Detailed information for compound 904865

Basic information

Technical information
  • TDR Targets ID: 904865
  • Name: 4-[(5-bromofuran-2-yl)methylidene]-2-(4-chlor ophenyl)-1,3-oxazol-5-one
  • MW: 352.567 | Formula: C14H7BrClNO3
  • H donors: 0 H acceptors: 1 LogP: 4.31 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1=NC(=Cc2ccc(o2)Br)C(=O)O1
  • InChi: 1S/C14H7BrClNO3/c15-12-6-5-10(19-12)7-11-14(18)20-13(17-11)8-1-3-9(16)4-2-8/h1-7H/b11-7-
  • InChiKey: ZCDZPOUCYPUMHQ-XFFZJAGNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4Z)-4-[(5-bromofuran-2-yl)methylidene]-2-(4-chlorophenyl)-1,3-oxazol-5-one
  • 4-[(5-bromo-2-furyl)methylene]-2-(4-chlorophenyl)oxazol-5-one
  • (4Z)-4-[(5-bromo-2-furyl)methylene]-2-(4-chlorophenyl)oxazol-5-one
  • 4-[(5-bromo-2-furyl)methylene]-2-(4-chlorophenyl)-5-oxazolone
  • (4Z)-4-[(5-bromo-2-furyl)methylene]-2-(4-chlorophenyl)-5-oxazolone
  • 4-(5-Bromo-furan-2-ylmethylene)-2-(4-chloro-phenyl)-4H-oxazol-5-one
  • BAS 00490256
  • ZINC04714181

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0201 0.2977 0.4392
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0558 0.0558
Entamoeba histolytica hypothetical protein 0.0035 0.0294 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0066 0.0793 0.751
Mycobacterium ulcerans polyketide synthase 0.0055 0.0616 0.5834
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0164 0.0141
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0053 0.0589 0.5576
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0164 0.0209
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0294 0.0678
Onchocerca volvulus Fatty acid synthase homolog 0.0099 0.133 0.2026
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0055 0.0616 0.5834
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0793 0.1928
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0066 0.0793 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.002 0.0053 0.0053
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0066 0.0793 0.1928
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0572 0.7124
Schistosoma mansoni tar DNA-binding protein 0.0265 0.4018 0.5939
Brugia malayi hypothetical protein 0.002 0.0053 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0572 0.7124
Echinococcus granulosus Smad4 0.0027 0.0164 0.0353
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0017 0.0006 0.0056
Brugia malayi MH2 domain containing protein 0.0027 0.0164 0.0164
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0044 0.0442 0.4188
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0793 1
Brugia malayi RNA recognition motif domain containing protein 0.0265 0.4018 0.4018
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0164 0.0141
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0023 0.5
Loa Loa (eye worm) acyl carrier protein 0.0025 0.0136 0.0113
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0019 0.0032 0.0306
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.003
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.041 0.6359 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0058 0.0671 0.6357
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0671 0.8419
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0106 0.0207
Schistosoma mansoni hypothetical protein 0.0434 0.6749 1
Loa Loa (eye worm) RNA binding protein 0.0265 0.4018 0.4004
Entamoeba histolytica hypothetical protein 0.0035 0.0294 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0058 0.0671 0.6337
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0201 0.2977 0.7395
Schistosoma mansoni regulator of G protein signaling 0.002 0.0053 0.0044
Mycobacterium leprae Probable polyketide synthase Pks1 0.0058 0.0671 0.6337
Brugia malayi DIX domain containing protein 0.002 0.0053 0.0053
Echinococcus granulosus GPCR family 2 0.0201 0.2977 0.7395
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0066 0.0793 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0793 1
Schistosoma mansoni smad1 5 8 and 0.0027 0.0164 0.0209
Loa Loa (eye worm) hypothetical protein 0.0201 0.2977 0.2961
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0023 0.0218
Loa Loa (eye worm) MH2 domain-containing protein 0.0397 0.6147 0.6138
Brugia malayi MH2 domain containing protein 0.0027 0.0164 0.0164
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0031 0.0232 0.2199
Loa Loa (eye worm) hypothetical protein 0.0052 0.0572 0.055
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.002 0.0053 0.0075
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0082 0.1056 1
Mycobacterium ulcerans fatty acid synthase Fas 0.0017 0.0006 0.0056
