Schistosoma mansoni	caspase-7 (C14 family)	0.0041	0.0014	0.0012
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0067	0.0049	0.0049
Onchocerca volvulus		0.009	0.008	0.4249
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0002	0.0002
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0142	0.015	0.015
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0036	0.0007	0.0007
Echinococcus granulosus	nuclear receptor nhr 48	0.0067	0.0049	0.0049
Onchocerca volvulus	Cell death protein 3 homolog	0.0041	0.0014	0.065
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0032	0.0002	0.0002
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.009	0.008	0.008
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0142	0.015	0.015
Brugia malayi	bicaudal-C	0.009	0.008	0.008
Loa Loa (eye worm)	tnks protein	0.009	0.008	0.008
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0142	0.015	0.015
Plasmodium falciparum	tyrosine kinase-like protein, putative	0.0447	0.056	1
Echinococcus granulosus	caspase 2	0.0041	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0041	0.0014	0.0012
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0067	0.0049	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0002	0.0002
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0044	0.0018	0.0018
Brugia malayi	cask-interacting protein 2	0.009	0.008	0.008
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0065	0.0045	0.0046
Brugia malayi	nuclear hormone receptor	0.0067	0.0049	0.0049
Onchocerca volvulus		0.0041	0.0014	0.065
Echinococcus multilocularis	tyrosine protein kinase shark	0.0032	0.0002	0.0002
Schistosoma mansoni	nuclear receptor nhr-48	0.0067	0.0049	0.0047
Onchocerca volvulus		0.009	0.008	0.4249
Brugia malayi	nuclear receptor NHR-88	0.0067	0.0049	0.0049
Onchocerca volvulus		0.009	0.008	0.4249
Schistosoma mansoni	coup transcription factor	0.0142	0.015	0.0149
Brugia malayi	protein C17H12.11	0.2854	0.3805	0.3805
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0142	0.015	0.015
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0142	0.015	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0142	0.015	0.015
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0142	0.015	0.015
Echinococcus multilocularis	mitogen activated protein kinase 14	0.1277	0.168	0.1683
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0041	0.0014	0.0014
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0065	0.0045	0.0046
Schistosoma mansoni	nuclear receptor	0.0067	0.0049	0.0047
Echinococcus granulosus	tyrosine protein kinase shark	0.0032	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0075	0.006	0.006
Schistosoma mansoni	protein kinase	0.0044	0.0018	0.0016
Loa Loa (eye worm)	AIDA-1b	0.009	0.008	0.008
Brugia malayi	hypothetical protein	0.0032	0.0002	0.0002
Brugia malayi	Shank2E	0.009	0.008	0.008
Echinococcus multilocularis	thyroid hormone receptor alpha	0.1914	0.2539	0.2543
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0142	0.015	0.015
Echinococcus multilocularis	FTZ F1 alpha	0.0142	0.015	0.015
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.0045	0.0046
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0142	0.015	0.8061
Echinococcus multilocularis	liprin alpha 2	0.009	0.008	0.008
Brugia malayi	Steroid receptor seven-up type 2	0.0142	0.015	0.015
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0142	0.015	0.0149
Brugia malayi	P38 map kinase family protein 2	0.1277	0.168	0.168
Loa Loa (eye worm)	hypothetical protein	0.0142	0.015	0.015
Echinococcus granulosus	histone acetyltransferase myst3	0.009	0.008	0.008
Echinococcus granulosus	sphingomyelin synthase protein 1	0.009	0.008	0.008
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0067	0.0049	0.0049
Echinococcus multilocularis	mitogen activated protein kinase 11	0.1277	0.168	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Onchocerca volvulus	Protein ultraspiracle homolog	0.0142	0.015	0.8061
Echinococcus multilocularis	Sterile alpha motif SAM	0.009	0.008	0.008
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.1772	0.2347	0.2351
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0142	0.015	0.015
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0065	0.0045	0.0046
Echinococcus multilocularis	polyhomeotic protein 2	0.009	0.008	0.008
Schistosoma mansoni	Protein aveugle	0.009	0.008	0.0078
Onchocerca volvulus	Tankyrase homolog	0.009	0.008	0.4249
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0075	0.006	0.0058