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0053 0.0075
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0058 0.0671 0.6357
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0793 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0066 0.0793 0.1928
Echinococcus granulosus Pleckstrin G protein interacting region 0.002 0.0053 0.0075
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.0616 0.5834
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.0616 0.5834
Echinococcus granulosus smad 0.0027 0.0164 0.0353
Toxoplasma gondii hypothetical protein 0.002 0.0053 0.0387
Onchocerca volvulus 0.0051 0.0558 0.08
Loa Loa (eye worm) TAR-binding protein 0.0265 0.4018 0.4004
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0053 0.0053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0201 0.2977 0.7395
Schistosoma mansoni smad 0.0027 0.0164 0.0209
Brugia malayi RNA binding protein 0.0265 0.4018 0.4018
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0036 0.0315 0.2981
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0023 0.5
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0066 0.0793 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0104 0.1413 0.1413
Loa Loa (eye worm) fatty acid synthase 0.0054 0.0604 0.0583
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0202
Loa Loa (eye worm) hypothetical protein 0.041 0.6359 0.635
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0294 0.0678
Mycobacterium ulcerans polyketide synthase 0.0058 0.0671 0.6357
Echinococcus granulosus segment polarity protein dishevelled 0.002 0.0053 0.0075
Schistosoma mansoni hypothetical protein 0.0201 0.2977 0.4392
Schistosoma mansoni hypothetical protein 0.0201 0.2977 0.4392
Brugia malayi Isocitrate dehydrogenase 0.0066 0.0793 0.0793
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0051 0.0558 0.528
Brugia malayi Latrophilin receptor protein 2 0.0201 0.2977 0.2977
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0164 0.0353
Loa Loa (eye worm) hypothetical protein 0.0434 0.6749 0.6742
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0055 0.0616 0.581
Schistosoma mansoni hypothetical protein 0.0023 0.0106 0.0123
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0045 0.0454 0.4299
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0176 0.1987
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0044 0.0442 0.4188
Loa Loa (eye worm) hypothetical protein 0.0092 0.1221 0.1201
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0572 0.7124
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0164 0.0353
Brugia malayi hypothetical protein 0.0052 0.0572 0.0572
Schistosoma mansoni hypothetical protein 0.0201 0.2977 0.4392
Schistosoma mansoni hypothetical protein 0.0035 0.0294 0.0403
Schistosoma mansoni dep domain containing protein 0.002 0.0053 0.0044
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0082 0.1056 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0053 0.003
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.004 0.0366 0.3461
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0053 0.0075
Brugia malayi latrophilin 2 splice variant baaae 0.0434 0.6749 0.6749
Schistosoma mansoni dishevelled 0.002 0.0053 0.0044
Mycobacterium leprae Polyketide synthase Pks13 0.0082 0.1056 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0294 0.0403
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0036 0.0304 0.3643
Schistosoma mansoni tar DNA-binding protein 0.0265 0.4018 0.5939
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0055 0.0616 0.5834
Loa Loa (eye worm) isocitrate dehydrogenase 0.0066 0.0793 0.0772
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0164 0.0353
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.0616 0.5834
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0053 0.0075
Echinococcus multilocularis GPCR, family 2 0.0201 0.2977 0.7395
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0066 0.0793 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.003
Schistosoma mansoni smad1 5 8 and 0.0027 0.0164 0.0209
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.003
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0106 0.0207
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0201 0.2977 0.7395
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0572 0.7124
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.5
Schistosoma mansoni smad1 5 8 and 0.0027 0.0164 0.0209
Schistosoma mansoni Smad4 0.0027 0.0164 0.0209
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0058 0.0671 0.6337
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0793 0.1928
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0265 0.4018 0.4004
Echinococcus multilocularis segment polarity protein dishevelled 0.002 0.0053 0.0075
Loa Loa (eye worm) DIX domain-containing protein 0.002 0.0053 0.003
Toxoplasma gondii type I fatty acid synthase, putative 0.0039 0.036 0.4372
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0055 0.0616 0.5834
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0046 0.0468 0.4398
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0058 0.0671 0.6357
Brugia malayi hypothetical protein 0.0035 0.0294 0.0294
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0023 0.0023
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0022 0.0086 0.0817
Brugia malayi isocitrate dehydrogenase 0.0066 0.0793 0.0793
Mycobacterium ulcerans polyketide synthase Pks13 0.0082 0.1056 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0572 0.7124
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0058 0.0671 0.6357
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0044 0.0442 0.4155
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0201 0.2977 0.7395
Echinococcus multilocularis tar DNA binding protein 0.0265 0.4018 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0058 0.0671 0.6357
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.002 0.0053 0.0044
Brugia malayi MH2 domain containing protein 0.0397 0.6147 0.6147
Echinococcus multilocularis smad 0.0027 0.0164 0.0353
Echinococcus granulosus segment polarity protein dishevelled 0.002 0.0053 0.0075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0793 0.1928
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0201 0.2977 0.2977
Schistosoma mansoni tar DNA-binding protein 0.0265 0.4018 0.5939
Echinococcus multilocularis Smad4 0.0027 0.0164 0.0353
Onchocerca volvulus 0.0096 0.1275 0.1938
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.002 0.0053 0.0053
Loa Loa (eye worm) transcription factor SMAD2 0.0397 0.6147 0.6138
Mycobacterium tuberculosis Probable thioesterase TesA 0.0046 0.0468 0.443
Brugia malayi MH1 domain containing protein 0.0027 0.0164 0.0164
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0055 0.0616 0.5834
Schistosoma mansoni tar DNA-binding protein 0.0265 0.4018 0.5939
Schistosoma mansoni dishevelled 0.002 0.0053 0.0044
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0793 1
Loa Loa (eye worm) hypothetical protein 0.0635 1 1
Mycobacterium ulcerans thioesterase 0.0046 0.0468 0.443
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0053 0.0589 0.5576
Leishmania major hypothetical protein, conserved 0.0052 0.0572 0.7124
Brugia malayi hypothetical protein 0.002 0.0053 0.0053
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0053 0.0075
Brugia malayi TAR-binding protein 0.0265 0.4018 0.4018
Loa Loa (eye worm) Smad1 0.0027 0.0164 0.0141
Brugia malayi Smad1 0.0027 0.0164 0.0164
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0051 0.0558 0.0536
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0635 1 1
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0053 0.0044
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0572 0.7124
Mycobacterium ulcerans polyketide synthase Pks9 0.0036 0.0315 0.2981
Brugia malayi Calcitonin receptor-like protein seb-1 0.0635 1 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0036 0.0315 0.2941
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0066 0.0793 0.1928
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0572 0.7124
Entamoeba histolytica hypothetical protein 0.0035 0.0294 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0164 0.0353
Brugia malayi hypothetical protein 0.0034 0.0272 0.0272
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0023 0.5
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0793 1
Echinococcus multilocularis segment polarity protein dishevelled 0.002 0.0053 0.0075
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0055 0.0616 0.0616
Loa Loa (eye worm) latrophilin receptor protein 2 0.0201 0.2977 0.2961
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0055 0.0616 0.581
Brugia malayi N-terminal motif family protein 0.041 0.6359 0.6359
Echinococcus granulosus tar DNA binding protein 0.0265 0.4018 1
Mycobacterium ulcerans thioesterase TesA 0.0046 0.0468 0.443
Schistosoma mansoni tar DNA-binding protein 0.0265 0.4018 0.5939
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0023 0.0218
Entamoeba histolytica hypothetical protein 0.0035 0.0294 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0066 0.0793 0.1145
Brugia malayi MH1 domain containing protein 0.0027 0.0164 0.0164

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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