Onchocerca volvulus		0.009	0.008	0.4249
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Echinococcus multilocularis	Sterile alpha motif type	0.009	0.008	0.008
Echinococcus multilocularis	pdz domain containing protein	0.009	0.008	0.008
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0067	0.0049	0.0049
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0067	0.0049	0.0049
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0142	0.015	0.015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0142	0.015	0.015
Schistosoma mansoni	phd finger protein	0.009	0.008	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0075	0.006	0.006
Brugia malayi	nuclear hormone receptor family member odr-7	0.0067	0.0049	0.0049
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0067	0.0049	0.2553
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0142	0.015	0.015
Trichomonas vaginalis	cgi-62, putative	0.009	0.008	0.5
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0075	0.006	0.006
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0061	0.0041	0.0041
Schistosoma mansoni	protein kinase	0.0044	0.0018	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Loa Loa (eye worm)	SRC-1	0.0065	0.0045	0.0045
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0032	0.0002	0.0002
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0065	0.0045	0.0046
Echinococcus granulosus	liprin alpha 2	0.009	0.008	0.008
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0142	0.015	0.015
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0002	0.0002
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0142	0.015	0.0149
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0142	0.015	0.015
Brugia malayi	ecdysteroid receptor	0.0142	0.015	0.015
Echinococcus granulosus	liprin alpha 2	0.009	0.008	0.008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0142	0.015	0.015
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Echinococcus multilocularis	mitogen activated protein kinase 14	0.1277	0.168	0.1683
Schistosoma mansoni	retinoic acid receptor RXR	0.0142	0.015	0.0149
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0036	0.0007	0.0007
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0032	0.0002	0.0002
Echinococcus multilocularis	polycomb protein SCMH1	0.009	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0075	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.009	0.008	0.008
Brugia malayi	Protein kinase domain containing protein	0.2869	0.3826	0.3826
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0447	0.056	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.008	0.008
Brugia malayi	AIDA-1b	0.009	0.008	0.008
Loa Loa (eye worm)	steroid hormone receptor	0.0142	0.015	0.015
Echinococcus granulosus	tyrosine kinase	0.0061	0.0041	0.0041
Onchocerca volvulus		0.0067	0.0049	0.2553
Loa Loa (eye worm)	hypothetical protein	0.0142	0.015	0.015
Brugia malayi	Nuclear hormone receptor-like 1	0.0075	0.006	0.006
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0067	0.0049	0.0049
Echinococcus granulosus	polycomb protein SCMH1	0.009	0.008	0.008
Echinococcus granulosus	tyrosine protein kinase Lyn	0.008	0.0066	0.0066
Schistosoma mansoni	hypothetical protein	0.009	0.008	0.0078
Echinococcus granulosus	ecdysone induced protein 78C	0.0142	0.015	0.015
Echinococcus multilocularis	TGF beta receptor type 1	0.7436	0.9982	1
Echinococcus multilocularis	polyhomeotic proximal chromatin protein	0.009	0.008	0.008
Echinococcus granulosus	apoptotic protease activating factor 1	0.0041	0.0014	0.0014
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0179	0.0199	0.0199
Brugia malayi	Tyrosine-protein kinase abl-1	0.0036	0.0007	0.0007
Trypanosoma cruzi	Kinesin-13 5, putative	0.009	0.008	0.0375
Schistosoma mansoni	tyrosine kinase	0.0065	0.0045	0.0044
Echinococcus multilocularis	mitogen activated protein kinase 11	0.1277	0.168	0.1683
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0142	0.015	0.015
Echinococcus multilocularis	ecdysone induced protein 78C	0.0142	0.015	0.015
Echinococcus granulosus	TGF-beta receptor type-1	0.7436	0.9982	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0142	0.015	0.015
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0067	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.009	0.008	0.008
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.008	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0067	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Brugia malayi	orphan nuclear receptor NR2E1	0.0067	0.0049	0.0049
Schistosoma mansoni	nuclear hormone receptor	0.0067	0.0049	0.0047
Loa Loa (eye worm)	DR-78	0.0067	0.0049	0.0049
Echinococcus multilocularis	liprin alpha 2	0.009	0.008	0.008
Echinococcus granulosus	mitogen activated protein kinase 14	0.1277	0.168	0.1683
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.2869	0.3826	0.3826
Echinococcus multilocularis	nuclear receptor nhr 48	0.0067	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.009	0.008	0.008
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0032	0.0002	0.0002
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0142	0.015	0.0149
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0142	0.015	0.015
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0065	0.0045	0.0046
Brugia malayi	SH2 domain containing protein	0.0032	0.0002	0.0002
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.3361	0.4489	0.4497
Loa Loa (eye worm)	hypothetical protein	0.2854	0.3805	0.3805
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0002	0.0002
Onchocerca volvulus		0.0138	0.0144	0.7734
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0142	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0014	0.0014
Trypanosoma cruzi	Kinesin-13 5, putative	0.009	0.008	0.0375
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0142	0.015	0.015
Schistosoma mansoni	protein kinase	0.7436	0.9982	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.008	0.008
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0142	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.009	0.008	0.008
Schistosoma mansoni	nuclear receptor	0.0067	0.0049	0.0047
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0065	0.0045	0.0046
Brugia malayi	hypothetical protein	0.009	0.008	0.008
Schistosoma mansoni	spingomyelin synthetase-related	0.009	0.008	0.0078
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0036	0.0007	0.0005
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0067	0.0049	0.0047
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0036	0.0036
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0067	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0142	0.015	0.015
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.009	0.008	0.008
Echinococcus granulosus	mitogen activated protein kinase 11	0.1277	0.168	0.1683
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0067	0.0049	0.0049
Schistosoma mansoni	sex comb on midleg homolog	0.009	0.008	0.0078
Echinococcus granulosus	Sterile alpha motif type	0.009	0.008	0.008
Echinococcus granulosus	polyhomeotic protein 2	0.009	0.008	0.008
Echinococcus granulosus	TGF beta receptor type 1	0.7436	0.9982	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0065	0.0045	0.0046
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0142	0.015	0.0149
Echinococcus multilocularis	caspase 2	0.0041	0.0014	0.0014
Brugia malayi	nuclear receptor RXR	0.0067	0.0049	0.0049
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0142	0.015	0.015
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Brugia malayi	conserved hypotetical protein	0.0067	0.0049	0.0049
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.009	0.008	0.0078
Giardia lamblia	Kinesin-13	0.009	0.008	0.5
Brugia malayi	hypothetical protein	0.0075	0.006	0.006
Onchocerca volvulus		0.009	0.008	0.4249
Schistosoma mansoni	thyroid hormone receptor	0.1914	0.2539	0.2542
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Brugia malayi	Nuclear hormone receptor-like 1	0.0075	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0142	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Brugia malayi	Nuclear hormone receptor E75	0.0067	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0049	0.0049
Schistosoma mansoni	tyrosine kinase	0.0034	0.0004	0.0002
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.2869	0.3826	0.3826
Schistosoma mansoni	zinc finger protein	0.0067	0.0049	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.0032	0.0002	0.0002
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.009	0.008	0.008
Schistosoma mansoni	tyrosine kinase	0.0036	0.0007	0.0005
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	0.0041	0.0041
Schistosoma mansoni	DNAj-like protein	0.009	0.008	0.0078
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0142	0.015	0.015
Echinococcus granulosus	Sterile alpha motif SAM	0.009	0.008	0.008
Onchocerca volvulus		0.009	0.008	0.4249

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 904819